Details for: CHAD

Gene ID: 1101

Symbol: CHAD

Ensembl ID: ENSG00000136457

Description: chondroadherin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1942
    Cell Significance Index: 227.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0916
    Cell Significance Index: 29.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.0527
    Cell Significance Index: -2.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9029
    Cell Significance Index: -1.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7478
    Cell Significance Index: 73.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6853
    Cell Significance Index: 618.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5865
    Cell Significance Index: 12.4900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5382
    Cell Significance Index: 2.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4934
    Cell Significance Index: 12.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4129
    Cell Significance Index: 44.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3927
    Cell Significance Index: 63.8700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3692
    Cell Significance Index: 4.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3598
    Cell Significance Index: 71.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3255
    Cell Significance Index: 19.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2927
    Cell Significance Index: 2.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2439
    Cell Significance Index: 16.8700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2395
    Cell Significance Index: 2.4700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2022
    Cell Significance Index: 1.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1876
    Cell Significance Index: 3.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1693
    Cell Significance Index: 5.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1556
    Cell Significance Index: 3.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1552
    Cell Significance Index: 2.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1514
    Cell Significance Index: 27.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1442
    Cell Significance Index: 6.5400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1426
    Cell Significance Index: 2.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1406
    Cell Significance Index: 10.4800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1183
    Cell Significance Index: 1.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1163
    Cell Significance Index: 1.2600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1152
    Cell Significance Index: 1.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0989
    Cell Significance Index: 2.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0753
    Cell Significance Index: 1.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0657
    Cell Significance Index: 0.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0637
    Cell Significance Index: 9.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0583
    Cell Significance Index: 2.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0505
    Cell Significance Index: 6.2100
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.0370
    Cell Significance Index: 0.3400
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.0314
    Cell Significance Index: 0.2100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0256
    Cell Significance Index: 0.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0239
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0195
    Cell Significance Index: 36.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0194
    Cell Significance Index: 1.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0174
    Cell Significance Index: 23.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0144
    Cell Significance Index: 22.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0110
    Cell Significance Index: 2.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0110
    Cell Significance Index: 20.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0106
    Cell Significance Index: 0.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0042
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0037
    Cell Significance Index: 0.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0032
    Cell Significance Index: 0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0021
    Cell Significance Index: 1.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0016
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0027
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0042
    Cell Significance Index: -2.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0081
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0123
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0146
    Cell Significance Index: -1.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0162
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0163
    Cell Significance Index: -1.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0181
    Cell Significance Index: -2.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0189
    Cell Significance Index: -2.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0214
    Cell Significance Index: -2.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0227
    Cell Significance Index: -2.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0301
    Cell Significance Index: -0.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0323
    Cell Significance Index: -2.1800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0354
    Cell Significance Index: -0.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0380
    Cell Significance Index: -2.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0386
    Cell Significance Index: -2.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0392
    Cell Significance Index: -1.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0410
    Cell Significance Index: -0.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0451
    Cell Significance Index: -2.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0461
    Cell Significance Index: -1.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0488
    Cell Significance Index: -3.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0494
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0503
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0551
    Cell Significance Index: -0.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0556
    Cell Significance Index: -1.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0564
    Cell Significance Index: -2.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0564
    Cell Significance Index: -1.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0582
    Cell Significance Index: -1.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0588
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0650
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0661
    Cell Significance Index: -1.8000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0675
    Cell Significance Index: -1.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0688
    Cell Significance Index: -1.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0692
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0692
    Cell Significance Index: -1.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0696
    Cell Significance Index: -1.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0706
    Cell Significance Index: -2.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chondroadherin**: The CHAD gene encodes a protein called chondroadherin, which is a member of the adherin family of proteins. 2. **Bone Development**: CHAD is significantly involved in bone development, particularly in regulating bone trabecula formation. 3. **Immune Regulation**: CHAD has been found to be expressed in various immune cells, including hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, and granulocyte monocyte progenitor cells. 4. **Tissue-Specific Expression**: CHAD is expressed in various tissues, including the kidney, intestinal crypts, and cerebral cortex. **Pathways and Functions:** 1. **Bone Development**: CHAD plays a crucial role in regulating bone trabecula formation, which is essential for maintaining bone density and preventing bone-related disorders. 2. **Immune Regulation**: CHAD has been found to regulate immune responses by modulating the activity of immune cells, such as hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, and granulocyte monocyte progenitor cells. 3. **Extracellular Matrix**: CHAD is involved in regulating the extracellular matrix, which is essential for maintaining tissue structure and function. 4. **Negative Regulation**: CHAD has a negative regulatory effect on bone trabecula formation, which helps to prevent excessive bone resorption. **Clinical Significance:** 1. **Bone Disorders**: CHAD has been implicated in various bone disorders, including osteoporosis and bone cancer. 2. **Immune-Related Disorders**: CHAD has been found to be associated with immune-related disorders, such as autoimmune diseases and cancer. 3. **Cancer Therapy**: CHAD has been identified as a potential target for cancer therapy, particularly in treating bone-related cancers. 4. **Regenerative Medicine**: CHAD has the potential to be used in regenerative medicine to promote bone healing and tissue repair. In conclusion, the CHAD gene plays a crucial role in regulating bone development and immune regulation. Further studies are needed to fully understand the mechanisms by which CHAD regulates bone trabecula formation and immune responses. However, the clinical significance of CHAD is evident, and it has the potential to be used in the treatment of various bone and immune-related disorders.

Genular Protein ID: 2631195385

Symbol: CHAD_HUMAN

Name: Chondroadherin

UniProtKB Accession Codes:

O15335 A8K812 Q6GTU0 Q96RJ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344663

Title: The structure and chromosome location of the human chondroadherin gene (CHAD).

PubMed ID: 9344663

DOI: 10.1006/geno.1997.4951

PubMed ID: 11445564

Title: Association of chondroadherin with collagen type II.

PubMed ID: 11445564

DOI: 10.1074/jbc.m101680200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 40476
  • Checksum: CF24D2B5A5DFCF0C
  • Sequence:
    • MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS EKTKLLNLQR 
NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ LIYLYLSHND IRVLRAGAFD 
DLTELTYLYL DHNKVTELPR GLLSPLVNLF ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE 
NALSSLQPGA LDDVENLAKF HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ 
SFGRYLETLW LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN 
PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT KRSKKAGRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.