Details for: TMSB15A

Gene ID: 11013

Symbol: TMSB15A

Ensembl ID: ENSG00000158164

Description: thymosin beta 15A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.9
    Marker Score: 1,143
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.71
    Marker Score: 1,443
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.66
    Marker Score: 2,502
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.58
    Marker Score: 34,047
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.5
    Marker Score: 1,670
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.49
    Marker Score: 1,997
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.48
    Marker Score: 2,652
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.29
    Marker Score: 1,438
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.19
    Marker Score: 5,166
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2
    Marker Score: 4,178
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,992
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.92
    Marker Score: 3,347
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.78
    Marker Score: 3,032
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.76
    Marker Score: 849
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.73
    Marker Score: 1,029
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.72
    Marker Score: 578
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.61
    Marker Score: 760
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.51
    Marker Score: 1,599
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.25
    Marker Score: 410
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.19
    Marker Score: 7,759
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.18
    Marker Score: 855
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,665
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,812
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.11
    Marker Score: 1,590
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.07
    Marker Score: 1,130
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.03
    Marker Score: 2,816
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.03
    Marker Score: 859
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.03
    Marker Score: 355
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.02
    Marker Score: 294
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.96
    Marker Score: 638
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.94
    Marker Score: 266
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.88
    Marker Score: 1,220
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1,347
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.76
    Marker Score: 420
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.71
    Marker Score: 296
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.64
    Marker Score: 796
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.62
    Marker Score: 145
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.62
    Marker Score: 332
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.6
    Marker Score: 150
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6
    Marker Score: 249
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6
    Marker Score: 1,210
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.59
    Marker Score: 223
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.57
    Marker Score: 721
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.56
    Marker Score: 868
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.54
    Marker Score: 1,479
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.52
    Marker Score: 5,230
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.48
    Marker Score: 462
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.45
    Marker Score: 473
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.45
    Marker Score: 306
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.43
    Marker Score: 462
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.4
    Marker Score: 582
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.39
    Marker Score: 145
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 739
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.36
    Marker Score: 922
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 204
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.35
    Marker Score: 2,078
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 646
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.33
    Marker Score: 233
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.32
    Marker Score: 71
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.31
    Marker Score: 101
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.31
    Marker Score: 3,440
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3
    Marker Score: 217
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.29
    Marker Score: 77
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 113
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.28
    Marker Score: 55
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.27
    Marker Score: 503
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.27
    Marker Score: 148
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.27
    Marker Score: 4,170
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.26
    Marker Score: 291
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.26
    Marker Score: 136
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.26
    Marker Score: 60
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.26
    Marker Score: 133
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.26
    Marker Score: 8,841
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.25
    Marker Score: 388

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMSB15A exhibits several key characteristics that distinguish it from other thymosins. These include: 1. **Actin-binding properties**: TMSB15A has been shown to bind to actin monomers, regulating their sequestration and influencing actin filament organization. 2. **Cytoskeletal regulation**: By modulating actin dynamics, TMSB15A plays a crucial role in regulating cell migration, shape changes, and cellular movement. 3. **Cell-type specificity**: TMSB15A is expressed in a wide range of cell types, including tracheobronchial smooth muscle cells, enteric neurons, and neural crest cells, suggesting its involvement in various physiological and pathological processes. 4. **Conserved sequence**: The amino acid sequence of TMSB15A is highly conserved across species, indicating its evolutionary significance and functional importance. **Pathways and Functions** TMSB15A is involved in several key cellular pathways, including: 1. **Actin filament organization**: TMSB15A regulates actin filament organization by binding to actin monomers, influencing their sequestration and dynamics. 2. **Regulation of cell migration**: By modulating actin dynamics, TMSB15A plays a crucial role in regulating cell migration, shape changes, and cellular movement. 3. **Cytoskeleton dynamics**: TMSB15A influences cytoskeleton dynamics, including the organization and rearrangement of actin filaments, microtubules, and intermediate filaments. 4. **Neurodevelopment and neural crest cell migration**: TMSB15A is expressed in neural crest cells and plays a crucial role in their migration and differentiation during neurodevelopment. **Clinical Significance** TMSB15A has significant clinical implications, particularly in the context of: 1. **Respiratory diseases**: Alterations in TMSB15A expression have been linked to respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 2. **Neurological disorders**: TMSB15A has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cardiovascular diseases**: TMSB15A has been shown to play a role in cardiovascular diseases, including atherosclerosis and cardiac remodeling. 4. **Cancer**: TMSB15A has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in cancer progression and metastasis. In conclusion, TMSB15A is a multifunctional cytokine that plays a crucial role in regulating various cellular processes, including actin filament organization, cell migration, and cytoskeleton dynamics. Its significance in various physiological and pathological processes highlights its importance as a potential therapeutic target for the treatment of diseases, including respiratory, neurological, cardiovascular, and cancer diseases.

Genular Protein ID: 3012550299

Symbol: TB15A_HUMAN

Name: Thymosin beta-15A

UniProtKB Accession Codes:

P0CG34 A8K614 Q99406

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 4 EPD 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneWiki 2 Genevisible 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 2 MANE-Select 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 3 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9039501

Title: Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles.

PubMed ID: 9039501

DOI: 10.1093/dnares/3.5.311

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19296525

Title: Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1.

PubMed ID: 19296525

DOI: 10.1002/gcc.20659

Sequence Information:

  • Length: 45
  • Mass: 5229
  • Checksum: B1182868530D59C2
  • Sequence:
    • MSDKPDLSEV EKFDRSKLKK TNTEEKNTLP SKETIQQEKE CVQTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.