CCDC85B | ENSG00000175602 | NCBI 11007

Details for: CCDC85B

Associated with

Adherens junction
(GO:0005912)
Cell differentiation
(GO:0030154)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Delta-catenin binding
(GO:0070097)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

megakaryocyte-erythroid progenitor cell CL0000050

CSI 45.81

rCSI 41.37%

PRS 18.11
common myeloid progenitor CL0000049

CSI 39.25

rCSI 31.74%

PRS 20.16
OFF-bipolar cell CL0000750

CSI 38.2

rCSI 52.23%

PRS 31.34
granulocyte monocyte progenitor cell CL0000557

CSI 36.22

rCSI 31.36%

PRS 22.65
fallopian tube secretory epithelial cell CL4030006

CSI 35.55

rCSI 34.22%

PRS 20.83
endothelial cell of artery CL1000413

CSI 34.48

rCSI 50.52%

PRS 69.09
pulmonary artery endothelial cell CL1001568

CSI 32.29

rCSI 43.94%

PRS 30.45
cardiac muscle cell CL0000746

CSI 32.01

rCSI 45.93%

PRS 15.64
blood vessel endothelial cell CL0000071

CSI 30.51

rCSI 63.31%

PRS 20.07
capillary endothelial cell CL0002144

CSI 25.24

rCSI 46.27%

PRS 59.12
promyelocyte CL0000836

CSI 24.62

rCSI 35.5%

PRS 28.11
cerebral cortex endothelial cell CL1001602

CSI 24.58

rCSI 42.51%

PRS 15.36
vein endothelial cell CL0002543

CSI 19.64

rCSI 53.59%

PRS 63.18
lung endothelial cell CL1001567

CSI 19.49

rCSI 45.45%

PRS 45.88
hematopoietic stem cell CL0000037

CSI 19.32

rCSI 12.84%

PRS 24.07
retinal ganglion cell CL0000740

CSI 18.9

rCSI 41.75%

PRS 14.44
microcirculation associated smooth muscle cell CL0008035

CSI 18.65

rCSI 54%

PRS 22.77
stromal cell of ovary CL0002132

CSI 17.28

rCSI 47.47%

PRS 32.97
activated type II NK T cell CL0000931

CSI 17.19

rCSI 19.35%

PRS 31.99
common dendritic progenitor CL0001029

CSI 16.48

rCSI 20.68%

PRS 26.04
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 15.61

rCSI 11.71%

PRS 53.55
endothelial cell of placenta CL0009092

CSI 15.04

rCSI 74.16%

PRS 27.26
secretory cell CL0000151

CSI 12.81

rCSI 13.37%

PRS 20.63
large pre-B-II cell CL0000957

CSI 12.63

rCSI 36.07%

PRS 33.83
retinal cone cell CL0000573

CSI 12.52

rCSI 20.16%

PRS 15.42
natural T-regulatory cell CL0000903

CSI 12.51

rCSI 23.7%

PRS 51.86
vein endothelial cell of respiratory system CL4033008

CSI 12.34

rCSI 84.73%

PRS 38.68
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 12.17

rCSI 55.83%

PRS 46.61
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 11.38

rCSI 7.99%

PRS 46.31
mammary gland epithelial cell CL0002327

CSI 11.08

rCSI 38.87%

PRS 34.75
plasmablast CL0000980

CSI 11.02

rCSI 8.67%

PRS 24.26
pancreatic stellate cell CL0002410

CSI 10.75

rCSI 62.52%

PRS 29.79
extravillous trophoblast CL0008036

CSI 10.72

rCSI 13.26%

PRS 17.65
endothelial cell of uterus CL0009095

CSI 10.68

rCSI 78.08%

PRS 52
amacrine cell CL0000561

CSI 9.05

rCSI 26.24%

PRS 15.45
perivascular cell CL4033054

CSI 8.92

rCSI 12.2%

PRS 22.81
mature B cell CL0000785

CSI 8.46

rCSI 7.36%

PRS 25.2
endothelial cell of venule CL1000414

CSI 8.36

rCSI 74.17%

PRS 63.31
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 8.23

rCSI 14.09%

PRS 38.57
vasa recta ascending limb cell CL1001131

CSI 8.12

rCSI 36.73%

PRS 59.02
retinal pigment epithelial cell CL0002586

CSI 8.08

rCSI 16.05%

PRS 21.2
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 7.85

rCSI 4.64%

PRS 28.08
vasa recta descending limb cell CL1001285

CSI 7.67

rCSI 61.25%

PRS 64.75
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 7.59

rCSI 9.54%

PRS 68.83
fibroblast of lung CL0002553

CSI 7.43

rCSI 6.91%

PRS 20.19
collagen secreting cell CL0000667

CSI 7.26

rCSI 41.66%

PRS 57.13
memory B cell CL0000787

CSI 7.08

rCSI 6.99%

PRS 64.26
group 2 innate lymphoid cell CL0001069

CSI 6.48

rCSI 35.05%

PRS 61.08
alveolar adventitial fibroblast CL4028006

CSI 6.48

rCSI 10.23%

PRS 20.23
promonocyte CL0000559

CSI 6.31

rCSI 10.81%

PRS 27.14
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 6.1

rCSI 8.39%

PRS 39.22
activated CD8-positive, alpha-beta T cell CL0000906

CSI 5.63

rCSI 5.54%

PRS 52.61
transitional stage B cell CL0000818

CSI 5.63

rCSI 18.43%

PRS 51.63
ionocyte CL0005006

CSI 5.6

rCSI 6%

PRS 18.53
bronchus fibroblast of lung CL2000093

CSI 5.32

rCSI 4.33%

PRS 21.25
B cell CL0000236

CSI 5.2

rCSI 6.96%

PRS 63.3
myofibroblast cell CL0000186

CSI 5.1

rCSI 7.06%

PRS 28.42
activated CD4-positive, alpha-beta T cell CL0000896

CSI 4.96

rCSI 4.59%

PRS 35.96
retinal blood vessel endothelial cell CL0002585

CSI 4.91

rCSI 7.84%

PRS 22.09
mature alpha-beta T cell CL0000791

CSI 4.87

rCSI 17.62%

PRS 34.24
type EC enteroendocrine cell CL0000577

CSI 4.8

rCSI 17.03%

PRS 32.6
intraepithelial lymphocyte CL0002496

CSI 4.79

rCSI 13.04%

PRS 65.42
pulmonary capillary endothelial cell CL4028001

CSI 4.75

rCSI 9.06%

PRS 31.75
basal cell of prostate epithelium CL0002341

CSI 4.73

rCSI 13.7%

PRS 42.4
T follicular helper cell CL0002038

CSI 4.72

rCSI 3.53%

PRS 31.69
megakaryocyte CL0000556

CSI 4.67

rCSI 20.28%

PRS 34.82
mononuclear phagocyte CL0000113

CSI 4.65

rCSI 10.24%

PRS 22.72
cerebral cortex neuron CL0010012

CSI 4.58

rCSI 18.66%

PRS 20.61
CD8-positive, alpha-beta thymocyte CL0000811

CSI 4.55

rCSI 7.09%

PRS 45.16
bronchiolar smooth muscle cell CL4033017

CSI 4.49

rCSI 67.43%

PRS 54.13
elicited macrophage CL0000861

CSI 4.39

rCSI 4.03%

PRS 23.51
hematopoietic precursor cell CL0008001

CSI 4.38

rCSI 4.51%

PRS 32.63
thymocyte CL0000893

CSI 4.38

rCSI 15.56%

PRS 58.18
ciliated epithelial cell CL0000067

CSI 4.3

rCSI 3.78%

PRS 14.65
T-helper 1 cell CL0000545

CSI 4.29

rCSI 7.75%

PRS 48.02
retinal bipolar neuron CL0000748

CSI 4.28

rCSI 8.02%

PRS 14.49
naive T cell CL0000898

CSI 4.24

rCSI 2.95%

PRS 28.37
lung microvascular endothelial cell CL2000016

CSI 4.24

rCSI 81.81%

PRS 54.19
mast cell CL0000097

CSI 4.2

rCSI 9.06%

PRS 66.24
lamp5 GABAergic cortical interneuron CL4023011

CSI 4.11

rCSI 6.9%

PRS 11.9
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 4.1

rCSI 3.73%

PRS 30.64
CD14-low, CD16-positive monocyte CL0002396

CSI 4.05

rCSI 3.12%

PRS 18.63
myeloid lineage restricted progenitor cell CL0000839

CSI 3.98

rCSI 20.53%

PRS 38.97
enteric smooth muscle cell CL0002504

CSI 3.95

rCSI 5.63%

PRS 22.67
pre-conventional dendritic cell CL0002010

CSI 3.94

rCSI 52.1%

PRS 56.95
early lymphoid progenitor CL0000936

CSI 3.89

rCSI 3.42%

PRS 23.12
dendritic cell CL0000451

CSI 3.86

rCSI 4.76%

PRS 54.95
pancreatic D cell CL0000173

CSI 3.85

rCSI 3.78%

PRS 21.77
myeloid leukocyte CL0000766

CSI 3.83

rCSI 3.53%

PRS 20.83
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 3.74

rCSI 8.95%

PRS 13.08
alveolar type 1 fibroblast cell CL4028004

CSI 3.69

rCSI 4.04%

PRS 22.75
respiratory suprabasal cell CL4033048

CSI 3.68

rCSI 4.72%

PRS 23.28
endothelial cell of lymphatic vessel CL0002138

CSI 3.58

rCSI 7.09%

PRS 52.94
neural crest cell CL0011012

CSI 3.55

rCSI 2.81%

PRS 13.83
CD4-positive helper T cell CL0000492

CSI 3.5

rCSI 2.65%

PRS 27.6
CD14-positive monocyte CL0001054

CSI 3.5

rCSI 4.36%

PRS 28.4
double negative thymocyte CL0002489

CSI 3.48

rCSI 2.42%

PRS 24.04
eosinophil CL0000771

CSI 3.45

rCSI 22.66%

PRS 49.64
epithelial cell CL0000066

CSI 3.43

rCSI 5.26%

PRS 27.58
non-classical monocyte CL0000875

CSI 3.43

rCSI 5.49%

PRS 53.22

ciliated cell CL0000064

CSI -2.6

rCSI -4.3%

PRS 20.4%
alpha-beta T cell CL0000789

CSI -0.3

rCSI -0.4%

PRS 27.5%
neural cell CL0002319

CSI -0.2

rCSI -0.8%

PRS 26.6%
enteroendocrine cell of colon CL0009042

CSI 0.0

rCSI -0.2%

PRS 49.4%
mesenchymal stem cell CL0000134

CSI 0.1

rCSI 0.8%

PRS 35.7%
odontoblast CL0000060

CSI 0.1

rCSI 1.9%

PRS 67.3%
granulocyte CL0000094

CSI 0.1

rCSI 0.2%

PRS 25.9%
GABAergic amacrine cell CL4030027

CSI 0.1

rCSI 0.4%

PRS 17.6%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.7%

PRS 29.4%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 0.1

rCSI 0.3%

PRS 74.6%
B-2 B cell CL0000822

CSI 0.1

rCSI 3.1%

PRS 74.5%
Merkel cell CL0000242

CSI 0.2

rCSI 4.7%

PRS 86.3%
erythroid progenitor cell CL0000038

CSI 0.2

rCSI 1.2%

PRS 30.2%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.3

rCSI 1.5%

PRS 43.8%
myoepithelial cell CL0000185

CSI 0.3

rCSI 0.7%

PRS 24.9%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.3

rCSI 3.7%

PRS 65.5%
myelocyte CL0002193

CSI 0.3

rCSI 2.2%

PRS 57.4%
transit amplifying cell of colon CL0009011

CSI 0.3

rCSI 0.4%

PRS 23.3%
tracheobronchial serous cell CL0019001

CSI 0.4

rCSI 1.8%

PRS 36.8%
sst GABAergic cortical interneuron CL4023017

CSI 0.4

rCSI 0.5%

PRS 12.5%
deuterosomal cell CL4033044

CSI 0.4

rCSI 1.4%

PRS 31.9%
pancreatic ductal cell CL0002079

CSI 0.4

rCSI 0.8%

PRS 20.6%
follicular dendritic cell CL0000442

CSI 0.4

rCSI 7.1%

PRS 71.3%
blood vessel smooth muscle cell CL0019018

CSI 0.5

rCSI 3.8%

PRS 20.2%
transit amplifying cell of small intestine CL0009012

CSI 0.5

rCSI 2.2%

PRS 36.9%
podocyte CL0000653

CSI 0.5

rCSI 2.2%

PRS 19.8%
epithelial cell of urethra CL1000296

CSI 0.5

rCSI 13.0%

PRS 53.8%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.6

rCSI 1.1%

PRS 33.3%
transit amplifying cell CL0009010

CSI 0.6

rCSI 0.9%

PRS 32.5%
respiratory basal cell CL0002633

CSI 0.6

rCSI 0.6%

PRS 23.7%
helper T cell CL0000912

CSI 0.6

rCSI 0.9%

PRS 27.7%
follicular B cell CL0000843

CSI 0.6

rCSI 2.2%

PRS 60.7%
astrocyte of the cerebral cortex CL0002605

CSI 0.7

rCSI 1.5%

PRS 12.4%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.7

rCSI 1.6%

PRS 11.7%
smooth muscle cell of prostate CL1000487

CSI 0.7

rCSI 4.0%

PRS 60.6%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.7

rCSI 2.8%

PRS 32.9%
lung ciliated cell CL1000271

CSI 0.7

rCSI 0.9%

PRS 14.8%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.7

rCSI 2.3%

PRS 13.7%
mucus secreting cell CL0000319

CSI 0.8

rCSI 1.2%

PRS 25.9%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.8

rCSI 2.8%

PRS 11.2%
myeloid dendritic cell, human CL0001057

CSI 0.8

rCSI 4.4%

PRS 57.6%
pancreatic PP cell CL0002275

CSI 0.8

rCSI 3.1%

PRS 34.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.8

rCSI 1.4%

PRS 11.9%
luminal epithelial cell of mammary gland CL0002326

CSI 0.8

rCSI 1.4%

PRS 30.6%
Hofbauer cell CL3000001

CSI 0.8

rCSI 1.5%

PRS 25.4%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.8

rCSI 6.0%

PRS 52.4%
choroid plexus epithelial cell CL0000706

CSI 0.8

rCSI 1.3%

PRS 15.5%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.8

rCSI 1.5%

PRS 42.3%
rod bipolar cell CL0000751

CSI 0.8

rCSI 1.5%

PRS 16.7%
dendritic cell, human CL0001056

CSI 0.8

rCSI 1.3%

PRS 24.0%
uterine smooth muscle cell CL0002601

CSI 0.8

rCSI 5.4%

PRS 72.3%
late pro-B cell CL0002048

CSI 0.9

rCSI 2.2%

PRS 53.3%
immature B cell CL0000816

CSI 0.9

rCSI 0.7%

PRS 29.7%
VIP GABAergic cortical interneuron CL4023016

CSI 1.0

rCSI 1.2%

PRS 11.7%
erythroid lineage cell CL0000764

CSI 1.0

rCSI 6.2%

PRS 43.4%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 1.0

rCSI 2.1%

PRS 14.2%
IgG plasma cell CL0000985

CSI 1.0

rCSI 1.2%

PRS 34.7%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.0

rCSI 3.8%

PRS 12.2%
intestinal epithelial cell CL0002563

CSI 1.0

rCSI 1.1%

PRS 21.0%
B-1 B cell CL0000819

CSI 1.1

rCSI 27.4%

PRS 72.4%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.1

rCSI 2.9%

PRS 49.7%
tendon cell CL0000388

CSI 1.1

rCSI 2.9%

PRS 49.8%
glioblast CL0000030

CSI 1.2

rCSI 1.8%

PRS 17.3%
retinal rod cell CL0000604

CSI 1.2

rCSI 2.0%

PRS 19.8%
Cajal-Retzius cell CL0000695

CSI 1.2

rCSI 9.2%

PRS 39.9%
erythrocyte CL0000232

CSI 1.2

rCSI 2.7%

PRS 26.9%
hair follicular keratinocyte CL2000092

CSI 1.2

rCSI 21.1%

PRS 66.4%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.2

rCSI 1.4%

PRS 17.6%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.2

rCSI 3.8%

PRS 30.1%
Bergmann glial cell CL0000644

CSI 1.3

rCSI 1.7%

PRS 20.0%
alternatively activated macrophage CL0000890

CSI 1.3

rCSI 1.6%

PRS 30.8%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.3

rCSI 7.6%

PRS 12.4%
muscle cell CL0000187

CSI 1.3

rCSI 2.7%

PRS 43.1%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.3

rCSI 1.3%

PRS 31.2%
neural progenitor cell CL0011020

CSI 1.3

rCSI 5.8%

PRS 18.9%
Kupffer cell CL0000091

CSI 1.4

rCSI 3.1%

PRS 19.6%
hematopoietic multipotent progenitor cell CL0000837

CSI 1.4

rCSI 3.3%

PRS 31.9%
radial glial cell CL0000681

CSI 1.4

rCSI 1.9%

PRS 20.6%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.4

rCSI 7.0%

PRS 26.5%
ON-bipolar cell CL0000749

CSI 1.4

rCSI 2.1%

PRS 24.0%
epithelial cell of lung CL0000082

CSI 1.4

rCSI 1.2%

PRS 19.1%
club cell CL0000158

CSI 1.4

rCSI 2.1%

PRS 23.1%
regulatory T cell CL0000815

CSI 1.4

rCSI 1.6%

PRS 52.3%
pulmonary ionocyte CL0017000

CSI 1.4

rCSI 1.7%

PRS 25.2%
chondrocyte CL0000138

CSI 1.4

rCSI 2.3%

PRS 17.0%
foveolar cell of stomach CL0002179

CSI 1.5

rCSI 3.1%

PRS 32.0%
class switched memory B cell CL0000972

CSI 1.5

rCSI 1.1%

PRS 33.7%
lung macrophage CL1001603

CSI 1.5

rCSI 3.4%

PRS 23.3%
multi-ciliated epithelial cell CL0005012

CSI 1.5

rCSI 1.5%

PRS 17.2%
germinal center B cell CL0000844

CSI 1.6

rCSI 4.6%

PRS 45.3%
pluripotent stem cell CL0002248

CSI 1.6

rCSI 46.7%

PRS 43.7%
colon macrophage CL0009038

CSI 1.6

rCSI 7.3%

PRS 41.3%
T-helper 17 cell CL0000899

CSI 1.6

rCSI 1.3%

PRS 35.6%
myeloid dendritic cell CL0000782

CSI 1.6

rCSI 2.3%

PRS 30.2%
intestine goblet cell CL0019031

CSI 1.6

rCSI 1.4%

PRS 20.3%
acinar cell CL0000622

CSI 1.6

rCSI 2.4%

PRS 26.4%
inhibitory interneuron CL0000498

CSI 1.6

rCSI 3.8%

PRS 16.3%
intermediate monocyte CL0002393

CSI 1.6

rCSI 2.5%

PRS 20.3%
common lymphoid progenitor CL0000051

CSI 1.7

rCSI 2.2%

PRS 38.1%
glutamatergic neuron CL0000679

CSI 1.7

rCSI 3.5%

PRS 20.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Coiled-coil domain containing 85B, encoded by the [CCDC85B](/details-gene/11007) gene, is a protein implicated in the regulation of fundamental cellular processes including cell differentiation, transcriptional control, and the maintenance of cell-cell adhesion. **Overall**, expression data reveals its significant role in hematopoietic progenitor populations, such as [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050) and [common myeloid progenitors](/details-cell/CL0000049), as well as in various types of endothelial cells, including those of the arteries and capillaries. Functional annotations link [CCDC85B](/details-gene/11007) to the negative regulation of cell growth and transcription, with its protein product localizing to the cytoplasm, nucleus, and adherens junctions. Research suggests it can act as a transcriptional repressor ([Link](https://doi.org/10.1016/j.yexmp.2006.07.008)) and may modulate beta-catenin activity ([Link](https://doi.org/10.1038/sj.onc.1210801)), underscoring its potential importance in development and tissue homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [CCDC85B](/details-gene/11007) highlights its prominent role in two major biological systems: hematopoiesis and the vascular endothelium. Within the hematopoietic system, [CCDC85B](/details-gene/11007) shows high significance in several progenitor cell types, including [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050) (CSI: 45.81), [common myeloid progenitors](/details-cell/CL0000049) (CSI: 39.25), [granulocyte monocyte progenitor cells](/details-cell/CL0000557) (CSI: 36.22), and [hematopoietic stem cells](/details-cell/CL0000037) (CSI: 19.32). This pattern suggests a crucial function in the early stages of blood cell development and lineage commitment, preceding terminal differentiation. Concurrently, [CCDC85B](/details-gene/11007) is a key gene across a broad range of endothelial cells. It is highly significant in [endothelial cells of arteries](/details-cell/CL1000413) (CSI: 34.48), [pulmonary artery endothelial cells](/details-cell/CL1001568) (CSI: 32.29), general [blood vessel endothelial cells](/details-cell/CL0000071) (CSI: 30.51), and [capillary endothelial cells](/details-cell/CL0002144) (CSI: 25.24). This consistent, high-level expression across different vascular beds points to a conserved role in maintaining endothelial cell function or identity. The gene also demonstrates high significance in other specialized cell types such as [cardiac muscle cells](/details-cell/CL0000746) and [fallopian tube secretory epithelial cells](/details-cell/CL4030006). Conversely, the low to negligible significance of [CCDC85B](/details-gene/11007) in terminally differentiated cell types like [ciliated cells](/details-cell/CL0000064), [alpha-beta T cells](/details-cell/CL0000789), and [neural cells](/details-cell/CL0002319) reinforces its specific role in progenitor and select structural cell populations, rather than as a ubiquitously expressed housekeeping gene. ## Pathways and Molecular Function The functions of [CCDC85B](/details-gene/11007) are consistent with its observed cellular expression patterns. Its involvement in 'Cell differentiation ([GO:0030154](https://www.ebi.ac.uk/QuickGO/term/GO:0030154))' aligns directly with its high significance in multiple hematopoietic progenitor populations, where precise control over differentiation programs is paramount. The gene's role as a 'Negative regulation of dna-templated transcription ([GO:0045892](https://www.ebi.ac.uk/QuickGO/term/GO:0045892))' and 'Negative regulation of cell growth ([GO:0030308](https://www.ebi.ac.uk/QuickGO/term/GO:0030308))' suggests it may act as a brake on proliferation or specific gene expression programs, guiding cells toward specific fates. This is supported by studies demonstrating its function as a transcriptional repressor ([Link](https://doi.org/10.1016/j.yexmp.2006.07.008)) and a suppressor of beta-catenin activity ([Link](https://doi.org/10.1038/sj.onc.1210801)). Furthermore, its localization to the 'Adherens junction ([GO:0005912](https://www.ebi.ac.uk/QuickGO/term/GO:0005912))' and its known 'Delta-catenin binding ([GO:0070097](https://www.ebi.ac.uk/QuickGO/term/GO:0070097))' function provide a molecular basis for its importance in endothelial cells ([Link](https://doi.org/10.1091/mbc.e13-08-0492)). Adherens junctions are critical for maintaining the integrity of the vascular barrier, suggesting [CCDC85B](/details-gene/11007) is a key component of this structural and signaling hub in the endothelium. Its additional role in the 'Negative regulation of fat cell differentiation ([GO:0045599](https://www.ebi.ac.uk/QuickGO/term/GO:0045599))' has also been noted experimentally ([Link](https://doi.org/10.1371/journal.pone.0038130)). ## Research Directions The widespread significance of [CCDC85B](/details-gene/11007) in both hematopoietic progenitors and the vascular endothelium suggests it is a critical node in coordinating cell fate and tissue structure. Future research should focus on dissecting its precise molecular mechanisms in these contexts. **Proposed Hypotheses:** 1. Given its high expression in early hematopoietic progenitors and its function as a transcriptional repressor, [CCDC85B](/details-gene/11007) acts as a key gatekeeper in hematopoiesis, suppressing lineage-inappropriate genes to ensure proper commitment to either the myeloid or megakaryocyte-erythroid pathways. 2. Based on its localization to adherens junctions and high expression across diverse endothelial populations, [CCDC85B](/details-gene/11007) is essential for the stabilization of vascular endothelial cell-cell junctions, thereby regulating barrier permeability in response to physiological or pathological cues like inflammation. **Experimental Approach for Hypothesis 2:** To test the role of [CCDC85B](/details-gene/11007) in endothelial barrier function, a series of in vitro experiments could be performed. Human Umbilical Vein Endothelial Cells (HUVECs) could be cultured on transwell inserts to form a monolayer. The [CCDC85B](/details-gene/11007) gene would be knocked down using siRNA or knocked out using CRISPR-Cas9. The impact on barrier integrity would be quantified by measuring transendothelial electrical resistance (TEER) and the passage of fluorescently-labeled dextran across the monolayer, both at baseline and after challenge with an inflammatory cytokine like TNF-alpha. Furthermore, immunofluorescence microscopy could be used to assess changes in the organization and localization of key adherens junction proteins, such as VE-cadherin and p120-catenin, at cell-cell contacts. **Therapeutic Potential:** As an intracellular protein involved in fundamental processes like hematopoiesis and vascular integrity, [CCDC85B](/details-gene/11007) presents a challenging therapeutic target. Systemic inhibition could lead to significant toxicity, including impaired blood cell production or compromised vascular barrier function. However, if [CCDC85B](/details-gene/11007) were found to be aberrantly overexpressed in specific pathologies, such as in tumor-associated endothelial cells to promote angiogenesis, a highly targeted delivery of an inhibitor (e.g., via lipid nanoparticles) could be a viable strategy. The therapeutic approach would likely involve inhibition, aiming to disrupt its function in a disease-specific context, rather than activation.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Coiled-coil domain-containing protein 85B

Genular Protein ID: 4269942852

Symbol: CC85B_HUMAN

Name: Coiled-coil domain-containing protein 85B

UniProtKB Accession Codes:

Q15834 B2R598 Q96HA0

Database IDs:

Citations:

PubMed ID: 8810253

Title: A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution.

PubMed ID: 8810253

DOI: 10.1126/science.274.5284.90

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17014843

Title: DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.

PubMed ID: 17014843

DOI: 10.1016/j.yexmp.2006.07.008

PubMed ID: 17873903

Title: Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner.

PubMed ID: 17873903

DOI: 10.1038/sj.onc.1210801

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25009281

Title: DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

PubMed ID: 25009281

DOI: 10.1091/mbc.e13-08-0492

Sequence Information:

Length: 202
Mass: 22091
Checksum: EA92D1B712A54047
Sequence:

MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN RQLQGHLGEI 
RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL FGTQASRAVR EDLGGCWQKL 
AELEGRQEEL LRENLALKEL CLALGEEWGP RGGPSGAGGS GAGPAPELAL PPCGPRDLGD 
GSSSTGSVGS PDQLPLACSP DD

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Stomach UBERON0000945
	Substantia nigra pars compacta UBERON0001965
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: CCDC85B

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. PubMed ID: 8810253

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. PubMed ID: 17014843

Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. PubMed ID: 17873903

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PubMed ID: 22666460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. PubMed ID: 25009281