Details for: KLK11

Gene ID: 11012

Symbol: KLK11

Ensembl ID: ENSG00000167757

Description: kallikrein related peptidase 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.95
    Marker Score: 809
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.83
    Marker Score: 5,170
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.7
    Marker Score: 21,045
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.59
    Marker Score: 22,334
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.29
    Marker Score: 6,239
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.22
    Marker Score: 16,508
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2
    Marker Score: 839
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.99
    Marker Score: 574
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.88
    Marker Score: 926
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.81
    Marker Score: 2,110
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.79
    Marker Score: 1,410
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.71
    Marker Score: 550
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.71
    Marker Score: 436
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.62
    Marker Score: 3,968
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.56
    Marker Score: 1,881
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51,754
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1,457
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.41
    Marker Score: 1,488
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.41
    Marker Score: 446
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.35
    Marker Score: 3,057
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.27
    Marker Score: 865
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.21
    Marker Score: 526
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2
    Marker Score: 2,542
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.16
    Marker Score: 431
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.15
    Marker Score: 594
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,804
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.14
    Marker Score: 666
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.14
    Marker Score: 591
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.1
    Marker Score: 7,014
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.05
    Marker Score: 355
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.05
    Marker Score: 489
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,038
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.97
    Marker Score: 388
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1,048
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,235
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.87
    Marker Score: 1,428
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.87
    Marker Score: 1,979
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.84
    Marker Score: 337
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.83
    Marker Score: 579
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.81
    Marker Score: 196
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.81
    Marker Score: 279
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.79
    Marker Score: 892
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.77
    Marker Score: 639
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.76
    Marker Score: 979
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.75
    Marker Score: 671
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.73
    Marker Score: 9,742
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.71
    Marker Score: 477
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.69
    Marker Score: 200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 428
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.64
    Marker Score: 1,576
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 402
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.62
    Marker Score: 381
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.61
    Marker Score: 272
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.6
    Marker Score: 308
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.56
    Marker Score: 887
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.55
    Marker Score: 2,035
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.53
    Marker Score: 2,798
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.53
    Marker Score: 1,693
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.48
    Marker Score: 346
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.48
    Marker Score: 422
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.47
    Marker Score: 324
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.41
    Marker Score: 144
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4
    Marker Score: 184
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.36
    Marker Score: 177
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.36
    Marker Score: 87,677
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.36
    Marker Score: 100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.35
    Marker Score: 673
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.35
    Marker Score: 436
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.35
    Marker Score: 3,020
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.33
    Marker Score: 107
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.33
    Marker Score: 81
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.32
    Marker Score: 98
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.31
    Marker Score: 83
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.31
    Marker Score: 586
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 275

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK11 exhibits serine-type endopeptidase activity, which enables it to cleave a wide range of substrates, including growth factors, cytokines, and chemokines. This enzymatic activity is essential for regulating cellular signaling pathways and modulating immune responses. KLK11 is also associated with the extracellular exosome, Golgi apparatus, and secretory granules, indicating its role in regulating the secretion of proteins and peptides. **Pathways and Functions:** KLK11 is involved in various signaling pathways, including: 1. **Proteolysis**: KLK11's enzymatic activity enables it to cleave substrates, leading to the activation of downstream signaling pathways. 2. **Extracellular Space**: KLK11 is secreted from epithelial cells, where it plays a role in regulating the extracellular environment. 3. **Golgi Apparatus**: KLK11 is associated with the Golgi apparatus, where it regulates the processing and secretion of proteins. 4. **Serine-type Endopeptidase Activity**: KLK11's enzymatic activity enables it to cleave a wide range of substrates, including growth factors, cytokines, and chemokines. 5. **Serine-type Peptidase Activity**: KLK11's serine-type peptidase activity enables it to regulate cellular signaling pathways and modulate immune responses. **Clinical Significance:** KLK11 has been implicated in various respiratory diseases, including: 1. **Asthma**: KLK11 has been shown to play a role in regulating airway inflammation and remodeling. 2. **Chronic Obstructive Pulmonary Disease (COPD)**: KLK11 has been implicated in the regulation of airway inflammation and remodeling in COPD. 3. **Respiratory Goblet Cell Hyperplasia**: KLK11 has been shown to regulate the proliferation and differentiation of respiratory goblet cells, which are involved in airway diseases. In conclusion, KLK11 plays a crucial role in regulating immune responses and maintaining epithelial homeostasis. Its involvement in various respiratory diseases highlights the potential of KLK11 as a therapeutic target for the treatment of airway diseases. Further research is needed to fully elucidate the mechanisms by which KLK11 regulates immune responses and to explore its potential as a therapeutic agent.

Genular Protein ID: 377650212

Symbol: KLK11_HUMAN

Name: Kallikrein-11

UniProtKB Accession Codes:

Q9UBX7 O75837 Q0WXX5 Q8IXD7 Q9NS65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 9 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9765601

Title: cDNA cloning and expression of a novel serine protease, TLSP.

PubMed ID: 9765601

DOI: 10.1016/s0167-4781(98)00116-x

PubMed ID: 10872828

Title: A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate.

PubMed ID: 10872828

DOI: 10.1006/bbrc.2000.2761

PubMed ID: 10662548

Title: Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family.

PubMed ID: 10662548

DOI: 10.1006/geno.1999.6072

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 12539228

Title: Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate.

PubMed ID: 12539228

DOI: 10.1002/pros.10191

PubMed ID: 16911518

Title: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin.

PubMed ID: 16911518

DOI: 10.1111/j.1742-4658.2006.05372.x

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16467084

Title: Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma.

PubMed ID: 16467084

DOI: 10.1158/1078-0432.ccr-05-1696

Sequence Information:

  • Length: 282
  • Mass: 31059
  • Checksum: B442DDE613EE0A17
  • Sequence:
    • MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC 
KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT 
ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG 
STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV 
CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN

Genular Protein ID: 249687056

Symbol: A0A1R3UDR5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1R3UDR5

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 28224083

Title: Comparative genomic analysis of eutherian kallikrein genes.

PubMed ID: 28224083

DOI: 10.1016/j.ymgmr.2017.01.009

Title: Eutherian third-party data gene collections.

DOI: 10.1016/j.genrep.2019.100414

Sequence Information:

  • Length: 250
  • Mass: 27466
  • Checksum: 192D910BBCDC7A56
  • Sequence:
    • MRILQLILLA LATGLVGGET RIIKGFECKP HSQPWQAALF EKTRLLCGAT LIAPRWLLTA 
AHCLKPRYIV HLGQHNLQKE EGCEQTRTAT ESFPHPGFNN SLPNKDHRND IMLVKMASPV 
SITWAVRPLT LSSRCVTAGT SCLISGWGST SSPQLRLPHT LRCANITIIE HQKCENAYPG 
NITDTMVCAS VQEGGKDSCQ GDSGGPLVCN QSLQGIISWG QDPCAITRKP GVYTKVCKYV 
DWIQETMKNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.