Details for: CHD3

Gene ID: 1107

Symbol: CHD3

Ensembl ID: ENSG00000170004

Description: chromodomain helicase DNA binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.5947
    Cell Significance Index: -37.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.7739
    Cell Significance Index: -35.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.7494
    Cell Significance Index: -39.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.4263
    Cell Significance Index: -33.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.4384
    Cell Significance Index: -38.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.0741
    Cell Significance Index: -39.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.9832
    Cell Significance Index: -33.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5745
    Cell Significance Index: -38.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9948
    Cell Significance Index: -37.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6204
    Cell Significance Index: -32.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9492
    Cell Significance Index: -39.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2467
    Cell Significance Index: -15.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.7739
    Cell Significance Index: 87.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0063
    Cell Significance Index: 104.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9503
    Cell Significance Index: 31.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7722
    Cell Significance Index: 108.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5982
    Cell Significance Index: 38.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5053
    Cell Significance Index: 1359.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4998
    Cell Significance Index: 40.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2768
    Cell Significance Index: 157.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2221
    Cell Significance Index: 220.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0749
    Cell Significance Index: 174.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9717
    Cell Significance Index: 20.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9591
    Cell Significance Index: 192.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9491
    Cell Significance Index: 8.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9416
    Cell Significance Index: 25.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9145
    Cell Significance Index: 99.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8501
    Cell Significance Index: 116.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8468
    Cell Significance Index: 39.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8259
    Cell Significance Index: 23.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7382
    Cell Significance Index: 264.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6464
    Cell Significance Index: 447.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5799
    Cell Significance Index: 4.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5590
    Cell Significance Index: 36.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5552
    Cell Significance Index: 303.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4468
    Cell Significance Index: 197.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3950
    Cell Significance Index: 17.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3727
    Cell Significance Index: 25.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3183
    Cell Significance Index: 37.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3146
    Cell Significance Index: 7.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2705
    Cell Significance Index: 34.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2425
    Cell Significance Index: 10.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2344
    Cell Significance Index: 44.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2084
    Cell Significance Index: 7.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1602
    Cell Significance Index: 3.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1596
    Cell Significance Index: 31.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1531
    Cell Significance Index: 4.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1520
    Cell Significance Index: 7.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1430
    Cell Significance Index: 4.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1223
    Cell Significance Index: 20.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1152
    Cell Significance Index: 11.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1082
    Cell Significance Index: 7.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0632
    Cell Significance Index: 2.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0406
    Cell Significance Index: 2.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0376
    Cell Significance Index: 70.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0279
    Cell Significance Index: 1.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0135
    Cell Significance Index: 6.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0093
    Cell Significance Index: 17.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0149
    Cell Significance Index: -10.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0149
    Cell Significance Index: -11.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0166
    Cell Significance Index: -10.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -14.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0191
    Cell Significance Index: -26.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0216
    Cell Significance Index: -13.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0310
    Cell Significance Index: -4.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0360
    Cell Significance Index: -20.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0367
    Cell Significance Index: -0.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0435
    Cell Significance Index: -6.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0497
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0505
    Cell Significance Index: -3.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0718
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0919
    Cell Significance Index: -19.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1000
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1070
    Cell Significance Index: -30.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1233
    Cell Significance Index: -3.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1352
    Cell Significance Index: -15.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1367
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1465
    Cell Significance Index: -16.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1605
    Cell Significance Index: -16.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1889
    Cell Significance Index: -10.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1960
    Cell Significance Index: -6.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2212
    Cell Significance Index: -4.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2526
    Cell Significance Index: -8.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2546
    Cell Significance Index: -6.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2567
    Cell Significance Index: -13.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2803
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2971
    Cell Significance Index: -33.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3425
    Cell Significance Index: -35.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3952
    Cell Significance Index: -30.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4001
    Cell Significance Index: -31.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4609
    Cell Significance Index: -4.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4698
    Cell Significance Index: -29.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5050
    Cell Significance Index: -5.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5261
    Cell Significance Index: -15.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5643
    Cell Significance Index: -9.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5764
    Cell Significance Index: -18.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6003
    Cell Significance Index: -19.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHD3 is a 46-kDa protein that belongs to the CHD family of chromatin remodelers. It contains a chromodomain, a helicase domain, and a DNA-binding domain, which enable it to recognize and bind to specific DNA sequences. CHD3 is highly expressed in various tissues, including the brain, where it is predominantly found in GABAergic neurons and cortical thymic epithelial cells. The protein is also present in other cell types, such as nasal mucosa goblet cells, basal cells of the trachea, and bladder urothelial cells. **Pathways and Functions:** CHD3 plays a crucial role in various cellular pathways, including: 1. **Epigenetic regulation of gene expression:** CHD3 recognizes and binds to specific DNA sequences, facilitating the remodeling of chromatin structure and the regulation of gene expression. It interacts with other proteins, such as histone deacetylases (HDACs) and polycomb ring finger proteins (PRFs), to modulate the activity of transcription factors and chromatin-modifying enzymes. 2. **Transcriptional regulation:** CHD3 regulates the transcription of specific genes, including those involved in cell fate specification, stem cell differentiation, and immune responses. It interacts with RNA polymerase II and other transcriptional regulators to modulate the activity of transcriptional machinery. 3. **Cell fate specification:** CHD3 plays a crucial role in the specification of cell fate, particularly in the development of neural cells. It interacts with transcription factors and other proteins to regulate the expression of genes involved in neural cell differentiation and survival. 4. **Infectious disease:** CHD3 has been implicated in the regulation of viral infections, including SARS-CoV and HIV-1. It interacts with viral proteins and host cell factors to modulate the activity of transcriptional machinery and immune responses. **Clinical Significance:** CHD3 has been implicated in various diseases, including: 1. **Cancer:** CHD3 is often overexpressed in cancer cells, where it promotes the expression of oncogenic genes and suppresses the expression of tumor suppressor genes. 2. **Neurological disorders:** CHD3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It interacts with transcription factors and other proteins to regulate the expression of genes involved in neuronal function and survival. 3. **Infectious diseases:** CHD3 has been implicated in the regulation of viral infections, including SARS-CoV and HIV-1. It interacts with viral proteins and host cell factors to modulate the activity of transcriptional machinery and immune responses. 4. **Immune responses:** CHD3 plays a crucial role in the regulation of immune responses, particularly in the development of T cells and B cells. It interacts with transcription factors and other proteins to regulate the expression of genes involved in immune cell function and survival. In conclusion, CHD3 is a multifunctional protein that plays a crucial role in various cellular processes, including epigenetic regulation, transcription, and cell fate specification. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and infectious diseases. Further studies are needed to fully understand the mechanisms by which CHD3 regulates cellular processes and to develop therapeutic strategies targeting this protein in disease contexts.

Genular Protein ID: 4018974379

Symbol: CHD3_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 3

UniProtKB Accession Codes:

Q12873 D3DTQ9 E9PG89 Q9Y4I0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 7 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 28 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 21 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 Rhea 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9688266

Title: Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family.

PubMed ID: 9688266

DOI: 10.1046/j.1432-1327.1998.2540558.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 9326634

Title: Characterization of the CHD family of proteins.

PubMed ID: 9326634

DOI: 10.1073/pnas.94.21.11472

PubMed ID: 7560064

Title: Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen.

PubMed ID: 7560064

DOI: 10.1172/jci118218

PubMed ID: 9804427

Title: Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.

PubMed ID: 9804427

DOI: 10.1038/27699

PubMed ID: 11230151

Title: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.

PubMed ID: 11230151

DOI: 10.1101/gad.869501

PubMed ID: 14609633

Title: Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.

PubMed ID: 14609633

DOI: 10.1016/j.virusres.2003.09.001

PubMed ID: 12505151

Title: Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.

PubMed ID: 12505151

DOI: 10.1016/s0014-5793(02)03737-7

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 17626165

Title: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.

PubMed ID: 17626165

DOI: 10.1091/mbc.e06-07-0604

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 27068747

Title: Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2alpha.

PubMed ID: 27068747

DOI: 10.1074/jbc.m115.713370

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

PubMed ID: 30397230

Title: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

PubMed ID: 30397230

DOI: 10.1038/s41467-018-06014-6

Sequence Information:

  • Length: 2000
  • Mass: 226592
  • Checksum: 4494F56E5D0E7083
  • Sequence:
    • MKAADTVILW ARSKNDQLRI SFPPGLCWGD RMPDKDDIRL LPSALGVKKR KRGPKKQKEN 
KPGKPRKRKK RDSEEEFGSE RDEYREKSES GGSEYGTGPG RKRRRKHREK KEKKTKRRKK 
GEGDGGQKQV EQKSSATLLL TWGLEDVEHV FSEEDYHTLT NYKAFSQFMR PLIAKKNPKI 
PMSKMMTILG AKWREFSANN PFKGSAAAVA AAAAAAAAAV AEQVSAAVSS ATPIAPSGPP 
ALPPPPAADI QPPPIRRAKT KEGKGPGHKR RSKSPRVPDG RKKLRGKKMA PLKIKLGLLG 
GKRKKGGSYV FQSDEGPEPE AEESDLDSGS VHSASGRPDG PVRTKKLKRG RPGRKKKKVL 
GCPAVAGEEE VDGYETDHQD YCEVCQQGGE IILCDTCPRA YHLVCLDPEL DRAPEGKWSC 
PHCEKEGVQW EAKEEEEEYE EEGEEEGEKE EEDDHMEYCR VCKDGGELLC CDACISSYHI 
HCLNPPLPDI PNGEWLCPRC TCPVLKGRVQ KILHWRWGEP PVAVPAPQQA DGNPDVPPPR 
PLQGRSEREF FVKWVGLSYW HCSWAKELQL EIFHLVMYRN YQRKNDMDEP PPLDYGSGED 
DGKSDKRKVK DPHYAEMEEK YYRFGIKPEW MTVHRIINHS VDKKGNYHYL VKWRDLPYDQ 
STWEEDEMNI PEYEEHKQSY WRHRELIMGE DPAQPRKYKK KKKELQGDGP PSSPTNDPTV 
KYETQPRFIT ATGGTLHMYQ LEGLNWLRFS WAQGTDTILA DEMGLGKTIQ TIVFLYSLYK 
EGHTKGPFLV SAPLSTIINW EREFQMWAPK FYVVTYTGDK DSRAIIRENE FSFEDNAIKG 
GKKAFKMKRE AQVKFHVLLT SYELITIDQA ALGSIRWACL VVDEAHRLKN NQSKFFRVLN 
GYKIDHKLLL TGTPLQNNLE ELFHLLNFLT PERFNNLEGF LEEFADISKE DQIKKLHDLL 
GPHMLRRLKA DVFKNMPAKT ELIVRVELSP MQKKYYKYIL TRNFEALNSR GGGNQVSLLN 
IMMDLKKCCN HPYLFPVAAM ESPKLPSGAY EGGALIKSSG KLMLLQKMLR KLKEQGHRVL 
IFSQMTKMLD LLEDFLDYEG YKYERIDGGI TGALRQEAID RFNAPGAQQF CFLLSTRAGG 
LGINLATADT VIIFDSDWNP HNDIQAFSRA HRIGQANKVM IYRFVTRASV EERITQVAKR 
KMMLTHLVVR PGLGSKAGSM SKQELDDILK FGTEELFKDE NEGENKEEDS SVIHYDNEAI 
ARLLDRNQDA TEDTDVQNMN EYLSSFKVAQ YVVREEDKIE EIEREIIKQE ENVDPDYWEK 
LLRHHYEQQQ EDLARNLGKG KRVRKQVNYN DAAQEDQDNQ SEYSVGSEEE DEDFDERPEG 
RRQSKRQLRN EKDKPLPPLL ARVGGNIEVL GFNTRQRKAF LNAVMRWGMP PQDAFTTQWL 
VRDLRGKTEK EFKAYVSLFM RHLCEPGADG SETFADGVPR EGLSRQQVLT RIGVMSLVKK 
KVQEFEHING RWSMPELMPD PSADSKRSSR ASSPTKTSPT TPEASATNSP CTSKPATPAP 
SEKGEGIRTP LEKEEAENQE EKPEKNSRIG EKMETEADAP SPAPSLGERL EPRKIPLEDE 
VPGVPGEMEP EPGYRGDREK SATESTPGER GEEKPLDGQE HRERPEGETG DLGKREDVKG 
DRELRPGPRD EPRSNGRREE KTEKPRFMFN IADGGFTELH TLWQNEERAA ISSGKLNEIW 
HRRHDYWLLA GIVLHGYARW QDIQNDAQFA IINEPFKTEA NKGNFLEMKN KFLARRFKLL 
EQALVIEEQL RRAAYLNLSQ EPAHPAMALH ARFAEAECLA ESHQHLSKES LAGNKPANAV 
LHKVLNQLEE LLSDMKADVT RLPATLSRIP PIAARLQMSE RSILSRLASK GTEPHPTPAY 
PPGPYATPPG YGAAFSAAPV GALAAAGANY SQMPAGSFIT AATNGPPVLV KKEKEMVGAL 
VSDGLDRKEP RAGEVICIDD

Genular Protein ID: 1823138143

Symbol: Q2TAZ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2TAZ1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 1 SMART 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 661
  • Mass: 73526
  • Checksum: 61B9D39D2DC3B33C
  • Sequence:
    • GKRVRKQVNY NDAAQEDQDN QSEYSVGSEE EDEDFDERPE GRRQSKRQLR NEKDKPLPPL 
LARVGGNIEV LGFNTRQRKA FLNAVMRWGM PPQDAFTTQW LVRDLRGKTE KEFKAYVSLF 
MRHLCEPGAD GSETFADGVP REGLSRQQVL TRIGVMSLVK KKVQEFEHIN GRWSMPELMP 
DPSADSKRSS RASSPTKTSP TTPEASATNS PCTSKPATPA PSEKGEGIRT PLEKEEAENQ 
EEKPEKNSRI GEKMETEADA PSPAPSLGER LEPRKIPLED EVPGVPGEME PEPGYRGDRE 
KSATESTPGE RGEEKPLDGQ EHRERPEGET GDLGKREDVK GDRELRPGPR DEPRSNGRRE 
EKTEKPRFMF NIADGGFTEL HTLWQNEERA AISSGKLNEI WHRRHDYWLL AGIVLHGYAR 
WQDIQNDAQF AIINEPFKTE ANKGNFLEMK NKFLARRFKL LEQALVIEEQ LRRAAYLNLS 
QEPAHPAMAL HARFAEAECL AESHQHLSKE SLAGNKPANA VLHKVLNQLE ELLSDMKADV 
TRLPATLSRI PPIAARLQMS ERSILSRLAS KGTEPHPTPA YPPGPYATPP GYGAAFSAAP 
VGALAAAGAN YSQMPAGSFI TAATNGPPVL VKKEKEMVGA LVSDGLDRKE PRAGEVICID 
D

Genular Protein ID: 802007798

Symbol: B3KWV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWV4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 1 SMART 2

Sequence Information:

  • Length: 577
  • Mass: 63784
  • Checksum: 23EACA99690835BE
  • Sequence:
    • MRWGMPPQDA FTTQWLVRDL RGKTEKEFKA YVSLFMRHLC EPGADGSETF ADGVPREGLS 
RQQVLTRIGV MSLVKKKVQE FEHINGRWSM PELMPDPSAD SKRSSRASSP TKTSPTTPEA 
SATNSPCTSK PATPAPSEKG EGIRTPLEKE EAENQEEKPE KNSRIGEKME TEADAPSPAP 
SLGERLEPRK IPLEDEVPGV PGEMEPEPGY RGDREKSATE STPGERGEEK PLDGQEHRER 
PEGETGDLGK RAEDVKGDRE LRPGPRDEPR SNGRREEKTE KPRFMFNIAD GGFTELHTLW 
QNEERAAISS GKLNEIWHRR HDYWLLAGIV LHGYARWQDI QNDAQFAIIN EPFKTEANKG 
NFLEMKNKFL ARRFKLLEQA LVIEEQLRRA AYLNLSQEPA HPAMALHARF AEAECLAESH 
QHLSKESLAG NKPANAVLHK VLNQLEELLS DMKADVTRLP ATLSRIPPIA ARLQMSERSI 
LSRLASKGTE PHPTPAYPPG PYATPPGYGA AFSAAPVGAL AAAGANYSQM PAGSFITAAT 
NGPPVLVKKE KEMVGALVSD GLDRKEPRAG EVICIDD

Genular Protein ID: 2132719813

Symbol: A0A8V8TR54_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TR54

Database IDs:

ARBA 14 CDD 7 CTD 1 ChEBI 5 EC 1 EMBL 2 Ensembl 2 GO 7 Gene3D 6 GeneTree 1 HGNC 1 InterPro 21 NCBI Taxonomy 1 PANTHER 2 PROSITE 11 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 8 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 1 SMART 6 SMR 1 SUPFAM 4

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 2114
  • Mass: 238543
  • Checksum: E9CAA6DDB4FC3A24
  • Sequence:
    • MASPLRDEEE EEEEMVVSEE EEEEEEEGDE EEEEEVEAAD EDDEEDDDEG VLGRGPGHDR 
GRDRHSPPGC HLFPPPPPPP PPLPPPPPPP PPDKDDIRLL PSALGVKKRK RGPKKQKENK 
PGKPRKRKKR DSEEEFGSER DEYREKSESG GSEYGTGPGR KRRRKHREKK EKKTKRRKKG 
EGDGGQKQVE QKSSATLLLT WGLEDVEHVF SEEDYHTLTN YKAFSQFMRP LIAKKNPKIP 
MSKMMTILGA KWREFSANNP FKGSAAAVAA AAAAAAAAVA EQVSAAVSSA TPIAPSGPPA 
LPPPPAADIQ PPPIRRAKTK EGKGPGHKRR SKSPRVPDGR KKLRGKKMAP LKIKLGLLGG 
KRKKGGSYVF QSDEGPEPEA EESDLDSGSV HSASGRPDGP VRTKKLKRGR PGRKKKKVLG 
CPAVAGEEEV DGYETDHQDY CEVCQQGGEI ILCDTCPRAY HLVCLDPELD RAPEGKWSCP 
HCEKEGVQWE AKEEEEEYEE EGEEEGEKEE EDDHMEYCRV CKDGGELLCC DACISSYHIH 
CLNPPLPDIP NGEWLCPRCT CPVLKGRVQK ILHWRWGEPP VAVPAPQQAD GNPDVPPPRP 
LQGRSEREFF VKWVGLSYWH CSWAKELQLE IFHLVMYRNY QRKNDMDEPP PLDYGSGEDD 
GKSDKRKVKD PHYAEMEEKY YRFGIKPEWM TVHRIINHSV DKKGNYHYLV KWRDLPYDQS 
TWEEDEMNIP EYEEHKQSYW RHRELIMGED PAQPRKYKKK KKELQGDGPP SSPTNDPTVK 
YETQPRFITA TGGTLHMYQL EGLNWLRFSW AQGTDTILAD EMGLGKTIQT IVFLYSLYKE 
GHTKGPFLVS APLSTIINWE REFQMWAPKF YVVTYTGDKD SRAIIRENEF SFEDNAIKGG 
KKAFKMKREA QVKFHVLLTS YELITIDQAA LGSIRWACLV VDEAHRLKNN QSKFFRVLNG 
YKIDHKLLLT GTPLQNNLEE LFHLLNFLTP ERFNNLEGFL EEFADISKED QIKKLHDLLG 
PHMLRRLKAD VFKNMPAKTE LIVRVELSPM QKKYYKYILT RNFEALNSRG GGNQVSLLNI 
MMDLKKCCNH PYLFPVAAME SPKLPSGAYE GGALIKSSGK LMLLQKMLRK LKEQGHRVLI 
FSQMTKMLDL LEDFLDYEGY KYERIDGGIT GALRQEAIDR FNAPGAQQFC FLLSTRAGGL 
GINLATADTV IIFDSDWNPH NDIQAFSRAH RIGQANKVMI YRFVTRASVE ERITQVAKRK 
MMLTHLVVRP GLGSKAGSMS KQELDDILKF GTEELFKDEN EGENKEEDSS VIHYDNEAIA 
RLLDRNQDAT EDTDVQNMNE YLSSFKVAQY VVREEDKIEE IEREIIKQEE NVDPDYWEKL 
LRHHYEQQQE DLARNLGKGK RVRKQVNYND AAQEDQDNQS EYSVGSEEED EDFDERPEGR 
RQSKRQLRNE KDKPLPPLLA RVGGNIEVLG FNTRQRKAFL NAVMRWGMPP QDAFTTQWLV 
RDLRGKTEKE FKAYVSLFMR HLCEPGADGS ETFADGVPRE GLSRQQVLTR IGVMSLVKKK 
VQEFEHINGR WSMPELMPDP SADSKRSSRA SSPTKTSPTT PEASATNSPC TSKPATPAPS 
EKGEGIRTPL EKEEAENQEE KPEKNSRIGE KMETEADAPS PAPSLGERLE PRKIPLEDEV 
PGVPGEMEPE PGYRGDREKS ATESTPGERG EEKPLDGQEH RERPEGETGD LGKREDVKGD 
RELRPGPRDE PRSNGRREEK TEKPRFMFNI ADGGFTELHT LWQNEERAAI SSGKLNEIWH 
RRHDYWLLAG IVLHGYARWQ DIQNDAQFAI INEPFKTEAN KGNFLEMKNK FLARRFKLLE 
QALVIEEQLR RAAYLNLSQE PAHPAMALHA RFAEAECLAE SHQHLSKESL AGNKPANAVL 
HKGKGRGGPA RGRAHNAASE PAGGVAERHE GGRDPPASHA VPNTPHRSPP SDVRAQHPQP 
AGQQGHGASP HTGLPAGSLR YTSGVRGGLQ RRTRRGPGRR RRQLQPDACR VLHHSRHQRP 
SSACEEGEGN GGGIGVRRAG SEGAPSRGGD LYRRLTGSQA CPSPRPRPRG RPPAQALGPA 
ASPPPSPPLG PSLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.