Details for: LILRA1

Gene ID: 11024

Symbol: LILRA1

Ensembl ID: ENSG00000104974

Description: leukocyte immunoglobulin like receptor A1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.95
    Marker Score: 2,079
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.8
    Marker Score: 1,094
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.8
    Marker Score: 3,498
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.51
    Marker Score: 3,641
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.48
    Marker Score: 6,136
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72,816
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,810
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.97
    Marker Score: 983
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.91
    Marker Score: 693
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.84
    Marker Score: 9,782
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.83
    Marker Score: 565
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.77
    Marker Score: 1,919
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 490
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.52
    Marker Score: 181
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 467
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.43
    Marker Score: 220
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4
    Marker Score: 4,089
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.38
    Marker Score: 995
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.33
    Marker Score: 225
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 492
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.3
    Marker Score: 194
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.28
    Marker Score: 83
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.26
    Marker Score: 263
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.26
    Marker Score: 198
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.25
    Marker Score: 331
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.24
    Marker Score: 435
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.24
    Marker Score: 118
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.21
    Marker Score: 242
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.21
    Marker Score: 138
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.19
    Marker Score: 1,165
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.17
    Marker Score: 185
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.16
    Marker Score: 67
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.16
    Marker Score: 117
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 281
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 417
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.13
    Marker Score: 47
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 86
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.12
    Marker Score: 109
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 126
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.09
    Marker Score: 80
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 56
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.06
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor**: LILRA1 is a transmembrane receptor protein, consisting of an extracellular immunoglobulin-like domain, a transmembrane domain, and an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). 2. **Inhibitory Function**: LILRA1 exhibits inhibitory MHC class I receptor activity, suggesting its role in modulating immune responses by regulating the activity of MHC class I molecules. 3. **Cell Surface Signaling**: LILRA1 is involved in cell surface signaling pathways, including the cytokine-mediated signaling pathway, which involves the interaction with cytokines and other signaling molecules. 4. **Expression on Immune Cells**: LILRA1 is expressed on various immune cells, including CD14-low, CD16-positive monocytes, myeloid dendritic cells, and classical monocytes, highlighting its importance in immune cell function and regulation. **Pathways and Functions:** 1. **Adaptive Immune Response**: LILRA1 is involved in regulating the adaptive immune response, including the activation and suppression of T cells and B cells. 2. **Antigen Binding**: LILRA1 binds to antigens, which triggers signaling pathways that modulate immune responses. 3. **Inhibitory Signaling**: LILRA1's inhibitory function is crucial in regulating immune responses by inhibiting the activity of MHC class I molecules. 4. **Neuroimmunological Interactions**: LILRA1 is also expressed in neurons, suggesting its role in neuroimmunological interactions and potentially in neurological disorders. **Clinical Significance:** 1. **Autoimmune Diseases**: LILRA1's role in regulating the adaptive immune response makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer Immunotherapy**: LILRA1's inhibitory function on MHC class I molecules may be exploited in cancer immunotherapy to enhance anti-tumor responses. 3. **Neurological Disorders**: LILRA1's expression in neurons suggests its potential involvement in neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Infectious Diseases**: LILRA1's role in regulating immune responses may also be relevant to the control of infectious diseases, such as tuberculosis and HIV. In conclusion, LILRA1 is a complex protein with multiple functions in the immune system and potentially in other physiological processes. Further research is necessary to fully elucidate its role in human disease and to explore its therapeutic potential.

Genular Protein ID: 3297861337

Symbol: LIRA1_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily A member 1

UniProtKB Accession Codes:

O75019 O75018 Q3MJA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 6 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9548455

Title: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

PubMed ID: 9548455

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 489
  • Mass: 53275
  • Checksum: 44469FD4884EA068
  • Sequence:
    • MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL 
YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG 
AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA 
IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE 
SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA 
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA 
GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS 
GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF 
EAQHSQRSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.