Details for: CHD2

Gene ID: 1106

Symbol: CHD2

Ensembl ID: ENSG00000173575

Description: chromodomain helicase DNA binding protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.89
    Marker Score: 832
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.85
    Marker Score: 60,802
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.77
    Marker Score: 2,391
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.69
    Marker Score: 91,523
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.62
    Marker Score: 1,456
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41,769
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.57
    Marker Score: 1,977
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.47
    Marker Score: 4,323
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.46
    Marker Score: 2,094
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.45
    Marker Score: 10,238
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.44
    Marker Score: 714
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.41
    Marker Score: 6,768
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.38
    Marker Score: 2,508
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.37
    Marker Score: 2,729
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.36
    Marker Score: 1,241
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.3
    Marker Score: 34,325
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.28
    Marker Score: 86,677
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.24
    Marker Score: 1,699
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.23
    Marker Score: 5,590
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 17,048
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.22
    Marker Score: 9,237
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.21
    Marker Score: 39,176
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.19
    Marker Score: 43,525
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.15
    Marker Score: 1,251
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2,589
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.12
    Marker Score: 1,054
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.12
    Marker Score: 78,128
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.1
    Marker Score: 2,831
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.09
    Marker Score: 1,815
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.07
    Marker Score: 8,620
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.04
    Marker Score: 856
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7,865
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.03
    Marker Score: 2,301
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.03
    Marker Score: 8,408
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.01
    Marker Score: 2,956
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.96
    Marker Score: 1,100
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.95
    Marker Score: 9,592
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.94
    Marker Score: 102,644
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.94
    Marker Score: 1,517
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119,158
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18,089
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.91
    Marker Score: 606
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9
    Marker Score: 2,104
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9
    Marker Score: 454
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.9
    Marker Score: 1,133
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.89
    Marker Score: 932
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19,312
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.87
    Marker Score: 2,577
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.86
    Marker Score: 12,143
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.86
    Marker Score: 904
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.85
    Marker Score: 1,079
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7,488
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.84
    Marker Score: 402
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.83
    Marker Score: 1,248
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.83
    Marker Score: 788
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.82
    Marker Score: 3,320
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.82
    Marker Score: 3,989
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.81
    Marker Score: 3,491
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.81
    Marker Score: 4,341
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.8
    Marker Score: 730
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.8
    Marker Score: 2,096
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.79
    Marker Score: 1,246
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17,007
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.78
    Marker Score: 1,918
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.77
    Marker Score: 1,454
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.77
    Marker Score: 558
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.77
    Marker Score: 2,184
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.77
    Marker Score: 641
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.77
    Marker Score: 2,279
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.76
    Marker Score: 659
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.76
    Marker Score: 718
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.75
    Marker Score: 1,612
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,026
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.75
    Marker Score: 514
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.74
    Marker Score: 1,851
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.74
    Marker Score: 1,542
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.74
    Marker Score: 1,162
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.73
    Marker Score: 1,709
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.72
    Marker Score: 601
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.71
    Marker Score: 631
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.7
    Marker Score: 708
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7
    Marker Score: 17,182
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.69
    Marker Score: 682
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.68
    Marker Score: 2,371
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.67
    Marker Score: 374
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.67
    Marker Score: 1,574
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.67
    Marker Score: 2,989
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.66
    Marker Score: 5,902
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.66
    Marker Score: 829
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.66
    Marker Score: 3,470
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.65
    Marker Score: 1,661
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.65
    Marker Score: 1,798
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.65
    Marker Score: 1,063
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.65
    Marker Score: 1,028
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.65
    Marker Score: 956
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.64
    Marker Score: 4,013
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.64
    Marker Score: 357
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.62
    Marker Score: 7,513
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.62
    Marker Score: 2,871
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.61
    Marker Score: 441

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHD2 is a member of the CHD family of proteins, which are known for their ability to remodel chromatin structure. This gene is characterized by its unique chromodomain and helicase domains, allowing it to bind to specific DNA sequences and facilitate chromatin remodeling. CHD2 is specifically expressed in various cell types, including lung goblet cells, astrocytes, and germ cells, highlighting its broad range of cellular functions. **Pathways and Functions:** CHD2 is involved in several key pathways, including: 1. **ATP-dependent chromatin remodeler activity:** CHD2 utilizes ATP hydrolysis to drive chromatin remodeling, allowing for the regulation of gene expression and the maintenance of genome stability. 2. **DNA damage response:** CHD2 plays a crucial role in the response to DNA damage, facilitating the repair of chromatin structures and preventing the propagation of genetic mutations. 3. **Gene expression:** CHD2 regulates gene expression by remodeling chromatin and facilitating the binding of transcription factors to specific DNA sequences. 4. **Hematopoietic stem cell differentiation:** CHD2 is essential for the differentiation of hematopoietic stem cells, ensuring the proper development of the immune system. **Functions:** CHD2 functions as a chromatin remodeling complex, allowing for the regulation of gene expression and the maintenance of genome stability. Its functions can be divided into three main categories: 1. **Chromatin binding:** CHD2 binds to specific DNA sequences, facilitating chromatin remodeling and regulating gene expression. 2. **Helicase activity:** CHD2 utilizes its helicase activity to unwind chromatin structures, allowing for the regulation of gene expression and DNA damage response. 3. **ATP binding and hydrolysis:** CHD2 binds to ATP, driving the hydrolysis of ATP and facilitating chromatin remodeling. **Clinical Significance:** CHD2 has been implicated in various diseases, including: 1. **Immune system disorders:** CHD2 dysfunction has been linked to immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer:** CHD2 is often overexpressed in various types of cancer, including leukemia and lymphoma, highlighting its potential role in tumorigenesis. 3. **Neurological disorders:** CHD2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in neurodegenerative diseases. In conclusion, CHD2 is a complex gene with multifaceted immunological significance. Its involvement in various cellular processes, including gene expression, DNA damage response, and hematopoietic stem cell differentiation, highlights its importance in the immune system. Further research is necessary to fully elucidate the functions of CHD2 and its role in various diseases.

Genular Protein ID: 3849165456

Symbol: CHD2_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9326634

Title: Characterization of the CHD family of proteins.

PubMed ID: 9326634

DOI: 10.1073/pnas.94.21.11472

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23708187

Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.

PubMed ID: 23708187

DOI: 10.1038/ng.2646

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 33798445

Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.

PubMed ID: 33798445

DOI: 10.1016/j.ajhg.2021.03.013

Sequence Information:

  • Length: 1828
  • Mass: 211344
  • Checksum: 13139D6059210F00
  • Sequence:
  • MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG SESNSSSESS 
    ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW EEYPDVYGVR RSNRSRQEPS 
    RFNIKEEASS GSESGSPKRR GQRQLKKQEK WKQEPSEDEQ EQGTSAESEP EQKKVKARRP 
    VPRRTVPKPR VKKQPKTQRG KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET 
    DSDDLIEMTG EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK 
    DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ WLGKVSPEDV 
    EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA HSRKPAPSNE PEYLCKWMGL 
    PYSECSWEDE ALIGKKFQNC IDSFHSRNNS KTIPTRECKA LKQRPRFVAL KKQPAYLGGE 
    NLELRDYQLE GLNWLAHSWC KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV 
    PLSTLTSWQR EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL 
    KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ NSLKELWSLL 
    HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR VKKDVEKSLP AKVEQILRVE 
    MSALQKQYYK WILTRNYKAL AKGTRGSTSG FLNIVMELKK CCNHCYLIKP PEENERENGQ 
    EILLSLIRSS GKLILLDKLL TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS 
    IKGEIRKQAL DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR 
    AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI LENNSGRSNS 
    NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR LAETRENEVS TSATDELLSQ 
    FKVANFATME DEEELEERPH KDWDEIIPEE QRKKVEEEER QKELEEIYML PRIRSSTKKA 
    QTNDSDSDTE SKRQAQRSSA SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI 
    KAYKKFGLPL ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK 
    GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC RVKAAHFDVE 
    WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE TDKKPQGKQL QTRADYLLKL 
    LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN KVPRLKEEHG IELSSPRHSD NPSEEGEVKD 
    DGLEKSPMKK KQKKKENKEN KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR 
    SQGPVHITAG SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE 
    HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK LYKMAHKKRS 
    QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN LHPQKPHLPA SHGPQMHGHP 
    RDNYNHPNKR HFSNADRGDW QRERKFNYGG GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH 
    MDAHRSGSYR PNNMSRKRPY DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD 
    FRRMSDHRPA MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK 
    SPLDHRSPLE RSLEQKNNPD YNWNVRKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.