TPPP | ENSG00000171368 | NCBI 11076

Details for: TPPP

Gene ID: 11076

Symbol: TPPP

Ensembl ID: ENSG00000171368

Description: tubulin polymerization promoting protein

Associated with

Astral microtubule organization
(GO:0030953)
Cell division
(GO:0051301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Golgi apparatus
(GO:0005794)
Gtpase activity
(GO:0003924)
Magnesium ion binding
(GO:0000287)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Microtubule bundle
(GO:0097427)
Microtubule bundle formation
(GO:0001578)
Microtubule nucleation by microtubule organizing center
(GO:0051418)
Microtubule nucleator activity
(GO:0140490)
Microtubule organizing center
(GO:0005815)
Microtubule polymerization
(GO:0046785)
Mitochondrion
(GO:0005739)
Mitotic spindle
(GO:0072686)
Myelin assembly
(GO:0032288)
Negative regulation of tubulin deacetylation
(GO:1904428)
Nucleus
(GO:0005634)
Oligodendrocyte development
(GO:0014003)
Oligodendrocyte differentiation
(GO:0048709)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of myelination
(GO:0031643)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein polymerization
(GO:0032273)
Postsynaptic golgi apparatus
(GO:0150051)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Tubulin binding
(GO:0015631)

Other Information

Proteins

Genular Protein ID: 2799869071

Symbol: TPPP_HUMAN

Name: p24

UniProtKB Accession Codes:

O94811

Database IDs:

Citations:

PubMed ID: 10083737

Title: A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3.

PubMed ID: 10083737

DOI: 10.1007/s100380050122

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15590652

Title: p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.

PubMed ID: 15590652

DOI: 10.1074/jbc.m410409200

PubMed ID: 17105200

Title: Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.

PubMed ID: 17105200

DOI: 10.1021/bi061305e

PubMed ID: 17027006

Title: Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.

PubMed ID: 17027006

DOI: 10.1016/j.febslet.2006.09.037

PubMed ID: 18028908

Title: The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.

PubMed ID: 18028908

DOI: 10.1016/j.yexcr.2007.08.012

PubMed ID: 17693641

Title: Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases.

PubMed ID: 17693641

DOI: 10.1074/jbc.m703466200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20308065

Title: TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.

PubMed ID: 20308065

DOI: 10.1074/jbc.m109.096578

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21995432

Title: Zn2+-induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity.

PubMed ID: 21995432

DOI: 10.1021/bi201447w

PubMed ID: 21565174

Title: A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.

PubMed ID: 21565174

DOI: 10.1016/j.bbrc.2011.04.130

PubMed ID: 21316364

Title: Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity.

PubMed ID: 21316364

DOI: 10.1016/j.febslet.2011.02.006

PubMed ID: 22484033

Title: Microtubule assembly-derived by dimerization of TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data.

PubMed ID: 22484033

DOI: 10.1016/j.bbagen.2012.03.011

PubMed ID: 23093407

Title: Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.

PubMed ID: 23093407

DOI: 10.1074/jbc.m112.394965

PubMed ID: 22328514

Title: TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.

PubMed ID: 22328514

DOI: 10.1242/jcs.096818

PubMed ID: 23355470

Title: Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.

PubMed ID: 23355470

DOI: 10.1074/jbc.m112.441048

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25445539

Title: Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.

PubMed ID: 25445539

DOI: 10.1016/j.bbadis.2014.10.015

PubMed ID: 26289831

Title: Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.

PubMed ID: 26289831

DOI: 10.1038/srep13242

PubMed ID: 31505170

Title: Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.

PubMed ID: 31505170

DOI: 10.1016/j.bbamcr.2019.118556

PubMed ID: 31522887

Title: The Golgi outpost protein TPPP nucleates microtubules and is critical for myelination.

PubMed ID: 31522887

DOI: 10.1016/j.cell.2019.08.025

PubMed ID: 33831707

Title: Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins.

PubMed ID: 33831707

DOI: 10.1016/j.ceca.2021.102404

Sequence Information:

Length: 219
Mass: 23694
Checksum: F8B2C814EA59129A
Sequence:

MADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA LEEAFRRFAV 
HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF SKIKGKSCRT ITFEQFQEAL 
EELAKKRFKD KSSEEAVREV HRLIEGKAPI ISGVTKAISS PTVSRLTDTT KFTGSHKERF 
DPSGKGKGKA GRVDLVDESG YVSGYKHAGT YDQKVQGGK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TPPP

Associated with

Other Information

A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. PubMed ID: 10083737

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. PubMed ID: 15590652

Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. PubMed ID: 17105200

Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. PubMed ID: 17027006

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. PubMed ID: 18028908

Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. PubMed ID: 17693641

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. PubMed ID: 20308065

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Zn2+-induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity. PubMed ID: 21995432

A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis. PubMed ID: 21565174

Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity. PubMed ID: 21316364

Microtubule assembly-derived by dimerization of TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data. PubMed ID: 22484033

Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration. PubMed ID: 23093407

TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation. PubMed ID: 22328514

Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation. PubMed ID: 23355470

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome. PubMed ID: 25445539

Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling. PubMed ID: 26289831

Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8. PubMed ID: 31505170

The Golgi outpost protein TPPP nucleates microtubules and is critical for myelination. PubMed ID: 31522887

Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins. PubMed ID: 33831707