Details for: RCC1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 90.7775
Cell Significance Index: -14.1200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 53.9340
Cell Significance Index: -13.6800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 45.8068
Cell Significance Index: -18.8700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 40.4485
Cell Significance Index: -16.4300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 39.1106
Cell Significance Index: -18.4700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 17.2350
Cell Significance Index: -16.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.2909
Cell Significance Index: -17.6200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.7566
Cell Significance Index: -18.1000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.0953
Cell Significance Index: -13.3400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.6173
Cell Significance Index: -18.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.0601
Cell Significance Index: 85.5200 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.4699
Cell Significance Index: 21.9300 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.5571
Cell Significance Index: 9.9400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3275
Cell Significance Index: 263.4500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.2598
Cell Significance Index: 37.0000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1232
Cell Significance Index: 1014.2000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0034
Cell Significance Index: 13.6900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9525
Cell Significance Index: 154.9100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9253
Cell Significance Index: 55.5500 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.9050
Cell Significance Index: 23.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8855
Cell Significance Index: 46.0000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8573
Cell Significance Index: 40.2900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8288
Cell Significance Index: 9.0100 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.7294
Cell Significance Index: 4.5000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7020
Cell Significance Index: 82.7900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6802
Cell Significance Index: 67.2900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6033
Cell Significance Index: 16.1100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4950
Cell Significance Index: 34.2300 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.4311
Cell Significance Index: 2.8600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4251
Cell Significance Index: 11.3700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3800
Cell Significance Index: 24.5200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3392
Cell Significance Index: 185.2200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3254
Cell Significance Index: 6.9300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3213
Cell Significance Index: 57.9300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3206
Cell Significance Index: 14.5300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3101
Cell Significance Index: 62.2000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3036
Cell Significance Index: 10.5500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2923
Cell Significance Index: 7.9600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.2716
Cell Significance Index: 1.8400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2676
Cell Significance Index: 50.9300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2273
Cell Significance Index: 6.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2201
Cell Significance Index: 27.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2001
Cell Significance Index: 27.4800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1983
Cell Significance Index: 4.1500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1900
Cell Significance Index: 24.5500 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.1787
Cell Significance Index: 1.1000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1642
Cell Significance Index: 58.8800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1385
Cell Significance Index: 61.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1324
Cell Significance Index: 3.8200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1142
Cell Significance Index: 8.5100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1075
Cell Significance Index: 6.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0828
Cell Significance Index: 2.9100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0585
Cell Significance Index: 40.5000 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.0566
Cell Significance Index: 1.3800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0414
Cell Significance Index: 1.9300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0343
Cell Significance Index: 4.4000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0331
Cell Significance Index: 2.3400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0237
Cell Significance Index: 4.0500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0016
Cell Significance Index: -2.4000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0027
Cell Significance Index: -0.1800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0027
Cell Significance Index: -5.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0028
Cell Significance Index: -5.2900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0030
Cell Significance Index: -2.2500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0094
Cell Significance Index: -1.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0114
Cell Significance Index: -15.5600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0185
Cell Significance Index: -11.7700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0203
Cell Significance Index: -0.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0219
Cell Significance Index: -0.7000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0228
Cell Significance Index: -16.6900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0234
Cell Significance Index: -17.3300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0321
Cell Significance Index: -20.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0328
Cell Significance Index: -14.8700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0330
Cell Significance Index: -18.5900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0341
Cell Significance Index: -0.5700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0508
Cell Significance Index: -0.6500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0526
Cell Significance Index: -15.1300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0574
Cell Significance Index: -5.8600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0597
Cell Significance Index: -6.9600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0668
Cell Significance Index: -0.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0691
Cell Significance Index: -1.9800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0809
Cell Significance Index: -6.2100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0958
Cell Significance Index: -20.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0970
Cell Significance Index: -11.1100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1695
Cell Significance Index: -17.6500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1912
Cell Significance Index: -11.7200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2232
Cell Significance Index: -17.6800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2261
Cell Significance Index: -4.9500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2295
Cell Significance Index: -12.0500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2309
Cell Significance Index: -6.8000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2432
Cell Significance Index: -6.9400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2470
Cell Significance Index: -15.1800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2494
Cell Significance Index: -11.0300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2504
Cell Significance Index: -15.7800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2700
Cell Significance Index: -2.8000 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.2711
Cell Significance Index: -1.1800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2740
Cell Significance Index: -4.7000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2764
Cell Significance Index: -1.6700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2803
Cell Significance Index: -14.6000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3003
Cell Significance Index: -11.3700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.3136
Cell Significance Index: -5.0600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3790097226
Symbol: RCC1_HUMAN
Name: Regulator of chromosome condensation
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3678831
Title: Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.
PubMed ID: 3678831
DOI: 10.1101/gad.1.6.585
PubMed ID: 1769659
Title: Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis.
PubMed ID: 1769659
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7983178
Title: Mammalian cells have two functional RCC1 proteins produced by alternative splicing.
PubMed ID: 7983178
PubMed ID: 2236072
Title: A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation.
PubMed ID: 2236072
PubMed ID: 1944575
Title: Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1.
PubMed ID: 1944575
DOI: 10.1038/354080a0
PubMed ID: 12194828
Title: Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.
PubMed ID: 12194828
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16820410
Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.
PubMed ID: 16820410
DOI: 10.1242/jcs.03046
PubMed ID: 17435751
Title: N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.
PubMed ID: 17435751
DOI: 10.1038/ncb1572
PubMed ID: 18762580
Title: Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.
PubMed ID: 18762580
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20668449
Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
PubMed ID: 20668449
DOI: 10.1038/nature09343
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22215983
Title: Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts.
PubMed ID: 22215983
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29040603
Title: Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.
PubMed ID: 29040603
DOI: 10.1093/jmcb/mjx045
PubMed ID: 34564892
Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.
PubMed ID: 34564892
DOI: 10.1002/ana.26228
PubMed ID: 9510255
Title: The 1.7-A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.
PubMed ID: 9510255
DOI: 10.1038/32204
PubMed ID: 11336674
Title: Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).
PubMed ID: 11336674
PubMed ID: 29042532
Title: Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1.
PubMed ID: 29042532
Sequence Information:
- Length: 421
- Mass: 44969
- Checksum: F6D225AF81928305
- Sequence:
MSPKRIAKRR SPPADAIPKS KKVKVSHRSH STEPGLVLTL GQGDVGQLGL GENVMERKKP ALVSIPEDVV QAEAGGMHTV CLSKSGQVYS FGCNDEGALG RDTSVEGSEM VPGKVELQEK VVQVSAGDSH TAALTDDGRV FLWGSFRDNN GVIGLLEPMK KSMVPVQVQL DVPVVKVASG NDHLVMLTAD GDLYTLGCGE QGQLGRVPEL FANRGGRQGL ERLLVPKCVM LKSRGSRGHV RFQDAFCGAY FTFAISHEGH VYGFGLSNYH QLGTPGTESC FIPQNLTSFK NSTKSWVGFS GGQHHTVCMD SEGKAYSLGR AEYGRLGLGE GAEEKSIPTL ISRLPAVSSV ACGASVGYAV TKDGRVFAWG MGTNYQLGTG QDEDAWSPVE MMGKQLENRV VLSVSSGGQH TVLLVKDKEQ S
Genular Protein ID: 3876311110
Symbol: A0A0S2Z404_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 452
- Mass: 48146
- Checksum: A31255E99A01A25F
- Sequence:
MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QGACGPSPPD QKTRPVSHRS HSTEPGLVLT LGQGDVGQLG LGENVMERKK PALVSIPEDV VQAEAGGMHT VCLSKSGQVY SFGCNDEGAL GRDTSVEGSE MVPGKVELQE KVVQVSAGDS HTAALTDDGR VFLWGSFRDN NGVIGLLEPM KKSMVPVQVQ LDVPVVKVAS GNDHLVMLTA DGDLYTLGCG EQGQLGRVPE LFANRGGRQG LERLLVPKCV MLKSRGSRGH VRFQDAFCGA YFTFAISHEG HVYGFGLSNY HQLGTPGTES CFIPQNLTSF KNSTKSWVGF SGGQHHTVCM DSEGKAYSLG RAEYGRLGLG EGAEEKSIPT LISRLPAVSS VACGASVGYA VTKDGRVFAW GMGTNYQLGT GQDEDAWSPV EMMGKQLENR VVLSVSSGGQ HTVLLVKDKE QS
Genular Protein ID: 1865271710
Symbol: A0A0S2Z3I4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 438
- Mass: 46753
- Checksum: 223B8046E301E535
- Sequence:
MSPKRIAKRR SPPADAIPKS KKVKDTRAAA SRRVPGARSC QVSHRSHSTE PGLVLTLGQG DVGQLGLGEN VMERKKPALV SIPEDVVQAE AGGMHTVCLS KSGQVYSFGC NDEGALGRDT SVEGSEMVPG KVELQEKVVQ VSAGDSHTAA LTDDGRVFLW GSFRDNNGVI GLLEPMKKSM VPVQVQLDVP VVKVASGNDH LVMLTADGDL YTLGCGEQGQ LGRVPELFAN RGGRQGLERL LVPKCVMLKS RGSRGHVRFQ DAFCGAYFTF AISHEGHVYG FGLSNYHQLG TPGTESCFIP QNLTSFKNST KSWVGFSGGQ HHTVCMDSEG KAYSLGRAEY GRLGLGEGAE EKSIPTLISR LPAVSSVACG ASVGYAVTKD GRVFAWGMGT NYQLGTGQDE DAWSPVEMMG KQLENRVVLS VSSGGQHTVL LVKDKEQS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.