WWP1 | ENSG00000123124 | NCBI 11059

Details for: WWP1

Gene ID: 11059

Symbol: WWP1

Ensembl ID: ENSG00000123124

Description: WW domain containing E3 ubiquitin protein ligase 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Downregulation of erbb4 signaling
(R-HSA-1253288)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Ion channel transport
(R-HSA-983712)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by erbb4
(R-HSA-1236394)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Stimuli-sensing channels
(R-HSA-2672351)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transport of small molecules
(R-HSA-382551)
Central nervous system development
(GO:0007417)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Monoatomic ion transmembrane transport
(GO:0034220)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Signal transduction
(GO:0007165)
Symbiont entry into host cell
(GO:0046718)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

NEDD4-like E3 ubiquitin-protein ligase WWP1

Genular Protein ID: 4096981227

Symbol: WWP1_HUMAN

Name: NEDD4-like E3 ubiquitin-protein ligase WWP1

UniProtKB Accession Codes:

Q9H0M0 O00307 Q5YLC1 Q96BP4

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 11779188

Title: Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

PubMed ID: 11779188

DOI: 10.1006/bbrc.2001.6206

PubMed ID: 15359284

Title: The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.

PubMed ID: 15359284

DOI: 10.1038/sj.emboj.7600398

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169421

Title: Identification of novel human WW domain-containing proteins by cloning of ligand targets.

PubMed ID: 9169421

DOI: 10.1074/jbc.272.23.14611

PubMed ID: 9647693

Title: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

PubMed ID: 9647693

DOI: 10.1006/mcne.1998.0677

PubMed ID: 12450395

Title: Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.

PubMed ID: 12450395

DOI: 10.1021/bi020125b

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 17609263

Title: The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1.

PubMed ID: 17609263

DOI: 10.1128/jvi.00642-07

PubMed ID: 18724389

Title: The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.

PubMed ID: 18724389

DOI: 10.1038/onc.2008.288

PubMed ID: 19580544

Title: Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.

PubMed ID: 19580544

DOI: 10.1042/bj20082398

PubMed ID: 19343052

Title: Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.

PubMed ID: 19343052

DOI: 10.1038/embor.2009.30

PubMed ID: 19561640

Title: WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.

PubMed ID: 19561640

DOI: 10.1038/onc.2009.162

PubMed ID: 21191027

Title: Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

PubMed ID: 21191027

DOI: 10.1128/jvi.02045-10

PubMed ID: 28768865

Title: Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress.

PubMed ID: 28768865

DOI: 10.1128/jvi.00812-17

PubMed ID: 12535537

Title: Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.

PubMed ID: 12535537

DOI: 10.1016/s1097-2765(02)00774-8

Sequence Information:

Length: 922
Mass: 105202
Checksum: 35B6E1C03A3147DA
Sequence:

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS 
NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 
LSLENKNGIA QTGELTVVLD GLVIEQENIT NCSSSPTIEI QENGDALHEN GEPSARTTAR 
LAVEGTNGID NHVPTSTLVQ NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD 
TVNGESSSFA PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS 
AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET LPSGWEQRKD 
PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV DHNTRTTTWQ RPTMESVRNF 
EQWQSQRNQL QGAMQQFNQR YLYSASMLAA ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK 
TTQWEDPRTQ GLQNEEPLPE GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ 
IAYERGFRWK LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF 
RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN PDHLSYFCFI 
GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID TEFYNSLIWI RDNNIEECGL 
EMYFSVDMEI LGKVTSHDLK LGGSNILVTE ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF 
NEVVPLQWLQ YFDEKELEVM LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN 
EVRMRLLQFV TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK 
SYEQLKEKLL FAIEETEGFG QE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WWP1

Associated with

Other Information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. PubMed ID: 11779188

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. PubMed ID: 15359284

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel human WW domain-containing proteins by cloning of ligand targets. PubMed ID: 9169421

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. PubMed ID: 9647693

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. PubMed ID: 12450395

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). PubMed ID: 15221015

The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1. PubMed ID: 17609263

The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. PubMed ID: 18724389

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. PubMed ID: 19580544

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. PubMed ID: 19343052

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. PubMed ID: 19561640

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. PubMed ID: 21191027

Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. PubMed ID: 28768865

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. PubMed ID: 12535537