Details for: CCDC85B

Gene ID: 11007

Symbol: CCDC85B

Ensembl ID: ENSG00000175602

Description: coiled-coil domain containing 85B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.83
    Marker Score: 5,647
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.82
    Marker Score: 7,171
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.62
    Marker Score: 5,523
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.61
    Marker Score: 3,773
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.49
    Marker Score: 24,638
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.49
    Marker Score: 3,002
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.38
    Marker Score: 10,249
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.36
    Marker Score: 4,220
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.35
    Marker Score: 2,610
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.34
    Marker Score: 14,933
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.33
    Marker Score: 1,163
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3
    Marker Score: 78,133
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.29
    Marker Score: 1,974
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.29
    Marker Score: 2,465
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.29
    Marker Score: 2,159
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.28
    Marker Score: 7,185
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.27
    Marker Score: 2,140
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.26
    Marker Score: 1,290
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.22
    Marker Score: 4,506
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.17
    Marker Score: 5,982
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.15
    Marker Score: 18,903
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24,207
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.12
    Marker Score: 3,079
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.1
    Marker Score: 1,884
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.08
    Marker Score: 8,519
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.08
    Marker Score: 3,514
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.06
    Marker Score: 8,818
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.02
    Marker Score: 2,971
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2
    Marker Score: 864
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.99
    Marker Score: 1,696
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.99
    Marker Score: 5,805
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.99
    Marker Score: 1,744
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.97
    Marker Score: 1,778
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.95
    Marker Score: 5,480
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.94
    Marker Score: 657
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.93
    Marker Score: 684
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.92
    Marker Score: 101,422
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.91
    Marker Score: 19,329
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.89
    Marker Score: 1,374
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.88
    Marker Score: 1,594
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.88
    Marker Score: 582
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.87
    Marker Score: 4,567
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.87
    Marker Score: 4,899
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.84
    Marker Score: 3,210
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.84
    Marker Score: 1,330
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.83
    Marker Score: 1,322
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.82
    Marker Score: 102,037
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.82
    Marker Score: 387
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.82
    Marker Score: 398
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.81
    Marker Score: 1,938
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.79
    Marker Score: 1,049
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.79
    Marker Score: 1,271
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.78
    Marker Score: 1,455
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.77
    Marker Score: 429
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.76
    Marker Score: 11,477
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.75
    Marker Score: 1,650
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1,326
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.74
    Marker Score: 2,857
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.74
    Marker Score: 4,240
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.73
    Marker Score: 1,016
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.72
    Marker Score: 412
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.72
    Marker Score: 1,250
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.71
    Marker Score: 346
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.71
    Marker Score: 548
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.7
    Marker Score: 1,336
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.69
    Marker Score: 2,399
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.68
    Marker Score: 653
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.68
    Marker Score: 475
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.67
    Marker Score: 1,496
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.67
    Marker Score: 551
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.66
    Marker Score: 1,558
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.66
    Marker Score: 8,146
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.65
    Marker Score: 57,293
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.64
    Marker Score: 42,129
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.64
    Marker Score: 1,383
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.64
    Marker Score: 393
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.63
    Marker Score: 3,070
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.63
    Marker Score: 679
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.63
    Marker Score: 1,193
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.63
    Marker Score: 594
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.63
    Marker Score: 836
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.62
    Marker Score: 1,635
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.62
    Marker Score: 1,041
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.61
    Marker Score: 1,626
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.6
    Marker Score: 1,745
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.6
    Marker Score: 964
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.6
    Marker Score: 560
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.59
    Marker Score: 1,045
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.59
    Marker Score: 418
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.59
    Marker Score: 1,002
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.58
    Marker Score: 547
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.58
    Marker Score: 1,703
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.58
    Marker Score: 5,850
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.57
    Marker Score: 1,766
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.57
    Marker Score: 652
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.57
    Marker Score: 352
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.56
    Marker Score: 2,159
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.56
    Marker Score: 552
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.56
    Marker Score: 708
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.55
    Marker Score: 356

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Coiled-coil domain structure**: CCDC85B contains a coiled-coil domain, which is a characteristic feature of many coiled-coil domain containing proteins. This domain is crucial for the formation of heterotrimeric complexes and the regulation of cell signaling pathways. 2. **Cellular localization**: CCDC85B is expressed in various cell types, including endothelial cells, T cells, and neurons, suggesting its involvement in cell-cell interactions and immune responses. 3. **Regulation of cell growth and differentiation**: CCDC85B is involved in the regulation of cell growth and differentiation, as evidenced by its involvement in the negative regulation of cell growth and fat cell differentiation. 4. **Protein-protein interactions**: CCDC85B interacts with other proteins, including delta-catenin and CCDC85A, to regulate cell signaling pathways. **Pathways and Functions:** 1. **Adherens junction**: CCDC85B is involved in the regulation of adherens junctions, which are critical for cell-cell interactions and tissue structure. 2. **Cell differentiation**: CCDC85B regulates cell differentiation, particularly in the context of fat cell differentiation and T cell development. 3. **Negative regulation of cell growth**: CCDC85B inhibits cell growth, suggesting its role as a tumor suppressor gene. 4. **Negative regulation of DNA-templated transcription**: CCDC85B regulates DNA-templated transcription, which is essential for gene expression and cellular differentiation. 5. **Cytoplasm and nucleus**: CCDC85B is localized to both the cytoplasm and nucleus, suggesting its involvement in both cytoplasmic and nuclear signaling pathways. **Clinical Significance:** 1. **Cancer**: CCDC85B's role as a tumor suppressor gene suggests its potential involvement in cancer development and progression. 2. **Immune response**: CCDC85B's expression in T cells and neurons suggests its involvement in immune responses and neurological disorders. 3. **Endothelial dysfunction**: CCDC85B's role in regulating adherens junctions and cell growth suggests its potential involvement in endothelial dysfunction and cardiovascular disease. 4. **Neurological disorders**: CCDC85B's expression in neurons suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CCDC85B is a novel regulator of cell growth, differentiation, and immune response, with significant implications for our understanding of cellular biology and disease. Further research is necessary to elucidate the mechanisms by which CCDC85B regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 4269942852

Symbol: CC85B_HUMAN

Name: Coiled-coil domain-containing protein 85B

UniProtKB Accession Codes:

Q15834 B2R598 Q96HA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8810253

Title: A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution.

PubMed ID: 8810253

DOI: 10.1126/science.274.5284.90

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17014843

Title: DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.

PubMed ID: 17014843

DOI: 10.1016/j.yexmp.2006.07.008

PubMed ID: 17873903

Title: Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner.

PubMed ID: 17873903

DOI: 10.1038/sj.onc.1210801

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25009281

Title: DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

PubMed ID: 25009281

DOI: 10.1091/mbc.e13-08-0492

Sequence Information:

  • Length: 202
  • Mass: 22091
  • Checksum: EA92D1B712A54047
  • Sequence:
    • MEAEAGGLEE LTDEEMAALG KEELVRRLRR EEAARLAALV QRGRLMQEVN RQLQGHLGEI 
RELKQLNRRL QAENRELRDL CCFLDSERQR GRRAARQWQL FGTQASRAVR EDLGGCWQKL 
AELEGRQEEL LRENLALKEL CLALGEEWGP RGGPSGAGGS GAGPAPELAL PPCGPRDLGD 
GSSSTGSVGS PDQLPLACSP DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.