Details for: RCC1

Gene ID: 1104

Symbol: RCC1

Ensembl ID: ENSG00000180198

Description: regulator of chromosome condensation 1

Associated with

Other Information

Genular Protein ID: 3790097226

Symbol: RCC1_HUMAN

Name: Regulator of chromosome condensation

UniProtKB Accession Codes:

P18754 Q16269 Q6NT97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3678831

Title: Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

PubMed ID: 3678831

DOI: 10.1101/gad.1.6.585

PubMed ID: 1769659

Title: Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis.

PubMed ID: 1769659

DOI: 10.1016/0888-7543(91)90156-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7983178

Title: Mammalian cells have two functional RCC1 proteins produced by alternative splicing.

PubMed ID: 7983178

DOI: 10.1242/jcs.107.8.2203

PubMed ID: 2236072

Title: A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation.

PubMed ID: 2236072

DOI: 10.1073/pnas.87.21.8617

PubMed ID: 1944575

Title: Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.

PubMed ID: 1944575

DOI: 10.1038/354080a0

PubMed ID: 12194828

Title: Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.

PubMed ID: 12194828

DOI: 10.1016/s0960-9822(02)01076-x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 17435751

Title: N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.

PubMed ID: 17435751

DOI: 10.1038/ncb1572

PubMed ID: 18762580

Title: Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.

PubMed ID: 18762580

DOI: 10.1083/jcb.200803110

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20668449

Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

PubMed ID: 20668449

DOI: 10.1038/nature09343

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22215983

Title: Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.

PubMed ID: 22215983

DOI: 10.1371/journal.pbio.1001225

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29040603

Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

PubMed ID: 29040603

DOI: 10.1093/jmcb/mjx045

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 9510255

Title: The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.

PubMed ID: 9510255

DOI: 10.1038/32204

PubMed ID: 11336674

Title: Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).

PubMed ID: 11336674

DOI: 10.1016/s0092-8674(01)00315-4

PubMed ID: 29042532

Title: Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1.

PubMed ID: 29042532

DOI: 10.1038/s41467-017-01057-7

Sequence Information:

  • Length: 421
  • Mass: 44969
  • Checksum: F6D225AF81928305
  • Sequence:
    • MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP 
ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK 
VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG 
NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV 
RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS 
GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV 
TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ 
S

Genular Protein ID: 3876311110

Symbol: A0A0S2Z404_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z404

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 452
  • Mass: 48146
  • Checksum: A31255E99A01A25F
  • Sequence:
    • MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QGACGPSPPD QKTRPVSHRS 
HSTEPGLVLT LGQGDVGQLG LGENVMERKK PALVSIPEDV VQAEAGGMHT VCLSKSGQVY 
SFGCNDEGAL GRDTSVEGSE MVPGKVELQE KVVQVSAGDS HTAALTDDGR VFLWGSFRDN 
NGVIGLLEPM KKSMVPVQVQ LDVPVVKVAS GNDHLVMLTA DGDLYTLGCG EQGQLGRVPE 
LFANRGGRQG LERLLVPKCV MLKSRGSRGH VRFQDAFCGA YFTFAISHEG HVYGFGLSNY 
HQLGTPGTES CFIPQNLTSF KNSTKSWVGF SGGQHHTVCM DSEGKAYSLG RAEYGRLGLG 
EGAEEKSIPT LISRLPAVSS VACGASVGYA VTKDGRVFAW GMGTNYQLGT GQDEDAWSPV 
EMMGKQLENR VVLSVSSGGQ HTVLLVKDKE QS

Genular Protein ID: 1865271710

Symbol: A0A0S2Z3I4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3I4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 438
  • Mass: 46753
  • Checksum: 223B8046E301E535
  • Sequence:
    • MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QVSHRSHSTE PGLVLTLGQG 
DVGQLGLGEN VMERKKPALV SIPEDVVQAE AGGMHTVCLS KSGQVYSFGC NDEGALGRDT 
SVEGSEMVPG KVELQEKVVQ VSAGDSHTAA LTDDGRVFLW GSFRDNNGVI GLLEPMKKSM 
VPVQVQLDVP VVKVASGNDH LVMLTADGDL YTLGCGEQGQ LGRVPELFAN RGGRQGLERL 
LVPKCVMLKS RGSRGHVRFQ DAFCGAYFTF AISHEGHVYG FGLSNYHQLG TPGTESCFIP 
QNLTSFKNST KSWVGFSGGQ HHTVCMDSEG KAYSLGRAEY GRLGLGEGAE EKSIPTLISR 
LPAVSSVACG ASVGYAVTKD GRVFAWGMGT NYQLGTGQDE DAWSPVEMMG KQLENRVVLS 
VSSGGQHTVL LVKDKEQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.