Details for: TDRKH

Gene ID: 11022

Symbol: TDRKH

Ensembl ID: ENSG00000182134

Description: tudor and KH domain containing

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.68
    Marker Score: 4,674
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.18
    Marker Score: 4,520
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,620
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.44
    Marker Score: 2,064
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.14
    Marker Score: 830
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.09
    Marker Score: 1,363
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,039
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.99
    Marker Score: 284
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,231
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 615
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.86
    Marker Score: 213
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1,183
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.74
    Marker Score: 6,353
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1,363
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 11,009
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 276
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,882
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1,399
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1,197
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.57
    Marker Score: 34,903
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 180
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.53
    Marker Score: 5,470
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 334
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 154
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.48
    Marker Score: 1,956
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.48
    Marker Score: 439
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.41
    Marker Score: 3,819
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.39
    Marker Score: 14,830
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.38
    Marker Score: 14,188
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.37
    Marker Score: 3,554
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.35
    Marker Score: 1,367
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.34
    Marker Score: 1,317
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.33
    Marker Score: 4,997
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 153
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.32
    Marker Score: 2,452
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 209
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.31
    Marker Score: 1,288
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.28
    Marker Score: 570
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.27
    Marker Score: 264
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.26
    Marker Score: 5,247
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.24
    Marker Score: 141
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.24
    Marker Score: 537
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.23
    Marker Score: 957
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.23
    Marker Score: 1,444
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.23
    Marker Score: 91
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 126
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.21
    Marker Score: 207
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2
    Marker Score: 225
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2
    Marker Score: 110
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.19
    Marker Score: 142
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.19
    Marker Score: 181
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.19
    Marker Score: 231
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.18
    Marker Score: 259
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.18
    Marker Score: 221
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.17
    Marker Score: 109
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.17
    Marker Score: 85
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.17
    Marker Score: 84
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.17
    Marker Score: 488
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 146
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 149
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.17
    Marker Score: 124
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 36
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 392
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.16
    Marker Score: 87
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.16
    Marker Score: 48

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TDRKH gene is a non-coding RNA gene that exhibits a unique combination of Tudor and KH domain-containing motifs. These motifs are known to play crucial roles in various post-transcriptional regulatory mechanisms, including RNA binding, gene silencing, and microRNA-mediated regulation. The TDRKH gene is also notable for its high expression levels in primordial germ cells, which are essential for the development of gametes. **Pathways and Functions:** The TDRKH gene is implicated in several key cellular pathways, including: 1. **Fertilization:** TDRKH has been shown to play a role in the regulation of fertilization, a complex process involving the interaction of sperm and egg cells. 2. **Gene Expression (Transcription):** The TDRKH gene is involved in the regulation of gene expression, particularly in the context of germ cell development. 3. **Gene Silencing by RNA:** TDRKH has been shown to interact with microRNAs, which are small non-coding RNAs that regulate gene expression by binding to target mRNAs. 4. **Mitochondrion:** TDRKH has been implicated in the regulation of mitochondrial function, which is essential for energy production and cellular homeostasis. 5. **Pi-body and Pip-body:** TDRKH has been shown to interact with Piwi-interacting RNAs (piRNAs), which are small RNAs that regulate gene expression in the germ cells. **Clinical Significance:** The TDRKH gene has been associated with several human diseases, including: 1. **Infertility:** Mutations in the TDRKH gene have been linked to infertility, a complex condition involving the failure to conceive or carry a pregnancy to term. 2. **Neurodevelopmental Disorders:** TDRKH has been implicated in the regulation of gene expression in the brain, and mutations in the gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder. 3. **Cancer:** TDRKH has been shown to interact with microRNAs that regulate gene expression in cancer cells, and alterations in the gene have been associated with cancer development and progression. In conclusion, the TDRKH gene is a complex non-coding RNA gene that plays a critical role in various cellular pathways, including fertilization, gene expression, and mitochondrial function. Its dysregulation has been implicated in several human diseases, highlighting the importance of further research into the immunological significance of this gene.

Genular Protein ID: 3735021923

Symbol: TDRKH_HUMAN

Name: Tudor and KH domain-containing protein

UniProtKB Accession Codes:

Q9Y2W6 D3DV24 Q5SZR3 Q5SZR5 Q8N582 Q9NYV5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 10 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10767542

Title: Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains.

PubMed ID: 10767542

DOI: 10.1016/s0378-1119(00)00087-1

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25621951

Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

PubMed ID: 25621951

DOI: 10.1038/ncb3097

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 561
  • Mass: 62046
  • Checksum: F89EBBDC48A8D420
  • Sequence:
    • MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP 
QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT 
ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ 
KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT 
SSSMEPTAPL VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF 
SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE DLTVHVGDIV 
AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK DLRALRSDFL SLPFQAIECS 
LARIAPSGDQ WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSNGKKL 
DIGLELVHKG YAIELPEDIE ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC 
LSLSEAASMS GDDNLEDDYL L

Genular Protein ID: 3969951359

Symbol: B4DJ68_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJ68

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Gene3D 2 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 337
  • Mass: 37166
  • Checksum: C7168A73B227A646
  • Sequence:
    • MTEPGGAGEP ALWKNTSSSM EPTAPLVTPP PKGGGDMAVV VSKEGSWEKP SDDSFQKSEA 
QAIPEMPMFE IPSPDFSFHA DEYLEVYVSA SEHPNHFWIQ IVGSRSLQLD KLVNEMTQHY 
ENSVPEDLTV HVGDIVAAPL PTNGSWYRAR VLGTLENGNL DLYFVDFGDN GDCPLKDLRA 
LRSDFLSLPF QAIECSLARI APSGDQWEEE ALDEFDRLTH CADWKPLVAK ISSYVQTGIS 
TWPKIYLYDT SNGKKLDIGL ELVHKGYAIE LPEDIEENRA VPDMLKDMAT ETDASLSTLL 
TETKKSSGEI THTLSCLSLS EAASMSGDDN LEDDYLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.