Details for: ATF7

Gene ID: 11016

Symbol: ATF7

Ensembl ID: ENSG00000170653

Description: activating transcription factor 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.52
    Marker Score: 53,729
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.99
    Marker Score: 2,289
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.7
    Marker Score: 1,016
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.48
    Marker Score: 22,099
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.46
    Marker Score: 11,200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.46
    Marker Score: 12,518
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.45
    Marker Score: 89,230
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.43
    Marker Score: 54,127
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13,430
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.39
    Marker Score: 3,325
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.38
    Marker Score: 5,744
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5,158
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.33
    Marker Score: 2,697
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2,505
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.29
    Marker Score: 12,102
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.28
    Marker Score: 538
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1,970
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.27
    Marker Score: 1,246
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.27
    Marker Score: 25,174
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46,349
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.21
    Marker Score: 2,842
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.17
    Marker Score: 366
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.16
    Marker Score: 2,062
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,152
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.16
    Marker Score: 4,794
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.15
    Marker Score: 2,819
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.1
    Marker Score: 954
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.07
    Marker Score: 1,723
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.07
    Marker Score: 2,443
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.07
    Marker Score: 345
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.03
    Marker Score: 729
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1
    Marker Score: 274
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 284
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,924
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.99
    Marker Score: 549
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.98
    Marker Score: 226
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,392
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.98
    Marker Score: 258
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1,015
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.92
    Marker Score: 265
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.91
    Marker Score: 453
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9
    Marker Score: 1,580
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9
    Marker Score: 16,033
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.9
    Marker Score: 1,089
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,456
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,069
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.88
    Marker Score: 680
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.87
    Marker Score: 752
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.86
    Marker Score: 29,171
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,233
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7,351
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 506
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.84
    Marker Score: 1,237
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.82
    Marker Score: 3,407
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.82
    Marker Score: 768
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.81
    Marker Score: 1,005
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.8
    Marker Score: 3,273
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.8
    Marker Score: 5,225
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.8
    Marker Score: 484
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.79
    Marker Score: 426
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.78
    Marker Score: 1,656
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.78
    Marker Score: 192
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.78
    Marker Score: 26,445
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.77
    Marker Score: 826
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.76
    Marker Score: 4,090
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.74
    Marker Score: 2,437
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.73
    Marker Score: 2,830
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.73
    Marker Score: 672
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.73
    Marker Score: 3,580
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.73
    Marker Score: 784
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.72
    Marker Score: 549
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.72
    Marker Score: 2,558
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 340
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.7
    Marker Score: 306
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.7
    Marker Score: 182
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.7
    Marker Score: 365
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.69
    Marker Score: 382
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.69
    Marker Score: 3,641
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.69
    Marker Score: 576
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.69
    Marker Score: 4,077
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,877
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.68
    Marker Score: 199
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.67
    Marker Score: 5,258
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.67
    Marker Score: 945
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 611
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.67
    Marker Score: 135

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATF7 is a transcription factor that belongs to the cyclic AMP-dependent (AP-1) transcription factor family. It is characterized by its ability to bind to specific DNA sequences, known as Camp response elements (CRE), and regulate the expression of target genes involved in various cellular processes. ATF7 is a multifunctional protein that interacts with numerous transcription factors, signaling pathways, and regulatory proteins, including metal ion-binding proteins, RNA polymerase II, and mitogen-activated protein kinases (MAPKs). Its expression is restricted to specific cell types, including astrocytes, endothelial cells, and certain types of neurons. **Pathways and Functions:** ATF7 plays a central role in several signaling pathways that regulate gene expression, including: 1. **MAPK/ERK pathway**: ATF7 interacts with MAPKs to regulate the expression of genes involved in cell proliferation, differentiation, and survival. 2. **CREB pathway**: ATF7 binds to CRE to activate the transcription of genes involved in neuronal development, synaptic plasticity, and immune response. 3. **RNA polymerase II**: ATF7 regulates the expression of genes involved in transcriptional regulation, including the transcription of genes involved in immune response and neuronal function. 4. **Protein-protein interactions**: ATF7 interacts with various transcription factors, signaling proteins, and regulatory proteins to modulate gene expression. ATF7's functions include: 1. **Immune regulation**: ATF7 regulates the expression of genes involved in immune response, including the production of cytokines and chemokines. 2. **Neuronal development**: ATF7 regulates the expression of genes involved in neuronal development, including the differentiation of astrocytes and endothelial cells. 3. **Gene regulation**: ATF7 regulates the expression of genes involved in transcriptional regulation, including the regulation of CREB and other transcription factors. **Clinical Significance:** Dysregulation of ATF7 has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases**: ATF7's role in regulating gene expression has been linked to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune disorders**: ATF7's involvement in immune regulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: ATF7's role in regulating gene expression has been linked to the development and progression of various cancers, including glioblastoma and breast cancer. In conclusion, ATF7 is a multifunctional transcription factor that plays a crucial role in regulating gene expression, immune response, and neuronal development. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of ATF7 in maintaining immune homeostasis and neuronal function. Further research is needed to elucidate the mechanisms of ATF7's functions and its role in disease pathogenesis.

Genular Protein ID: 1327856087

Symbol: ATF7_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-7

UniProtKB Accession Codes:

P17544 A5D6Y4 B2RMP1 B4DQL4 Q13814 Q8IVR8 Q9UD83

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 13 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 10 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1694576

Title: Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells.

PubMed ID: 1694576

DOI: 10.1093/nar/18.12.3467

PubMed ID: 8288576

Title: ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers.

PubMed ID: 8288576

DOI: 10.1016/s0021-9258(17)42236-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1827203

Title: Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

PubMed ID: 1827203

DOI: 10.1073/pnas.88.9.3720

PubMed ID: 8417352

Title: Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a.

PubMed ID: 8417352

DOI: 10.1128/mcb.13.1.561-570.1993

PubMed ID: 8290251

Title: Jun and Fos heterodimerize with ATFa, a member of the ATF/CREB family and modulate its transcriptional activity.

PubMed ID: 8290251

PubMed ID: 10376527

Title: Role of the ATFa/JNK2 complex in Jun activation.

PubMed ID: 10376527

DOI: 10.1038/sj.onc.1202723

PubMed ID: 15735663

Title: A functional interaction between ATF7 and TAF12 that is modulated by TAF4.

PubMed ID: 15735663

DOI: 10.1038/sj.onc.1208565

PubMed ID: 17264123

Title: Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity.

PubMed ID: 17264123

DOI: 10.1093/nar/gkl1168

PubMed ID: 18950637

Title: p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive.

PubMed ID: 18950637

DOI: 10.1016/j.jmb.2008.10.008

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21858082

Title: A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.

PubMed ID: 21858082

DOI: 10.1371/journal.pone.0023351

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29490055

Title: ATF7 mediates TNF-alpha-induced telomere shortening.

PubMed ID: 29490055

DOI: 10.1093/nar/gky155

Sequence Information:

  • Length: 483
  • Mass: 51757
  • Checksum: 07080BC24FED635B
  • Sequence:
    • MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 
CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS TPDIKIKEEE PVEVDSSPPD 
SPASSPCSPP LKEKEVTPKP VLISTPTPTI VRPGSLPLHL GYDPLHPTLP SPTSVITQAP 
PSNRQMGSPT GSLPLVMHLA NGQTMPVLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN 
SSGSISPSGH PIPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP 
DAPSPAQPQV SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR QKRKLWVSSL 
EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV TALQKKTQGY LESPKESSEP 
TGSPAPVIQH SSATAPSNGL SVRSAAEAVA TSVLTQMASQ RTELSMPIQS HVIMTPQSQS 
AGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.