RIPK3 | ENSG00000129465 | NCBI 11035

Details for: RIPK3

Gene ID: 11035

Symbol: RIPK3

Ensembl ID: ENSG00000129465

Description: receptor interacting serine/threonine kinase 3

Associated with

Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Defective ripk1-mediated regulated necrosis
(R-HSA-9693928)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Ion channel transport
(R-HSA-983712)
Microbial modulation of ripk1-mediated regulated necrosis
(R-HSA-9686347)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation of necroptotic cell death
(R-HSA-5675482)
Rip-mediated nfkb activation via zbp1
(R-HSA-1810476)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-1-mediated effects on programmed cell death
(R-HSA-9692913)
Sars-cov infections
(R-HSA-9679506)
Stimuli-sensing channels
(R-HSA-2672351)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tlr3-mediated ticam1-dependent programmed cell death
(R-HSA-9013957)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Transport of small molecules
(R-HSA-382551)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Trif-mediated programmed cell death
(R-HSA-2562578)
Trp channels
(R-HSA-3295583)
Viral infection pathways
(R-HSA-9824446)
Zbp1(dai) mediated induction of type i ifns
(R-HSA-1606322)
Activation of protein kinase activity
(GO:0032147)
Amyloid fibril formation
(GO:1990000)
Apoptotic signaling pathway
(GO:0097190)
Atp binding
(GO:0005524)
Cellular response to hydrogen peroxide
(GO:0070301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Execution phase of necroptosis
(GO:0097528)
Identical protein binding
(GO:0042802)
Lymph node development
(GO:0048535)
Necroptotic process
(GO:0070266)
Necroptotic signaling pathway
(GO:0097527)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of necroptotic process
(GO:0060545)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of phosphatase activity
(GO:0010922)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Programmed necrotic cell death
(GO:0097300)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein modification process
(GO:0036211)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Reactive oxygen species metabolic process
(GO:0072593)
Regulation of activated t cell proliferation
(GO:0046006)
Regulation of activation-induced cell death of t cells
(GO:0070235)
Regulation of adaptive immune response
(GO:0002819)
Regulation of apoptotic process
(GO:0042981)
Regulation of cd8-positive, alpha-beta cytotoxic t cell extravasation
(GO:2000452)
Regulation of t cell mediated cytotoxicity
(GO:0001914)
Regulation of type ii interferon production
(GO:0032649)
Signal transduction
(GO:0007165)
Spleen development
(GO:0048536)
T cell differentiation in thymus
(GO:0033077)
T cell homeostasis
(GO:0043029)
Thymus development
(GO:0048538)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

RIPK3_HUMAN

Genular Protein ID: 1341247392

Symbol: RIPK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y572 B4DJL9 C4AM87 Q5J795 Q5J796 Q6P5Y1

Database IDs:

Citations:

PubMed ID: 10339433

Title: Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.

PubMed ID: 10339433

DOI: 10.1016/s0960-9822(99)80239-5

PubMed ID: 10358032

Title: RIP3, a novel apoptosis-inducing kinase.

PubMed ID: 10358032

DOI: 10.1074/jbc.274.24.16871

PubMed ID: 15896315

Title: RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis.

PubMed ID: 15896315

DOI: 10.1016/j.bbrc.2005.04.114

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11734559

Title: Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.

PubMed ID: 11734559

DOI: 10.1074/jbc.m109488200

PubMed ID: 19498109

Title: RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

PubMed ID: 19498109

DOI: 10.1126/science.1172308

PubMed ID: 19524512

Title: Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.

PubMed ID: 19524512

DOI: 10.1016/j.cell.2009.05.021

PubMed ID: 19524513

Title: Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

PubMed ID: 19524513

DOI: 10.1016/j.cell.2009.05.037

PubMed ID: 20354226

Title: The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.

PubMed ID: 20354226

DOI: 10.1126/scisignal.3115re4

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22265413

Title: Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

PubMed ID: 22265413

DOI: 10.1016/j.cell.2011.11.031

PubMed ID: 22265414

Title: The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

PubMed ID: 22265414

DOI: 10.1016/j.cell.2011.11.030

PubMed ID: 21887730

Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

PubMed ID: 21887730

DOI: 10.1002/ibd.21851

PubMed ID: 22421439

Title: Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.

PubMed ID: 22421439

DOI: 10.1073/pnas.1200012109

PubMed ID: 25316792

Title: Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense.

PubMed ID: 25316792

DOI: 10.1073/pnas.1412767111

PubMed ID: 25674983

Title: Herpes simplex virus suppresses necroptosis in human cells.

PubMed ID: 25674983

DOI: 10.1016/j.chom.2015.01.003

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

PubMed ID: 32298652

Title: Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense.

PubMed ID: 32298652

DOI: 10.1016/j.cell.2020.03.040

PubMed ID: 32657447

Title: A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8.

PubMed ID: 32657447

DOI: 10.15252/embj.2020104469

PubMed ID: 33348174

Title: Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins.

PubMed ID: 33348174

DOI: 10.1016/j.bpc.2020.106524

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29681455

Title: The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex.

PubMed ID: 29681455

DOI: 10.1016/j.cell.2018.03.032

Sequence Information:

Length: 518
Mass: 56887
Checksum: BF755F8A0B1810A1
Sequence:

MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE 
VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL 
LKEVVLGMFY LHDQNPVLLH RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QSGTGSGEPG 
GTLGYLAPEL FVNVNRKAST ASDVYSFGIL MWAVLAGREV ELPTEPSLVY EAVCNRQNRP 
SLAELPQAGP ETPGLEGLKE LMQLCWSSEP KDRPSFQECL PKTDEVFQMV ENNMNAAVST 
VKDFLSQLRS SNRRFSIPES GQGGTEMDGF RRTIENQHSR NDVMVSEWLN KLNLEEPPSS 
VPKKCPSLTK RSRAQEEQVP QAWTAGTSSD SMAQPPQTPE TSTFRNQMPS PTSTGTPSPG 
PRGNQGAERQ GMNWSCRTPE PNPVTGRPLV NIYNCSGVQV GDNNYLTMQQ TTALPTWGLA 
PSGKGRGLQH PPPVGSQEGP KDPEAWSRPQ GWYNHSGK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RIPK3

Associated with

Other Information

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. PubMed ID: 10339433

RIP3, a novel apoptosis-inducing kinase. PubMed ID: 10358032

RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. PubMed ID: 15896315

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. PubMed ID: 11734559

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. PubMed ID: 19498109

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. PubMed ID: 19524512

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. PubMed ID: 19524513

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. PubMed ID: 20354226

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. PubMed ID: 22265413

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. PubMed ID: 22265414

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. PubMed ID: 21887730

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. PubMed ID: 22421439

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. PubMed ID: 25316792

Herpes simplex virus suppresses necroptosis in human cells. PubMed ID: 25674983

PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. PubMed ID: 29883609

Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. PubMed ID: 32298652

A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8. PubMed ID: 32657447

Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins. PubMed ID: 33348174

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex. PubMed ID: 29681455