MID2 | ENSG00000080561 | NCBI 11043

Details for: MID2

Gene ID: 11043

Symbol: MID2

Ensembl ID: ENSG00000080561

Description: midline 2

Associated with

Cytoplasm
(GO:0005737)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Innate immune response
(GO:0045087)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Negative regulation of viral entry into host cell
(GO:0046597)
Negative regulation of viral transcription
(GO:0032897)
Phosphoprotein binding
(GO:0051219)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein homodimerization activity
(GO:0042803)
Protein localization to microtubule
(GO:0035372)
Protein ubiquitination
(GO:0016567)
Suppression of viral release by host
(GO:0044790)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Probable E3 ubiquitin-protein ligase MID2

Genular Protein ID: 1290602

Symbol: TRIM1_HUMAN

Name: Probable E3 ubiquitin-protein ligase MID2

UniProtKB Accession Codes:

Q9UJV3 A6NEL8 A6PVI5 Q5JYF5 Q8WWK1 Q9UJR9

Database IDs:

Citations:

PubMed ID: 10644436

Title: FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.

PubMed ID: 10644436

DOI: 10.1006/geno.1999.6043

PubMed ID: 10400986

Title: MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development.

PubMed ID: 10400986

DOI: 10.1093/hmg/8.8.1397

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11806752

Title: MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.

PubMed ID: 11806752

DOI: 10.1186/1471-2121-3-1

PubMed ID: 24115387

Title: Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India.

PubMed ID: 24115387

DOI: 10.1002/humu.22453

PubMed ID: 35266954

Title: The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.

PubMed ID: 35266954

DOI: 10.1083/jcb.202010065

Sequence Information:

Length: 735
Mass: 83210
Checksum: 22A0EC26B050EA21
Sequence:

MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC FSCAHRILVS 
SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSES 
RRERTYRPTT AMSSERIACQ FCEQDPPRDA VKTCITCEVS YCDRCLRATH PNKKPFTSHR 
LVEPVPDTHL RGITCLDHEN EKVNMYCVSD DQLICALCKL VGRHRDHQVA SLNDRFEKLK 
QTLEMNLTNL VKRNSELENQ MAKLIQICQQ VEVNTAMHEA KLMEECDELV EIIQQRKQMI 
AVKIKETKVM KLRKLAQQVA NCRQCLERST VLINQAEHIL KENDQARFLQ SAKNIAERVA 
MATASSQVLI PDINFNDAFE NFALDFSREK KLLEGLDYLT APNPPSIREE LCTASHDTIT 
VHWISDDEFS ISSYELQYTI FTGQANFISK SWCSWGLWPE IRKCKEAVSC SRLAGAPRGL 
YNSVDSWMIV PNIKQNHYTV HGLQSGTRYI FIVKAINQAG SRNSEPTRLK TNSQPFKLDP 
KMTHKKLKIS NDGLQMEKDE SSLKKSHTPE RFSGTGCYGA AGNIFIDSGC HYWEVVMGSS 
TWYAIGIAYK SAPKNEWIGK NASSWVFSRC NSNFVVRHNN KEMLVDVPPH LKRLGVLLDY 
DNNMLSFYDP ANSLHLHTFD VTFILPVCPT FTIWNKSLMI LSGLPAPDFI DYPERQECNC 
RPQESPYVSG MKTCH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MID2

Associated with

Other Information

FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules. PubMed ID: 10644436

MID2, a homologue of the Opitz syndrome gene MID1: similarities in a sub-cellular localization and differences in expression during development. PubMed ID: 10400986

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders. PubMed ID: 11806752

Targeted deep resequencing identifies MID2 mutation for X-linked intellectual disability with varied disease severity in a large kindred from India. PubMed ID: 24115387

The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. PubMed ID: 35266954