Details for: LILRB3

Gene ID: 11025

Symbol: LILRB3

Ensembl ID: ENSG00000204577

Description: leukocyte immunoglobulin like receptor B3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.53
    Marker Score: 2,492
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.8
    Marker Score: 11,645
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.55
    Marker Score: 1,549
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.12
    Marker Score: 118,371
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.94
    Marker Score: 4,843
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,478
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.4
    Marker Score: 1,601
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.39
    Marker Score: 3,357
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.26
    Marker Score: 1,288
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.21
    Marker Score: 31,105
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.17
    Marker Score: 2,271
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,627
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.1
    Marker Score: 380
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.07
    Marker Score: 12,412
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,805
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.01
    Marker Score: 423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,048
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.99
    Marker Score: 6,039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 658
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.96
    Marker Score: 2,479
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 386
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.93
    Marker Score: 511
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,265
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.85
    Marker Score: 369
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3,337
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,183
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.58
    Marker Score: 352
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.55
    Marker Score: 286
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.52
    Marker Score: 633
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.49
    Marker Score: 491
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.48
    Marker Score: 481
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.42
    Marker Score: 377
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.42
    Marker Score: 466
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.41
    Marker Score: 274
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.38
    Marker Score: 491
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 351
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.36
    Marker Score: 379
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.35
    Marker Score: 269
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.34
    Marker Score: 490
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.34
    Marker Score: 230
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.34
    Marker Score: 93
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.27
    Marker Score: 175
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.27
    Marker Score: 133
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.26
    Marker Score: 179
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.24
    Marker Score: 210
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 113
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.17
    Marker Score: 109
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.15
    Marker Score: 109
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.15
    Marker Score: 975
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.14
    Marker Score: 181
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 279
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.13
    Marker Score: 65
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 237
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 145
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.12
    Marker Score: 122
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 23
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.12
    Marker Score: 99
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.12
    Marker Score: 27

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Receptor:** LILRB3 is a transmembrane receptor with a single extracellular immunoglobulin-like domain, which mediates interactions with various ligands, including MHC class I molecules, CD94, and HLA-E. 2. **Immune Regulation:** LILRB3 is involved in the negative regulation of immune responses, acting as a checkpoint molecule to prevent excessive or autoimmune reactions. 3. **Myeloid Cell Expression:** This receptor is specifically expressed on subsets of myeloid cells, including classical and non-classical monocytes, dendritic cells, and macrophages. 4. **Ligand Interactions:** LILRB3 interacts with several ligands, including MHC class I molecules, CD94, and HLA-E, which are involved in immune regulation and tolerance. **Pathways and Functions:** 1. **Adaptive Immune Response:** LILRB3 regulates the adaptive immune response by modulating the activity of T cells and dendritic cells. 2. **Innate Immune Response:** This receptor also plays a role in the innate immune response, particularly in the regulation of neutrophil degranulation and osteoclast differentiation. 3. **Immune Evasion:** LILRB3 can inhibit the activation of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), thereby promoting immune evasion by tumor cells. 4. **Tolerance and Immune Suppression:** LILRB3 is involved in the establishment of immune tolerance, particularly in the context of organ transplantation and cancer immunotherapy. **Clinical Significance:** 1. **Autoimmune Disorders:** Dysregulation of LILRB3 has been implicated in various autoimmune disorders, including multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Cancer Immunotherapy:** LILRB3 is a promising target for cancer immunotherapy, as its dysregulation can lead to immune evasion and tumor progression. 3. **Infectious Diseases:** This receptor may also play a role in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. 4. **Transplantation:** LILRB3 is involved in the regulation of immune responses in the context of organ transplantation, and its dysregulation can lead to graft rejection. In conclusion, LILRB3 is a critical immunoregulatory receptor that plays a significant role in modulating immune responses, from innate to adaptive immunity. Its dysregulation has been implicated in various immune-related disorders, and it presents a promising target for cancer immunotherapy and transplantation. Further research is needed to fully elucidate the functional significance of LILRB3 and its potential applications in human disease.

Genular Protein ID: 4227746912

Symbol: C9JWL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JWL8

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 631
  • Mass: 69433
  • Checksum: C7ACB0BDCC783CC9
  • Sequence:
    • MTPALTALLC LGLSLGPRTR MQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSLEAQEYQL 
DKEGSPEPWD RNNPLEPKNK ARFSIPSMTQ HHAGRYRCHY YSSAGWSEPS DPLELVMTGF 
YNKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSGGFQAL 
FPVGPVTPSH RWRFTCYYYY TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS 
LTLQCGSDVG YDRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH 
NLSSEWSAPS DPLDILITGQ IYDTVSLSAQ PGPTVASGEN MTLLCQSRGY FDTFLLTKEG 
AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSR SSNPHLLSFP SEPLELMVSG 
HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV AFVLLLFLLL FLLLLRQRHS KHRTSDQRKT 
DFQRPAGAAE TEPKDRGLLR RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA 
VTYAPVKHSS PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS 
LTLRRKATEP PPSQEGEPPA EPSIYATLAI H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.