Details for: KDELR2

Gene ID: 11014

Symbol: KDELR2

Ensembl ID: ENSG00000136240

Description: KDEL endoplasmic reticulum protein retention receptor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.19
    Marker Score: 15,654
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.81
    Marker Score: 17,924
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.75
    Marker Score: 6,234
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.62
    Marker Score: 1,850
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.62
    Marker Score: 89,109
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.59
    Marker Score: 5,911
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.59
    Marker Score: 1,573
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.58
    Marker Score: 11,147
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.58
    Marker Score: 2,198
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.56
    Marker Score: 2,455
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.44
    Marker Score: 5,968
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.41
    Marker Score: 83,569
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.41
    Marker Score: 15,682
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.41
    Marker Score: 14,626
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.4
    Marker Score: 31,647
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.39
    Marker Score: 3,291
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.38
    Marker Score: 1,357
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.35
    Marker Score: 3,618
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.32
    Marker Score: 8,959
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3
    Marker Score: 25,866
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.26
    Marker Score: 1,018
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.26
    Marker Score: 940
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.26
    Marker Score: 3,627
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.24
    Marker Score: 658
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.22
    Marker Score: 8,737
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.2
    Marker Score: 10,563
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.2
    Marker Score: 1,734
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.19
    Marker Score: 6,873
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.16
    Marker Score: 18,582
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.15
    Marker Score: 4,500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.13
    Marker Score: 604
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.13
    Marker Score: 16,631
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.12
    Marker Score: 886
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.11
    Marker Score: 1,491
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.11
    Marker Score: 5,524
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.11
    Marker Score: 5,175
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.1
    Marker Score: 524
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.09
    Marker Score: 524
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.08
    Marker Score: 1,768
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.08
    Marker Score: 4,896
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.07
    Marker Score: 10,890
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.07
    Marker Score: 4,908
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.06
    Marker Score: 1,841
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.06
    Marker Score: 1,060
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.03
    Marker Score: 2,171
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.03
    Marker Score: 829
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.98
    Marker Score: 1,253
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.96
    Marker Score: 3,471
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.95
    Marker Score: 8,146
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.94
    Marker Score: 709
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.93
    Marker Score: 3,287
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.93
    Marker Score: 2,842
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.93
    Marker Score: 6,315
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.92
    Marker Score: 12,271
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.89
    Marker Score: 2,004
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.89
    Marker Score: 2,220
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.87
    Marker Score: 1,046
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.87
    Marker Score: 748
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.87
    Marker Score: 421
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.87
    Marker Score: 814
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.86
    Marker Score: 5,144
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.86
    Marker Score: 3,714
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.86
    Marker Score: 537
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.86
    Marker Score: 47,583
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.85
    Marker Score: 1,020
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.85
    Marker Score: 12,044
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.85
    Marker Score: 1,232
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.84
    Marker Score: 1,072
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.83
    Marker Score: 7,620
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.83
    Marker Score: 710
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.83
    Marker Score: 1,718
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.82
    Marker Score: 1,711
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.82
    Marker Score: 2,414
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.82
    Marker Score: 848
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.81
    Marker Score: 32,143
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.81
    Marker Score: 1,542
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.81
    Marker Score: 2,599
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.8
    Marker Score: 1,020
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.79
    Marker Score: 1,916
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.79
    Marker Score: 2,159
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.78
    Marker Score: 4,848
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.78
    Marker Score: 1,917
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.77
    Marker Score: 1,480
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.77
    Marker Score: 436
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.76
    Marker Score: 663
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.75
    Marker Score: 1,749
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.75
    Marker Score: 1,857
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.74
    Marker Score: 620
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.74
    Marker Score: 551
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.73
    Marker Score: 852
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.71
    Marker Score: 3,220
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.71
    Marker Score: 580
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7
    Marker Score: 3,597
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.7
    Marker Score: 1,912
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.7
    Marker Score: 684
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.69
    Marker Score: 2,046
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.67
    Marker Score: 1,913
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.66
    Marker Score: 574
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.66
    Marker Score: 1,191
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.66
    Marker Score: 617

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **ER Retention Function**: KDELR2 is a receptor that binds to ER lumen proteins, specifically ERD22, and facilitates their retention within the ER lumen. 2. **Retrograde Transport**: KDELR2 is involved in retrograde transport, which is the movement of proteins and lipids from the Golgi apparatus to the ER. 3. **KDEL Sequence Binding**: KDELR2 binds to the KDEL sequence, a specific amino acid sequence found in ER lumen proteins, which is essential for their retention in the ER lumen. 4. **Expression in Specific Cell Types**: KDELR2 is specifically expressed in various cell types, including myoepithelial cells of the mammary gland, foveolar cells of the stomach, and myeloid dendritic cells. **Pathways and Functions** 1. **Endoplasmic Reticulum (ER) Function**: KDELR2 plays a crucial role in maintaining the proper functioning of the ER by facilitating the retention of ER lumen proteins within the ER lumen. 2. **Retrograde Transport**: KDELR2 is involved in retrograde transport, which is the movement of proteins and lipids from the Golgi apparatus to the ER. 3. **Protein Retention**: KDELR2 facilitates the retention of ER lumen proteins within the ER lumen, which is essential for their proper functioning. 4. **Anterograde Transport**: KDELR2 is also involved in anterograde transport, which is the movement of proteins and lipids from the ER to the Golgi apparatus. **Clinical Significance** 1. **Cancer Research**: KDELR2 has been identified as a potential biomarker for cancer, particularly in breast cancer, where it is overexpressed. 2. **Immune System**: KDELR2 plays a crucial role in the immune system, particularly in the function of myeloid dendritic cells, which are involved in antigen presentation. 3. **Gastrointestinal Disorders**: KDELR2 has been implicated in gastrointestinal disorders, such as inflammatory bowel disease, where its expression is altered. 4. **Protein Misfolding Diseases**: KDELR2 has been identified as a potential target for the treatment of protein misfolding diseases, such as Alzheimer's disease, where protein misfolding is a key feature. In conclusion, KDELR2 is a crucial protein that plays a vital role in maintaining the localization of proteins within the endoplasmic reticulum lumen. Its dysregulation has been implicated in various diseases, including cancer, immune system disorders, and gastrointestinal disorders. Further research is needed to fully understand the functions and clinical significance of KDELR2.

Genular Protein ID: 574860933

Symbol: ERD22_HUMAN

Name: ER lumen protein-retaining receptor 2

UniProtKB Accession Codes:

P33947 A4D2P4 Q6IPC5 Q96E30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1325562

Title: Sequence of a second human KDEL receptor.

PubMed ID: 1325562

DOI: 10.1016/0022-2836(92)91039-r

PubMed ID: 1316805

Title: A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.

PubMed ID: 1316805

DOI: 10.1016/0092-8674(92)90226-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18086916

Title: A molecular specificity code for the three mammalian KDEL receptors.

PubMed ID: 18086916

DOI: 10.1083/jcb.200705180

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33053334

Title: Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2.

PubMed ID: 33053334

DOI: 10.1016/j.ajhg.2020.09.009

PubMed ID: 33964184

Title: Two novel bi-allelic KDELR2 missense variants cause osteogenesis imperfecta with neurodevelopmental features.

PubMed ID: 33964184

DOI: 10.1002/ajmg.a.62221

Sequence Information:

  • Length: 212
  • Mass: 24422
  • Checksum: 81BECB983E503142
  • Sequence:
    • MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD LFTSFISLYN 
TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV PVGGLSFLVN HDFSPLEILW 
TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA 
VVAGVVQTIL YCDFFYLYIT KVLKGKKLSL PA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.