Details for: CHAD

Gene ID: 1101

Symbol: CHAD

Ensembl ID: ENSG00000136457

Description: chondroadherin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.36
    Marker Score: 1771
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.54
    Marker Score: 3193
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.39
    Marker Score: 579.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.97
    Marker Score: 2740
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 376.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 505
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2898.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1602
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.67
    Marker Score: 513
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.63
    Marker Score: 283
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.57
    Marker Score: 308
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 594
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.49
    Marker Score: 207
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.49
    Marker Score: 286
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 213
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.36
    Marker Score: 103
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.35
    Marker Score: 164.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.35
    Marker Score: 331
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.34
    Marker Score: 190
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.34
    Marker Score: 3385
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.32
    Marker Score: 1349
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 175
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.29
    Marker Score: 58
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4395
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1673
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.25
    Marker Score: 453
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.25
    Marker Score: 298
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 442
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 366
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 280
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.21
    Marker Score: 289
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 187
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2
    Marker Score: 789
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2
    Marker Score: 204
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.2
    Marker Score: 369
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 242
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 115
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 41
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.18
    Marker Score: 2381
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.16
    Marker Score: 138
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.15
    Marker Score: 315
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.15
    Marker Score: 299.5
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.14
    Marker Score: 200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.14
    Marker Score: 260
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 155
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.12
    Marker Score: 164
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 207.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.12
    Marker Score: 713
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 353
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.11
    Marker Score: 189

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Other Information

**Key characteristics:** * CHAD is a transmembrane protein with a molecular weight of approximately 180 kDa. * It is expressed in the extracellular matrix, where it helps to hold cells together and form tissue structures. * CHAD is a key regulator of bone development and homeostasis. * It is expressed in high levels in hematopoietic stem cells and kidney cells, where it is involved in the formation of blood and kidney tissue, respectively. * It is also expressed in the gut, where it plays a role in the development of the intestinal epithelium. **Pathways and functions:** * CHAD is a key regulator of bone development. It is expressed in the developing bones and is essential for the formation of cartilage and bone tissue. * It also plays a role in bone remodeling, where it is expressed in the osteoblasts and osteocytes that are responsible for the formation and resorption of bone. * CHAD is also involved in the regulation of the immune system. It is expressed in a variety of immune cells, including hematopoietic stem cells, macrophages, and dendritic cells. * In hematopoietic stem cells, CHAD is essential for the survival and differentiation of these cells into blood cells. * In macrophages and dendritic cells, CHAD is involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the CHAD gene have been linked to a number of human diseases, including osteoporosis, rheumatoid arthritis, and cancer. * These mutations can disrupt the normal function of CHAD, leading to the formation of bone defects and other problems. * Therefore, CHAD is a promising target for the treatment of these diseases.

Genular Protein ID: 2631195385

Symbol: CHAD_HUMAN

Name: Chondroadherin

UniProtKB Accession Codes:

O15335 A8K812 Q6GTU0 Q96RJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344663

Title: The structure and chromosome location of the human chondroadherin gene (CHAD).

PubMed ID: 9344663

DOI: 10.1006/geno.1997.4951

PubMed ID: 11445564

Title: Association of chondroadherin with collagen type II.

PubMed ID: 11445564

DOI: 10.1074/jbc.m101680200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 40476
  • Checksum: CF24D2B5A5DFCF0C
  • Sequence:
    • MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS EKTKLLNLQR 
NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ LIYLYLSHND IRVLRAGAFD 
DLTELTYLYL DHNKVTELPR GLLSPLVNLF ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE 
NALSSLQPGA LDDVENLAKF HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ 
SFGRYLETLW LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN 
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT KRSKKAGRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.