Details for: RCBTB2

Gene ID: 1102

Symbol: RCBTB2

Ensembl ID: ENSG00000136161

Description: RCC1 and BTB domain containing protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.42
    Marker Score: 1933
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.07
    Marker Score: 8460
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.37
    Marker Score: 680
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.31
    Marker Score: 1442
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.25
    Marker Score: 8162.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.25
    Marker Score: 1337
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.19
    Marker Score: 2426
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.14
    Marker Score: 277
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 366
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.13
    Marker Score: 676
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.12
    Marker Score: 1051
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.09
    Marker Score: 1896
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.08
    Marker Score: 519
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58549
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16067
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.01
    Marker Score: 1556
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47958
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.92
    Marker Score: 978
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.91
    Marker Score: 1903
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.9
    Marker Score: 33089
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.89
    Marker Score: 1512
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5247
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4910
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.85
    Marker Score: 52547
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.83
    Marker Score: 1611
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.82
    Marker Score: 9505
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.81
    Marker Score: 872
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.81
    Marker Score: 855
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.77
    Marker Score: 829
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4646
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.77
    Marker Score: 1027
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.77
    Marker Score: 874
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.77
    Marker Score: 763.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1221
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.75
    Marker Score: 4779
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 217
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 232
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.73
    Marker Score: 1603
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3060
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.72
    Marker Score: 875
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.72
    Marker Score: 357
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.72
    Marker Score: 7265
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.71
    Marker Score: 9428.5
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.7
    Marker Score: 3680.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5923
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6886.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 326
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.68
    Marker Score: 236
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.68
    Marker Score: 744
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.68
    Marker Score: 22830
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.68
    Marker Score: 758
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.67
    Marker Score: 421
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.66
    Marker Score: 285
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.66
    Marker Score: 1203
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.66
    Marker Score: 751
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 845
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.65
    Marker Score: 753
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.64
    Marker Score: 232
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.64
    Marker Score: 379.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.63
    Marker Score: 644
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.63
    Marker Score: 701
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.63
    Marker Score: 1210.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.62
    Marker Score: 1415
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.62
    Marker Score: 3331
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.62
    Marker Score: 2520
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.61
    Marker Score: 588
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 651
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.6
    Marker Score: 552
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.59
    Marker Score: 138
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 391
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.59
    Marker Score: 287
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1391.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.59
    Marker Score: 398
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.58
    Marker Score: 2414
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.58
    Marker Score: 950
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.58
    Marker Score: 308
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.57
    Marker Score: 507
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.57
    Marker Score: 684
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.56
    Marker Score: 700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.56
    Marker Score: 4141
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 259
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.55
    Marker Score: 226
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.55
    Marker Score: 559
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.55
    Marker Score: 391
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.55
    Marker Score: 135
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.55
    Marker Score: 607

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Other Information

**Key characteristics:** * RCBTB2 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including pulmonary interstitial fibroblast, pro-T cell, central nervous system macrophage, corneal epithelial cell, interstitial cell of ovary, neural crest cell, immature innate lymphoid cell, and endothelial cell of sinusoid. * It is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. **Pathways and functions:** * RCBTB2 is involved in the regulation of epithelial cell growth and migration by interacting with a variety of signaling pathways. * It is a key regulator of epithelial cell migration by binding to the E-cadherin-1 complex and promoting its interaction with the integrin-beta1 receptor. * It also interacts with the TGF-beta receptor and inhibits its activity, which leads to the inhibition of epithelial cell migration. * RCBTB2 is also involved in the regulation of cell cycle regulation by binding to the Cyclin-dependent kinase 4 (CDK4) and inhibiting its activity. **Clinical significance:** * Mutations in RCBTB2 have been linked to a number of human cancers, including lung cancer, breast cancer, and colon cancer. * Overexpression of RCBTB2 has been shown to promote epithelial cell proliferation and migration, which can lead to the development of cancer. * Inhibition of RCBTB2 has been shown to inhibit epithelial cell migration and proliferation, which can lead to the development of cancer.

Genular Protein ID: 345136329

Symbol: RCBT2_HUMAN

Name: RCC1 and BTB domain-containing protein 2

UniProtKB Accession Codes:

O95199 B2RDW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9806834

Title: cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor.

PubMed ID: 9806834

DOI: 10.1006/geno.1998.5498

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 551
  • Mass: 60315
  • Checksum: 0965A7FAC8143F03
  • Sequence:
    • MEEELPLFSG DSGKPVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY 
TTVNDEIFVL GTNCCGCLGL GDVQSTIEPR RLDSLNGKKI ACLSYGSGPH IVLATTEGEV 
FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN 
SGQVGSGSTV NQPIPRRVTG CLQNKVVVTI ACGQMCCMAV VDTGEVYVWG YNGNGQLGLG 
NSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQVYA WGANSYGQLG TGNKSNQSYP 
TPVTVEKDRI IEIAACHSTH TSAAKTQGGH VYMWGQCRGQ SVILPHLTHF SCTDDVFACF 
ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR 
SSLEDNEDDI VEMSEFSYPV YRAFLEYLYT DSISLSPEEA VGLLDLATFY RENRLKKLCQ 
QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI 
SKASRVGAFK N

Genular Protein ID: 1906675475

Symbol: B4E372_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E372

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 4 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 277
  • Mass: 31017
  • Checksum: B74ACEDACEA0049B
  • Sequence:
    • MSGVTTETGS LDSATVATSQ PLAEWQLCKA SVSRGIIEIA ACHSTHTSAA KTQGGHVYMW 
GQCRGQSVIL PHLTHFSCTD DVFACFATPA VTWRLLSVEP DDHLTVAESL KREFDNPDTA 
DLKFLVDGKY IYAHKVLLKI RCEHFRSSLE DNEDDIVEMS EFSYPVYRAF LEYLYTDSIS 
LSPEEAVGLL DLATFYRENR LKKLCQQTIK QGICEENAIA LLSAAVKYDA QDLEEFCFRF 
CINHLTVVTQ TSGFAEMDHD LLKNFISKAS RVGAFKN

Genular Protein ID: 3978558050

Symbol: B4DWG0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWG0

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 4 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 556
  • Mass: 60975
  • Checksum: 3A9EDD3B3DD5FB5D
  • Sequence:
    • MSALPRDLEL SNPREKLTKP VQATLSSLKM LDVGKWPIFS LCSEEELQLI RQACVFGSAG 
NEVLYTTVND EIFVLGTNCC GCLGLGDVQS TIEPRRLDSL NGKKIACLSY GSGPHIVLAT 
TEGEVFTWGH NAYSQLGNGT TNHGLVPCHI STNLSNKQVI EVACGSYHSL VLTSDGEVFA 
WGYNNSGQVG SGSTVNQPIP RRVTGCLQNK VVVTIACGQM CCMAVVDTGE VYVWGYNGNG 
QLGLGNSGNQ PTPCRVAALQ GIRVQRVACG YAHTLVLTDE GQVYAWGANS YGQLGTGNKS 
NQSYPTPVTV EKDRIIEIAA CHSTHTSAAK TQGGHVYMWG QCRGQSVILP HLTHFSCTDD 
VFACFATPAV TWRLLSVEPD DHLTVAESLK REFDNPDTAD LKFLVDGKYI YAHKVLLKIR 
CEHFRSSLED NEDDIVEMSE FSYPVYRAFL EYLYTDSISL SPEEAVGLLD LATFYRENRL 
KKLCQQTIKQ GICEENAIAL LSAAVKYDAQ DLEEFCFRFC INHLTVVTQT SGFAEMDHDL 
LKNFISKASR VGAFKN

Genular Protein ID: 3391086303

Symbol: Q59FB7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FB7

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 3 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 556
  • Mass: 60699
  • Checksum: 1C5C7BA4CACB9A8D
  • Sequence:
    • PCSNRYPGGG ADKAPACEEP VQATLSSLKM LDVGKWPIFS LCSEEELQLI RQACVFGSAG 
NEVLYTTVND EIFVLGTNCC GCLGLGDVQS TIEPRRLDSL NGKKIACLSY GSGPHIVLAT 
TEGEVFTWGH NAYSQLGNGT TNHGLVPCHI STNLSNKQVI EVACGSYHSL VLTSDGEVFA 
WGYNNSGQVG SGSTVNQPIP RRVTGCLQNK VVVTIACGQM CCMAVVDTGE VYVWGYNGNG 
QLGLGNSGNQ PTPCRVAALQ GIRVQRVACG YAHTLVLTDE GQVYAWGANS YGQLGTGNKS 
NQSYPTPVTV EKDRIIEIAA CHSTHTSAAK TQGGHVYMWG QCRGQSVILP HLTHFSCTDD 
VFACFATPAV TWRLLSVEPD DHLTVAESLK REFDNPDTAD LKFLVDGKYI YAHKVLLKIR 
CEHFRSSLED NEDDIVEMSE FSYPVYRAFL EYLYTDSISL SPEEAVGLLD LATFYRENRL 
KKLCQQTIKQ GICEENAIAL LSAAVKYDAQ DLEEFCFRFC INHLTVVTQT SGFAEMDHDL 
LKNFISKASR VGAFKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.