Details for: GLIPR1

Gene ID: 11010

Symbol: GLIPR1

Ensembl ID: ENSG00000139278

Description: GLI pathogenesis related 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.85
    Marker Score: 159,221
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.58
    Marker Score: 2,950
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.48
    Marker Score: 4,836
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.41
    Marker Score: 28,030
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.33
    Marker Score: 5,814
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.26
    Marker Score: 6,498
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.19
    Marker Score: 5,342
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9,302
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.1
    Marker Score: 650
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.1
    Marker Score: 2,096
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.01
    Marker Score: 2,051
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.89
    Marker Score: 4,889
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.87
    Marker Score: 2,074
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.86
    Marker Score: 18,413
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.86
    Marker Score: 20,919
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.85
    Marker Score: 5,203
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.85
    Marker Score: 4,471
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.85
    Marker Score: 755
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.84
    Marker Score: 5,797
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.83
    Marker Score: 1,072
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.83
    Marker Score: 8,979
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.81
    Marker Score: 997
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.73
    Marker Score: 7,404
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.65
    Marker Score: 710
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.64
    Marker Score: 818
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.6
    Marker Score: 1,156
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.58
    Marker Score: 814
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.53
    Marker Score: 1,112
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.5
    Marker Score: 1,314
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.49
    Marker Score: 1,080
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.48
    Marker Score: 845
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.46
    Marker Score: 1,005
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.45
    Marker Score: 2,835
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.43
    Marker Score: 8,676
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.42
    Marker Score: 5,821
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.42
    Marker Score: 36,298
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.41
    Marker Score: 1,698
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.4
    Marker Score: 2,066
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.4
    Marker Score: 581
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.34
    Marker Score: 671
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.34
    Marker Score: 1,194
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.34
    Marker Score: 379
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.33
    Marker Score: 1,241
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.32
    Marker Score: 1,821
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.32
    Marker Score: 8,452
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.32
    Marker Score: 2,301
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.28
    Marker Score: 3,732
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.28
    Marker Score: 965
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.27
    Marker Score: 548
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.27
    Marker Score: 1,135
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.24
    Marker Score: 1,712
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.24
    Marker Score: 1,195
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.23
    Marker Score: 1,038
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.23
    Marker Score: 276
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.21
    Marker Score: 782
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2
    Marker Score: 812
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.2
    Marker Score: 4,965
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.19
    Marker Score: 686
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.19
    Marker Score: 62,931
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.18
    Marker Score: 1,001
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.18
    Marker Score: 295
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.18
    Marker Score: 801
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.17
    Marker Score: 270
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.17
    Marker Score: 858
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.15
    Marker Score: 1,276
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.15
    Marker Score: 498
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.15
    Marker Score: 407
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.14
    Marker Score: 2,390
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.14
    Marker Score: 562
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.14
    Marker Score: 566
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.13
    Marker Score: 249
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.13
    Marker Score: 696
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.13
    Marker Score: 1,062
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.13
    Marker Score: 2,657
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.12
    Marker Score: 550
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.12
    Marker Score: 1,355
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4,700
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.08
    Marker Score: 351
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.08
    Marker Score: 327
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.07
    Marker Score: 1,053
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.07
    Marker Score: 710
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.06
    Marker Score: 367
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.05
    Marker Score: 2,356
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.04
    Marker Score: 758
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.03
    Marker Score: 256
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.02
    Marker Score: 673
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.02
    Marker Score: 256
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.02
    Marker Score: 866
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.01
    Marker Score: 350
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.01
    Marker Score: 10,260
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.01
    Marker Score: 556
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.01
    Marker Score: 590
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1
    Marker Score: 633
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,656
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1
    Marker Score: 1,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,880
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.99
    Marker Score: 194
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.98
    Marker Score: 1,062
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.98
    Marker Score: 2,399
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in Immune Cells:** GLIPR1 is significantly expressed in various immune cells, including CD14-positive monocytes, lung macrophages, and CD16-positive monocytes. This suggests that GLIPR1 plays a crucial role in regulating the function of these cells. 2. **Regulation of Lipid Metabolism:** GLIPR1 is involved in the regulation of lipid metabolism, particularly in the activation of PPARα, a key regulator of lipid metabolism. This interaction highlights the importance of GLIPR1 in modulating lipid metabolism in various cell types. 3. **Protein Binding:** GLIPR1 interacts with various proteins, including PPARα, which suggests that it may play a role in regulating the activity of these proteins. **Pathways and Functions:** 1. **Immune Response:** GLIPR1 is involved in the regulation of immune responses, particularly in the activation of neutrophils and the production of inflammatory mediators. 2. **Lipid Metabolism:** GLIPR1 regulates lipid metabolism by interacting with PPARα, which is a key regulator of lipid metabolism. This interaction highlights the importance of GLIPR1 in modulating lipid metabolism in various cell types. 3. **Neutrophil Degranulation:** GLIPR1 is involved in the regulation of neutrophil degranulation, which is a key process in the immune response. **Clinical Significance:** 1. **Inflammatory Disorders:** GLIPR1's role in regulating immune responses and lipid metabolism makes it a potential target for the treatment of inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 2. **Cancer:** GLIPR1's interaction with PPARα suggests that it may play a role in regulating lipid metabolism in cancer cells, which could have implications for the development of cancer therapies. 3. **Neurological Disorders:** GLIPR1's expression in retinal cone cells and basal cells of prostate epithelium suggests that it may play a role in regulating lipid metabolism in the central nervous system, which could have implications for the treatment of neurological disorders, such as Alzheimer's disease. In conclusion, GLIPR1 is a gene that plays a crucial role in regulating immune responses and lipid metabolism. Its interaction with PPARα highlights the importance of GLIPR1 in modulating lipid metabolism in various cell types. Further research is needed to fully understand the role of GLIPR1 in the immune system and lipid metabolism, but its potential as a therapeutic target for inflammatory disorders and cancer makes it an exciting area of study.

Genular Protein ID: 3378790380

Symbol: GLIP1_HUMAN

Name: Glioma pathogenesis-related protein 1

UniProtKB Accession Codes:

P48060 A7YET6 F8VUC2 Q15409 Q969K2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7607567

Title: The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.

PubMed ID: 7607567

DOI: 10.1016/0378-1119(95)00061-a

PubMed ID: 8973356

Title: RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin.

PubMed ID: 8973356

DOI: 10.1016/s0378-1119(96)00431-3

PubMed ID: 17825796

Title: Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.

PubMed ID: 17825796

DOI: 10.1016/j.bbrc.2007.08.138

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9482873

Title: Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.

PubMed ID: 9482873

DOI: 10.1073/pnas.95.5.2262

Sequence Information:

  • Length: 266
  • Mass: 30366
  • Checksum: C0466C085EFB2B7A
  • Sequence:
    • MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW 
DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE 
IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN 
YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV 
NSVILILSVI ITILVQHKYP NLVLLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.