Details for: CHD1

Gene ID: 1105

Symbol: CHD1

Ensembl ID: ENSG00000153922

Description: chromodomain helicase DNA binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.02
    Marker Score: 3224
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.75
    Marker Score: 2342
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.34
    Marker Score: 79559
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1
    Marker Score: 2209.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.01
    Marker Score: 1520
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2
    Marker Score: 833
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.94
    Marker Score: 566
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.93
    Marker Score: 959
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.89
    Marker Score: 4565
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.88
    Marker Score: 2525
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.86
    Marker Score: 2255
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.85
    Marker Score: 1867
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.83
    Marker Score: 2154
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.79
    Marker Score: 2595
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.78
    Marker Score: 7468.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.73
    Marker Score: 626
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.73
    Marker Score: 1671
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.73
    Marker Score: 621
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.72
    Marker Score: 1034
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.71
    Marker Score: 95825
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.71
    Marker Score: 1601
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.7
    Marker Score: 827
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.7
    Marker Score: 1674
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.69
    Marker Score: 4728
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.68
    Marker Score: 402
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.67
    Marker Score: 2914
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.65
    Marker Score: 1127
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.65
    Marker Score: 1776
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.65
    Marker Score: 3612.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.64
    Marker Score: 1814
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.64
    Marker Score: 4086
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.64
    Marker Score: 1285
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.63
    Marker Score: 1881
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.62
    Marker Score: 467
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.62
    Marker Score: 1080
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.61
    Marker Score: 6552
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.6
    Marker Score: 2064
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.58
    Marker Score: 1909
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.58
    Marker Score: 986.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.58
    Marker Score: 558
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.57
    Marker Score: 786
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.57
    Marker Score: 581
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.57
    Marker Score: 1708
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.57
    Marker Score: 57872
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.56
    Marker Score: 96148
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.55
    Marker Score: 628
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.55
    Marker Score: 381
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.54
    Marker Score: 921
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.54
    Marker Score: 337
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.54
    Marker Score: 81358
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.54
    Marker Score: 3222
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.53
    Marker Score: 474
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.53
    Marker Score: 622
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.53
    Marker Score: 1434
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57821
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.52
    Marker Score: 529
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.52
    Marker Score: 1637
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.51
    Marker Score: 653
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.51
    Marker Score: 515
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.51
    Marker Score: 452
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.5
    Marker Score: 327
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.5
    Marker Score: 1264
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.49
    Marker Score: 13074
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.49
    Marker Score: 438
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.48
    Marker Score: 1361.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.48
    Marker Score: 1119
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.48
    Marker Score: 861
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.48
    Marker Score: 466
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.46
    Marker Score: 385
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.46
    Marker Score: 364
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.46
    Marker Score: 364
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.45
    Marker Score: 364
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.44
    Marker Score: 2126
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.44
    Marker Score: 524
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.44
    Marker Score: 14625
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165108
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.44
    Marker Score: 21466
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.44
    Marker Score: 329
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.43
    Marker Score: 536
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.43
    Marker Score: 484
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.43
    Marker Score: 14156
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.43
    Marker Score: 5935
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.43
    Marker Score: 870
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.42
    Marker Score: 1491
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.42
    Marker Score: 5891
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.42
    Marker Score: 317
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.42
    Marker Score: 596
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.42
    Marker Score: 395
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.41
    Marker Score: 1029
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4
    Marker Score: 3429
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4
    Marker Score: 24860
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.39
    Marker Score: 2538
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.39
    Marker Score: 483
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.39
    Marker Score: 10636
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 1.39
    Marker Score: 391
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.39
    Marker Score: 397.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.38
    Marker Score: 794
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.38
    Marker Score: 11870
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.38
    Marker Score: 3814
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.38
    Marker Score: 3367

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Other Information

**Key characteristics:** * CHD1 is a chromatin helicase that is involved in the regulation of gene expression. * It is a key regulator of cell proliferation, differentiation, and apoptosis. * It is also involved in the regulation of inflammation and tissue remodeling. **Pathways and functions:** * CHD1 is a key regulator of the cell cycle. It is expressed in proliferating cells and is required for their proliferation. * It is also expressed in differentiated cells and is required for their survival. * It is involved in the regulation of inflammation and tissue remodeling. * It is also involved in the regulation of cell migration and invasion. **Clinical significance:** * Mutations in the CHD1 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * CHD1 inhibitors are being investigated as a potential treatment for these diseases. * A better understanding of the role of CHD1 in cancer and cardiovascular disease could lead to the development of new therapies. **Conclusion:** The CHD1 gene is a critical regulator of cell growth, differentiation, and survival. Its mutations have a significant impact on human health, making it a promising target for the development of new therapies for a variety of diseases.

Genular Protein ID: 3286497535

Symbol: CHD1_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9326634

Title: Characterization of the CHD family of proteins.

PubMed ID: 9326634

DOI: 10.1073/pnas.94.21.11472

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16263726

Title: Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.

PubMed ID: 16263726

DOI: 10.1074/jbc.c500395200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17433364

Title: Molecular implications of evolutionary differences in CHD double chromodomains.

PubMed ID: 17433364

DOI: 10.1016/j.jmb.2007.03.024

PubMed ID: 18042460

Title: Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

PubMed ID: 18042460

DOI: 10.1016/j.molcel.2007.11.010

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28866611

Title: Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability.

PubMed ID: 28866611

DOI: 10.1136/jmedgenet-2017-104759

PubMed ID: 16372014

Title: Double chromodomains cooperate to recognize the methylated histone H3 tail.

PubMed ID: 16372014

DOI: 10.1038/nature04290

PubMed ID: 27591891

Title: The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.

PubMed ID: 27591891

DOI: 10.1016/j.jmb.2016.08.028

Sequence Information:

  • Length: 1710
  • Mass: 196688
  • Checksum: D888AAA46FDA31B1
  • Sequence:
  • MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS DSDSGSESGS 
    QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA ILKKQQQQQQ QQQHQASSNS 
    GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ MSGSGSPSQS GSDSESEEER EKSSCDETES 
    DYEPKNKVKS RKPQNRSKSK NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV 
    SYKEDEEMKT DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD 
    GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD NYKKKDQETK 
    RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ KSAAGYPDYY CKWQGLPYSE 
    CSWEDGALIS KKFQACIDEY FSRNQSKTTP FKDCKVLKQR PRFVALKKQP SYIGGHEGLE 
    LRDYQLNGLN WLAHSWCKGN SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS 
    TLTSWQREIQ TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK 
    AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL KELWSLLHFI 
    MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK DVEKSLPAKV EQILRMEMSA 
    LQKQYYKWIL TRNYKALSKG SKGSTSGFLN IMMELKKCCN HCYLIKPPDN NEFYNKQEAL 
    QHLIRSSGKL ILLDKLLIRL RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG 
    ELRKQALDHF NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR 
    IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT GSAPSSSTPF 
    NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE THENEPGPLT VGDELLSQFK 
    VANFSNMDED DIELEPERNS KNWEEIIPED QRRRLEEEER QKELEEIYML PRMRNCAKQI 
    SFNGSEGRRS RSRRYSGSDS DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK 
    FGGPLERLDA IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP 
    TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD IDWGKEDDSN 
    LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK QLQTRADYLI KLLSRDLAKK 
    EALSGAGSSK RRKARAKKNK AMKSIKVKEE IKSDSSPLPS EKSDEDDDKL SESKSDGRER 
    SKKSSVSDAP VHITASGEPV PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE 
    REQLEHTRQC LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA 
    IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL TQYHDHHKDR 
    HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD REKHRKLDDH RSRDHRSNLE 
    GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD 
    QRSPYGSRSP FEHSVEHKST PEHTWSSRKT

Genular Protein ID: 62369221

Symbol: B3KT33_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 301
  • Mass: 35853
  • Checksum: E0B9ADAA441DD6D1
  • Sequence:
  • MFSFTGVLVI YEVLKKCIGK LISLRVCSIE GCVCVYVFVP GGKEFHEKKL NIFHQTNLIC 
    LFLNSSRNLW IFVSKFTEFD ARKLHKLYKH AIKKRQESQQ NSDQNSNLNP HVIRNPDVER 
    LKENTNHDDS SRDSYSSDRH LTQYHDHHKD RHQGDSYKKS DSRKRPYSSF SNGKDHRDWD 
    HYKQDSRYYS DREKHRKLDD HRSRDHRSNL EGSLKDRSHS DHRSHSDHRL HSDHRSSSEY 
    THHKSSRDYR YHSDWQMDHR ASSSGPRSPL DQRSPYGSRS PFEHSVEHKS TPEHTWSSRK 
    T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.