CPSF6 | ENSG00000111605 | NCBI 11052

Details for: CPSF6

Gene ID: 11052

Symbol: CPSF6

Ensembl ID: ENSG00000111605

Description: cleavage and polyadenylation specific factor 6

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Gene expression (transcription)
(R-HSA-74160)
Metabolism of rna
(R-HSA-8953854)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Processing of capped intronless pre-mrna
(R-HSA-75067)
Processing of intronless pre-mrnas
(R-HSA-77595)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription termination
(R-HSA-73856)
Signaling by cytosolic fgfr1 fusion mutants
(R-HSA-1839117)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr in disease
(R-HSA-1226099)
Cytoplasm
(GO:0005737)
Exon-exon junction complex binding
(GO:1990448)
Interchromatin granule
(GO:0035061)
Localization
(GO:0051179)
Membrane
(GO:0016020)
Messenger ribonucleoprotein complex assembly
(GO:1990120)
Mrna 3'-end processing
(GO:0031124)
Mrna alternative polyadenylation
(GO:0110104)
Mrna binding
(GO:0003729)
Mrna cleavage and polyadenylation specificity factor complex
(GO:0005847)
Mrna cleavage factor complex
(GO:0005849)
Mrna processing
(GO:0006397)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Paraspeckles
(GO:0042382)
Perichromatin fibrils
(GO:0005726)
Positive regulation of rna export from nucleus
(GO:0046833)
Protein binding
(GO:0005515)
Protein heterotetramerization
(GO:0051290)
Protein tetramerization
(GO:0051262)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal large subunit binding
(GO:0043023)
Rna binding
(GO:0003723)

Other Information

Proteins

Cleavage and polyadenylation specificity factor 68 kDa subunit

Genular Protein ID: 2910961282

Symbol: CPSF6_HUMAN

Name: Cleavage and polyadenylation specificity factor 68 kDa subunit

UniProtKB Accession Codes:

Q16630 A8K7K9 Q53ES1 Q9BSJ7 Q9BW18

Database IDs:

Citations:

PubMed ID: 9659921

Title: Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.

PubMed ID: 9659921

DOI: 10.1016/s1097-2765(00)80025-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8626397

Title: Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.

PubMed ID: 8626397

DOI: 10.1074/jbc.271.11.6107

PubMed ID: 14690600

Title: A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.

PubMed ID: 14690600

DOI: 10.1016/s1097-2765(03)00453-2

PubMed ID: 14561889

Title: Association of polyadenylation cleavage factor I with U1 snRNP.

PubMed ID: 14561889

DOI: 10.1261/rna.5104603

PubMed ID: 15169763

Title: Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

PubMed ID: 15169763

DOI: 10.1074/jbc.m403927200

PubMed ID: 17267687

Title: Subnuclear localization and dynamics of the pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit.

PubMed ID: 17267687

DOI: 10.1091/mbc.e06-09-0846

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19864460

Title: Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.

PubMed ID: 19864460

DOI: 10.1091/mbc.e09-05-0389

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20695905

Title: Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation.

PubMed ID: 20695905

DOI: 10.1111/j.1365-2443.2010.01436.x

PubMed ID: 20562214

Title: Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I.

PubMed ID: 20562214

DOI: 10.1261/rna.2164210

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23187700

Title: Cleavage factor Im is a key regulator of 3' UTR length.

PubMed ID: 23187700

DOI: 10.4161/rna.22570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24130490

Title: Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.

PubMed ID: 24130490

DOI: 10.1371/journal.ppat.1003693

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29507755

Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.

PubMed ID: 29507755

DOI: 10.1038/s41421-018-0019-0

PubMed ID: 29997211

Title: Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells.

PubMed ID: 29997211

DOI: 10.1128/jvi.00648-18

PubMed ID: 29276085

Title: Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation.

PubMed ID: 29276085

DOI: 10.1016/j.molcel.2017.11.031

PubMed ID: 21295486

Title: Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping.

PubMed ID: 21295486

DOI: 10.1016/j.str.2010.12.021

PubMed ID: 30916345

Title: Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

PubMed ID: 30916345

DOI: 10.1093/nar/gkz206

Sequence Information:

Length: 551
Mass: 59210
Checksum: 721A5DA1B456AA79
Sequence:

MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV 
GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN 
GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM 
SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP 
LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV 
PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA 
FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR 
NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI 
ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR 
ERDREREYRH R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CPSF6

Associated with

Other Information

Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. PubMed ID: 9659921

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. PubMed ID: 8626397

A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. PubMed ID: 14690600

Association of polyadenylation cleavage factor I with U1 snRNP. PubMed ID: 14561889

Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. PubMed ID: 15169763

Subnuclear localization and dynamics of the pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. PubMed ID: 17267687

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export. PubMed ID: 19864460

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. PubMed ID: 20695905

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. PubMed ID: 20562214

Initial characterization of the human central proteome. PubMed ID: 21269460

Cleavage factor Im is a key regulator of 3' UTR length. PubMed ID: 23187700

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PubMed ID: 24130490

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. PubMed ID: 29507755

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells. PubMed ID: 29997211

Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation. PubMed ID: 29276085

Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. PubMed ID: 21295486

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. PubMed ID: 30916345