Details for: TLK2
Associated with
Other Information
Genular Protein ID: 1919602307
Symbol: TLK2_HUMAN
Name: Serine/threonine-protein kinase tousled-like 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9427565
Title: cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.
PubMed ID: 9427565
PubMed ID: 10523312
Title: Mammalian homologues of the plant tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.
PubMed ID: 10523312
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9662073
Title: From mosquito to man: identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues.
PubMed ID: 9662073
DOI: 10.1007/bf02258367
PubMed ID: 10455159
Title: Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.
PubMed ID: 10455159
PubMed ID: 11470414
Title: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.
PubMed ID: 11470414
PubMed ID: 12660173
Title: Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
PubMed ID: 12660173
DOI: 10.1093/emboj/cdg151
PubMed ID: 12955071
Title: Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
PubMed ID: 12955071
PubMed ID: 16484223
Title: FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.
PubMed ID: 16484223
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20016786
Title: Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.
PubMed ID: 20016786
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22354037
Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
PubMed ID: 22354037
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29955062
Title: Molecular basis of Tousled-Like Kinase 2 activation.
PubMed ID: 29955062
PubMed ID: 35136069
Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
PubMed ID: 35136069
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 21572417
Title: Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations.
PubMed ID: 21572417
DOI: 10.1038/ng.835
PubMed ID: 27479843
Title: Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.
PubMed ID: 27479843
DOI: 10.1038/nn.4352
PubMed ID: 29861108
Title: De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.
PubMed ID: 29861108
PubMed ID: 33323470
Title: Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.
PubMed ID: 33323470
Sequence Information:
- Length: 772
- Mass: 87661
- Checksum: 765EE37ED4A4ADEC
- Sequence:
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP GRSVPPVARS SPQHSLSNPL PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ KQRKSKTNGA ENETPSSGNT ELKDTAPALG AHSLLRLTLA EYHEQEEIFK LRLGHLKKEE AEIQAELERL ERVRNLHIRE LKRIHNEDNS QFKDHPTLND RYLLLHLLGR GGFSEVYKAF DLTEQRYVAV KIHQLNKNWR DEKKENYHKH ACREYRIHKE LDHPRIVKLY DYFSLDTDSF CTVLEYCEGN DLDFYLKQHK LMSEKEARSI IMQIVNALKY LNEIKPPIIH YDLKPGNILL VNGTACGEIK ITDFGLSKIM DDDSYNSVDG MELTSQGAGT YWYLPPECFV VGKEPPKISN KVDVWSVGVI FYQCLYGRKP FGHNQSQQDI LQENTILKAT EVQFPPKPVV TPEAKAFIRR CLAYRKEDRI DVQQLACDPY LLPHIRKSVS TSSPAGAAIA STSGASNNSS SN
Genular Protein ID: 3729043115
Symbol: J3QLK5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
Sequence Information:
- Length: 601
- Mass: 69288
- Checksum: 2478295131C8A418
- Sequence:
MSVMLAKPRL DTEQLAQRGA GLCFTFVSAQ QNSPSSTGSG NTEHSCSSQK QISIQHRQTQ SDLTIEKISA LENSKNSDLE KKEGRIDDLL RANCDLRRQI DEQQKMLEKY KERLNRCVTM SKKLLIEKSK QEKMACRDKS MQDRLRLGHF TTVRHGASFT EQWTDGYAFQ NLIKQQERIN SQREEIERQR KMLAKRKPPA MGQAPPATNE QKQRKSKTNG AENETLTLAE YHEQEEIFKL RLGHLKKEEA EIQAELERLE RVRNLHIREL KRIHNEDNSQ FKDHPTLNDR YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL LPHIRKSVST SSPAGAAIAS TSGASNNSSS N
Genular Protein ID: 3553319136
Symbol: A0A804HK10_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
Sequence Information:
- Length: 655
- Mass: 75411
- Checksum: 4CB447A816561C7D
- Sequence:
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ RNRKRKAEPY ETSQGKGTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV MLAKPRLDTE QLAQRGAGLC FTFVSANCDL RRQIDEQQKM LEKYKERLNR CVTMSKKLLI EKSKQEKMAC RDKSMQDRLR LGHFTTVRHG ASFTEQWTDG YAFQNLIKQQ ERINSQREEI ERQRKMLAKR KPPAMGQAPP ATNEQKQRKS KTNGAENETL TLAEYHEQEE IFKLRLGHLK KEEAEIQAEL ERLERVRNLH IRELKRIHNE DNSQFKDHPT LNDRYLLLHL LGRGGFSEVY KAFDLTEQRY VAVKIHQLNK NWRDEKKENY HKHACREYRI HKELDHPRIV KLYDYFSLDT DSFCTVLEYC EGNDLDFYLK QHKLMSEKEA RSIIMQIVNA LKYLNEIKPP IIHYDLKPGN ILLVNGTACG EIKITDFGLS KIMDDDSYNS VDGMELTSQG AGTYWYLPPE CFVVGKEPPK ISNKVDVWSV GVIFYQCLYG RKPFGHNQSQ QDILQENTIL KATEVQFPPK PVVTPEAKAF IRRCLAYRKE DRIDVQQLAC DPYLLPHIRK SVSTSSPAGA AIASTSGASN NSSSN
Genular Protein ID: 1963060890
Symbol: A0A804HJZ9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
Sequence Information:
- Length: 687
- Mass: 78506
- Checksum: 187DF3162E6CB6BE
- Sequence:
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP GRSVPPVARS SPQHSLSNPL PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSANC DLRRQIDEQQ KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR LRLGHFTTVR HGASFTEQWT DGYAFQNLIK QQERINSQRE EIERQRKMLA KRKPPAMGQA PPATNEQKQR KSKTNGAENE TLTLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY LKQHKLMSEK EARSIIMQIV NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR KEDRIDVQQL ACDPYLLPHI RKSVSTSSPA GAAIASTSGA SNNSSSN
Genular Protein ID: 1256772798
Symbol: B4DUC2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 718
- Mass: 82418
- Checksum: CC92364657BEFD2D
- Sequence:
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ RNRKRKAEPY ETSQGKDTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV MLAKPRLDTE QLAQRGAGLC FTFVSAQQNS PSSTGSGNTE HSCSSQKQIS IQHRQTQSDL IIEKISALEN SKNSDLEKKE GRIDDLLRAN CDLRRQIDEQ QKMLEKYKER LNRCVTMSKK LLIEKSKQEK MACRDKSMQD RLRLGHFTTV RHGASFTEQW TDGYAFQNLI KQQERINSQR EEIERQRKML AKRKPPAMGQ APPATNEQKQ RKSKTNGAEN ETLTLAEYHE QEEIFKLRLG HLKKEEAEIQ AELERLERVR NLHIRELKRI HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS EVYKAFDLTE QRYVAVKIHQ LNKNWRDEKK ENYHKHACRE YRIHKELDHP RIVKLYDYFS LDTDSFCTVL EYCEGNDLDF YLKQHKLMSE KEARSIIMQI VNALKYLNEI KPPIIHYDLK PGNILLVNGT ACGEIKITDF GLSKIMDDDS YNSVDGMELT SQGAGTYWYL PPECFVVGKE PPKISNKVDV WSVGVIFYQC LYGRKPFGHN QSQQDILQEN TILKATEVQF PPKPVVTPEA KAFIRRCLAY RKEDRIDVQQ LACDPYLLPH IRKSVSTSSP AGAAIASTSG ASNNSSSN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.