Details for: TMED1

Gene ID: 11018

Symbol: TMED1

Ensembl ID: ENSG00000099203

Description: transmembrane p24 trafficking protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.74
    Marker Score: 6,857
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.58
    Marker Score: 3,291
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.51
    Marker Score: 1,009
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.48
    Marker Score: 51,129
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.42
    Marker Score: 2,355
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.31
    Marker Score: 371
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3
    Marker Score: 8,445
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.27
    Marker Score: 2,166
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.23
    Marker Score: 680
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.23
    Marker Score: 5,323
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.19
    Marker Score: 280
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.18
    Marker Score: 1,276
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.16
    Marker Score: 1,231
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.16
    Marker Score: 15,303
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.15
    Marker Score: 2,889
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11,161
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.08
    Marker Score: 2,944
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11,925
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.03
    Marker Score: 262
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1
    Marker Score: 497
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1
    Marker Score: 2,673
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,697
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,922
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,392
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1,857
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.97
    Marker Score: 3,601
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.95
    Marker Score: 1,012
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 983
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.95
    Marker Score: 960
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.94
    Marker Score: 1,245
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.93
    Marker Score: 992
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.92
    Marker Score: 7,996
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9
    Marker Score: 5,349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,693
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.89
    Marker Score: 201
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.89
    Marker Score: 429
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.89
    Marker Score: 1,429
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.89
    Marker Score: 489
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,043
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.87
    Marker Score: 820
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.87
    Marker Score: 590
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.87
    Marker Score: 2,039
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,226
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.86
    Marker Score: 1,964
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1,214
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.84
    Marker Score: 1,158
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.83
    Marker Score: 308
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.82
    Marker Score: 2,276
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.82
    Marker Score: 924
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 516
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.82
    Marker Score: 388
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1,198
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.81
    Marker Score: 399
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8
    Marker Score: 1,887
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.78
    Marker Score: 520
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.78
    Marker Score: 1,237
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.78
    Marker Score: 3,010
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.78
    Marker Score: 2,992
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 969
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.76
    Marker Score: 257
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2,596
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.75
    Marker Score: 394
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.75
    Marker Score: 1,225
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.75
    Marker Score: 797
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.74
    Marker Score: 696
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.74
    Marker Score: 145
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.74
    Marker Score: 1,386
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 3,008
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.73
    Marker Score: 1,458
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.72
    Marker Score: 216
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.72
    Marker Score: 1,702
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.71
    Marker Score: 5,297
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.71
    Marker Score: 382
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.71
    Marker Score: 325
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 368
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.71
    Marker Score: 228
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.71
    Marker Score: 172
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.71
    Marker Score: 1,855
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.71
    Marker Score: 1,340
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.69
    Marker Score: 239
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.69
    Marker Score: 199
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.69
    Marker Score: 807
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.68
    Marker Score: 23,175
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.68
    Marker Score: 1,537
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.67
    Marker Score: 678

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMED1 is a transmembrane protein belonging to the emp24 family, characterized by its unique transmembrane domain and p24 protein sequence. Its structure allows it to interact with various proteins and lipids, facilitating the transport of cargo between the ER and Golgi apparatus. TMED1's expression is tissue-specific, with significant levels detected in placental villous trophoblasts, epithelial cells of the nephron, and mesenchymal cells. This specificity suggests that TMED1 plays a critical role in the development and function of these cell types. **Pathways and Functions** TMED1 is involved in several key cellular pathways, including: 1. **Cargo receptor activity**: TMED1 acts as a receptor for cargo proteins, facilitating their transport between the ER and Golgi apparatus. 2. **Cell-cell signaling**: TMED1 interacts with signaling molecules, modulating cell-cell communication and influencing cellular responses to external stimuli. 3. **Copii-coated ER to Golgi transport vesicle**: TMED1 is involved in the formation and function of copii-coated vesicles, which are essential for the transport of cargo proteins between the ER and Golgi apparatus. 4. **Endoplasmic reticulum (ER) to Golgi vesicle-mediated transport**: TMED1 regulates the transport of proteins between the ER and Golgi apparatus, ensuring proper protein folding, modification, and sorting. 5. **Innate immune response**: TMED1 is involved in the recognition and response to pathogens, highlighting its importance in maintaining immune homeostasis. **Clinical Significance** Dysregulation of TMED1 has been implicated in various diseases, including: 1. **Cancer**: Alterations in TMED1 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: TMED1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Immune system disorders**: TMED1 plays a crucial role in the regulation of the immune response, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis. In conclusion, TMED1 is a vital gene involved in various cellular processes, including protein transport, cell signaling, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of TMED1 in human health and disease.

Genular Protein ID: 1171585833

Symbol: TMED1_HUMAN

Name: Transmembrane emp24 domain-containing protein 1

UniProtKB Accession Codes:

Q13445

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8621446

Title: Cloning of a putative ligand for the T1/ST2 receptor.

PubMed ID: 8621446

DOI: 10.1074/jbc.271.10.5784

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 10852829

Title: Coupled transport of p24 family members.

PubMed ID: 10852829

DOI: 10.1242/jcs.113.13.2507

PubMed ID: 12237308

Title: Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.

PubMed ID: 12237308

DOI: 10.1074/jbc.m206989200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23319592

Title: The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.

PubMed ID: 23319592

DOI: 10.1074/jbc.m112.403899

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32614325

Title: Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.

PubMed ID: 32614325

DOI: 10.7554/elife.57306

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 227
  • Mass: 25206
  • Checksum: 058C5274E05F8575
  • Sequence:
    • MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY 
QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF 
FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA 
RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.