Details for: CHD2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 628.4346
Cell Significance Index: -97.7500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 373.0829
Cell Significance Index: -94.6300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 238.7440
Cell Significance Index: -98.3500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 217.8248
Cell Significance Index: -102.8400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 199.5165
Cell Significance Index: -81.0600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 184.5893
Cell Significance Index: -94.9500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 153.5568
Cell Significance Index: -103.0400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 85.3162
Cell Significance Index: -81.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 79.7514
Cell Significance Index: -98.3300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 35.6271
Cell Significance Index: -95.4400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 30.8551
Cell Significance Index: -94.7700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 25.5737
Cell Significance Index: -100.9200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.8980
Cell Significance Index: -41.3600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 7.4634
Cell Significance Index: 2147.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.3217
Cell Significance Index: 45.3200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.7396
Cell Significance Index: 153.7300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5072
Cell Significance Index: 502.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.3838
Cell Significance Index: 855.0100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.9773
Cell Significance Index: 55.2600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.8245
Cell Significance Index: 112.1400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.7906
Cell Significance Index: 137.4100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7505
Cell Significance Index: 347.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6942
Cell Significance Index: 48.5700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.6483
Cell Significance Index: 1140.0400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4871
Cell Significance Index: 182.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.4303
Cell Significance Index: 41.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2511
Cell Significance Index: 225.5300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2418
Cell Significance Index: 33.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2253
Cell Significance Index: 55.5400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9802
Cell Significance Index: 186.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.9549
Cell Significance Index: 606.4500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9336
Cell Significance Index: 60.2300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8170
Cell Significance Index: 21.8200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.7230
Cell Significance Index: 17.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6782
Cell Significance Index: 31.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6721
Cell Significance Index: 367.0700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5898
Cell Significance Index: 80.9900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5221
Cell Significance Index: 27.1200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4849
Cell Significance Index: 214.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4506
Cell Significance Index: 19.9300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4405
Cell Significance Index: 829.5000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4220
Cell Significance Index: 15.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3895
Cell Significance Index: 29.0300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3564
Cell Significance Index: 35.2600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3248
Cell Significance Index: 293.2500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2728
Cell Significance Index: 6.8200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1955
Cell Significance Index: 301.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1808
Cell Significance Index: 333.4400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1411
Cell Significance Index: 18.2300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0951
Cell Significance Index: 1.1800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0949
Cell Significance Index: 3.3400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0920
Cell Significance Index: 11.8000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0650
Cell Significance Index: 3.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0479
Cell Significance Index: 21.7300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0271
Cell Significance Index: 36.8100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0233
Cell Significance Index: 3.9900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0455
Cell Significance Index: -28.4100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0610
Cell Significance Index: -45.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0671
Cell Significance Index: -9.7600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0785
Cell Significance Index: -57.5700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0907
Cell Significance Index: -1.7700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0961
Cell Significance Index: -72.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0976
Cell Significance Index: -2.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1017
Cell Significance Index: -6.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1417
Cell Significance Index: -79.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1654
Cell Significance Index: -7.7100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1946
Cell Significance Index: -2.3200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2178
Cell Significance Index: -4.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2357
Cell Significance Index: -24.0800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3036
Cell Significance Index: -63.9500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3165
Cell Significance Index: -36.1300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.3353
Cell Significance Index: -23.1900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4105
Cell Significance Index: -3.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4395
Cell Significance Index: -51.8300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4935
Cell Significance Index: -57.5200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5165
Cell Significance Index: -56.1800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5229
Cell Significance Index: -13.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5585
Cell Significance Index: -39.5000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6492
Cell Significance Index: -74.3800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6542
Cell Significance Index: -34.3500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6966
Cell Significance Index: -43.9100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6974
Cell Significance Index: -72.6200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9301
Cell Significance Index: -15.9400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.9691
Cell Significance Index: -5.8600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9751
Cell Significance Index: -16.4300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -1.0317
Cell Significance Index: -11.2400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1062
Cell Significance Index: -87.6100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.1389
Cell Significance Index: -19.0600 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.1797
Cell Significance Index: -7.2600 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -1.1901
Cell Significance Index: -16.0600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3208
Cell Significance Index: -35.3900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.3892
Cell Significance Index: -70.2000 - Cell Name: peg cell (CL4033014)
Fold Change: -1.4152
Cell Significance Index: -32.7000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4275
Cell Significance Index: -87.5200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.6266
Cell Significance Index: -97.6500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.6620
Cell Significance Index: -48.8100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.6736
Cell Significance Index: -47.7600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.6743
Cell Significance Index: -58.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.7383
Cell Significance Index: -37.6600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.7835
Cell Significance Index: -26.3300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3849165456
Symbol: CHD2_HUMAN
Name: Chromodomain-helicase-DNA-binding protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9326634
Title: Characterization of the CHD family of proteins.
PubMed ID: 9326634
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23708187
Title: Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.
PubMed ID: 23708187
DOI: 10.1038/ng.2646
PubMed ID: 25356899
Title: De novo mutations in moderate or severe intellectual disability.
PubMed ID: 25356899
PubMed ID: 33798445
Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.
PubMed ID: 33798445
Sequence Information:
- Length: 1828
- Mass: 211344
- Checksum: 13139D6059210F00
- Sequence:
MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG SESNSSSESS ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW EEYPDVYGVR RSNRSRQEPS RFNIKEEASS GSESGSPKRR GQRQLKKQEK WKQEPSEDEQ EQGTSAESEP EQKKVKARRP VPRRTVPKPR VKKQPKTQRG KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET DSDDLIEMTG EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ WLGKVSPEDV EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA HSRKPAPSNE PEYLCKWMGL PYSECSWEDE ALIGKKFQNC IDSFHSRNNS KTIPTRECKA LKQRPRFVAL KKQPAYLGGE NLELRDYQLE GLNWLAHSWC KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV PLSTLTSWQR EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ NSLKELWSLL HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR VKKDVEKSLP AKVEQILRVE MSALQKQYYK WILTRNYKAL AKGTRGSTSG FLNIVMELKK CCNHCYLIKP PEENERENGQ EILLSLIRSS GKLILLDKLL TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS IKGEIRKQAL DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI LENNSGRSNS NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR LAETRENEVS TSATDELLSQ FKVANFATME DEEELEERPH KDWDEIIPEE QRKKVEEEER QKELEEIYML PRIRSSTKKA QTNDSDSDTE SKRQAQRSSA SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI KAYKKFGLPL ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC RVKAAHFDVE WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE TDKKPQGKQL QTRADYLLKL LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN KVPRLKEEHG IELSSPRHSD NPSEEGEVKD DGLEKSPMKK KQKKKENKEN KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR SQGPVHITAG SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK LYKMAHKKRS QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN LHPQKPHLPA SHGPQMHGHP RDNYNHPNKR HFSNADRGDW QRERKFNYGG GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH MDAHRSGSYR PNNMSRKRPY DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD FRRMSDHRPA MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK SPLDHRSPLE RSLEQKNNPD YNWNVRKT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.