Details for: KDELR3

Gene ID: 11015

Symbol: KDELR3

Ensembl ID: ENSG00000100196

Description: KDEL endoplasmic reticulum protein retention receptor 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.64
    Marker Score: 2,250
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,053
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.45
    Marker Score: 4,153
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.41
    Marker Score: 398
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.27
    Marker Score: 2,888
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.16
    Marker Score: 2,640
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.07
    Marker Score: 1,022
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,781
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.03
    Marker Score: 2,696
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 784
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.96
    Marker Score: 6,134
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,256
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.91
    Marker Score: 380
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,533
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.8
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.72
    Marker Score: 8,148
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.72
    Marker Score: 354
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.7
    Marker Score: 620
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.69
    Marker Score: 23,896
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,754
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.66
    Marker Score: 338
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.65
    Marker Score: 2,798
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.64
    Marker Score: 3,086
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.64
    Marker Score: 2,466
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.63
    Marker Score: 142
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1,176
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.61
    Marker Score: 1,282
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.61
    Marker Score: 325
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 380
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.59
    Marker Score: 216
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.58
    Marker Score: 364
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.58
    Marker Score: 230
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.57
    Marker Score: 1,389
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.56
    Marker Score: 861
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.54
    Marker Score: 245
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.53
    Marker Score: 2,801
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 367
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 503
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.52
    Marker Score: 3,377
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.5
    Marker Score: 429
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.49
    Marker Score: 1,227
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.48
    Marker Score: 282
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.48
    Marker Score: 6,451
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1,266
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.46
    Marker Score: 289
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.46
    Marker Score: 732
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2,724
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.45
    Marker Score: 1,062
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.43
    Marker Score: 128
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 105
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.42
    Marker Score: 169
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 131
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.4
    Marker Score: 497
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 815
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4
    Marker Score: 92
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4
    Marker Score: 231
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.4
    Marker Score: 724
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 105
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.39
    Marker Score: 142
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.39
    Marker Score: 598
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 393
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.38
    Marker Score: 174
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.37
    Marker Score: 173
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.37
    Marker Score: 207
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.36
    Marker Score: 104
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 305
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.34
    Marker Score: 223
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.32
    Marker Score: 387
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.32
    Marker Score: 100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.31
    Marker Score: 229
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 130
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.31
    Marker Score: 77
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.31
    Marker Score: 194
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.31
    Marker Score: 221
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.31
    Marker Score: 273
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.3
    Marker Score: 92
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.3
    Marker Score: 177
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3
    Marker Score: 471
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.3
    Marker Score: 81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KDELR3 is a type II transmembrane protein that is specifically localized to the ER lumen. It is characterized by the presence of a KDEL (lumenal ER retention) motif, which is recognized by the ER-associated degradation (ERAD) pathway. Upon binding to KDEL-containing proteins, KDELR3 facilitates their retention in the ER lumen, preventing their degradation by the ERAD pathway. This mechanism is essential for maintaining protein homeostasis and ensuring the proper folding and maturation of ER-resident proteins. **Pathways and Functions:** KDELR3 is involved in various cellular processes, including: 1. **Protein Retention in ER Lumen:** KDELR3 plays a critical role in retaining proteins in the ER lumen, preventing their degradation by the ERAD pathway. This ensures the proper folding and maturation of ER-resident proteins. 2. **ER Stress Response:** KDELR3 is activated in response to ER stress, triggering the unfolded protein response (UPR). The UPR is a complex signaling pathway that aims to restore ER homeostasis by regulating protein synthesis, folding, and degradation. 3. **Golgi-to-ER Retrograde Transport:** KDELR3 is also involved in the regulation of golgi-to-ER retrograde transport, a process that involves the transport of proteins from the Golgi apparatus to the ER. 4. **Anterograde Transport:** KDELR3 facilitates anterograde transport, a process that involves the transport of proteins from the ER to other organelles, such as the Golgi apparatus and lysosomes. **Clinical Significance:** Dysregulation of KDELR3 has been implicated in various diseases, including: 1. **Cancer:** Alterations in KDELR3 expression have been observed in several types of cancer, including breast, lung, and colon cancer. These changes may contribute to tumorigenesis and cancer progression. 2. **Neurodegenerative Diseases:** KDELR3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Dysregulation of KDELR3 may contribute to protein misfolding and aggregation, leading to neuronal damage. 3. **Infectious Diseases:** KDELR3 has been identified as a potential target for antiviral therapies. Alterations in KDELR3 expression have been observed in response to viral infections, suggesting its role in regulating the host response to pathogens. In conclusion, KDELR3 is a critical component of the ER quality control system, playing a pivotal role in protein retention, ER stress response, and golgi-to-ER retrograde transport. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 1529403035

Symbol: ERD23_HUMAN

Name: ER lumen protein-retaining receptor 3

UniProtKB Accession Codes:

O43731 A8K7T7 B8ZZ26 O95557 Q4V750 Q4V767 Q53FP4 Q53GK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18086916

Title: A molecular specificity code for the three mammalian KDEL receptors.

PubMed ID: 18086916

DOI: 10.1083/jcb.200705180

Sequence Information:

  • Length: 214
  • Mass: 25027
  • Checksum: ED5F7D303390B314
  • Sequence:
    • MNVFRILGDL SHLLAMILLL GKIWRSKCCK GISGKSQILF ALVFTTRYLD LFTNFISIYN 
TVMKVVFLLC AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV PVIGLSFLEN YSFTLLEILW 
TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLANWIRRY QTENFYDQIA 
VVSGVVQTIF YCDFFYLYVT KVLKGKKLSL PMPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.