ADAMTS5 | ENSG00000154736 | NCBI 11096

Details for: ADAMTS5

Gene ID: 11096

Symbol: ADAMTS5

Ensembl ID: ENSG00000154736

Description: ADAM metallopeptidase with thrombospondin type 1 motif 5

Associated with

Defective b3galtl causes pps
(R-HSA-5083635)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Diseases associated with o-glycosylation of proteins
(R-HSA-3906995)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Metabolism of proteins
(R-HSA-392499)
O-glycosylation of tsr domain-containing proteins
(R-HSA-5173214)
O-linked glycosylation
(R-HSA-5173105)
Post-translational protein modification
(R-HSA-597592)
Aortic valve morphogenesis
(GO:0003180)
Collagen-containing extracellular matrix
(GO:0062023)
Defense response to bacterium
(GO:0042742)
Endocardial cushion morphogenesis
(GO:0003203)
Endopeptidase activity
(GO:0004175)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular matrix
(GO:0031012)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix disassembly
(GO:0022617)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Metalloendopeptidase activity
(GO:0004222)
Metallopeptidase activity
(GO:0008237)
Myoblast fusion
(GO:0007520)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Peptidase activity
(GO:0008233)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Pulmonary valve morphogenesis
(GO:0003184)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

A disintegrin and metalloproteinase with thrombospondin motifs 5

Genular Protein ID: 1729671594

Symbol: ATS5_HUMAN

Name: A disintegrin and metalloproteinase with thrombospondin motifs 5

UniProtKB Accession Codes:

Q9UNA0 Q52LV4 Q9UKP2

Database IDs:

Citations:

PubMed ID: 10438522

Title: Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

PubMed ID: 10438522

DOI: 10.1074/jbc.274.33.23443

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10464288

Title: ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.

PubMed ID: 10464288

DOI: 10.1074/jbc.274.36.25555

PubMed ID: 16133547

Title: Human glioblastomas overexpress ADAMTS-5 that degrades brevican.

PubMed ID: 16133547

DOI: 10.1007/s00401-005-1032-6

PubMed ID: 18992360

Title: Characterization of proADAMTS5 processing by proprotein convertases.

PubMed ID: 18992360

DOI: 10.1016/j.biocel.2008.10.008

PubMed ID: 19671700

Title: Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.

PubMed ID: 19671700

DOI: 10.1074/jbc.m109.038059

PubMed ID: 18042673

Title: Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.

PubMed ID: 18042673

DOI: 10.1110/ps.073287008

Sequence Information:

Length: 930
Mass: 101718
Checksum: 8CCE448A15A29CE8
Sequence:

MLLGWASLLL CAFRLPLAAV GPAATPAQDK AGQPPTAAAA AQPRRRQGEE VQERAEPPGH 
PHPLAQRRRS KGLVQNIDQL YSGGGKVGYL VYAGGRRFLL DLERDGSVGI AGFVPAGGGT 
SAPWRHRSHC FYRGTVDGSP RSLAVFDLCG GLDGFFAVKH ARYTLKPLLR GPWAEEEKGR 
VYGDGSARIL HVYTREGFSF EALPPRASCE TPASTPEAHE HAPAHSNPSG RAALASQLLD 
QSALSPAGGS GPQTWWRRRR RSISRARQVE LLLVADASMA RLYGRGLQHY LLTLASIANR 
LYSHASIENH IRLAVVKVVV LGDKDKSLEV SKNAATTLKN FCKWQHQHNQ LGDDHEEHYD 
AAILFTREDL CGHHSCDTLG MADVGTICSP ERSCAVIEDD GLHAAFTVAH EIGHLLGLSH 
DDSKFCEETF GSTEDKRLMS SILTSIDASK PWSKCTSATI TEFLDDGHGN CLLDLPRKQI 
LGPEELPGQT YDATQQCNLT FGPEYSVCPG MDVCARLWCA VVRQGQMVCL TKKLPAVEGT 
PCGKGRICLQ GKCVDKTKKK YYSTSSHGNW GSWGSWGQCS RSCGGGVQFA YRHCNNPAPR 
NNGRYCTGKR AIYRSCSLMP CPPNGKSFRH EQCEAKNGYQ SDAKGVKTFV EWVPKYAGVL 
PADVCKLTCR AKGTGYYVVF SPKVTDGTEC RLYSNSVCVR GKCVRTGCDG IIGSKLQYDK 
CGVCGGDNSS CTKIVGTFNK KSKGYTDVVR IPEGATHIKV RQFKAKDQTR FTAYLALKKK 
NGEYLINGKY MISTSETIID INGTVMNYSG WSHRDDFLHG MGYSATKEIL IVQILATDPT 
KPLDVRYSFF VPKKSTPKVN SVTSHGSNKV GSHTSQPQWV TGPWLACSRT CDTGWHTRTV 
QCQDGNRKLA KGCPLSQRPS AFKQCLLKKC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADAMTS5

Associated with

Other Information

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. PubMed ID: 10438522

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. PubMed ID: 10464288

Human glioblastomas overexpress ADAMTS-5 that degrades brevican. PubMed ID: 16133547

Characterization of proADAMTS5 processing by proprotein convertases. PubMed ID: 18992360

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. PubMed ID: 19671700

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. PubMed ID: 18042673