Details for: RAB35

Gene ID: 11021

Symbol: RAB35

Ensembl ID: ENSG00000111737

Description: RAB35, member RAS oncogene family

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,698
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,922
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,391
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.96
    Marker Score: 9,891
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.94
    Marker Score: 642
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2,171
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14,144
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,695
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1,843
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.85
    Marker Score: 423
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,804
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 269
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.81
    Marker Score: 446
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 729
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.79
    Marker Score: 3,304
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1,593
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.78
    Marker Score: 776
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3,032
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1,160
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45,498
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.72
    Marker Score: 6,795
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,964
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.69
    Marker Score: 460
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5,890
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1,652
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.67
    Marker Score: 980
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.65
    Marker Score: 477
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 199
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.63
    Marker Score: 4,032
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.63
    Marker Score: 397
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.62
    Marker Score: 5,866
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.62
    Marker Score: 422
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 651
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 369
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.61
    Marker Score: 120
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.61
    Marker Score: 881
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.6
    Marker Score: 244
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.6
    Marker Score: 2,423
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.59
    Marker Score: 129
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.59
    Marker Score: 1,031
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.59
    Marker Score: 145
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 141
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.58
    Marker Score: 5,037
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.58
    Marker Score: 139
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.58
    Marker Score: 1,171
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.57
    Marker Score: 382
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.57
    Marker Score: 643
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.57
    Marker Score: 115
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.57
    Marker Score: 1,689
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.57
    Marker Score: 127
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.57
    Marker Score: 5,630
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.57
    Marker Score: 385
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3,388
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.56
    Marker Score: 140
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.56
    Marker Score: 499
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 601
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.56
    Marker Score: 525
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.56
    Marker Score: 353
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.55
    Marker Score: 554
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.55
    Marker Score: 596
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.54
    Marker Score: 340
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.54
    Marker Score: 4,228
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.54
    Marker Score: 719
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.54
    Marker Score: 617
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.54
    Marker Score: 19,825
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.54
    Marker Score: 139
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.54
    Marker Score: 1,069
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.53
    Marker Score: 122
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.53
    Marker Score: 304
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.53
    Marker Score: 893
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.53
    Marker Score: 1,429
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.52
    Marker Score: 253
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.52
    Marker Score: 3,351
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.52
    Marker Score: 472
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.52
    Marker Score: 753
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.52
    Marker Score: 466
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.52
    Marker Score: 309
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.52
    Marker Score: 132
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.52
    Marker Score: 113
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.52
    Marker Score: 149
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.52
    Marker Score: 135
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.52
    Marker Score: 144
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.51
    Marker Score: 251

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB35 is a member of the RAS superfamily, which consists of small GTPases that regulate various cellular processes. RAB35 is characterized by its ability to bind GTP and GDP, and its activation involves the exchange of GDP for GTP. This process is mediated by the guanine nucleotide exchange factor (GEF) RabGAPs and the GTPase-activating protein (GAP) RabGDS. RAB35 is also geranylgeranylated, a post-translational modification that anchors the protein to the plasma membrane. **Pathways and Functions:** RAB35 is involved in several key pathways, including: 1. **Antigen Processing and Presentation:** RAB35 regulates the transport of antigens from the endoplasmic reticulum to the Golgi apparatus, where they are processed and presented to the immune system. 2. **Membrane Trafficking:** RAB35 influences the movement of vesicles within the cell, regulating the transport of proteins and lipids between the plasma membrane and endosomes. 3. **Protein Localization:** RAB35 regulates the localization of proteins to specific compartments within the cell, including the endoplasmic reticulum, Golgi apparatus, and lysosomes. 4. **Endosomal Transport:** RAB35 regulates the transport of proteins and lipids between endosomes and the plasma membrane, influencing the recycling of cellular components. **Clinical Significance:** RAB35 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** RAB35 has been shown to be involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of membrane trafficking and protein localization contributes to disease progression. 2. **Cancer:** RAB35 has been found to be overexpressed in various types of cancer, including breast cancer and colon cancer, where it contributes to tumor progression and metastasis. 3. **Immunological Disorders:** RAB35 has been implicated in immunological disorders, such as autoimmune diseases and inflammatory conditions, where dysregulation of antigen processing and presentation contributes to disease pathology. In conclusion, RAB35 is a critical regulator of cellular processes, including membrane trafficking, protein localization, and endosomal transport. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of RAB35 in human disease and to develop therapeutic strategies to target this gene in the treatment of various disorders.

Genular Protein ID: 4057798855

Symbol: RAB35_HUMAN

Name: Ras-related protein Rab-35

UniProtKB Accession Codes:

Q15286 B2R6E0 B4E390

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SMART 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7811277

Title: Molecular cloning of two small GTP-binding proteins from human skeletal muscle.

PubMed ID: 7811277

DOI: 10.1006/bbrc.1994.2889

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16950109

Title: Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis.

PubMed ID: 16950109

DOI: 10.1016/j.cub.2006.07.020

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 20154091

Title: The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.

PubMed ID: 20154091

DOI: 10.1074/jbc.m109.050930

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21822290

Title: Modulation of Rab GTPase function by a protein phosphocholine transferase.

PubMed ID: 21822290

DOI: 10.1038/nature10335

PubMed ID: 22307087

Title: Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins.

PubMed ID: 22307087

DOI: 10.1038/emboj.2012.16

PubMed ID: 21951725

Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.

PubMed ID: 21951725

DOI: 10.1111/j.1600-0854.2011.01294.x

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 22065758

Title: Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.

PubMed ID: 22065758

DOI: 10.1073/pnas.1110415108

Sequence Information:

  • Length: 201
  • Mass: 23025
  • Checksum: 31EB15D6D42E076E
  • Sequence:
    • MARDYDHLFK LLIIGDSGVG KSSLLLRFAD NTFSGSYITT IGVDFKIRTV EINGEKVKLQ 
IWDTAGQERF RTITSTYYRG THGVIVVYDV TSAESFVNVK RWLHEINQNC DDVCRILVGN 
KNDDPERKVV ETEDAYKFAG QMGIQLFETS AKENVNVEEM FNCITELVLR AKKDNLAKQQ 
QQQQNDVVKL TKNSKRKKRC C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.