Details for: LILRA2

Gene ID: 11027

Symbol: LILRA2

Ensembl ID: ENSG00000239998

Description: leukocyte immunoglobulin like receptor A2

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Antigen binding
    (GO:0003823)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Defense response
    (GO:0006952)
  • Extracellular region
    (GO:0005576)
  • Igm binding
    (GO:0001791)
  • Inhibitory mhc class i receptor activity
    (GO:0032396)
  • Innate immune response
    (GO:0045087)
  • Innate immune response activating cell surface receptor signaling pathway
    (GO:0002220)
  • Negative regulation of lipopolysaccharide-mediated signaling pathway
    (GO:0031665)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Neutrophil activation involved in immune response
    (GO:0002283)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of calcium ion transport
    (GO:0051928)
  • Positive regulation of cell activation
    (GO:0050867)
  • Positive regulation of granulocyte colony-stimulating factor production
    (GO:0071657)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Signaling receptor activity
    (GO:0038023)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 3465794295

Symbol: LIRA2_HUMAN

Name: Leukocyte immunoglobulin-like receptor subfamily A member 2

UniProtKB Accession Codes:

Q8N149 O75020

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9548455

Title: A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

PubMed ID: 9548455

PubMed ID: 19658091

Title: Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.

PubMed ID: 19658091

DOI: 10.1002/eji.200839080

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12529506

Title: Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.

PubMed ID: 12529506

DOI: 10.1073/pnas.0337567100

PubMed ID: 22479404

Title: LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes.

PubMed ID: 22479404

DOI: 10.1371/journal.pone.0033478

PubMed ID: 27572839

Title: Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2.

PubMed ID: 27572839

DOI: 10.1038/nmicrobiol.2016.54

PubMed ID: 19230061

Title: Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes.

PubMed ID: 19230061

DOI: 10.1016/j.jmb.2009.01.006

Sequence Information:

  • Length: 483
  • Mass: 52966
  • Checksum: 07F891B9515BC1B6
  • Sequence:
    • MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVII QGSPVTLRCQ GSLQAEEYHL 
YRENKSASWV RRIQEPGKNG QFPIPSITWE HAGRYHCQYY SHNHSSEYSD PLELVVTGAY 
SKPTLSALPS PVVTSGGNVT LQCVSQVAFD GFILCKEGED EHPQRLNSHS HARGWSWAIF 
SVGPVSPSRR WSYRCYAYDS NSPYVWSLPS DLLELLVPGV SKKPSLSVQP GPMVAPGESL 
TLQCVSDVGY DRFVLYKEGE RDFLQRPGWQ PQAGLSQANF TLGPVSPSHG GQYRCYSAHN 
LSSEWSAPSD PLDILITGQF YDRPSLSVQP VPTVAPGKNV TLLCQSRGQF HTFLLTKEGA 
GHPPLHLRSE HQAQQNQAEF RMGPVTSAHV GTYRCYSSLS SNPYLLSLPS DPLELVVSEA 
AETLSPSQNK TDSTTTSLGQ HPQDYTVENL IRMGVAGLVL VVLGILLFEA QHSQRSLQDA 
AGR

Genular Protein ID: 2500021576

Symbol: A8MZH0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MZH0

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 454
  • Mass: 49956
  • Checksum: 0CB0FF8B3007821B
  • Sequence:
    • MTPILTVLIC LGHLPKPTLW AEPGSVIIQG SPVTLRCQGS LQAEEYHLYR ENKSASWVRR 
IQEPGKNGQF PIPSITWEHA GRYHCQYYSH NHSSEYSDPL ELVVTGAYSK PTLSALPSPV 
VTSGGNVTLQ CVSQVAFDGF ILCKEGEDEH PQRLNSHSHA RGWSWAIFSV GPVSPSRRWS 
YRCYAYDSNS PYVWSLPSDL LELLVPGVSK KPSLSVQPGP MVAPGESLTL QCVSDVGYDR 
FVLYKEGERD FLQRPGWQPQ AGLSQANFTL GPVSPSHGGQ YRCYSAHNLS SEWSAPSDPL 
DILITGQFYD RPSLSVQPVP TVAPGKNVTL LCQSRGQFHT FLLTKEGAGH PPLHLRSEHQ 
AQQNQAEFRM GPVTSAHVGT YRCYSSLSSN PYLLSLPSDP LELVVSASLG QHPQDYTVEN 
LIRMGVAGLV LVVLGILLFE AQHSQRSLQD AAGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.