Details for: IL24

Gene ID: 11009

Symbol: IL24

Ensembl ID: ENSG00000162892

Description: interleukin 24

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 4.49
    Marker Score: 5550
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7556
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.05
    Marker Score: 2656
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1395
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.84
    Marker Score: 846
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.83
    Marker Score: 186
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.76
    Marker Score: 1017
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.64
    Marker Score: 1132
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1214
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8039
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 432
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 652
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 203
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.3
    Marker Score: 218
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.25
    Marker Score: 1227
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.21
    Marker Score: 208
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.19
    Marker Score: 10126
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.18
    Marker Score: 253
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 191
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 82
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 255
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.15
    Marker Score: 189
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.13
    Marker Score: 69
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 122.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 262
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.12
    Marker Score: 796
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.12
    Marker Score: 76
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1
    Marker Score: 308
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 87
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 106
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.08
    Marker Score: 261
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 146.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 32

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Other Information

**Key characteristics:** * IL-24 is a cytokine that is involved in the regulation of cell proliferation, migration, and survival. * It is a pro-apoptotic cytokine that is expressed in response to a variety of stimuli, including cell death, inflammation, and infection. * IL-24 signaling is mediated by the IL-24 receptor, which is expressed on a variety of cell types. * It has been shown to have both pro- and anti-apoptotic effects depending on the context. **Pathways and functions:** * IL-24 signaling is involved in the regulation of cell proliferation in a variety of immune cells. * In lymphoid cells, IL-24 signaling promotes the proliferation and survival of naive B cells. * In myeloid cells, IL-24 signaling promotes the survival and migration of myeloid progenitor cells. * In tumor cells, IL-24 signaling can promote cell proliferation and survival. **Clinical significance:** * IL-24 is a potential therapeutic target for a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. * Studies have shown that IL-24 can be used to inhibit cancer growth and metastasis. * IL-24 is currently being investigated as a potential treatment for autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. **Additional information:** * The gene encoding IL-24 is located on chromosome 1. * It is a member of the interleukin-20 family of cytokines. * IL-24 is produced by a variety of cell types, including macrophages, dendritic cells, and tumor cells. * It is a pleiotropic cytokine that has both pro- and anti-apoptotic effects.

Genular Protein ID: 1205876804

Symbol: IL24_HUMAN

Name: Interleukin-24

UniProtKB Accession Codes:

Q13007 Q2YHE5 Q53XZ7 Q5YLN8 Q96DB0 Q96KG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 5 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8545104

Title: Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.

PubMed ID: 8545104

PubMed ID: 11704829

Title: Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.

PubMed ID: 11704829

DOI: 10.1038/sj.onc.1204897

PubMed ID: 15304100

Title: Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma.

PubMed ID: 15304100

DOI: 10.1111/j.0022-202x.2004.23321.x

PubMed ID: 16313301

Title: Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.

PubMed ID: 16313301

DOI: 10.1111/j.1744-313x.2005.00540.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9826712

Title: The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.

PubMed ID: 9826712

DOI: 10.1073/pnas.95.24.14400

PubMed ID: 11706020

Title: Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

PubMed ID: 11706020

DOI: 10.1074/jbc.m106043200

PubMed ID: 23078624

Title: Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24.

PubMed ID: 23078624

DOI: 10.1089/jir.2012.0055

PubMed ID: 25168428

Title: Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors.

PubMed ID: 25168428

DOI: 10.1016/j.taap.2014.08.019

PubMed ID: 27687232

Title: MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication.

PubMed ID: 27687232

DOI: 10.1007/s12275-016-6383-2

PubMed ID: 30111632

Title: Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2.

PubMed ID: 30111632

DOI: 10.4049/jimmunol.1800726

Sequence Information:

  • Length: 206
  • Mass: 23825
  • Checksum: CB8135083EAB8DDD
  • Sequence:
    • MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ GQEFHFGPCQ 
VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV 
FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL 
DVEAALTKAL GEVDILLTWM QKFYKL

Genular Protein ID: 4107508327

Symbol: A0A7R8C2Y5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7R8C2Y5

Database IDs:

ARBA 2 AlphaFoldDB 1 CTD 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 NCBI Taxonomy 1 PRINTS 1 PROSITE 1 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 207
  • Mass: 23912
  • Checksum: 17687A467B9CB551
  • Sequence:
    • MNFQQRLQSL WTLASRPFCP PLLATASQMQ MVVLPCLGFT LLLWSQVSGA QGQEFHFGPC 
QVKGVVPQKL WEAFWAVKDT MQAQDNITSA RLLQQEVLQN VSDAESCYLV HTLLEFYLKT 
VFKNYHNRTV EVRTLKSFST LANNFVLIVS QLQPSQENEM FSIRDSAHRR FLLFRRAFKQ 
LDVEAALTKA LGEVDILLTW MQKFYKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.