Details for: SNRNP27

Gene ID: 11017

Symbol: SNRNP27

Ensembl ID: ENSG00000124380

Description: small nuclear ribonucleoprotein U4/U6.U5 subunit 27

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.71
    Marker Score: 4,732
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.74
    Marker Score: 4,268
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.67
    Marker Score: 1,747
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3,316
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.52
    Marker Score: 5,892
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.49
    Marker Score: 2,143
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.46
    Marker Score: 3,044
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.44
    Marker Score: 1,526
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.43
    Marker Score: 1,436
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.41
    Marker Score: 570
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.4
    Marker Score: 1,577
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4
    Marker Score: 47,707
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.37
    Marker Score: 914
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.32
    Marker Score: 1,600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.31
    Marker Score: 891
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.27
    Marker Score: 1,194
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.26
    Marker Score: 3,422
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.24
    Marker Score: 617
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.24
    Marker Score: 456
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.24
    Marker Score: 2,101
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.22
    Marker Score: 1,305
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.21
    Marker Score: 283
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.16
    Marker Score: 562
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.16
    Marker Score: 1,642
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.16
    Marker Score: 328
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.16
    Marker Score: 345
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 266
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.14
    Marker Score: 4,223
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.14
    Marker Score: 1,754
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.13
    Marker Score: 14,870
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4,409
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.11
    Marker Score: 523
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.1
    Marker Score: 627
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.09
    Marker Score: 1,940
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.09
    Marker Score: 1,164
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.09
    Marker Score: 1,275
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.09
    Marker Score: 4,681
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.08
    Marker Score: 218
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.06
    Marker Score: 2,934
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.06
    Marker Score: 998
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.06
    Marker Score: 584
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.06
    Marker Score: 1,457
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.06
    Marker Score: 667
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.05
    Marker Score: 26,961
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.05
    Marker Score: 36,341
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.03
    Marker Score: 255
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.03
    Marker Score: 687
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.03
    Marker Score: 231
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.02
    Marker Score: 344
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.02
    Marker Score: 261
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.02
    Marker Score: 5,019
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.01
    Marker Score: 952
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.01
    Marker Score: 635
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.01
    Marker Score: 1,757
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.01
    Marker Score: 2,291
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1
    Marker Score: 8,639
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1,471
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,607
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.99
    Marker Score: 2,950
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.99
    Marker Score: 1,195
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,830
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.99
    Marker Score: 526
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.99
    Marker Score: 6,313
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.98
    Marker Score: 584
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,375
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.98
    Marker Score: 3,766
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.98
    Marker Score: 2,784
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.97
    Marker Score: 191
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.97
    Marker Score: 240
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.97
    Marker Score: 231
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1,013
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.96
    Marker Score: 1,541
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.95
    Marker Score: 2,360
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.94
    Marker Score: 245
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.94
    Marker Score: 2,223
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.94
    Marker Score: 227
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.94
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,377
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.94
    Marker Score: 1,534
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.93
    Marker Score: 1,864
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.93
    Marker Score: 245
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.92
    Marker Score: 1,222
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.91
    Marker Score: 10,304
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.91
    Marker Score: 456
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.91
    Marker Score: 897
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.91
    Marker Score: 1,708
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.91
    Marker Score: 281
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.91
    Marker Score: 1,136
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 261
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.9
    Marker Score: 873
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.9
    Marker Score: 1,066
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.9
    Marker Score: 389
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,700
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.9
    Marker Score: 10,474
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9
    Marker Score: 804
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.9
    Marker Score: 2,354
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.9
    Marker Score: 5,452
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.89
    Marker Score: 539

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNRNP27 is a member of the U4/U6.U5 small nuclear ribonucleoprotein (snRNP) complex, a key player in the RNA splicing process. This complex is composed of five subunits, each with distinct functions: U1, U2, U4, U5, and U6. SNRNP27 specifically interacts with the U4/U6.U5 tri-snRNP complex, facilitating the recognition and binding of introns to the spliceosome. The U4/U6.U5 tri-snRNP complex is responsible for the catalytic activity of the spliceosome, which ultimately results in the removal of introns and the formation of mature mRNA. **Pathways and Functions:** The SNRNP27 gene is intricately linked to several cellular processes, including: 1. **RNA Splicing**: SNRNP27 plays a critical role in the recognition and binding of introns to the spliceosome, ensuring accurate splicing of precursor mRNAs. 2. **Metabolism of RNA**: SNRNP27 is involved in the regulation of RNA metabolism, including the processing of capped intron-containing pre-mRNAs. 3. **Nucleic Acid Binding**: SNRNP27 binds to nucleic acids, facilitating the interaction between the U4/U6.U5 tri-snRNP complex and the pre-mRNA. 4. **Spliceosome Assembly**: SNRNP27 contributes to the assembly of the U4/U6.U5 tri-snRNP complex, a critical step in the spliceosome-mediated RNA splicing process. **Clinical Significance:** Dysregulation of SNRNP27 has been implicated in various diseases, including: 1. **Splice Site Variants**: Mutations in the SNRNP27 gene can lead to aberrant splicing, resulting in the production of aberrant mRNAs and proteins. 2. **Neurological Disorders**: SNRNP27 has been linked to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), where aberrant RNA splicing contributes to disease progression. 3. **Cancer**: Alterations in SNRNP27 expression have been observed in various types of cancer, suggesting a potential role in tumorigenesis and cancer progression. In conclusion, the SNRNP27 gene is a crucial component of the spliceosome complex, playing a pivotal role in RNA processing and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms underlying SNRNP27 function. Further research is necessary to unravel the intricacies of SNRNP27 and its role in maintaining cellular homeostasis.

Genular Protein ID: 3197844269

Symbol: SNR27_HUMAN

Name: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

UniProtKB Accession Codes:

Q8WVK2 Q15410

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7931148

Title: Altered expression of the novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1.

PubMed ID: 7931148

DOI: 10.1099/0022-1317-75-10-2625

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9085842

Title: The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.

PubMed ID: 9085842

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 155
  • Mass: 18860
  • Checksum: 26BC291950E49B9F
  • Sequence:
    • MGRSRSRSPR RERRRSRSTS RERERRRRER SRSRERDRRR SRSRSPHRRR SRSPRRHRST 
SPSPSRLKER RDEEKKETKE TKSKERQITE EDLEGKTEEE IEMMKLMGFA SFDSTKGKKV 
DGSVNAYAIN VSQKRKYRQY MNRKGGFNRP LDFIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.