Details for: CHD4

Gene ID: 1108

Symbol: CHD4

Ensembl ID: ENSG00000111642

Description: chromodomain helicase DNA binding protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 338.8082
    Cell Significance Index: -52.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.5755
    Cell Significance Index: -47.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.7647
    Cell Significance Index: -57.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 115.4564
    Cell Significance Index: -46.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.9238
    Cell Significance Index: -55.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.4502
    Cell Significance Index: -58.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.7254
    Cell Significance Index: -47.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.7332
    Cell Significance Index: -57.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9260
    Cell Significance Index: -50.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.4324
    Cell Significance Index: -47.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8275
    Cell Significance Index: -58.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3909
    Cell Significance Index: -24.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7319
    Cell Significance Index: 176.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5811
    Cell Significance Index: 134.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9807
    Cell Significance Index: 357.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9648
    Cell Significance Index: 213.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8898
    Cell Significance Index: 232.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7593
    Cell Significance Index: 47.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5051
    Cell Significance Index: 84.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4726
    Cell Significance Index: 804.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4568
    Cell Significance Index: 13.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2860
    Cell Significance Index: 176.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0649
    Cell Significance Index: 28.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0401
    Cell Significance Index: 208.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9519
    Cell Significance Index: 122.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8838
    Cell Significance Index: 41.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8036
    Cell Significance Index: 355.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7498
    Cell Significance Index: 88.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7448
    Cell Significance Index: 25.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7382
    Cell Significance Index: 21.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7192
    Cell Significance Index: 19.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6163
    Cell Significance Index: 556.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5999
    Cell Significance Index: 119.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5625
    Cell Significance Index: 13.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5587
    Cell Significance Index: 106.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5486
    Cell Significance Index: 4.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5134
    Cell Significance Index: 23.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5051
    Cell Significance Index: 34.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4606
    Cell Significance Index: 32.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4406
    Cell Significance Index: 158.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3928
    Cell Significance Index: 30.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3428
    Cell Significance Index: 17.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2482
    Cell Significance Index: 11.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2273
    Cell Significance Index: 6.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1651
    Cell Significance Index: 28.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1274
    Cell Significance Index: 6.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1159
    Cell Significance Index: 2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1045
    Cell Significance Index: 2.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0826
    Cell Significance Index: 10.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0779
    Cell Significance Index: 12.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0778
    Cell Significance Index: 4.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0529
    Cell Significance Index: 38.7800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0259
    Cell Significance Index: 0.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0097
    Cell Significance Index: -0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0124
    Cell Significance Index: -23.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0198
    Cell Significance Index: -1.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0293
    Cell Significance Index: -53.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0314
    Cell Significance Index: -0.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0358
    Cell Significance Index: -55.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0359
    Cell Significance Index: -22.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0439
    Cell Significance Index: -59.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0593
    Cell Significance Index: -3.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0634
    Cell Significance Index: -40.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0722
    Cell Significance Index: -7.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0779
    Cell Significance Index: -43.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1143
    Cell Significance Index: -51.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1322
    Cell Significance Index: -27.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1482
    Cell Significance Index: -2.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1629
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1670
    Cell Significance Index: -19.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1672
    Cell Significance Index: -4.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1721
    Cell Significance Index: -49.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2027
    Cell Significance Index: -12.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2051
    Cell Significance Index: -5.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2614
    Cell Significance Index: -9.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2675
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2932
    Cell Significance Index: -33.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3094
    Cell Significance Index: -36.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3371
    Cell Significance Index: -3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3396
    Cell Significance Index: -15.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3484
    Cell Significance Index: -50.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3694
    Cell Significance Index: -6.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4466
    Cell Significance Index: -11.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4715
    Cell Significance Index: -37.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4785
    Cell Significance Index: -10.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4806
    Cell Significance Index: -18.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5600
    Cell Significance Index: -58.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6000
    Cell Significance Index: -30.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6074
    Cell Significance Index: -3.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6594
    Cell Significance Index: -21.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7183
    Cell Significance Index: -9.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7639
    Cell Significance Index: -8.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8112
    Cell Significance Index: -9.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8493
    Cell Significance Index: -57.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9102
    Cell Significance Index: -26.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9189
    Cell Significance Index: -56.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9711
    Cell Significance Index: -23.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Chromatin remodeler activity**: CHD4 is a member of the CHD family of proteins, which are known for their ability to remodel chromatin structure and regulate gene expression. 2. **DNA-binding domain**: The CHD4 protein possesses a unique DNA-binding domain that allows it to interact with specific DNA sequences and regulate transcriptional activity. 3. **Helicase activity**: CHD4 also possesses helicase activity, which enables it to unwind DNA and regulate chromatin organization. 4. **Epigenetic regulation**: CHD4 plays a critical role in regulating epigenetic marks, particularly histone modifications, which are essential for gene expression and chromatin organization. 5. **Negative regulation of transcription**: CHD4 acts as a negative regulator of transcriptional activity, particularly in the context of DNA-templated transcription. **Pathways and Functions** 1. **Atp-dependent chromatin remodeler activity**: CHD4 is involved in the regulation of chromatin structure and gene expression through its ATP-dependent chromatin remodeler activity. 2. **Epigenetic regulation of gene expression**: CHD4 plays a critical role in regulating epigenetic marks, particularly histone modifications, which are essential for gene expression and chromatin organization. 3. **Transcriptional regulation by TP53**: CHD4 interacts with TP53, a key transcription factor involved in cell cycle regulation and apoptosis, to regulate transcriptional activity. 4. **Regulation of cell fate specification**: CHD4 is involved in the regulation of cell fate specification, particularly in the context of neural development and stem cell differentiation. 5. **Regulation of synapse assembly**: CHD4 plays a critical role in regulating synapse assembly and function, particularly in the context of neuronal development and synaptic plasticity. **Clinical Significance** 1. **Neurological disorders**: CHD4 has been implicated in the pathogenesis of various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer**: CHD4 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, and has been implicated in the regulation of tumorigenesis and cancer progression. 3. **Infectious diseases**: CHD4 has been implicated in the regulation of immune responses to viral infections, including SARS-CoV and HIV. 4. **Therapeutic potential**: CHD4 has been identified as a potential therapeutic target for various diseases, including neurological disorders and cancer, due to its role in regulating gene expression and chromatin organization. In conclusion, CHD4 is a critical regulator of gene expression and chromatin organization, and its dysregulation has been implicated in various diseases, including neurological disorders and cancer. Further research is needed to fully elucidate the role of CHD4 in human disease and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 3165157091

Symbol: CHD4_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 4

UniProtKB Accession Codes:

Q14839 Q8IXZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 5 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 3 Rhea 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7575689

Title: The major dermatomyositis specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

PubMed ID: 7575689

DOI: 10.1002/art.1780381006

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9804427

Title: Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.

PubMed ID: 9804427

DOI: 10.1038/27699

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 10204490

Title: Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

PubMed ID: 10204490

DOI: 10.1016/s1074-7613(00)80034-5

PubMed ID: 12198550

Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.

PubMed ID: 12198550

DOI: 10.1038/nature01024

PubMed ID: 14530259

Title: Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.

PubMed ID: 14530259

DOI: 10.1074/jbc.m309198200

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17626165

Title: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.

PubMed ID: 17626165

DOI: 10.1091/mbc.e06-07-0604

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19644445

Title: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.

PubMed ID: 19644445

DOI: 10.1038/emboj.2009.211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21555454

Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

PubMed ID: 21555454

DOI: 10.1128/mcb.01341-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23149945

Title: Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

PubMed ID: 23149945

DOI: 10.1128/mcb.01195-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27732854

Title: ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

PubMed ID: 27732854

DOI: 10.1016/j.celrep.2016.09.037

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 36064715

Title: ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.

PubMed ID: 36064715

DOI: 10.1038/s41419-022-05212-x

PubMed ID: 12842043

Title: Engineering a protein scaffold from a PHD finger.

PubMed ID: 12842043

DOI: 10.1016/s0969-2126(03)00122-9

PubMed ID: 29567837

Title: The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

PubMed ID: 29567837

DOI: 10.1074/jbc.ra117.000678

PubMed ID: 32543371

Title: Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.

PubMed ID: 32543371

DOI: 10.7554/elife.56178

PubMed ID: 27616479

Title: De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.

PubMed ID: 27616479

DOI: 10.1016/j.ajhg.2016.08.001

PubMed ID: 27479907

Title: Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

PubMed ID: 27479907

DOI: 10.1038/ng.3627

Sequence Information:

  • Length: 1912
  • Mass: 218005
  • Checksum: 765ED8485B7BBB85
  • Sequence:
    • MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP 
RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA LRSDSEGSDY TPGKKKKKKL 
GPKKEKKSKS KRKEEEEEED DDDDSKEPKS SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA 
FSQFVRPLIA AKNPKIAVSK MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM 
VTATEVAPPP PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG 
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK KKKKGEEEVT 
AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD MEKAPEGKWS CPHCEKEGIQ 
WEAKEDNSEG EEILEEVGGD LEEEDDHHME FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL 
PEIPNGEWLC PRCTCPALKG KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE 
RQFFVKWQGM SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN 
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD QASWESEDVE 
IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP PETPTVDPTV KYERQPEYLD 
ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV 
SAPLSTIINW EREFEMWAPD MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE 
ASVKFHVLLT SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL 
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML GPHMLRRLKA 
DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR GGGNQVSLLN VVMDLKKCCN 
HPYLFPVAAM EAPKMPNGMY DGSALIRASG KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD 
LLEDFLEHEG YKYERIDGGI TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT 
VIIYDSDWNP HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR 
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD DKAIERLLDR 
NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER EIIKQEESVD PDYWEKLLRH 
HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ EDRDWQDDQS DNQSDYSVAS EEGDEDFDER 
SEAPRRPSRK GLRNDKDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT 
TQWLVRDLRG KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS 
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ PNTPAPVPPA 
EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP ASEDEKVVVE PPEGEEKVEK 
AEVKERTEEP METEPKGAAD VEKVEEKSAI DLTPIVVEDK EEKKEEEEKK EVMLQNGETP 
KDLNDEKQKK NIKQRFMFNI ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG 
IINHGYARWQ DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR 
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL HKVLKQLEEL 
LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA PEPTPQQVAQ QQ

Genular Protein ID: 700169024

Symbol: F5GWX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GWX5

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 5 GeneTree 1 HGNC 1 IntAct 1 InterPro 19 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 8 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 1 SAM 1 SMART 6 SMR 1 SUPFAM 3 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1905
  • Mass: 217103
  • Checksum: D7B59A71C25EB701
  • Sequence:
    • MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP 
RDPKIPKSKR QKKELGDSSG EGPEFVEEEE EVALRSDSEG SDYTPGKKKK KKLGPKKEKK 
SKSKRKEEEE EEDDDDDSKE PKSSAQLLED WGMEDIDHVF SEEDYRTLTN YKAFSQFVRP 
LIAAKNPKIA VSKMMMVLGA KWREFSTNNP FKGSSGASVA AAAAAAVAVV ESMVTATEVA 
PPPPPVEVPI RKAKTKEGKG PNARRKPKGS PRVPDAKKPK PKKVAPLKIK LGGFGSKRKR 
SSSEDDDLDV ESDFDDASIN SYSVSDGSTS RSSRSRKKLR TTKKKKKGEE EVTAVDGYET 
DHQDYCEVCQ QGGEIILCDT CPRAYHMVCL DPDMEKAPEG KWSCPHCEKE GIQWEAKEDN 
SEGEEILEEV GGDLEEEDDH HMEFCRVCKD GGELLCCDTC PSSYHIHCLN PPLPEIPNGE 
WLCPRCTCPA LKGKVQKILI WKWGQPPSPT PVPRPPDADP NTPSPKPLEG RPERQFFVKW 
QGMSYWHCSW VSELQLELHC QVMFRNYQRK NDMDEPPSGD FGGDEEKSRK RKNKDPKFAE 
MEERFYRYGI KPEWMMIHRI LNHSVDKKGH VHYLIKWRDL PYDQASWESE DVEIQDYDLF 
KQSYWNHREL MRGEEGRPGK KLKKVKLRKL ERPPETPTVD PTVKYERQPE YLDATGGTLH 
PYQMEGLNWL RFSWAQGTDT ILADEMGLGK TVQTAVFLYS LYKEGHSKGP FLVSAPLSTI 
INWEREFEMW APDMYVVTYV GDKDSRAIIR ENEFSFEDNA IRGGKKASRM KKEASVKFHV 
LLTSYELITI DMAILGSIDW ACLIVDEAHR LKNNQSKFFR VLNGYSLQHK LLLTGTPLQN 
NLEELFHLLN FLTPERFHNL EGFLEEFADI AKEDQIKKLH DMLGPHMLRR LKADVFKNMP 
SKTELIVRVE LSPMQKKYYK YILTRNFEAL NARGGGNQVS LLNVVMDLKK CCNHPYLFPV 
AAMEAPKMPN GMYDGSALIR ASGKLLLLQK MLKNLKEGGH RVLIFSQMTK MLDLLEDFLE 
HEGYKYERID GGITGNMRQE AIDRFNAPGA QQFCFLLSTR AGGLGINLAT ADTVIIYDSD 
WNPHNDIQAF SRAHRIGQNK KVMIYRFVTR ASVEERITQV AKKKMMLTHL VVRPGLGSKT 
GSMSKQELDD ILKFGTEELF KDEATDGGGD NKEGEDSSVI HYDDKAIERL LDRNQDETED 
TELQGMNEYL SSFKVAQYVV REEEMGEEEE VEREIIKQEE SVDPDYWEKL LRHHYEQQQE 
DLARNLGKGK RIRKQVNYND GSQEDRDWQD DQSDNQSDYS VASEEGDEDF DERSEAPRRP 
SRKGLRNDKD KPLPPLLARV GGNIEVLGFN ARQRKAFLNA IMRYGMPPQD AFTTQWLVRD 
LRGKSEKEFK AYVSLFMRHL CEPGADGAET FADGVPREGL SRQHVLTRIG VMSLIRKKVQ 
EFEHVNGRWS MPELAEVEEN KKMSQPGSPS PKTPTPSTPG DTQPNTPAPV PPAEDGIKIE 
ENSLKEEESI EGEKEVKSTA PETAIECTQA PAPASEDEKV VVEPPEGEEK VEKAEVKERT 
EEPMETEPKG AADVEKVEEK SAIDLTPIVV EDKEEKKEEE EKKEVMLQNG ETPKDLNDEK 
QKKNIKQRFM FNIADGGFTE LHSLWQNEER AATVTKKTYE IWHRRHDYWL LAGIINHGYA 
RWQDIQNDPR YAILNEPFKG EMNRGNFLEI KNKFLARRFK LLEQALVIEE QLRRAAYLNM 
SEDPSHPSMA LNTRFAEVEC LAESHQHLSK ESMAGNKPAN AVLHKVLKQL EELLSDMKAD 
VTRLPATIAR IPPVAVRLQM SERNILSRLA NRAPEPTPQQ VAQQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.