Details for: IFT27

Gene ID: 11020

Symbol: IFT27

Ensembl ID: ENSG00000100360

Description: intraflagellar transport 27

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.68
    Marker Score: 23,305
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.9
    Marker Score: 3,608
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.67
    Marker Score: 5,755
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.48
    Marker Score: 3,014
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.38
    Marker Score: 1,544
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.26
    Marker Score: 1,517
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.24
    Marker Score: 2,584
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.19
    Marker Score: 795
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.19
    Marker Score: 565
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.19
    Marker Score: 1,121
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.17
    Marker Score: 1,240
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.15
    Marker Score: 1,393
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.06
    Marker Score: 1,763
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.02
    Marker Score: 1,736
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.01
    Marker Score: 932
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1
    Marker Score: 1,256
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,674
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,897
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.98
    Marker Score: 3,637
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,387
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.98
    Marker Score: 364
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.98
    Marker Score: 229
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.96
    Marker Score: 1,421
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.95
    Marker Score: 432
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,391
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14,510
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.92
    Marker Score: 309
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.92
    Marker Score: 863
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.91
    Marker Score: 3,742
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.91
    Marker Score: 1,405
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.91
    Marker Score: 2,474
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.91
    Marker Score: 31,396
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,689
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.9
    Marker Score: 2,439
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.9
    Marker Score: 957
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.89
    Marker Score: 491
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.89
    Marker Score: 2,237
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.88
    Marker Score: 11,659
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.88
    Marker Score: 830
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.87
    Marker Score: 2,047
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.87
    Marker Score: 409
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.86
    Marker Score: 8,684
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,218
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.85
    Marker Score: 507
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.85
    Marker Score: 216
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.83
    Marker Score: 1,886
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4,722
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.83
    Marker Score: 890
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.82
    Marker Score: 2,200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.81
    Marker Score: 1,094
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.81
    Marker Score: 510
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.81
    Marker Score: 230
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.81
    Marker Score: 240
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.8
    Marker Score: 767
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.79
    Marker Score: 421
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.79
    Marker Score: 3,788
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.79
    Marker Score: 792
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.78
    Marker Score: 2,236
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.78
    Marker Score: 698
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5,067
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.77
    Marker Score: 523
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 222
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.77
    Marker Score: 3,300
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.76
    Marker Score: 148
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.75
    Marker Score: 1,793
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.75
    Marker Score: 800
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.75
    Marker Score: 1,081
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.75
    Marker Score: 306
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.75
    Marker Score: 15,902
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.74
    Marker Score: 634
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 239
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.74
    Marker Score: 27,311
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 640
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.73
    Marker Score: 5,457
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.73
    Marker Score: 4,674
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.73
    Marker Score: 852
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.73
    Marker Score: 7,530
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 434
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.72
    Marker Score: 2,813
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.71
    Marker Score: 160
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.71
    Marker Score: 985
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.7
    Marker Score: 713
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.7
    Marker Score: 1,082
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.7
    Marker Score: 346
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.69
    Marker Score: 339
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 216
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.69
    Marker Score: 1,571
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.69
    Marker Score: 164
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,878

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFT27 is a member of the IFT complex, which is composed of multiple subunits that work together to facilitate the transport of ciliary components. IFT27 is specifically involved in the anterograde transport of ciliary components from the basal body to the ciliary tip, ensuring the proper assembly and function of cilia. The protein exhibits high sequence similarity to IFT27 homologs from other species, suggesting its conserved role in ciliary function across different organisms. **Pathways and Functions:** IFT27 plays a crucial role in various cellular processes, including: 1. **Intraflagellar transport (IFT):** IFT27 is essential for the anterograde and retrograde transport of ciliary components, ensuring the proper assembly and function of cilia. 2. **Ciliary tip formation:** IFT27 is required for the formation of the ciliary tip, which is critical for the maintenance of ciliary function and the detection of external stimuli. 3. **Cochlear development:** IFT27 is involved in the development of the cochlea, a critical structure in the inner ear responsible for hearing. 4. **Spermatogenesis:** IFT27 is required for the development of the sperm flagellum, which is essential for fertilization. **Clinical Significance:** Dysregulation of IFT27 has been implicated in various human diseases, including: 1. **Kartagener syndrome:** A rare autosomal recessive disorder characterized by chronic sinusitis, bronchiectasis, and situs inversus. 2. **Primary ciliary dyskinesia (PCD):** A condition characterized by impaired ciliary function, leading to respiratory and reproductive complications. 3. **Congenital bilateral pericardial effusion (CBPE):** A rare condition characterized by fluid accumulation in the pericardial space, often associated with IFT27 mutations. In conclusion, IFT27 is a critical component of intraflagellar transport, essential for the maintenance of ciliary function and the development of various human organs. Dysregulation of IFT27 has been implicated in various human diseases, highlighting the importance of this gene in human health and disease. **Future Directions:** Further research is needed to fully understand the mechanisms of IFT27 and its role in human disease. Studies focusing on the functional characterization of IFT27 and its interactions with other ciliary proteins will provide valuable insights into the development of novel therapeutic strategies for IFT27-related disorders.

Genular Protein ID: 1618332863

Symbol: IFT27_HUMAN

Name: Intraflagellar transport protein 27 homolog

UniProtKB Accession Codes:

Q9BW83 O60897

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24488770

Title: IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.

PubMed ID: 24488770

DOI: 10.1093/hmg/ddu044

PubMed ID: 25443296

Title: The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.

PubMed ID: 25443296

DOI: 10.1016/j.devcel.2014.09.004

Sequence Information:

  • Length: 186
  • Mass: 20480
  • Checksum: 78CACF9ADF929B02
  • Sequence:
    • MVKLAAKCIL AGDPAVGKTA LAQIFRSDGA HFQKSYTLTT GMDLVVKTVP VPDTGDSVEL 
FIFDSAGKEL FSEMLDKLWE SPNVLCLVYD VTNEESFNNC SKWLEKARSQ APGISLPGVL 
VGNKTDLAGR RAVDSAEARA WALGQGLECF ETSVKEMENF EAPFHCLAKQ FHQLYREKVE 
VFRALA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.