Details for: TOPBP1
Associated with
Other Information
Genular Protein ID: 3511848797
Symbol: TOPB1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9461304
Title: A DNA topoisomerase II binding protein with eight repeating regions similar to DNA repair enzymes and to a cell cycle regulator.
PubMed ID: 9461304
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 10498869
Title: Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA.
PubMed ID: 10498869
PubMed ID: 11395493
Title: BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.
PubMed ID: 11395493
PubMed ID: 11714696
Title: Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.
PubMed ID: 11714696
PubMed ID: 12697828
Title: Regulation of E2F1 by BRCT domain-containing protein TopBP1.
PubMed ID: 12697828
PubMed ID: 12773567
Title: PML colocalizes with and stabilizes the DNA damage response protein TopBP1.
PubMed ID: 12773567
PubMed ID: 15138768
Title: TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.
PubMed ID: 15138768
PubMed ID: 15075294
Title: TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.
PubMed ID: 15075294
DOI: 10.1101/gad.1180204
PubMed ID: 16530042
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17575048
Title: The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
PubMed ID: 17575048
DOI: 10.1101/gad.1547007
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20545769
Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.
PubMed ID: 20545769
PubMed ID: 20080954
Title: A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
PubMed ID: 20080954
DOI: 10.1101/gad.1860310
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21482717
Title: MDC1 collaborates with TopBP1 in DNA replication checkpoint control.
PubMed ID: 21482717
PubMed ID: 21777809
Title: ATR autophosphorylation as a molecular switch for checkpoint activation.
PubMed ID: 21777809
PubMed ID: 21659603
Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
PubMed ID: 21659603
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25602520
Title: RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.
PubMed ID: 25602520
PubMed ID: 25933514
Title: Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.
PubMed ID: 25933514
PubMed ID: 26811421
Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
PubMed ID: 26811421
PubMed ID: 30898438
Title: MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.
PubMed ID: 30898438
PubMed ID: 33592542
Title: USP13 regulates the replication stress response by deubiquitinating TopBP1.
PubMed ID: 33592542
PubMed ID: 35121901
Title: The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.
PubMed ID: 35121901
PubMed ID: 35842428
Title: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
PubMed ID: 35842428
PubMed ID: 35597237
Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.
PubMed ID: 35597237
PubMed ID: 37165191
Title: Mitotic clustering of pulverized chromosomes from micronuclei.
PubMed ID: 37165191
PubMed ID: 37316668
Title: Mitotic tethering enables inheritance of shattered micronuclear chromosomes.
PubMed ID: 37316668
PubMed ID: 37674080
Title: Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis.
PubMed ID: 37674080
PubMed ID: 19937654
Title: Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1.
PubMed ID: 19937654
DOI: 10.1002/pro.290
PubMed ID: 23891287
Title: Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.
PubMed ID: 23891287
PubMed ID: 31135337
Title: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
PubMed ID: 31135337
DOI: 10.7554/elife.44353
Sequence Information:
- Length: 1522
- Mass: 170679
- Checksum: 02C25880EDCD6AC7
- Sequence:
MSRNDKEPFF VKFLKSSDNS KCFFKALESI KEFQSEEYLQ IITEEEALKI KENDRSLYIC DPFSGVVFDH LKKLGCRIVG PQVVIFCMHH QRCVPRAEHP VYNMVMSDVT ISCTSLEKEK REEVHKYVQM MGGRVYRDLN VSVTHLIAGE VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ EKKITRYTDI NMEDFKCPIF LGCIICVTGL CGLDRKEVQQ LTVKHGGQYM GQLKMNECTH LIVQEPKGQK YECAKRWNVH CVTTQWFFDS IEKGFCQDES IYKTEPRPEA KTMPNSSTPT SQINTIDSRT LSDVSNISNI NASCVSESIC NSLNSKLEPT LENLENLDVS AFQAPEDLLD GCRIYLCGFS GRKLDKLRRL INSGGGVRFN QLNEDVTHVI VGDYDDELKQ FWNKSAHRPH VVGAKWLLEC FSKGYMLSEE PYIHANYQPV EIPVSHKPES KAALLKKKNS SFSKKDFAPS EKHEQADEDL LSQYENGSST VVEAKTSEAR PFNDSTHAEP LNDSTHISLQ EENQSSVSHC VPDVSTITEE GLFSQKSFLV LGFSNENESN IANIIKENAG KIMSLLSRTV ADYAVVPLLG CEVEATVGEV VTNTWLVTCI DYQTLFDPKS NPLFTPVPVM TGMTPLEDCV ISFSQCAGAE KESLTFLANL LGASVQEYFV RKSNAKKGMF ASTHLILKER GGSKYEAAKK WNLPAVTIAW LLETARTGKR ADESHFLIEN STKEERSLET EITNGINLNS DTAEHPGTRL QTHRKTVVTP LDMNRFQSKA FRAVVSQHAR QVAASPAVGQ PLQKEPSLHL DTPSKFLSKD KLFKPSFDVK DALAALETPG RPSQQKRKPS TPLSEVIVKN LQLALANSSR NAVALSASPQ LKEAQSEKEE APKPLHKVVV CVSKKLSKKQ SELNGIAASL GADYRWSFDE TVTHFIYQGR PNDTNREYKS VKERGVHIVS EHWLLDCAQE CKHLPESLYP HTYNPKMSLD ISAVQDGRLC NSRLLSAVSS TKDDEPDPLI LEENDVDNMA TNNKESAPSN GSGKNDSKGV LTQTLEMREN FQKQLQEIMS ATSIVKPQGQ RTSLSRSGCN SASSTPDSTR SARSGRSRVL EALRQSRQTV PDVNTEPSQN EQIIWDDPTA REERARLASN LQWPSCPTQY SELQVDIQNL EDSPFQKPLH DSEIAKQAVC DPGNIRVTEA PKHPISEELE TPIKDSHLIP TPQAPSIAFP LANPPVAPHP REKIITIEET HEELKKQYIF QLSSLNPQER IDYCHLIEKL GGLVIEKQCF DPTCTHIVVG HPLRNEKYLA SVAAGKWVLH RSYLEACRTA GHFVQEEDYE WGSSSILDVL TGINVQQRRL ALAAMRWRKK IQQRQESGIV EGAFSGWKVI LHVDQSREAG FKRLLQSGGA KVLPGHSVPL FKEATHLFSD LNKLKPDDSG VNIAEAAAQN VYCLRTEYIA DYLMQESPPH VENYCLPEAI SFIQNNKELG TGLSQKRKAP TEKNKIKRPR VH
Genular Protein ID: 1647178305
Symbol: A0AV47_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 1435
- Mass: 160551
- Checksum: 959EFEBEF5257B00
- Sequence:
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR DLNVSVTHLI AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY TDINMEDFKC PIFLGCIICV TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE CTHLIVQEPK GQKYECAKRW NVHCVTTQWF FDSIEKGFCQ DESIYKTEPR PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE SICNSLNSKL EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML SEEPYIHANY QPVEIPVSHK PESKAALLKK KNSSFSKKDF APSEKHEQAD EDLLSQYENG SSTVVEAKTS EARPFNDSTH AEPLNDSTHI SLQEENQSSV SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN ESNIANIIKE NAGKIMSLLS RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD PKSNPLFTPV PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL IENSTKEERS LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ SKAFRAVVSQ HARQVAASPA VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF DVKDALAALE TPGRPSQQKR KPSTPLSEVI VKNLQLALAN SSRNAVALSA SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA ASLGADYRWS FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD NMATNNKESA PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP QGQRTSLSRS GCNSASSTPD STRSARSGRS RVLEALRQSR QTVPDVNTEP SQNEQIIWDD PTAREERARL ASNLQWPSCP TQYSELQVDI QNLEDSPFQK PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH LIPTPQAPSI AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC RTAGHFVQEE DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES GIVEGAFSGW KVILHVDQSR EAGFKRLLQS GGAKVLPGHS VPLFKEATHL FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE YIADYLMQES PPHVENYCLP EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH
Genular Protein ID: 867933731
Symbol: Q05BV8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 184
- Mass: 21390
- Checksum: EDD2EC0903AA1A8A
- Sequence:
MSRNDKEPFF VKFLKSSDNS KCFFKALESI KEFQSEEYLQ IITEEEALKI KENDRSLYIC DPFSGVVFDH LKKLGCRIVG PQVVIFCMHH QRCVPRAEHP VYNMVMSDVT ISCTSLEKEK REEVHKYVQM MGGRVYRDLN VSVTHLIAGE VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ KKKK
Genular Protein ID: 1023066180
Symbol: A7E2X7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 1435
- Mass: 160551
- Checksum: 39FF4399A076AF9B
- Sequence:
MHHQRCVPRA EHPVYNMVMS DVTISCTSLE KEKREEVHKY VQMMGGRVYR DLNVSVTHLI AGEVGSKKYL VAANLKKPIL LPSWIKTLWE KSQEKKITRY TDINMEDFKC PIFLGCIICV TGLCGLDRKE VQQLTVKHGG QYMGQLKMNE CTHLIVQEPK GQKYECAKRW NVHCVTTQWF FDSIEKGFCQ DESIYKTEPR PEAKTMPNSS TPTSQINTID SRTLSDVSNI SNINASCVSE SICNSLNSKL EPTLENLENL DVSAFQAPED LLDGCRIYLC GFSGRKLDKL RRLINSGGGV RFNQLNEDVT HVIVGDYDDE LKQFWNKSAH RPHVVGAKWL LECFSKGYML SEEPYIHANY QPVEIPVSHQ PESKAALLKK KNSSFSKKDF APSEKHEQAD EDLLSQYENG SSTVVEAKTS EARPFNDSTH AEPLNDSTHI SLQEENQSSV SHCVPDVSTI TEEGLFSQKS FLVLGFSNEN ESNIANIIKE NAGKIMSLLS RTVADYAVVP LLGCEVEATV GEVVTNTWLV TCIDYQTLFD PKSNPLFTPV PVMTGMTPLE DCVISFSQCA GAEKESLTFL ANLLGASVQE YFVRKSNAKK GMFASTHLIL KERGGSKYEA AKKWNLPAVT IAWLLETART GKRADESHFL IENSTKEERS LETEITNGIN LNSDTAEHPG TRLQTHRKTV VTPLDMNRFQ SKAFRAVVSQ HARQVAASPA VGQPLQKEPS LHLDTPSKFL SKDKLFKPSF DVKDALAALE TPGRPSQQKR KPSTPLSEVI VKNLQLALAN SSRNAVALSA SPQLKEAQSE KEEAPKPLHK VVVCVSKKLS KKQSELNGIA ASLGADYRWS FDETVTHFIY QGRPNDTNRE YKSVKERGVH IVSEHWLLDC AQECKHLPES LYPHTYNPKM SLDISAVQDG RLCNSRLLSA VSSTKDDEPD PLILEENDVD NMATNNKESA PSNGSGKNDS KGVLTQTLEM RENFQKQLQE IMSATSIVKP QGQRTSLSRS GCNSASSTPD STRSARSGRS RVLEALRQSR QTVPDVNTEP SQNEQIIWDD PTAREERARL ASNLQWPSCP TQYSELQVDI QNLEDSPFQK PLHDSEIAKQ AVCDPGNIRV TEAPKHPISE ELETPIKDSH LIPTPQAPSI AFPLANPPVA PHPREKIITI EETHEELKKQ YIFQLSSLNP QERIDYCHLI EKLGGLVIEK QCFDPTCTHI VVGHPLRNEK YLASVAAGKW VLHRSYLEAC RTAGHFVQEE DYEWGSSSIL DVLTGINVQQ RRLALAAMRW RKKIQQRQES GIVEGAFSGW KVILHVDQSR EAGFKRLLQS GGAKVLPGHS VPLFKEATHL FSDLNKLKPD DSGVNIAEAA AQNVYCLRTE YIADYLMQES PPHVENYCLP EAISFIQNNK ELGTGLSQKR KAPTEKNKIK RPRVH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.