WDR5 | ENSG00000196363 | NCBI 11091

Details for: WDR5

Gene ID: 11091

Symbol: WDR5

Ensembl ID: ENSG00000196363

Description: WD repeat domain 5

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Cardiogenesis
(R-HSA-9733709)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Developmental biology
(R-HSA-1266738)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hats acetylate histones
(R-HSA-3214847)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Pkmts methylate histone lysines
(R-HSA-3214841)
Post-translational protein modification
(R-HSA-597592)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Transcriptional regulation by runx1
(R-HSA-8878171)
Atac complex
(GO:0140672)
Gluconeogenesis
(GO:0006094)
Histone acetyltransferase complex
(GO:0000123)
Histone binding
(GO:0042393)
Histone h3k4 methyltransferase activity
(GO:0042800)
Histone methyltransferase complex
(GO:0035097)
Methylated histone binding
(GO:0035064)
Mitotic spindle
(GO:0072686)
Mll1 complex
(GO:0071339)
Mll1/2 complex
(GO:0044665)
Mll3/4 complex
(GO:0044666)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nsl complex
(GO:0044545)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gluconeogenesis
(GO:0045722)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of cell division
(GO:0051302)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of embryonic development
(GO:0045995)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of tubulin deacetylation
(GO:0090043)
Set1c/compass complex
(GO:0048188)
Skeletal system development
(GO:0001501)
Transcription initiation-coupled chromatin remodeling
(GO:0045815)

Other Information

Proteins

WD repeat-containing protein 5

Genular Protein ID: 2310605733

Symbol: WDR5_HUMAN

Name: WD repeat-containing protein 5

UniProtKB Accession Codes:

P61964 Q91VA5 Q9NWX7 Q9UGP9

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 14992727

Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

PubMed ID: 14992727

DOI: 10.1016/s1097-2765(04)00081-4

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 16253997

Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.

PubMed ID: 16253997

DOI: 10.1074/jbc.m508312200

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 17021013

Title: Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

PubMed ID: 17021013

DOI: 10.1073/pnas.0607313103

PubMed ID: 17355966

Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.

PubMed ID: 17355966

DOI: 10.1074/jbc.m609809200

PubMed ID: 17500065

Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

PubMed ID: 17500065

DOI: 10.1074/jbc.m701574200

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18378692

Title: CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.

PubMed ID: 18378692

DOI: 10.1128/mcb.00322-08

PubMed ID: 18838538

Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

PubMed ID: 18838538

DOI: 10.1128/mcb.00976-08

PubMed ID: 19131338

Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

PubMed ID: 19131338

DOI: 10.1074/jbc.m805872200

PubMed ID: 19556245

Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

PubMed ID: 19556245

DOI: 10.1074/jbc.m109.014498

PubMed ID: 19103755

Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

PubMed ID: 19103755

DOI: 10.1128/mcb.01599-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20018852

Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.

PubMed ID: 20018852

DOI: 10.1074/jbc.c109.087981

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23178126

Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

PubMed ID: 23178126

DOI: 10.1016/j.cell.2012.10.043

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34850113

Title: MLL1 is regulated by KSHV LANA and is important for virus latency.

PubMed ID: 34850113

DOI: 10.1093/nar/gkab1094

PubMed ID: 16946699

Title: Structural basis for molecular recognition and presentation of histone H3 by WDR5.

PubMed ID: 16946699

DOI: 10.1038/sj.emboj.7601316

PubMed ID: 16600877

Title: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.

PubMed ID: 16600877

DOI: 10.1016/j.molcel.2006.03.018

PubMed ID: 16829960

Title: Molecular recognition of histone H3 by the WD40 protein WDR5.

PubMed ID: 16829960

DOI: 10.1038/nsmb1116

PubMed ID: 16829959

Title: Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.

PubMed ID: 16829959

DOI: 10.1038/nsmb1119

PubMed ID: 18829459

Title: Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.

PubMed ID: 18829459

DOI: 10.1074/jbc.c800164200

PubMed ID: 18840606

Title: WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

PubMed ID: 18840606

DOI: 10.1074/jbc.m806900200

PubMed ID: 21220120

Title: Structural and biochemical insights into MLL1 core complex assembly.

PubMed ID: 21220120

DOI: 10.1016/j.str.2010.09.022

PubMed ID: 22665483

Title: Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

PubMed ID: 22665483

DOI: 10.1074/jbc.m112.364125

PubMed ID: 22266653

Title: The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

PubMed ID: 22266653

DOI: 10.1093/nar/gkr1235

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

Length: 334
Mass: 36588
Checksum: 4BF30914A2250286
Sequence:

MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 
CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN 
RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL 
WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH 
TDVVISTACH PTENIIASAA LENDKTIKLW KSDC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: WDR5

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. PubMed ID: 14992727

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. PubMed ID: 15199122

CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. PubMed ID: 16253997

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. PubMed ID: 15960975

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. PubMed ID: 17021013

Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. PubMed ID: 17355966

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. PubMed ID: 17500065

Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. PubMed ID: 17998332

CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. PubMed ID: 18378692

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. PubMed ID: 18838538

Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. PubMed ID: 19131338

On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. PubMed ID: 19556245

The double-histone-acetyltransferase complex ATAC is essential for mammalian development. PubMed ID: 19103755

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. PubMed ID: 20018852

Initial characterization of the human central proteome. PubMed ID: 21269460

Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. PubMed ID: 23178126

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

MLL1 is regulated by KSHV LANA and is important for virus latency. PubMed ID: 34850113

Structural basis for molecular recognition and presentation of histone H3 by WDR5. PubMed ID: 16946699

Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. PubMed ID: 16600877

Molecular recognition of histone H3 by the WD40 protein WDR5. PubMed ID: 16829960

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. PubMed ID: 16829959

Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. PubMed ID: 18829459

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. PubMed ID: 18840606

Structural and biochemical insights into MLL1 core complex assembly. PubMed ID: 21220120

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. PubMed ID: 22665483

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. PubMed ID: 22266653

A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. PubMed ID: 29463886