Details for: NUDT21

Gene ID: 11051

Symbol: NUDT21

Ensembl ID: ENSG00000167005

Description: nudix hydrolase 21

Associated with

Other Information

Genular Protein ID: 4278772661

Symbol: CPSF5_HUMAN

Name: Cleavage and polyadenylation specificity factor 25 kDa subunit

UniProtKB Accession Codes:

O43809 Q6IB85 Q6NE84

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 21 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9659921

Title: Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.

PubMed ID: 9659921

DOI: 10.1016/s1097-2765(00)80025-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626397

Title: Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.

PubMed ID: 8626397

DOI: 10.1074/jbc.271.11.6107

PubMed ID: 14690600

Title: A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.

PubMed ID: 14690600

DOI: 10.1016/s1097-2765(03)00453-2

PubMed ID: 14561889

Title: Association of polyadenylation cleavage factor I with U1 snRNP.

PubMed ID: 14561889

DOI: 10.1261/rna.5104603

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 15937220

Title: Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.

PubMed ID: 15937220

DOI: 10.1101/gad.1298605

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17024186

Title: An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.

PubMed ID: 17024186

DOI: 10.1038/sj.emboj.7601331

PubMed ID: 17098938

Title: Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs.

PubMed ID: 17098938

DOI: 10.1093/nar/gkl794

PubMed ID: 17172643

Title: Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.

PubMed ID: 17172643

DOI: 10.1074/jbc.m609745200

PubMed ID: 19864460

Title: Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.

PubMed ID: 19864460

DOI: 10.1091/mbc.e09-05-0389

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20695905

Title: Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation.

PubMed ID: 20695905

DOI: 10.1111/j.1365-2443.2010.01436.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22813749

Title: Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length.

PubMed ID: 22813749

DOI: 10.1016/j.celrep.2012.05.003

PubMed ID: 23187700

Title: Cleavage factor Im is a key regulator of 3' UTR length.

PubMed ID: 23187700

DOI: 10.4161/rna.22570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29507755

Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

PubMed ID: 29507755

DOI: 10.1038/s41421-018-0019-0

PubMed ID: 29276085

Title: Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation.

PubMed ID: 29276085

DOI: 10.1016/j.molcel.2017.11.031

PubMed ID: 18445629

Title: Crystal structure of the 25 kDa subunit of human cleavage factor Im.

PubMed ID: 18445629

DOI: 10.1093/nar/gkn079

PubMed ID: 18767156

Title: The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

PubMed ID: 18767156

DOI: 10.1002/prot.22198

PubMed ID: 20479262

Title: Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing.

PubMed ID: 20479262

DOI: 10.1073/pnas.1000848107

PubMed ID: 21295486

Title: Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping.

PubMed ID: 21295486

DOI: 10.1016/j.str.2010.12.021

Sequence Information:

  • Length: 227
  • Mass: 26227
  • Checksum: D204243E57F1CCC5
  • Sequence:
    • MSVVPPNRSQ TGWPRGVTQF GNKYIQQTKP LTLERTINLY PLTNYTFGTK EPLYEKDSSV 
AARFQRMREE FDKIGMRRTV EGVLIVHEHR LPHVLLLQLG TTFFKLPGGE LNPGEDEVEG 
LKRLMTEILG RQDGVLQDWV IDDCIGNWWR PNFEPPQYPY IPAHITKPKE HKKLFLVQLQ 
EKALFAVPKN YKLVAAPLFE LYDNAPGYGP IISSLPQLLS RFNFIYN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.