Details for: CHD4

Gene ID: 1108

Symbol: CHD4

Ensembl ID: ENSG00000111642

Description: chromodomain helicase DNA binding protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.71
    Marker Score: 11282
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.25
    Marker Score: 22828
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.24
    Marker Score: 1496
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.14
    Marker Score: 7348
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1
    Marker Score: 18474
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.08
    Marker Score: 10897
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.05
    Marker Score: 1062
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2
    Marker Score: 69416
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.99
    Marker Score: 7692
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.95
    Marker Score: 1373.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.94
    Marker Score: 1672
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.93
    Marker Score: 21758
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.87
    Marker Score: 7800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6921
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.81
    Marker Score: 2551
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.81
    Marker Score: 1233
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.8
    Marker Score: 1809
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.78
    Marker Score: 31607
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.77
    Marker Score: 3692
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.76
    Marker Score: 1882
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.68
    Marker Score: 6870
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.67
    Marker Score: 2367
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.67
    Marker Score: 2017
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.64
    Marker Score: 1547
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.64
    Marker Score: 1093
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.62
    Marker Score: 14037.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.58
    Marker Score: 33705
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.58
    Marker Score: 1074
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.56
    Marker Score: 2648
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.55
    Marker Score: 976
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.55
    Marker Score: 16039
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.54
    Marker Score: 11492
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.53
    Marker Score: 1625
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.49
    Marker Score: 1673
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.49
    Marker Score: 422
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.45
    Marker Score: 717
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.44
    Marker Score: 681
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.44
    Marker Score: 461
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.43
    Marker Score: 8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.43
    Marker Score: 341
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.43
    Marker Score: 393
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.41
    Marker Score: 487
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.41
    Marker Score: 748
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4
    Marker Score: 3305.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.4
    Marker Score: 329
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2058
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.4
    Marker Score: 841
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.39
    Marker Score: 3788
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.39
    Marker Score: 3731
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.39
    Marker Score: 678.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.39
    Marker Score: 2636
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.39
    Marker Score: 466
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.38
    Marker Score: 1361
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1486
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.37
    Marker Score: 1454
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.37
    Marker Score: 709
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.37
    Marker Score: 2570
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.37
    Marker Score: 76432
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.36
    Marker Score: 667
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.36
    Marker Score: 554
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.36
    Marker Score: 274
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.36
    Marker Score: 473
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.35
    Marker Score: 1862.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.35
    Marker Score: 546
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.34
    Marker Score: 17727
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.34
    Marker Score: 979
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.34
    Marker Score: 3752
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.33
    Marker Score: 1403.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.32
    Marker Score: 492
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.31
    Marker Score: 1315
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.31
    Marker Score: 777
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.31
    Marker Score: 1502
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.3
    Marker Score: 3280
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.3
    Marker Score: 941
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.3
    Marker Score: 1192.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.3
    Marker Score: 459
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.29
    Marker Score: 8412
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.29
    Marker Score: 1309
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.28
    Marker Score: 1210
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1983
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.27
    Marker Score: 2219
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.27
    Marker Score: 594
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.27
    Marker Score: 6665
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.26
    Marker Score: 441
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.26
    Marker Score: 3743
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.26
    Marker Score: 8047
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.26
    Marker Score: 786.5
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.26
    Marker Score: 528.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.26
    Marker Score: 1090
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.26
    Marker Score: 721
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.26
    Marker Score: 1934
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.25
    Marker Score: 1572
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.25
    Marker Score: 3411
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.25
    Marker Score: 2494
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.24
    Marker Score: 317
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.23
    Marker Score: 1773
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.23
    Marker Score: 270
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.23
    Marker Score: 793
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.23
    Marker Score: 1351
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.22
    Marker Score: 674

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Other Information

**Key characteristics:** - CHD4 is a highly conserved protein with a predicted molecular weight of approximately 120 kDa. - It is a member of the chromodomain helicase family of proteins, which are responsible for the removal of acetyl groups from histones and other proteins. - CHD4 is ubiquitinated by the E3 ubiquitin ligase MBL1 and undergoes proteolytic degradation, which is essential for its full activity. **Pathways and functions:** - CHD4 is involved in multiple cellular processes, including: - Chromatin remodeling: It facilitates the relaxation of chromatin structure by deacetylating histone tails, making them more accessible for transcription factors and RNA polymerase. - Transcription regulation: CHD4 is a key regulator of gene expression by deacetylating the enhancer regions of RNA polymerase II promoters, thereby promoting the initiation of transcription. - Cell cycle regulation: It is involved in cell cycle progression by preventing the re-replication of damaged DNA. - Apoptosis: CHD4 is also involved in apoptosis, where it facilitates the degradation of damaged DNA and promotes cell death. **Clinical significance:** - Mutations in the CHD4 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. - Targeting CHD4 is a promising therapeutic strategy for these diseases, as it could provide a novel approach to cancer treatment. **Additional notes:** - CHD4 is a highly dynamic protein that undergoes various post-translational modifications, which can influence its activity and cellular function. - It is a multi-functional protein that can interact with various proteins involved in chromatin remodeling, transcription, and cell cycle regulation.

Genular Protein ID: 3165157091

Symbol: CHD4_HUMAN

Name: Chromodomain-helicase-DNA-binding protein 4

UniProtKB Accession Codes:

Q14839 Q8IXZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 6 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EMDB 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 5 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 18 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 12 PRO 1 PROSITE 7 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 Rhea 1 SAM 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

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Title: The major dermatomyositis specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.

PubMed ID: 7575689

DOI: 10.1002/art.1780381006

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9804427

Title: Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.

PubMed ID: 9804427

DOI: 10.1038/27699

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 10204490

Title: Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

PubMed ID: 10204490

DOI: 10.1016/s1074-7613(00)80034-5

PubMed ID: 12198550

Title: A chromatin remodelling complex that loads cohesin onto human chromosomes.

PubMed ID: 12198550

DOI: 10.1038/nature01024

PubMed ID: 14530259

Title: Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.

PubMed ID: 14530259

DOI: 10.1074/jbc.m309198200

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17626165

Title: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.

PubMed ID: 17626165

DOI: 10.1091/mbc.e06-07-0604

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19644445

Title: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.

PubMed ID: 19644445

DOI: 10.1038/emboj.2009.211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21555454

Title: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

PubMed ID: 21555454

DOI: 10.1128/mcb.01341-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23149945

Title: Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

PubMed ID: 23149945

DOI: 10.1128/mcb.01195-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27732854

Title: ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

PubMed ID: 27732854

DOI: 10.1016/j.celrep.2016.09.037

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 36064715

Title: ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation.

PubMed ID: 36064715

DOI: 10.1038/s41419-022-05212-x

PubMed ID: 12842043

Title: Engineering a protein scaffold from a PHD finger.

PubMed ID: 12842043

DOI: 10.1016/s0969-2126(03)00122-9

PubMed ID: 32543371

Title: Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.

PubMed ID: 32543371

DOI: 10.7554/elife.56178

PubMed ID: 27616479

Title: De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms.

PubMed ID: 27616479

DOI: 10.1016/j.ajhg.2016.08.001

PubMed ID: 27479907

Title: Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

PubMed ID: 27479907

DOI: 10.1038/ng.3627

Sequence Information:

  • Length: 1912
  • Mass: 218005
  • Checksum: 765ED8485B7BBB85
  • Sequence:
    • MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP 
RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA LRSDSEGSDY TPGKKKKKKL 
GPKKEKKSKS KRKEEEEEED DDDDSKEPKS SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA 
FSQFVRPLIA AKNPKIAVSK MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM 
VTATEVAPPP PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG 
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK KKKKGEEEVT 
AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD MEKAPEGKWS CPHCEKEGIQ 
WEAKEDNSEG EEILEEVGGD LEEEDDHHME FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL 
PEIPNGEWLC PRCTCPALKG KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE 
RQFFVKWQGM SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN 
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD QASWESEDVE 
IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP PETPTVDPTV KYERQPEYLD 
ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV 
SAPLSTIINW EREFEMWAPD MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE 
ASVKFHVLLT SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL 
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML GPHMLRRLKA 
DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR GGGNQVSLLN VVMDLKKCCN 
HPYLFPVAAM EAPKMPNGMY DGSALIRASG KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD 
LLEDFLEHEG YKYERIDGGI TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT 
VIIYDSDWNP HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR 
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD DKAIERLLDR 
NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER EIIKQEESVD PDYWEKLLRH 
HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ EDRDWQDDQS DNQSDYSVAS EEGDEDFDER 
SEAPRRPSRK GLRNDKDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT 
TQWLVRDLRG KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS 
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ PNTPAPVPPA 
EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP ASEDEKVVVE PPEGEEKVEK 
AEVKERTEEP METEPKGAAD VEKVEEKSAI DLTPIVVEDK EEKKEEEEKK EVMLQNGETP 
KDLNDEKQKK NIKQRFMFNI ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG 
IINHGYARWQ DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR 
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL HKVLKQLEEL 
LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA PEPTPQQVAQ QQ

Genular Protein ID: 700169024

Symbol: F5GWX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GWX5

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 6 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 5 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 18 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 8 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 1 SAM 1 SMART 6 SMR 1 SUPFAM 3 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1905
  • Mass: 217103
  • Checksum: D7B59A71C25EB701
  • Sequence:
    • MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP 
RDPKIPKSKR QKKELGDSSG EGPEFVEEEE EVALRSDSEG SDYTPGKKKK KKLGPKKEKK 
SKSKRKEEEE EEDDDDDSKE PKSSAQLLED WGMEDIDHVF SEEDYRTLTN YKAFSQFVRP 
LIAAKNPKIA VSKMMMVLGA KWREFSTNNP FKGSSGASVA AAAAAAVAVV ESMVTATEVA 
PPPPPVEVPI RKAKTKEGKG PNARRKPKGS PRVPDAKKPK PKKVAPLKIK LGGFGSKRKR 
SSSEDDDLDV ESDFDDASIN SYSVSDGSTS RSSRSRKKLR TTKKKKKGEE EVTAVDGYET 
DHQDYCEVCQ QGGEIILCDT CPRAYHMVCL DPDMEKAPEG KWSCPHCEKE GIQWEAKEDN 
SEGEEILEEV GGDLEEEDDH HMEFCRVCKD GGELLCCDTC PSSYHIHCLN PPLPEIPNGE 
WLCPRCTCPA LKGKVQKILI WKWGQPPSPT PVPRPPDADP NTPSPKPLEG RPERQFFVKW 
QGMSYWHCSW VSELQLELHC QVMFRNYQRK NDMDEPPSGD FGGDEEKSRK RKNKDPKFAE 
MEERFYRYGI KPEWMMIHRI LNHSVDKKGH VHYLIKWRDL PYDQASWESE DVEIQDYDLF 
KQSYWNHREL MRGEEGRPGK KLKKVKLRKL ERPPETPTVD PTVKYERQPE YLDATGGTLH 
PYQMEGLNWL RFSWAQGTDT ILADEMGLGK TVQTAVFLYS LYKEGHSKGP FLVSAPLSTI 
INWEREFEMW APDMYVVTYV GDKDSRAIIR ENEFSFEDNA IRGGKKASRM KKEASVKFHV 
LLTSYELITI DMAILGSIDW ACLIVDEAHR LKNNQSKFFR VLNGYSLQHK LLLTGTPLQN 
NLEELFHLLN FLTPERFHNL EGFLEEFADI AKEDQIKKLH DMLGPHMLRR LKADVFKNMP 
SKTELIVRVE LSPMQKKYYK YILTRNFEAL NARGGGNQVS LLNVVMDLKK CCNHPYLFPV 
AAMEAPKMPN GMYDGSALIR ASGKLLLLQK MLKNLKEGGH RVLIFSQMTK MLDLLEDFLE 
HEGYKYERID GGITGNMRQE AIDRFNAPGA QQFCFLLSTR AGGLGINLAT ADTVIIYDSD 
WNPHNDIQAF SRAHRIGQNK KVMIYRFVTR ASVEERITQV AKKKMMLTHL VVRPGLGSKT 
GSMSKQELDD ILKFGTEELF KDEATDGGGD NKEGEDSSVI HYDDKAIERL LDRNQDETED 
TELQGMNEYL SSFKVAQYVV REEEMGEEEE VEREIIKQEE SVDPDYWEKL LRHHYEQQQE 
DLARNLGKGK RIRKQVNYND GSQEDRDWQD DQSDNQSDYS VASEEGDEDF DERSEAPRRP 
SRKGLRNDKD KPLPPLLARV GGNIEVLGFN ARQRKAFLNA IMRYGMPPQD AFTTQWLVRD 
LRGKSEKEFK AYVSLFMRHL CEPGADGAET FADGVPREGL SRQHVLTRIG VMSLIRKKVQ 
EFEHVNGRWS MPELAEVEEN KKMSQPGSPS PKTPTPSTPG DTQPNTPAPV PPAEDGIKIE 
ENSLKEEESI EGEKEVKSTA PETAIECTQA PAPASEDEKV VVEPPEGEEK VEKAEVKERT 
EEPMETEPKG AADVEKVEEK SAIDLTPIVV EDKEEKKEEE EKKEVMLQNG ETPKDLNDEK 
QKKNIKQRFM FNIADGGFTE LHSLWQNEER AATVTKKTYE IWHRRHDYWL LAGIINHGYA 
RWQDIQNDPR YAILNEPFKG EMNRGNFLEI KNKFLARRFK LLEQALVIEE QLRRAAYLNM 
SEDPSHPSMA LNTRFAEVEC LAESHQHLSK ESMAGNKPAN AVLHKVLKQL EELLSDMKAD 
VTRLPATIAR IPPVAVRLQM SERNILSRLA NRAPEPTPQQ VAQQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.