Details for: TLK2

Gene ID: 11011

Symbol: TLK2

Ensembl ID: ENSG00000146872

Description: tousled like kinase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.18
    Marker Score: 9,107
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.13
    Marker Score: 674
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.06
    Marker Score: 4,531
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.02
    Marker Score: 2,236
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2
    Marker Score: 2,692
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2
    Marker Score: 2,421
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.91
    Marker Score: 1,116
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.87
    Marker Score: 2,153
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.86
    Marker Score: 70,748
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.84
    Marker Score: 14,098
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.8
    Marker Score: 38,472
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.8
    Marker Score: 1,050
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.78
    Marker Score: 16,770
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.73
    Marker Score: 3,326
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7
    Marker Score: 104,516
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.68
    Marker Score: 61,927
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.68
    Marker Score: 15,949
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.67
    Marker Score: 2,077
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.66
    Marker Score: 37,202
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.65
    Marker Score: 24,717
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.65
    Marker Score: 6,715
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.61
    Marker Score: 5,727
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13,826
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.59
    Marker Score: 840
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.57
    Marker Score: 6,057
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.55
    Marker Score: 30,813
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.54
    Marker Score: 761
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.51
    Marker Score: 901
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 437
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.49
    Marker Score: 1,148
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.47
    Marker Score: 822
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.46
    Marker Score: 6,060
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2,232
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.42
    Marker Score: 2,060
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.4
    Marker Score: 1,507
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.37
    Marker Score: 14,134
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.34
    Marker Score: 1,523
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.31
    Marker Score: 1,135
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.27
    Marker Score: 1,214
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.25
    Marker Score: 22,201
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.23
    Marker Score: 596
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.22
    Marker Score: 845
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.21
    Marker Score: 19,426
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.19
    Marker Score: 663
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.17
    Marker Score: 492
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.17
    Marker Score: 5,390
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.15
    Marker Score: 625
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.14
    Marker Score: 1,129
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.13
    Marker Score: 416
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.11
    Marker Score: 2,784
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.1
    Marker Score: 980
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.1
    Marker Score: 398
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.08
    Marker Score: 276
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.08
    Marker Score: 311
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.08
    Marker Score: 1,525
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.08
    Marker Score: 1,153
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.07
    Marker Score: 401
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16,663
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.06
    Marker Score: 1,278
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.06
    Marker Score: 525
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.04
    Marker Score: 6,698
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 390
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.03
    Marker Score: 774
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.01
    Marker Score: 685
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,672
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.99
    Marker Score: 4,136
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Marker Score: 1,037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Marker Score: 333
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.97
    Marker Score: 641
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.97
    Marker Score: 4,183
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.97
    Marker Score: 264
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,395
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.94
    Marker Score: 527
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 279
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.93
    Marker Score: 2,232
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.93
    Marker Score: 295
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.93
    Marker Score: 333
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.92
    Marker Score: 333
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 617
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,471
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 261
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.91
    Marker Score: 961
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.91
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,699
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2,121
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.9
    Marker Score: 284
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.89
    Marker Score: 773
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.89
    Marker Score: 1,098
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.89
    Marker Score: 1,113
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.88
    Marker Score: 177
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.88
    Marker Score: 227
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.87
    Marker Score: 229
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.87
    Marker Score: 272
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.87
    Marker Score: 8,779
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.87
    Marker Score: 795

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TLK2 exhibits several distinct characteristics that set it apart from other serine/threonine kinases. Its amino acid sequence contains a unique tandem kinase domain, which allows it to phosphorylate and regulate the activity of multiple substrates. TLK2's kinase activity is also highly specific, with a preference for phosphorylating serine and threonine residues. Furthermore, TLK2 has been shown to interact with various protein partners, including chromatin-associated proteins and signaling molecules, to modulate its activity and regulate cellular responses. **Pathways and Functions** TLK2 is involved in numerous cellular pathways, including: 1. **Chromatin Organization**: TLK2 phosphorylates histone H4 and other chromatin-associated proteins, thereby regulating chromatin structure and function. 2. **DNA Damage Response**: TLK2 phosphorylates and activates proteins involved in the DNA damage response, including ATM and ATR. 3. **Intracellular Signaling**: TLK2 phosphorylates and regulates the activity of signaling molecules, including MAP kinases and PI3K. 4. **Autophagy Regulation**: TLK2 phosphorylates and inhibits key autophagy-related proteins, thereby regulating autophagy. These pathways and functions highlight TLK2's critical role in maintaining cellular homeostasis and responding to diverse stimuli. **Clinical Significance** TLK2's dysregulation has been implicated in various diseases, including: 1. **Cancer**: TLK2 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: TLK2 has been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Autoimmune Disorders**: TLK2 dysregulation has been implicated in autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. Inhibitors targeting TLK2 have shown promise in preclinical studies, suggesting that TLK2 may be a valuable therapeutic target for these diseases. **Conclusion** TLK2 is a multifaceted gene that plays a critical role in various cellular processes, including chromatin organization, DNA damage response, and intracellular signaling. Its dysregulation has been implicated in various diseases, highlighting the need for further research into TLK2's role in human health and disease. As an expert immunologist, I am excited to continue exploring the mysteries of TLK2 and its potential applications in immunology and medicine.

Genular Protein ID: 1919602307

Symbol: TLK2_HUMAN

Name: Serine/threonine-protein kinase tousled-like 2

UniProtKB Accession Codes:

Q86UE8 D3DU07 Q9UKI7 Q9Y4F7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 5 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 12 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9427565

Title: cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.

PubMed ID: 9427565

DOI: 10.1016/s0378-1119(97)00495-2

PubMed ID: 10523312

Title: Mammalian homologues of the plant tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.

PubMed ID: 10523312

DOI: 10.1093/emboj/18.20.5691

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9662073

Title: From mosquito to man: identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues.

PubMed ID: 9662073

DOI: 10.1007/bf02258367

PubMed ID: 10455159

Title: Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.

PubMed ID: 10455159

DOI: 10.1074/jbc.274.35.24865

PubMed ID: 11470414

Title: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.

PubMed ID: 11470414

DOI: 10.1016/s0960-9822(01)00298-6

PubMed ID: 12660173

Title: Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

PubMed ID: 12660173

DOI: 10.1093/emboj/cdg151

PubMed ID: 12955071

Title: Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

PubMed ID: 12955071

DOI: 10.1038/sj.onc.1206691

PubMed ID: 16484223

Title: FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.

PubMed ID: 16484223

DOI: 10.1074/jbc.m513280200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20016786

Title: Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.

PubMed ID: 20016786

DOI: 10.1371/journal.pone.0008328

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29955062

Title: Molecular basis of Tousled-Like Kinase 2 activation.

PubMed ID: 29955062

DOI: 10.1038/s41467-018-04941-y

PubMed ID: 35136069

Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.

PubMed ID: 35136069

DOI: 10.1038/s41467-022-28427-0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21572417

Title: Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations.

PubMed ID: 21572417

DOI: 10.1038/ng.835

PubMed ID: 27479843

Title: Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.

PubMed ID: 27479843

DOI: 10.1038/nn.4352

PubMed ID: 29861108

Title: De Novo and Inherited Loss-of-Function Variants in TLK2: Clinical and Genotype-Phenotype Evaluation of a Distinct Neurodevelopmental Disorder.

PubMed ID: 29861108

DOI: 10.1016/j.ajhg.2018.04.014

PubMed ID: 33323470

Title: Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.

PubMed ID: 33323470

DOI: 10.1136/jmedgenet-2020-107281

Sequence Information:

  • Length: 772
  • Mass: 87661
  • Checksum: 765EE37ED4A4ADEC
  • Sequence:
    • MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 
RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP GRSVPPVARS SPQHSLSNPL 
PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ 
NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 
ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 
TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 
KQRKSKTNGA ENETPSSGNT ELKDTAPALG AHSLLRLTLA EYHEQEEIFK LRLGHLKKEE 
AEIQAELERL ERVRNLHIRE LKRIHNEDNS QFKDHPTLND RYLLLHLLGR GGFSEVYKAF 
DLTEQRYVAV KIHQLNKNWR DEKKENYHKH ACREYRIHKE LDHPRIVKLY DYFSLDTDSF 
CTVLEYCEGN DLDFYLKQHK LMSEKEARSI IMQIVNALKY LNEIKPPIIH YDLKPGNILL 
VNGTACGEIK ITDFGLSKIM DDDSYNSVDG MELTSQGAGT YWYLPPECFV VGKEPPKISN 
KVDVWSVGVI FYQCLYGRKP FGHNQSQQDI LQENTILKAT EVQFPPKPVV TPEAKAFIRR 
CLAYRKEDRI DVQQLACDPY LLPHIRKSVS TSSPAGAAIA STSGASNNSS SN

Genular Protein ID: 3729043115

Symbol: J3QLK5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QLK5

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 4 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 2 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 601
  • Mass: 69288
  • Checksum: 2478295131C8A418
  • Sequence:
    • MSVMLAKPRL DTEQLAQRGA GLCFTFVSAQ QNSPSSTGSG NTEHSCSSQK QISIQHRQTQ 
SDLTIEKISA LENSKNSDLE KKEGRIDDLL RANCDLRRQI DEQQKMLEKY KERLNRCVTM 
SKKLLIEKSK QEKMACRDKS MQDRLRLGHF TTVRHGASFT EQWTDGYAFQ NLIKQQERIN 
SQREEIERQR KMLAKRKPPA MGQAPPATNE QKQRKSKTNG AENETLTLAE YHEQEEIFKL 
RLGHLKKEEA EIQAELERLE RVRNLHIREL KRIHNEDNSQ FKDHPTLNDR YLLLHLLGRG 
GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL DHPRIVKLYD 
YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL NEIKPPIIHY 
DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY WYLPPECFVV 
GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE VQFPPKPVVT 
PEAKAFIRRC LAYRKEDRID VQQLACDPYL LPHIRKSVST SSPAGAAIAS TSGASNNSSS 
N

Genular Protein ID: 3553319136

Symbol: A0A804HK10_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HK10

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 1 EMBL 2 EPD 1 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 655
  • Mass: 75411
  • Checksum: 4CB447A816561C7D
  • Sequence:
    • MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 
RNRKRKAEPY ETSQGKGTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV 
MLAKPRLDTE QLAQRGAGLC FTFVSANCDL RRQIDEQQKM LEKYKERLNR CVTMSKKLLI 
EKSKQEKMAC RDKSMQDRLR LGHFTTVRHG ASFTEQWTDG YAFQNLIKQQ ERINSQREEI 
ERQRKMLAKR KPPAMGQAPP ATNEQKQRKS KTNGAENETL TLAEYHEQEE IFKLRLGHLK 
KEEAEIQAEL ERLERVRNLH IRELKRIHNE DNSQFKDHPT LNDRYLLLHL LGRGGFSEVY 
KAFDLTEQRY VAVKIHQLNK NWRDEKKENY HKHACREYRI HKELDHPRIV KLYDYFSLDT 
DSFCTVLEYC EGNDLDFYLK QHKLMSEKEA RSIIMQIVNA LKYLNEIKPP IIHYDLKPGN 
ILLVNGTACG EIKITDFGLS KIMDDDSYNS VDGMELTSQG AGTYWYLPPE CFVVGKEPPK 
ISNKVDVWSV GVIFYQCLYG RKPFGHNQSQ QDILQENTIL KATEVQFPPK PVVTPEAKAF 
IRRCLAYRKE DRIDVQQLAC DPYLLPHIRK SVSTSSPAGA AIASTSGASN NSSSN

Genular Protein ID: 1963060890

Symbol: A0A804HJZ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HJZ9

Database IDs:

ARBA 5 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 1 EMBL 2 EPD 1 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 687
  • Mass: 78506
  • Checksum: 187DF3162E6CB6BE
  • Sequence:
    • MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 
RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP GRSVPPVARS SPQHSLSNPL 
PRRVEQPLYG LDGSAAKEAT EEQSALPTLM SVMLAKPRLD TEQLAQRGAG LCFTFVSANC 
DLRRQIDEQQ KMLEKYKERL NRCVTMSKKL LIEKSKQEKM ACRDKSMQDR LRLGHFTTVR 
HGASFTEQWT DGYAFQNLIK QQERINSQRE EIERQRKMLA KRKPPAMGQA PPATNEQKQR 
KSKTNGAENE TLTLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN LHIRELKRIH 
NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE 
NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY LKQHKLMSEK 
EARSIIMQIV NALKYLNEIK PPIIHYDLKP GNILLVNGTA CGEIKITDFG LSKIMDDDSY 
NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL YGRKPFGHNQ 
SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLAYR KEDRIDVQQL ACDPYLLPHI 
RKSVSTSSPA GAAIASTSGA SNNSSSN

Genular Protein ID: 1256772798

Symbol: B4DUC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUC2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 718
  • Mass: 82418
  • Checksum: CC92364657BEFD2D
  • Sequence:
    • MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 
RNRKRKAEPY ETSQGKDTPR GHKISDYFER RVEQPLYGLD GSAAKEATEE QSALPTLMSV 
MLAKPRLDTE QLAQRGAGLC FTFVSAQQNS PSSTGSGNTE HSCSSQKQIS IQHRQTQSDL 
IIEKISALEN SKNSDLEKKE GRIDDLLRAN CDLRRQIDEQ QKMLEKYKER LNRCVTMSKK 
LLIEKSKQEK MACRDKSMQD RLRLGHFTTV RHGASFTEQW TDGYAFQNLI KQQERINSQR 
EEIERQRKML AKRKPPAMGQ APPATNEQKQ RKSKTNGAEN ETLTLAEYHE QEEIFKLRLG 
HLKKEEAEIQ AELERLERVR NLHIRELKRI HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS 
EVYKAFDLTE QRYVAVKIHQ LNKNWRDEKK ENYHKHACRE YRIHKELDHP RIVKLYDYFS 
LDTDSFCTVL EYCEGNDLDF YLKQHKLMSE KEARSIIMQI VNALKYLNEI KPPIIHYDLK 
PGNILLVNGT ACGEIKITDF GLSKIMDDDS YNSVDGMELT SQGAGTYWYL PPECFVVGKE 
PPKISNKVDV WSVGVIFYQC LYGRKPFGHN QSQQDILQEN TILKATEVQF PPKPVVTPEA 
KAFIRRCLAY RKEDRIDVQQ LACDPYLLPH IRKSVSTSSP AGAAIASTSG ASNNSSSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.