UBE2C | ENSG00000175063 | NCBI 11065

Details for: UBE2C

Gene ID: 11065

Symbol: UBE2C

Ensembl ID: ENSG00000175063

Description: ubiquitin conjugating enzyme E2 C

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Post-translational protein modification
(R-HSA-597592)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Exit from mitosis
(GO:0010458)
Free ubiquitin chain polymerization
(GO:0010994)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of exit from mitosis
(GO:0031536)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Positive regulation of ubiquitin protein ligase activity
(GO:1904668)
Protein binding
(GO:0005515)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Genular Protein ID: 2878282667

Symbol: UBE2C_HUMAN

Name: Ubiquitin-conjugating enzyme E2 C

UniProtKB Accession Codes:

O00762 A6NP33 E1P5N7 G3XAB7

Database IDs:

Citations:

PubMed ID: 9122200

Title: Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.

PubMed ID: 9122200

DOI: 10.1073/pnas.94.6.2362

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15558010

Title: Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

PubMed ID: 15558010

DOI: 10.1038/nature03023

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19820702

Title: UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

PubMed ID: 19820702

DOI: 10.1038/ncb1983

PubMed ID: 19822757

Title: Identification of a physiological E2 module for the human anaphase-promoting complex.

PubMed ID: 19822757

DOI: 10.1073/pnas.0907887106

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11927573

Title: Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10.

PubMed ID: 11927573

DOI: 10.1074/jbc.m109398200

PubMed ID: 27259151

Title: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C.

PubMed ID: 27259151

DOI: 10.1016/j.cell.2016.05.037

Sequence Information:

Length: 179
Mass: 19652
Checksum: 0B6F58A1F0665D9A
Sequence:

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE 
KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP

Genular Protein ID: 448782114

Symbol: A0A0A0MSE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSE8

Database IDs:

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 79
Mass: 8093
Checksum: 81AD8B5292B3A723
Sequence:

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 
KWVGTIHGAA GTNPTLIVP

Genular Protein ID: 3758013662

Symbol: A0A087WVK1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVK1

Database IDs:

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

Length: 132
Mass: 14396
Checksum: 0B9BB12432D69D77
Sequence:

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMAVGSIRT SSTVCLLSGP 
RETQDSSKPL VWGLGWDMRL LLELTLQLFL QMPEPNIDSP LNTHAAELWK NPTAFKKYLQ 
ETYSKQVTSQ EP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2C

Associated with

Other Information

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. PubMed ID: 9122200

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. PubMed ID: 15558010

E3-independent monoubiquitination of ubiquitin-binding proteins. PubMed ID: 17588522

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. PubMed ID: 19820702

Identification of a physiological E2 module for the human anaphase-promoting complex. PubMed ID: 19822757

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. PubMed ID: 11927573

Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. PubMed ID: 27259151

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Database document:

PubMed ID: 9122200

PubMed ID: 11780052

PubMed ID: 15489334

PubMed ID: 15558010

PubMed ID: 17588522

PubMed ID: 18485873

PubMed ID: 19413330

PubMed ID: 19820702

PubMed ID: 19822757

PubMed ID: 20061386

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 11927573

PubMed ID: 27259151

PubMed ID: 11780052

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 11780052

PubMed ID: 19413330

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163