Details for: ADCY5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: microcirculation associated smooth muscle cell (CL0008035)
CSI Score: 7.2 - Cell Name: muscle cell (CL0000187)
CSI Score: 7.1 - Cell Name: myoepithelial cell (CL0000185)
CSI Score: 6.9 - Cell Name: pancreatic ductal cell (CL0002079)
CSI Score: 6.5 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
CSI Score: 6.2 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
CSI Score: 5.4 - Cell Name: smooth muscle cell (CL0000192)
CSI Score: 5.4 - Cell Name: oligodendrocyte (CL0000128)
CSI Score: 5.2 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
CSI Score: 4.8 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
CSI Score: 4.6 - Cell Name: fibroblast (CL0000057)
CSI Score: 4.4 - Cell Name: inhibitory interneuron (CL0000498)
CSI Score: 4.3 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
CSI Score: 4.1 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
CSI Score: 3.9 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
CSI Score: 3.9 - Cell Name: renal interstitial pericyte (CL1001318)
CSI Score: 3.7 - Cell Name: glutamatergic neuron (CL0000679)
CSI Score: 3.6 - Cell Name: GABAergic neuron (CL0000617)
CSI Score: 3.4 - Cell Name: oligodendrocyte precursor cell (CL0002453)
CSI Score: 3.3 - Cell Name: radial glial cell (CL0000681)
CSI Score: 3.3 - Cell Name: retinal bipolar neuron (CL0000748)
CSI Score: 3.2 - Cell Name: cardiac muscle cell (CL0000746)
CSI Score: 3.2 - Cell Name: mesenchymal stem cell (CL0000134)
CSI Score: 3.1 - Cell Name: retinal ganglion cell (CL0000740)
CSI Score: 3.0 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
CSI Score: 3.0 - Cell Name: mesenchymal cell (CL0008019)
CSI Score: 3.0 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
CSI Score: 2.9 - Cell Name: amacrine cell (CL0000561)
CSI Score: 2.8 - Cell Name: neuron (CL0000540)
CSI Score: 2.8 - Cell Name: myofibroblast cell (CL0000186)
CSI Score: 2.8 - Cell Name: astrocyte (CL0000127)
CSI Score: 2.5 - Cell Name: regular atrial cardiac myocyte (CL0002129)
CSI Score: 2.5 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
CSI Score: 2.5 - Cell Name: pericyte (CL0000669)
CSI Score: 2.3 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
CSI Score: 2.1 - Cell Name: cardiac endothelial cell (CL0010008)
CSI Score: 2.0 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
CSI Score: 1.9 - Cell Name: rod bipolar cell (CL0000751)
CSI Score: 1.8 - Cell Name: enteric smooth muscle cell (CL0002504)
CSI Score: 1.8 - Cell Name: OFF-bipolar cell (CL0000750)
CSI Score: 1.7 - Cell Name: glioblast (CL0000030)
CSI Score: 1.5 - Cell Name: epithelial cell of proximal tubule (CL0002306)
CSI Score: 1.5 - Cell Name: stromal cell (CL0000499)
CSI Score: 1.4 - Cell Name: epithelial cell (CL0000066)
CSI Score: 1.4 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
CSI Score: 1.4 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
CSI Score: 1.3 - Cell Name: contractile cell (CL0000183)
CSI Score: 1.3 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
CSI Score: 1.3 - Cell Name: ON-bipolar cell (CL0000749)
CSI Score: 1.2 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
CSI Score: 1.1 - Cell Name: hepatic stellate cell (CL0000632)
CSI Score: 1.0 - Cell Name: neural progenitor cell (CL0011020)
CSI Score: 0.9 - Cell Name: myeloid cell (CL0000763)
CSI Score: 0.9 - Cell Name: basal cell (CL0000646)
CSI Score: 0.9 - Cell Name: peripheral nervous system neuron (CL2000032)
CSI Score: 0.7 - Cell Name: malignant cell (CL0001064)
CSI Score: 0.7 - Cell Name: ionocyte (CL0005006)
CSI Score: 0.7 - Cell Name: innate lymphoid cell (CL0001065)
CSI Score: 0.6 - Cell Name: mural cell (CL0008034)
CSI Score: 0.6 - Cell Name: mesodermal cell (CL0000222)
CSI Score: 0.5 - Cell Name: interneuron (CL0000099)
CSI Score: 0.5 - Cell Name: squamous epithelial cell (CL0000076)
CSI Score: 0.5 - Cell Name: melanocyte (CL0000148)
CSI Score: 0.5 - Cell Name: fibroblast of cardiac tissue (CL0002548)
CSI Score: 0.4 - Cell Name: enterocyte (CL0000584)
CSI Score: 0.4 - Cell Name: intestinal epithelial cell (CL0002563)
CSI Score: 0.4 - Cell Name: pulmonary ionocyte (CL0017000)
CSI Score: 0.4 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
CSI Score: 0.3 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
CSI Score: 0.3 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
CSI Score: 0.2 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
CSI Score: 0.1 - Cell Name: endothelial cell of vascular tree (CL0002139)
CSI Score: 0.1 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
CSI Score: 0.0 - Cell Name: endothelial cell (CL0000115)
CSI Score: 0.0 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
CSI Score: 0.0 - Cell Name: renal alpha-intercalated cell (CL0005011)
CSI Score: -0.1 - Cell Name: cytotoxic T cell (CL0000910)
CSI Score: -0.3 - Cell Name: retinal rod cell (CL0000604)
CSI Score: -0.3 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
CSI Score: -0.4 - Cell Name: myeloid leukocyte (CL0000766)
CSI Score: -0.4 - Cell Name: parietal epithelial cell (CL1000452)
CSI Score: -0.5 - Cell Name: capillary endothelial cell (CL0002144)
CSI Score: -0.6 - Cell Name: cell of skeletal muscle (CL0000188)
CSI Score: -0.6 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
CSI Score: -0.7 - Cell Name: adipocyte (CL0000136)
CSI Score: -0.7 - Cell Name: medium spiny neuron (CL1001474)
CSI Score: -0.8 - Cell Name: vascular associated smooth muscle cell (CL0000359)
CSI Score: -0.8 - Cell Name: vascular leptomeningeal cell (CL4023051)
CSI Score: -0.9 - Cell Name: Mueller cell (CL0000636)
CSI Score: -1.0 - Cell Name: glial cell (CL0000125)
CSI Score: -1.2 - Cell Name: fibroblast of lung (CL0002553)
CSI Score: -1.4 - Cell Name: neural cell (CL0002319)
CSI Score: -1.4 - Cell Name: brain vascular cell (CL4023072)
CSI Score: -1.6 - Cell Name: chondrocyte (CL0000138)
CSI Score: -1.6 - Cell Name: exhausted T cell (CL0011025)
CSI Score: -1.7 - Cell Name: stem cell (CL0000034)
CSI Score: -1.7 - Cell Name: secretory cell (CL0000151)
CSI Score: -1.8 - Cell Name: epicardial adipocyte (CL1000309)
CSI Score: -1.8 - Cell Name: lung pericyte (CL0009089)
CSI Score: -1.9 - Cell Name: mature NK T cell (CL0000814)
CSI Score: -1.9
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 69629043
Symbol: ADCY5_HUMAN
Name: Adenylate cyclase type 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 12503609
Title: Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
PubMed ID: 12503609
PubMed ID: 10481931
Title: Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.
PubMed ID: 10481931
PubMed ID: 15385642
Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
PubMed ID: 15385642
DOI: 10.1124/mol.66.4.921
PubMed ID: 24740569
Title: ADCY5 couples glucose to insulin secretion in human islets.
PubMed ID: 24740569
DOI: 10.2337/db13-1607
PubMed ID: 26206488
Title: Adenylyl cyclase 5 regulation by Gbetagamma involves isoform specific use of multiple interaction sites.
PubMed ID: 26206488
PubMed ID: 22782511
Title: Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
PubMed ID: 22782511
PubMed ID: 24700542
Title: Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
PubMed ID: 24700542
DOI: 10.1002/ana.24119
PubMed ID: 26085604
Title: ADCY5 mutations are another cause of benign hereditary chorea.
PubMed ID: 26085604
PubMed ID: 28971144
Title: Autosomal recessive inheritance of ADCY5-related generalized dystonia and myoclonus.
PubMed ID: 28971144
PubMed ID: 30975617
Title: Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders.
PubMed ID: 30975617
PubMed ID: 33704598
Title: Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.
PubMed ID: 33704598
PubMed ID: 34631954
Title: A Novel Homozygous ADCY5 Variant is Associated with a Neurodevelopmental Disorder and Movement Abnormalities.
PubMed ID: 34631954
DOI: 10.1002/mdc3.13310
Sequence Information:
- Length: 1261
- Mass: 138908
- Checksum: C50492A0B053694F
- Sequence:
MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK SAWQERGGDD CGRGSRRQRR GAASGGSTRA PPAGGGGGSA AAAASAGGTE VRPRSVEVGL EERRGKGRAA DELEAGAVEG GEGSGDGGSS ADSGSGAGPG AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS SLTMLMAVLV LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA VLSGVLLSAL HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA EVSQRQAFQE TRECIQARLH SQRENQQQER LLLSVLPRHV AMEMKADINA KQEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GMDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK EEKAMIAKMN RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED PKDKNAQESA NPEDEVDEFL GRAIDARSID RLRSEHVRKF LLTFREPDLE KKYSKQVDDR FGAYVACASL VFLFICFVQI TIVPHSIFML SFYLTCSLLL TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF TITLVFLAAF VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP GVTLFDNADL LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA LYLHAQQVES TARLDFLWKL QATEEKEEME ELQAYNRRLL HNILPKDVAA HFLARERRND ELYYQSCECV AVMFASIANF SEFYVELEAN NEGVECLRLL NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY DKVGKTHIKA LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM TYFLNGGPPL S
Genular Protein ID: 346821613
Symbol: B3KWA8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
Sequence Information:
- Length: 919
- Mass: 103868
- Checksum: DC89BB6B6C4D9F6E
- Sequence:
MAPSRFRTQL ELVSNVLIFS CTNIVGVCTH YPAEVSQRQA FQETRECIQA RLHSQRENQQ QERLLLSVLP RHVAMEMKAD INAKQEDMMF HKIYIQKHDN VSILFADIEG FTSLASQCTA QELVMTLNEL FARFDKLAAE NHCLRIKILG DCYYCVSGLP EARADHAHCC VEMGMDMIEA ISLVREVTGV NVNMRVGIHS GRVHCGVLGL RKWQFDVWSN DVTLANHMEA GGKAGRIHIT KATLNYLNGD YEVEPGCGGE RNAYLKEHSI ETFLILRCTQ KRKEEKAMIA KMNRQRTNSI GHNPPHWGAE RPFYNHLGGN QVSKEMKRMG FEDPKDKNAQ ESANPEDEVD EFLGRAIDAR SIDRLRSEHV RKFLLTFREP DLEKKYSKQV DDRFGAYVAC ASLVFLFICF VQITIVPHSI FMLSFYLTCS LLLTLVVFVS VIYSCVKLFP SPLQTLSRKI VRSKMNSTLV GVFTITLVFL AAFVNMFTCN SRDLLGCLAQ EHNISASQVN ACHVAESAVN YSLGDEQGFC GSPWPNCNFP EYFTYSVLLS LLACSVFLQI SCIGKLVLML AIELIYVLIV EVPGVTLFDN ADLLVTANAI DFFNNGTSQW SLCENLRHRR MEAGTYFPSG VKEQSPEHAT KVALKVVTPI IISVFVLALY LHAQQVESTA RLDFLWKLQA TEEKEEMEEL QAYNRRLLHN ILPKDVAAHF LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS EDRFRQLEKI KTIGSTYMAA SGLNDSTYDK VGKTHIKALA DFAMKLMDQM KYINEHSFNN FQMKIGLNIG PVVAGVIGAR KPQYDIWGNT VNVASRMDST GVPDRIQVTT DMYQVLAANT YQLECRGVVK VKGKGEMMTY FLNGGPPLS
Genular Protein ID: 2074900770
Symbol: B7Z2C7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 978
- Mass: 110064
- Checksum: 1FF7FB611BD419A8
- Sequence:
MAVLCNRAAF HQDHMGLACY ALIAVVLAVQ VVGLLLPQPR SASEGIWWTV FFIYTIYTLL PVRMRAAVLS GVLLSALHLA IALRTNAQDQ FLLKQLVSNV LIFSCTNIVG VCTHYPAEVS QRQAFQETRE CIQARLHSQR ENQQQERLLL SVLPRHVAME MKADINAKQE DMMFHKIYIQ KHDNVSILFA DIEGFTSLAS QCTAQELVMT LNELFARFDK LAAENHCLRI KILGDCYYCV SGLPEARADH AHCCVEMGMD MIEAISLVRE VTGVNVNMRV GIHSGRVHCG VLGLRKWQFD VWSNDVTLAN HMEAGGKAGR IHITKATLNY LNGDYEVEPG CGGERNAYLK EHSIETFLIL RCTQKRKEEK AMIAKMNRQR TNSIGHNPPH WGAERPFYNH LGGNQVSKEM KRMGFEDPKD KNAQESANPE DEVDEFLGRA IDARSIDRLR SEHVRKFLLT FREPDLEKKY SKQVDDRFGA YVACASLVFL FICFVQITIV PHSIFMLSFY LTCSLLLTLV VFVSVIYSCV KLFPSPLQTL SRKIVRSKMN STLVGVFTIT LVFLAAFVNM FTCNSRDLLG CLAQEHNISA SQVNACHVAE SAVNYSLGDE QGFCGSPWPN CNFPEYFTYS VLLSLLACSV FLQISCIGKL VLMLAIELIY VLIVEVPGVT LFDNADLLVT ANAIDFFNNG TSQCPEHATK VALKVVTPII ISVFVLALYL HAQQVESTAR LDFLWKLQAT EEKEEMEELQ AYNRRLLHNI LPKDVAAHFL ARERRNDELY YQSCECVAVM FASIANFSEF YVELEANNEG VECLRLLNEI IADFDEIISE DRFRQLEKIK TIGSTYMAAS GLNDSTYDKV GKTHIKALAD FAMKLMDQMK YINEHSFNNF QMKIGLNIGP VVAGVIGARK PQYDIWGNTV NVASRMDSTG VPDRIQVTTD MYQVLAANTY QLECRGVVKV KGKGEMMTYF LNGGPPLS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.