Details for: GTF2A1L

Gene ID: 11036

Symbol: GTF2A1L

Ensembl ID: ENSG00000242441

Description: general transcription factor IIA subunit 1 like

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53,016
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.52
    Marker Score: 1,434
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.45
    Marker Score: 4,222
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2,172
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1,176
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.12
    Marker Score: 2,314
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.07
    Marker Score: 1,134
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,010
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1,735
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,180
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.73
    Marker Score: 428
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1,412
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 510
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,562
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.58
    Marker Score: 501
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.56
    Marker Score: 295
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.48
    Marker Score: 487
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.46
    Marker Score: 834
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 197
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.41
    Marker Score: 2,440
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 342
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.38
    Marker Score: 1,022
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.36
    Marker Score: 345
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.35
    Marker Score: 272
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.35
    Marker Score: 638
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 121
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 148
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.3
    Marker Score: 305
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.3
    Marker Score: 85
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 95
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 104
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 586
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.24
    Marker Score: 65
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.23
    Marker Score: 2,382
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.23
    Marker Score: 825
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 261
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.19
    Marker Score: 94
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.16
    Marker Score: 68
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 150
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 77
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.11
    Marker Score: 155
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1
    Marker Score: 182
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1
    Marker Score: 427
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.08
    Marker Score: 121
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.08
    Marker Score: 110
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 226
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 296
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.07
    Marker Score: 186
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of TFIIA:** GTF2A1L is a subunit of the general transcription factor IIA, which is a heterotrimeric complex composed of three subunits: alpha, beta, and gamma. The beta subunit (GTF2A1L) is specifically expressed in various cell types and is essential for the assembly and function of the TFIIA complex. 2. **RNA Polymerase II Association:** GTF2A1L interacts with RNA polymerase II (Pol II), the enzyme responsible for transcribing DNA to RNA. This interaction is crucial for the initiation and elongation phases of transcription. 3. **Transcriptional Regulation:** GTF2A1L is involved in the positive regulation of DNA-templated transcription, indicating its role in promoting gene expression. Its ability to interact with transcription factors and other regulatory proteins underscores its importance in modulating transcriptional programs. **Pathways and Functions:** 1. **Transcriptional Regulation:** GTF2A1L is involved in the regulation of transcription by RNA polymerase II, a key step in the expression of genes involved in cellular differentiation, development, and immune function. 2. **Immune Function:** GTF2A1L is expressed in various immune cells, including T cells, plasma cells, and B cells, suggesting its role in regulating immune responses and cell differentiation. 3. **Neurotransmission:** The expression of GTF2A1L in neurons and neural progenitor cells highlights its potential role in neurotransmission and synaptic plasticity. 4. **Developmental Processes:** GTF2A1L is also involved in developmental processes, such as cell proliferation and differentiation, in various cell types. **Clinical Significance:** 1. **Autoimmune Diseases:** Aberrant expression of GTF2A1L has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting its potential as a therapeutic target. 2. **Cancer:** Alterations in GTF2A1L expression have been observed in various cancers, suggesting its role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** The expression of GTF2A1L in neurons and neural progenitor cells underscores its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Gene Therapy:** GTF2A1L may serve as a target for gene therapy interventions aimed at regulating immune responses and promoting tissue repair in various diseases. In conclusion, GTF2A1L is a crucial component of the transcriptional machinery that plays a significant role in regulating gene expression, immune function, and developmental processes. Further research is needed to fully elucidate the functions and dysregulation of GTF2A1L in various diseases, and to explore its potential as a therapeutic target.

Genular Protein ID: 59414635

Symbol: TF2AY_HUMAN

Name: TFIIA-alpha and beta-like factor

UniProtKB Accession Codes:

Q9UNN4 B4DY14 Q53FD9 Q5D050

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10364255

Title: Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis.

PubMed ID: 10364255

DOI: 10.1074/jbc.274.25.18040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16525715

Title: Involvement of ALF in human spermatogenesis and male infertility.

PubMed ID: 16525715

Sequence Information:

  • Length: 478
  • Mass: 52444
  • Checksum: E63E9E4DD8DF9C59
  • Sequence:
    • MACLNPVPKL YRSVIEDVIE GVRNLFAEEG IEEQVLKDLK QLWETKVLQS KATEDFFRNS 
IQSPLFTLQL PHSLHQTLQS STASLVIPAG RTLPSFTTAE LGTSNSSANF TFPGYPIHVP 
AGVTLQTVSG HLYKVNVPIM VTETSGRAGI LQHPIQQVFQ QLGQPSVIQT SVPQLNPWSL 
QATTEKSQRI ETVLQQPAIL PSGPVDRKHL ENATSDILVS PGNEHKIVPE ALLCHQESSH 
YISLPGVVFS PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK 
NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQVD GSGDTSSNEE 
IGSTRDADEN EFLGNIDGGD LKVPEEEADS ISNEDSATNS SDNEDPQVNI VEEDPLNSGD 
DVSEQDVPDL FDTDNVIVCQ YDKIHRSKNK WKFYLKDGVM CFGGRDYVFA KAIGDAEW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.