Details for: CHD2

Gene ID: 1106

Symbol: CHD2

Ensembl ID: ENSG00000173575

Description: chromodomain helicase DNA binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.89
    Marker Score: 831.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.85
    Marker Score: 60802
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.77
    Marker Score: 2391
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91523
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.62
    Marker Score: 1456
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41769
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.57
    Marker Score: 1977
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.47
    Marker Score: 4323
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.46
    Marker Score: 2094
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.45
    Marker Score: 10238
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.44
    Marker Score: 714
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.41
    Marker Score: 6768
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.38
    Marker Score: 2508
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.37
    Marker Score: 2729
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.36
    Marker Score: 1241
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.3
    Marker Score: 34325
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.28
    Marker Score: 86677
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.24
    Marker Score: 1699
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.23
    Marker Score: 5590
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17048
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.22
    Marker Score: 9237
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.21
    Marker Score: 39176
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.19
    Marker Score: 43525
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.15
    Marker Score: 1251
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2589
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.12
    Marker Score: 1054
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.12
    Marker Score: 78128
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.1
    Marker Score: 2831
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.09
    Marker Score: 1815
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.07
    Marker Score: 8620
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.04
    Marker Score: 856
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7865
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.03
    Marker Score: 2301
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.03
    Marker Score: 8408
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.01
    Marker Score: 2956
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.96
    Marker Score: 1100
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.95
    Marker Score: 9592
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.94
    Marker Score: 102644
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.94
    Marker Score: 1517
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119158
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18089
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.91
    Marker Score: 606
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9
    Marker Score: 2104
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9
    Marker Score: 454
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.9
    Marker Score: 1133
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.89
    Marker Score: 932
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19312
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.87
    Marker Score: 2577
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.86
    Marker Score: 12143
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.86
    Marker Score: 904
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.85
    Marker Score: 1079
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7488
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.84
    Marker Score: 402
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.83
    Marker Score: 1248
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.83
    Marker Score: 788
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.82
    Marker Score: 3320
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.82
    Marker Score: 3989
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.81
    Marker Score: 3491
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.81
    Marker Score: 4341
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.8
    Marker Score: 730
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.8
    Marker Score: 2096
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.79
    Marker Score: 1246
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17007
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.78
    Marker Score: 1918
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.77
    Marker Score: 1454
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.77
    Marker Score: 558
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.77
    Marker Score: 2184
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.77
    Marker Score: 641
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.77
    Marker Score: 2279
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.76
    Marker Score: 659
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.76
    Marker Score: 717.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.75
    Marker Score: 1611.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15026
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.75
    Marker Score: 514
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.74
    Marker Score: 1850.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.74
    Marker Score: 1542
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.74
    Marker Score: 1162
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.73
    Marker Score: 1709
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.72
    Marker Score: 601
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.71
    Marker Score: 631
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.7
    Marker Score: 708
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7
    Marker Score: 17182
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.69
    Marker Score: 682
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.68
    Marker Score: 2371
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.67
    Marker Score: 374
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.67
    Marker Score: 1574
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.67
    Marker Score: 2988.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.66
    Marker Score: 5902
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.66
    Marker Score: 829
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.66
    Marker Score: 3470
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.65
    Marker Score: 1661
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.65
    Marker Score: 1798
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.65
    Marker Score: 1063
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.65
    Marker Score: 1028
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.65
    Marker Score: 956
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.64
    Marker Score: 4012.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.64
    Marker Score: 357
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.62
    Marker Score: 7513
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.62
    Marker Score: 2871
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.61
    Marker Score: 441

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Other Information

**Key characteristics:** - CHD2 is a highly conserved protein with a predicted molecular weight of approximately 130 kDa. - It is found in a variety of cell types, including lung goblet cells, astrocytes, taste receptor cells, fibroblasts, and renal cells. - It is expressed in high levels in germ cells, which are cells that are not yet differentiated into specific cell types. **Pathways and functions:** - CHD2 is a key regulator of gene expression in various cell types. - It is involved in the regulation of stem cell differentiation, as it is expressed in high levels in stem cells and is required for their differentiation into various cell types. - It is also involved in the regulation of cell cycle progression, as it is expressed in cells that are in the G1 phase of the cell cycle. - CHD2 also plays a role in DNA damage response, as it is one of the first proteins to be activated upon DNA damage. **Clinical significance:** - Mutations in the CHD2 gene have been linked to several human diseases, including cancer and developmental disorders. - In cancer, CHD2 mutations can lead to the activation of oncogenes and the formation of tumors. - Targeting CHD2 has been investigated as a potential therapeutic strategy for cancer. **Additional notes:** - CHD2 is a highly conserved protein, with a similar protein found in other vertebrates. - It is a multi-functional protein that can interact with a variety of other proteins. - It is a well-established target for cancer therapy.

Genular Protein ID: 3849165456

Symbol: CHD2_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 2

UniProtKB Accession Codes:

O14647 C6G482 Q96IP5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 5 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9326634

Title: Characterization of the CHD family of proteins.

PubMed ID: 9326634

DOI: 10.1073/pnas.94.21.11472

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23708187

Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

PubMed ID: 23708187

DOI: 10.1038/ng.2646

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 33798445

Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.

PubMed ID: 33798445

DOI: 10.1016/j.ajhg.2021.03.013

Sequence Information:

  • Length: 1828
  • Mass: 211344
  • Checksum: 13139D6059210F00
  • Sequence:
    • MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG SESNSSSESS 
ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW EEYPDVYGVR RSNRSRQEPS 
RFNIKEEASS GSESGSPKRR GQRQLKKQEK WKQEPSEDEQ EQGTSAESEP EQKKVKARRP 
VPRRTVPKPR VKKQPKTQRG KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET 
DSDDLIEMTG EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK 
DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ WLGKVSPEDV 
EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA HSRKPAPSNE PEYLCKWMGL 
PYSECSWEDE ALIGKKFQNC IDSFHSRNNS KTIPTRECKA LKQRPRFVAL KKQPAYLGGE 
NLELRDYQLE GLNWLAHSWC KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV 
PLSTLTSWQR EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL 
KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ NSLKELWSLL 
HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR VKKDVEKSLP AKVEQILRVE 
MSALQKQYYK WILTRNYKAL AKGTRGSTSG FLNIVMELKK CCNHCYLIKP PEENERENGQ 
EILLSLIRSS GKLILLDKLL TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS 
IKGEIRKQAL DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR 
AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI LENNSGRSNS 
NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR LAETRENEVS TSATDELLSQ 
FKVANFATME DEEELEERPH KDWDEIIPEE QRKKVEEEER QKELEEIYML PRIRSSTKKA 
QTNDSDSDTE SKRQAQRSSA SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI 
KAYKKFGLPL ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK 
GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC RVKAAHFDVE 
WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE TDKKPQGKQL QTRADYLLKL 
LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN KVPRLKEEHG IELSSPRHSD NPSEEGEVKD 
DGLEKSPMKK KQKKKENKEN KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR 
SQGPVHITAG SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE 
HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK LYKMAHKKRS 
QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN LHPQKPHLPA SHGPQMHGHP 
RDNYNHPNKR HFSNADRGDW QRERKFNYGG GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH 
MDAHRSGSYR PNNMSRKRPY DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD 
FRRMSDHRPA MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK 
SPLDHRSPLE RSLEQKNNPD YNWNVRKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.