AKR1C4 | ENSG00000198610 | NCBI 1109

Details for: AKR1C4

Gene ID: 1109

Symbol: AKR1C4

Ensembl ID: ENSG00000198610

Description: aldo-keto reductase family 1 member C4

Associated with

Bile acid and bile salt metabolism
(R-HSA-194068)
Metabolism
(R-HSA-1430728)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Retinoid metabolism and transport
(R-HSA-975634)
Sensory perception
(R-HSA-9709957)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-HSA-193368)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(R-HSA-193775)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-HSA-193807)
Visual phototransduction
(R-HSA-2187338)
5alpha-androstane-3beta,17beta-diol dehydrogenase activity
(GO:0047024)
Alditol:nadp+ 1-oxidoreductase activity
(GO:0004032)
Aldo-keto reductase (nadp) activity
(GO:0004033)
Androgen metabolic process
(GO:0008209)
Androstan-3-alpha,17-beta-diol dehydrogenase activity
(GO:0047044)
Androsterone dehydrogenase activity
(GO:0047023)
Bile acid and bile salt transport
(GO:0015721)
Bile acid binding
(GO:0032052)
Bile acid biosynthetic process
(GO:0006699)
Bile acid transmembrane transporter activity
(GO:0015125)
Cellular response to jasmonic acid stimulus
(GO:0071395)
Chlordecone reductase activity
(GO:0047743)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Daunorubicin metabolic process
(GO:0044597)
Dihydrotestosterone 17-beta-dehydrogenase activity
(GO:0035410)
Doxorubicin metabolic process
(GO:0044598)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Estradiol 17-beta-dehydrogenase [nad(p)] activity
(GO:0004303)
Extracellular exosome
(GO:0070062)
Ketosteroid monooxygenase activity
(GO:0047086)
Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
(GO:0016655)
Progesterone metabolic process
(GO:0042448)
Prostaglandin metabolic process
(GO:0006693)
Retinal dehydrogenase activity
(GO:0001758)
Retinoid metabolic process
(GO:0001523)
Steroid metabolic process
(GO:0008202)
Testosterone 17-beta-dehydrogenase (nadp+) activity
(GO:0047045)
Testosterone dehydrogenase (nad+) activity
(GO:0047035)

Other Information

Proteins

Aldo-keto reductase family 1 member C4

Genular Protein ID: 3201480692

Symbol: AK1C4_HUMAN

Name: Aldo-keto reductase family 1 member C4

UniProtKB Accession Codes:

P17516 Q5T6A3 Q8WW84 Q9NS54

Database IDs:

Citations:

PubMed ID: 8274401

Title: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PubMed ID: 8274401

DOI: 10.1016/0960-0760(93)90308-j

PubMed ID: 7650035

Title: Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

PubMed ID: 7650035

DOI: 10.1074/jbc.270.34.20162

PubMed ID: 7626489

Title: Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

PubMed ID: 7626489

DOI: 10.1016/0960-0760(95)00019-v

PubMed ID: 10634139

Title: Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver.

PubMed ID: 10634139

PubMed ID: 10672042

Title: Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

PubMed ID: 10672042

DOI: 10.1046/j.1365-2443.2000.00310.x

PubMed ID: 11158055

Title: Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.

PubMed ID: 11158055

DOI: 10.1210/jcem.86.2.7216

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2187532

Title: Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.

PubMed ID: 2187532

DOI: 10.1021/bi00456a034

PubMed ID: 8172617

Title: Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

PubMed ID: 8172617

DOI: 10.1042/bj2990545

PubMed ID: 1530633

Title: Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase.

PubMed ID: 1530633

DOI: 10.1016/0006-291x(92)91260-w

PubMed ID: 2427522

Title: Purification and characterization of chlordecone reductase from human liver.

PubMed ID: 2427522

DOI: 10.1016/s0021-9258(18)67136-4

PubMed ID: 10998348

Title: Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

PubMed ID: 10998348

DOI: 10.1042/0264-6021:3510067

PubMed ID: 14672942

Title: Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

PubMed ID: 14672942

DOI: 10.1074/jbc.m313308200

PubMed ID: 19218247

Title: Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

PubMed ID: 19218247

DOI: 10.1074/jbc.m809465200

PubMed ID: 21802064

Title: Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.

PubMed ID: 21802064

DOI: 10.1016/j.ajhg.2011.06.009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 323
Mass: 37067
Checksum: E728CE4B420E8C58
Sequence:

MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM 
ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP 
GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV 
LCALAKKHKQ TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN 
RNYRYVVMDF LMDHPDYPFS DEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AKR1C4

Associated with

Other Information

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. PubMed ID: 8274401

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases. PubMed ID: 7650035

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. PubMed ID: 7626489

Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver. PubMed ID: 10634139

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. PubMed ID: 10672042

Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. PubMed ID: 11158055

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. PubMed ID: 2187532

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. PubMed ID: 8172617

Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase. PubMed ID: 1530633

Purification and characterization of chlordecone reductase from human liver. PubMed ID: 2427522

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. PubMed ID: 10998348

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. PubMed ID: 14672942

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. PubMed ID: 19218247

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. PubMed ID: 21802064

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569