Details for: RCC1

Gene ID: 1104

Symbol: RCC1

Ensembl ID: ENSG00000180198

Description: regulator of chromosome condensation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.7775
    Cell Significance Index: -14.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.9340
    Cell Significance Index: -13.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.8068
    Cell Significance Index: -18.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.4485
    Cell Significance Index: -16.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.1106
    Cell Significance Index: -18.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.2350
    Cell Significance Index: -16.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.2909
    Cell Significance Index: -17.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7566
    Cell Significance Index: -18.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0953
    Cell Significance Index: -13.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6173
    Cell Significance Index: -18.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.0601
    Cell Significance Index: 85.5200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.4699
    Cell Significance Index: 21.9300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.5571
    Cell Significance Index: 9.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3275
    Cell Significance Index: 263.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2598
    Cell Significance Index: 37.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1232
    Cell Significance Index: 1014.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0034
    Cell Significance Index: 13.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9525
    Cell Significance Index: 154.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9253
    Cell Significance Index: 55.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9050
    Cell Significance Index: 23.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8855
    Cell Significance Index: 46.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8573
    Cell Significance Index: 40.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8288
    Cell Significance Index: 9.0100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7294
    Cell Significance Index: 4.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7020
    Cell Significance Index: 82.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6802
    Cell Significance Index: 67.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6033
    Cell Significance Index: 16.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4950
    Cell Significance Index: 34.2300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4311
    Cell Significance Index: 2.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4251
    Cell Significance Index: 11.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3800
    Cell Significance Index: 24.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3392
    Cell Significance Index: 185.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3254
    Cell Significance Index: 6.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3213
    Cell Significance Index: 57.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3206
    Cell Significance Index: 14.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3101
    Cell Significance Index: 62.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3036
    Cell Significance Index: 10.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2923
    Cell Significance Index: 7.9600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2716
    Cell Significance Index: 1.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2676
    Cell Significance Index: 50.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2273
    Cell Significance Index: 6.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2201
    Cell Significance Index: 27.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2001
    Cell Significance Index: 27.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1983
    Cell Significance Index: 4.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1900
    Cell Significance Index: 24.5500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1787
    Cell Significance Index: 1.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1642
    Cell Significance Index: 58.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1385
    Cell Significance Index: 61.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1324
    Cell Significance Index: 3.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1142
    Cell Significance Index: 8.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1075
    Cell Significance Index: 6.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0828
    Cell Significance Index: 2.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0585
    Cell Significance Index: 40.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0566
    Cell Significance Index: 1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0414
    Cell Significance Index: 1.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0343
    Cell Significance Index: 4.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0331
    Cell Significance Index: 2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0237
    Cell Significance Index: 4.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0027
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0203
    Cell Significance Index: -0.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0219
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0228
    Cell Significance Index: -16.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0328
    Cell Significance Index: -14.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0341
    Cell Significance Index: -0.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0508
    Cell Significance Index: -0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0526
    Cell Significance Index: -15.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0574
    Cell Significance Index: -5.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0597
    Cell Significance Index: -6.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0668
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0691
    Cell Significance Index: -1.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0809
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0958
    Cell Significance Index: -20.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0970
    Cell Significance Index: -11.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1695
    Cell Significance Index: -17.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1912
    Cell Significance Index: -11.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2232
    Cell Significance Index: -17.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2261
    Cell Significance Index: -4.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2295
    Cell Significance Index: -12.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2309
    Cell Significance Index: -6.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2432
    Cell Significance Index: -6.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2470
    Cell Significance Index: -15.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2494
    Cell Significance Index: -11.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2504
    Cell Significance Index: -15.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2700
    Cell Significance Index: -2.8000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2711
    Cell Significance Index: -1.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2740
    Cell Significance Index: -4.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2764
    Cell Significance Index: -1.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2803
    Cell Significance Index: -14.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3003
    Cell Significance Index: -11.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3136
    Cell Significance Index: -5.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RCC1 is a highly conserved gene, with high sequence identity across species, suggesting its critical role in fundamental cellular processes. The gene is primarily expressed in cells of the tracheobronchial tree, neural progenitor cells, and various types of immune cells, including CD4-positive T cells and alpha-beta memory T cells. RCC1's expression is also observed in non-immune cells, such as basal epithelial cells of the prostate and choroid plexus epithelial cells. The protein encoded by RCC1 (RCC1_HUMAN) exhibits guanyl-nucleotide exchange activity, binding to GTP and facilitating the exchange of GDP for GTP. **Pathways and Functions** RCC1 is integral to several key cellular pathways, including: 1. **Cell Cycle**: RCC1 plays a crucial role in the regulation of the cell cycle, specifically in the G1/S transition, mitotic metaphase, and anaphase. By activating the Rab2 GTPase, RCC1 promotes the proper separation of chromosomes during mitosis. 2. **Mitotic Spindle Organization**: RCC1's interaction with the mitotic spindle apparatus is essential for the proper alignment and separation of chromosomes during mitosis. 3. **Chromosome Condensation**: RCC1 regulates the condensation of chromosomes, ensuring that chromosomes are properly compacted and separated during cell division. 4. **Guanyl-Nucleotide Exchange Factor Activity**: RCC1's guanyl-nucleotide exchange activity facilitates the exchange of GDP for GTP, activating the Rab2 GTPase and promoting its interaction with the mitotic spindle apparatus. **Clinical Significance** RCC1's involvement in the regulation of the cell cycle and chromosome segregation makes it an attractive target for the development of cancer therapies. Alterations in RCC1 expression or function have been linked to various types of cancer, including: 1. **Cancer Therapy Resistance**: RCC1's role in the regulation of the cell cycle and chromosome segregation may contribute to cancer therapy resistance, as altered RCC1 expression or function can lead to impaired mitotic checkpoint function. 2. **Cancer Progression**: RCC1's involvement in the regulation of chromosome condensation and segregation may also contribute to cancer progression, as altered RCC1 expression or function can lead to chromosomal instability and aneuploidy. 3. **Immunotherapy**: RCC1's expression in immune cells, including CD4-positive T cells and alpha-beta memory T cells, makes it an attractive target for immunotherapy approaches, such as checkpoint inhibitors. In conclusion, RCC1 is a critical gene that plays a pivotal role in the regulation of the cell cycle and chromosome segregation. Its involvement in various cellular pathways and its expression in various cell types make it an attractive target for the development of cancer therapies and immunotherapies.

Genular Protein ID: 3790097226

Symbol: RCC1_HUMAN

Name: Regulator of chromosome condensation

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3678831

Title: Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.

PubMed ID: 3678831

DOI: 10.1101/gad.1.6.585

PubMed ID: 1769659

Title: Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis.

PubMed ID: 1769659

DOI: 10.1016/0888-7543(91)90156-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7983178

Title: Mammalian cells have two functional RCC1 proteins produced by alternative splicing.

PubMed ID: 7983178

DOI: 10.1242/jcs.107.8.2203

PubMed ID: 2236072

Title: A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation.

PubMed ID: 2236072

DOI: 10.1073/pnas.87.21.8617

PubMed ID: 1944575

Title: Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.

PubMed ID: 1944575

DOI: 10.1038/354080a0

PubMed ID: 12194828

Title: Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.

PubMed ID: 12194828

DOI: 10.1016/s0960-9822(02)01076-x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 17435751

Title: N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.

PubMed ID: 17435751

DOI: 10.1038/ncb1572

PubMed ID: 18762580

Title: Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.

PubMed ID: 18762580

DOI: 10.1083/jcb.200803110

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20668449

Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

PubMed ID: 20668449

DOI: 10.1038/nature09343

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22215983

Title: Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.

PubMed ID: 22215983

DOI: 10.1371/journal.pbio.1001225

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29040603

Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.

PubMed ID: 29040603

DOI: 10.1093/jmcb/mjx045

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 9510255

Title: The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.

PubMed ID: 9510255

DOI: 10.1038/32204

PubMed ID: 11336674

Title: Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).

PubMed ID: 11336674

DOI: 10.1016/s0092-8674(01)00315-4

PubMed ID: 29042532

Title: Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1.

PubMed ID: 29042532

DOI: 10.1038/s41467-017-01057-7

Sequence Information:

  • Length: 421
  • Mass: 44969
  • Checksum: F6D225AF81928305
  • Sequence:
  • MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP 
    ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK 
    VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG 
    NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV 
    RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS 
    GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV 
    TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ 
    S

Genular Protein ID: 3876311110

Symbol: A0A0S2Z404_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 452
  • Mass: 48146
  • Checksum: A31255E99A01A25F
  • Sequence:
  • MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QGACGPSPPD QKTRPVSHRS 
    HSTEPGLVLT LGQGDVGQLG LGENVMERKK PALVSIPEDV VQAEAGGMHT VCLSKSGQVY 
    SFGCNDEGAL GRDTSVEGSE MVPGKVELQE KVVQVSAGDS HTAALTDDGR VFLWGSFRDN 
    NGVIGLLEPM KKSMVPVQVQ LDVPVVKVAS GNDHLVMLTA DGDLYTLGCG EQGQLGRVPE 
    LFANRGGRQG LERLLVPKCV MLKSRGSRGH VRFQDAFCGA YFTFAISHEG HVYGFGLSNY 
    HQLGTPGTES CFIPQNLTSF KNSTKSWVGF SGGQHHTVCM DSEGKAYSLG RAEYGRLGLG 
    EGAEEKSIPT LISRLPAVSS VACGASVGYA VTKDGRVFAW GMGTNYQLGT GQDEDAWSPV 
    EMMGKQLENR VVLSVSSGGQ HTVLLVKDKE QS

Genular Protein ID: 1865271710

Symbol: A0A0S2Z3I4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 438
  • Mass: 46753
  • Checksum: 223B8046E301E535
  • Sequence:
  • MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QVSHRSHSTE PGLVLTLGQG 
    DVGQLGLGEN VMERKKPALV SIPEDVVQAE AGGMHTVCLS KSGQVYSFGC NDEGALGRDT 
    SVEGSEMVPG KVELQEKVVQ VSAGDSHTAA LTDDGRVFLW GSFRDNNGVI GLLEPMKKSM 
    VPVQVQLDVP VVKVASGNDH LVMLTADGDL YTLGCGEQGQ LGRVPELFAN RGGRQGLERL 
    LVPKCVMLKS RGSRGHVRFQ DAFCGAYFTF AISHEGHVYG FGLSNYHQLG TPGTESCFIP 
    QNLTSFKNST KSWVGFSGGQ HHTVCMDSEG KAYSLGRAEY GRLGLGEGAE EKSIPTLISR 
    LPAVSSVACG ASVGYAVTKD GRVFAWGMGT NYQLGTGQDE DAWSPVEMMG KQLENRVVLS 
    VSSGGQHTVL LVKDKEQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.