Details for: ADAM30

Gene ID: 11085

Symbol: ADAM30

Ensembl ID: ENSG00000134249

Description: ADAM metallopeptidase domain 30

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,081
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,284
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30,403
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,850
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.62
    Marker Score: 2,636
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.04
    Marker Score: 605
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,830
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2,537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,551
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.79
    Marker Score: 725
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,504
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 548
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1,263
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7,791
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2,630
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 245
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 158
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 247
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 55
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 39
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0
    Marker Score: 63
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 20

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM30 is a type II transmembrane protein, consisting of a disintegrin domain, a metalloprotease domain, and a cysteine-rich domain. The disintegrin domain is responsible for cell-cell interactions, while the metalloprotease domain is involved in protein processing and cleavage. ADAM30 is also known to interact with other proteins, including zona pellucida glycoproteins and cumulus cells, suggesting its role in fertilization and reproductive processes. The gene is highly expressed in various cell types, including neurons, oligodendrocytes, and endothelial cells, highlighting its potential involvement in neurodevelopment and vascular homeostasis. **Pathways and Functions:** ADAM30 is involved in several signaling pathways, including: 1. **Fertilization:** ADAM30 interacts with zona pellucida glycoproteins and cumulus cells, playing a crucial role in sperm-egg binding and fertilization. 2. **Male Gonad Development:** ADAM30 is expressed in the male gonads and is involved in the development and maturation of sperm cells. 3. **Neurodevelopment:** ADAM30 is highly expressed in the brain and is involved in the development and differentiation of neurons, particularly GABAergic interneurons. 4. **Proteolysis:** The metalloprotease domain of ADAM30 is involved in protein processing and cleavage, which is essential for various cellular processes, including cell signaling and adhesion. **Clinical Significance:** Dysregulation of ADAM30 has been implicated in various diseases, including: 1. **Infertility:** ADAM30 has been shown to play a crucial role in fertilization, and its dysfunction can lead to male infertility. 2. **Neurodegenerative Diseases:** ADAM30 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation can lead to neuronal dysfunction and degeneration. 3. **Cancer:** ADAM30 has been shown to be overexpressed in various types of cancer, including breast and lung cancer, where its dysregulation can contribute to tumor progression and metastasis. In conclusion, ADAM30 is a multifunctional protein involved in various physiological and pathological processes. Further research is needed to fully understand the mechanisms of ADAM30 and its role in human health and disease.

Genular Protein ID: 2558867585

Symbol: ADA30_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 30

UniProtKB Accession Codes:

Q9UKF2 A8K8W8 Q5T3X6 Q9UKF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10512762

Title: Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression.

PubMed ID: 10512762

DOI: 10.1006/bbrc.1999.1322

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 27333034

Title: ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

PubMed ID: 27333034

DOI: 10.1016/j.ebiom.2016.06.002

Sequence Information:

  • Length: 790
  • Mass: 88940
  • Checksum: 42EC8A5F6B5ACDA3
  • Sequence:
    • MRSVQIFLSQ CRLLLLLVPT MLLKSLGEDV IFHPEGEFDS YEVTIPEKLS FRGEVQGVVS 
PVSYLLQLKG KKHVLHLWPK RLLLPRHLRV FSFTEHGELL EDHPYIPKDC NYMGSVKESL 
DSKATISTCM GGLRGVFNID AKHYQIEPLK ASPSFEHVVY LLKKEQFGNQ VCGLSDDEIE 
WQMAPYENKA RLRDFPGSYK HPKYLELILL FDQSRYRFVN NNLSQVIHDA ILLTGIMDTY 
FQDVRMRIHL KALEVWTDFN KIRVGYPELA EVLGRFVIYK KSVLNARLSS DWAHLYLQRK 
YNDALAWSFG KVCSLEYAGS VSTLLDTNIL APATWSAHEL GHAVGMSHDE QYCQCRGRLN 
CIMGSGRTGF SNCSYISFFK HISSGATCLN NIPGLGYVLK RCGNKIVEDN EECDCGSTEE 
CQKDRCCQSN CKLQPGANCS IGLCCHDCRF RPSGYVCRQE GNECDLAEYC DGNSSSCPND 
VYKQDGTPCK YEGRCFRKGC RSRYMQCQSI FGPDAMEAPS ECYDAVNLIG DQFGNCEITG 
IRNFKKCESA NSICGRLQCI NVETIPDLPE HTTIISTHLQ AENLMCWGTG YHLSMKPMGI 
PDLGMINDGT SCGEGRVCFK KNCVNSSVLQ FDCLPEKCNT RGVCNNRKNC HCMYGWAPPF 
CEEVGYGGSI DSGPPGLLRG AIPSSIWVVS IIMFRLILLI LSVVFVFFRQ VIGNHLKPKQ 
EKMPLSKAKT EQEESKTKTV QEESKTKTGQ EESEAKTGQE ESKAKTGQEE SKANIESKRP 
KAKSVKKQKK

Genular Protein ID: 1650928594

Symbol: Q8TBZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TBZ7

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 3 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 790
  • Mass: 88941
  • Checksum: 42EC8A5F66ECCDA3
  • Sequence:
    • MRSVQIFLSQ CRLLLLLVPT MLLKSLGEDV IFHPEGEFDS YEVTIPEKLS FRGEVQGVVS 
PVSYLLQLKG KKHVLHLWPK RLLLPRHLRV FSFTEHGELL EDHPYIPKDC NYMGSVKESL 
DSKATISTCM GGLRGVFNID AKHYQIEPLK ASPSFEHVVY LLKKEQFGNQ VCGLSDDEIE 
WQMAPYENKA RLRDFPGSYK HPKYLELILL FDQSRYRFVN NNLSQVIHDA ILLTGIMDTY 
FQDVRMRIHL KALEVWTDFN KIRVGYPELA EVLGRFVIYK KSVLNARLSS DWAHLYLQRK 
YNDALAWSFG KVCSLEYAGS VSTLLDTNIL APATWSAHEL GHAVGMSHDE QYCQCRGRLN 
CIMGSGRTGF SNCSYISFFK HISSGATCLN NIPGLGYVLK RCGNKIVEDN EECDCGSTEE 
CQKDRCCQSN CKLQPGANCS IGLCCHDCRF RPSGYVCRQE GNECDLAEYC DGNSSSCPND 
VYKQDGTPCK YEGRCFRKGC RSRYMQCQSI FGPDAMEAPS ECYDAVNLIG DQFGNCEITG 
IRNFKKCESA NSICGRLQCI NVETIPDLPE HTTIISTHLQ AENLMCWGTG YHLSMKPMGI 
PDLGMINDGT SCGEGRVCFK KNCVNSSVLQ FDCLPEKCNT RGVCNNRKNC HCMYGWAPPF 
CEEVGYGGSI DSGPPGLLRG AIPSSIWVVS IIMFRLILLI LSVVFVFFRQ VIGNHLKPKQ 
EKMPLSKAKT EQEESKTKTV QEESKTKTGQ EESEAKTGQE ESKAKTGQEE SKANIESERP 
KAKSVKKQKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.