ADCY5 | ENSG00000173175 | NCBI 111

Details for: ADCY5

Gene ID: 111

Symbol: ADCY5

Ensembl ID: ENSG00000173175

Description: adenylate cyclase 5

Associated with

Activation of gabab receptors
(R-HSA-991365)
Adenylate cyclase activating pathway
(R-HSA-170660)
Adenylate cyclase inhibitory pathway
(R-HSA-170670)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating dopamine receptor signaling pathway
(GO:0007191)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway
(GO:0007195)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adenylate cyclase activity
(GO:0004016)
Adenylate cyclase binding
(GO:0008179)
Atp binding
(GO:0005524)
Camp biosynthetic process
(GO:0006171)
Cellular response to forskolin
(GO:1904322)
Cilium
(GO:0005929)
G protein-coupled adenosine receptor signaling pathway
(GO:0001973)
Intracellular signal transduction
(GO:0035556)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Neuromuscular process controlling balance
(GO:0050885)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Scaffold protein binding
(GO:0097110)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 63.2251
Cell Significance Index: -29.8500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.6953
Cell Significance Index: -31.3300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.6595
Cell Significance Index: -14.5800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 6.0180
Cell Significance Index: 266.1900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 5.4730
Cell Significance Index: 207.2500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.5117
Cell Significance Index: 269.4800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 3.1783
Cell Significance Index: 194.8600
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.3485
Cell Significance Index: 38.7000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5265
Cell Significance Index: 306.2200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0286
Cell Significance Index: 368.9600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9645
Cell Significance Index: 183.5600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8137
Cell Significance Index: 562.8100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7944
Cell Significance Index: 48.8300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5775
Cell Significance Index: 57.1300
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.5617
Cell Significance Index: 12.3000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5462
Cell Significance Index: 11.6800
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.5383
Cell Significance Index: 12.9100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5276
Cell Significance Index: 476.3900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5039
Cell Significance Index: 7.4400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4870
Cell Significance Index: 10.5500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3891
Cell Significance Index: 5.8300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3720
Cell Significance Index: 168.8500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2980
Cell Significance Index: 15.4800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.2948
Cell Significance Index: 7.1400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2893
Cell Significance Index: 47.0500
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.1953
Cell Significance Index: 0.8500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1459
Cell Significance Index: 7.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1424
Cell Significance Index: 15.4900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0691
Cell Significance Index: 12.4700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0525
Cell Significance Index: 10.4300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0514
Cell Significance Index: 2.3300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0435
Cell Significance Index: 27.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0408
Cell Significance Index: 25.9400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0108
Cell Significance Index: 5.9000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0085
Cell Significance Index: 0.3000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0023
Cell Significance Index: -4.4200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0045
Cell Significance Index: -0.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0108
Cell Significance Index: -16.6800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0124
Cell Significance Index: -9.1600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0139
Cell Significance Index: -25.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0144
Cell Significance Index: -1.0000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0154
Cell Significance Index: -20.9300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0194
Cell Significance Index: -0.5600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0250
Cell Significance Index: -18.3000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0264
Cell Significance Index: -2.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0279
Cell Significance Index: -15.7200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0303
Cell Significance Index: -4.1600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0312
Cell Significance Index: -0.7800
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.0349
Cell Significance Index: -0.4400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0441
Cell Significance Index: -33.3700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0553
Cell Significance Index: -6.8000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0602
Cell Significance Index: -4.0500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0619
Cell Significance Index: -10.5700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0767
Cell Significance Index: -16.1600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0784
Cell Significance Index: -11.3900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0867
Cell Significance Index: -24.9600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0984
Cell Significance Index: -12.6200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1189
Cell Significance Index: -1.4800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1505
Cell Significance Index: -2.1600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1996
Cell Significance Index: -20.3900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2004
Cell Significance Index: -5.7200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2021
Cell Significance Index: -4.2900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2386
Cell Significance Index: -30.8200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2406
Cell Significance Index: -4.8300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2470
Cell Significance Index: -28.7900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2567
Cell Significance Index: -29.3000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.2632
Cell Significance Index: -3.7400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2702
Cell Significance Index: -8.8500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3385
Cell Significance Index: -7.2100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3482
Cell Significance Index: -11.0900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3742
Cell Significance Index: -7.4000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3789
Cell Significance Index: -21.2600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3792
Cell Significance Index: -30.0300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4122
Cell Significance Index: -30.7200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4301
Cell Significance Index: -12.0200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4382
Cell Significance Index: -9.0900
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4718
Cell Significance Index: -6.0500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4814
Cell Significance Index: -10.4000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5117
Cell Significance Index: -17.9300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5276
Cell Significance Index: -27.4800
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.5448
Cell Significance Index: -23.6900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5633
Cell Significance Index: -35.5000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6138
Cell Significance Index: -28.8500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6176
Cell Significance Index: -16.4900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6381
Cell Significance Index: -29.7500
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.6846
Cell Significance Index: -7.3400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.6986
Cell Significance Index: -14.5800
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.7063
Cell Significance Index: -9.1600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7135
Cell Significance Index: -18.3400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7581
Cell Significance Index: -24.2800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7728
Cell Significance Index: -28.3700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.7819
Cell Significance Index: -10.4300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7859
Cell Significance Index: -9.8000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.8055
Cell Significance Index: -13.4800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.8198
Cell Significance Index: -20.4500
Cell Name: neural cell (CL0002319)
Fold Change: -0.8225
Cell Significance Index: -9.6000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8794
Cell Significance Index: -30.5600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8794
Cell Significance Index: -15.0700
Cell Name: neuron (CL0000540)
Fold Change: -0.8935
Cell Significance Index: -8.4700
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.9069
Cell Significance Index: -9.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Expression Pattern**: ADCY5 is highly expressed in cardiac myocytes, ciliary muscle cells, and various neuronal populations, including GABAergic cortical interneurons. 2. **Function**: ADCY5 catalyzes the conversion of ATP to cAMP, a secondary messenger molecule that mediates signal transduction events. 3. **Signaling Pathways**: ADCY5 is involved in multiple signaling pathways, including those regulating metabolism, insulin secretion, neurotransmission, and immune responses. 4. **Regulation**: ADCY5 activity is modulated by various factors, including G-protein coupled receptors, calcium-dependent events, and protein kinase A (PKA)-mediated phosphorylation. **Pathways and Functions** 1. **Adenylate Cyclase-Activating Signaling Pathways**: ADCY5 is involved in the activation of G-protein coupled receptors, including dopamine and GABA receptors, which leads to the stimulation of adenylate cyclase activity and the production of cAMP. 2. **Insulin Secretion Regulation**: ADCY5 plays a crucial role in regulating insulin secretion in response to glucose stimuli, with cAMP serving as a key second messenger molecule. 3. **Neurotransmission and Neuroprotection**: ADCY5 is involved in the regulation of neurotransmission, including the modulation of GABAergic neurotransmission, and has been implicated in neuroprotection against various neurodegenerative diseases. 4. **Immune Response**: ADCY5 is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the modulation of G-protein coupled receptors involved in immune signaling. 5. **Metabolic Regulation**: ADCY5 plays a role in regulating metabolism, including the modulation of glucagon signaling and the regulation of energy metabolism. **Clinical Significance** 1. **Cardiac Function**: Abnormalities in ADCY5 expression or function have been implicated in various cardiac disorders, including arrhythmias and cardiac failure. 2. **Neurological Disorders**: ADCY5 has been implicated in the pathogenesis of various neurological disorders, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. 3. **Immune System Disorders**: ADCY5 has been implicated in the regulation of immune responses, with abnormalities in ADCY5 expression or function potentially contributing to autoimmune disorders. 4. **Metabolic Disorders**: ADCY5 has been implicated in the regulation of metabolism, with abnormalities in ADCY5 expression or function potentially contributing to metabolic disorders, including insulin resistance and type 2 diabetes. In conclusion, ADCY5 is a critical enzyme involved in various cellular signaling pathways, playing a significant role in regulating multiple physiological processes. Further research is needed to fully elucidate the functions and clinical significance of ADCY5, but its importance in maintaining cellular homeostasis is evident.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 69629043

Symbol: ADCY5_HUMAN

Name: Adenylate cyclase type 5

UniProtKB Accession Codes:

O95622 B7Z8A6 Q7RTV7 Q8NFM3

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 12503609

Title: Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.

PubMed ID: 12503609

DOI: 10.1081/rrs-120014589

PubMed ID: 10481931

Title: Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.

PubMed ID: 10481931

DOI: 10.1016/s0009-8981(99)00067-4

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 24740569

Title: ADCY5 couples glucose to insulin secretion in human islets.

PubMed ID: 24740569

DOI: 10.2337/db13-1607

PubMed ID: 26206488

Title: Adenylyl cyclase 5 regulation by Gbetagamma involves isoform specific use of multiple interaction sites.

PubMed ID: 26206488

DOI: 10.1124/mol.115.099556

PubMed ID: 22782511

Title: Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.

PubMed ID: 22782511

DOI: 10.1001/archneurol.2012.54

PubMed ID: 24700542

Title: Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.

PubMed ID: 24700542

DOI: 10.1002/ana.24119

PubMed ID: 26085604

Title: ADCY5 mutations are another cause of benign hereditary chorea.

PubMed ID: 26085604

DOI: 10.1212/wnl.0000000000001720

PubMed ID: 28971144

Title: Autosomal recessive inheritance of ADCY5-related generalized dystonia and myoclonus.

PubMed ID: 28971144

DOI: 10.1212/nxg.0000000000000193

PubMed ID: 30975617

Title: Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders.

PubMed ID: 30975617

DOI: 10.1016/j.parkreldis.2019.02.039

PubMed ID: 33704598

Title: Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.

PubMed ID: 33704598

DOI: 10.1007/s10072-021-05152-y

PubMed ID: 34631954

Title: A Novel Homozygous ADCY5 Variant is Associated with a Neurodevelopmental Disorder and Movement Abnormalities.

PubMed ID: 34631954

DOI: 10.1002/mdc3.13310

Sequence Information:

Length: 1261
Mass: 138908
Checksum: C50492A0B053694F
Sequence:

MSGSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA RGSTKKPGGA 
VTPQQQQRLA SRWRSDDDDD PPLSGDDPLA GGFGFSFRSK SAWQERGGDD CGRGSRRQRR 
GAASGGSTRA PPAGGGGGSA AAAASAGGTE VRPRSVEVGL EERRGKGRAA DELEAGAVEG 
GEGSGDGGSS ADSGSGAGPG AVLSLGACCL ALLQIFRSKK FPSDKLERLY QRYFFRLNQS 
SLTMLMAVLV LVCLVMLAFH AARPPLQLPY LAVLAAAVGV ILIMAVLCNR AAFHQDHMGL 
ACYALIAVVL AVQVVGLLLP QPRSASEGIW WTVFFIYTIY TLLPVRMRAA VLSGVLLSAL 
HLAIALRTNA QDQFLLKQLV SNVLIFSCTN IVGVCTHYPA EVSQRQAFQE TRECIQARLH 
SQRENQQQER LLLSVLPRHV AMEMKADINA KQEDMMFHKI YIQKHDNVSI LFADIEGFTS 
LASQCTAQEL VMTLNELFAR FDKLAAENHC LRIKILGDCY YCVSGLPEAR ADHAHCCVEM 
GMDMIEAISL VREVTGVNVN MRVGIHSGRV HCGVLGLRKW QFDVWSNDVT LANHMEAGGK 
AGRIHITKAT LNYLNGDYEV EPGCGGERNA YLKEHSIETF LILRCTQKRK EEKAMIAKMN 
RQRTNSIGHN PPHWGAERPF YNHLGGNQVS KEMKRMGFED PKDKNAQESA NPEDEVDEFL 
GRAIDARSID RLRSEHVRKF LLTFREPDLE KKYSKQVDDR FGAYVACASL VFLFICFVQI 
TIVPHSIFML SFYLTCSLLL TLVVFVSVIY SCVKLFPSPL QTLSRKIVRS KMNSTLVGVF 
TITLVFLAAF VNMFTCNSRD LLGCLAQEHN ISASQVNACH VAESAVNYSL GDEQGFCGSP 
WPNCNFPEYF TYSVLLSLLA CSVFLQISCI GKLVLMLAIE LIYVLIVEVP GVTLFDNADL 
LVTANAIDFF NNGTSQCPEH ATKVALKVVT PIIISVFVLA LYLHAQQVES TARLDFLWKL 
QATEEKEEME ELQAYNRRLL HNILPKDVAA HFLARERRND ELYYQSCECV AVMFASIANF 
SEFYVELEAN NEGVECLRLL NEIIADFDEI ISEDRFRQLE KIKTIGSTYM AASGLNDSTY 
DKVGKTHIKA LADFAMKLMD QMKYINEHSF NNFQMKIGLN IGPVVAGVIG ARKPQYDIWG 
NTVNVASRMD STGVPDRIQV TTDMYQVLAA NTYQLECRGV VKVKGKGEMM TYFLNGGPPL 
S

Genular Protein ID: 346821613

Symbol: B3KWA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWA8

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

Length: 919
Mass: 103868
Checksum: DC89BB6B6C4D9F6E
Sequence:

MAPSRFRTQL ELVSNVLIFS CTNIVGVCTH YPAEVSQRQA FQETRECIQA RLHSQRENQQ 
QERLLLSVLP RHVAMEMKAD INAKQEDMMF HKIYIQKHDN VSILFADIEG FTSLASQCTA 
QELVMTLNEL FARFDKLAAE NHCLRIKILG DCYYCVSGLP EARADHAHCC VEMGMDMIEA 
ISLVREVTGV NVNMRVGIHS GRVHCGVLGL RKWQFDVWSN DVTLANHMEA GGKAGRIHIT 
KATLNYLNGD YEVEPGCGGE RNAYLKEHSI ETFLILRCTQ KRKEEKAMIA KMNRQRTNSI 
GHNPPHWGAE RPFYNHLGGN QVSKEMKRMG FEDPKDKNAQ ESANPEDEVD EFLGRAIDAR 
SIDRLRSEHV RKFLLTFREP DLEKKYSKQV DDRFGAYVAC ASLVFLFICF VQITIVPHSI 
FMLSFYLTCS LLLTLVVFVS VIYSCVKLFP SPLQTLSRKI VRSKMNSTLV GVFTITLVFL 
AAFVNMFTCN SRDLLGCLAQ EHNISASQVN ACHVAESAVN YSLGDEQGFC GSPWPNCNFP 
EYFTYSVLLS LLACSVFLQI SCIGKLVLML AIELIYVLIV EVPGVTLFDN ADLLVTANAI 
DFFNNGTSQW SLCENLRHRR MEAGTYFPSG VKEQSPEHAT KVALKVVTPI IISVFVLALY 
LHAQQVESTA RLDFLWKLQA TEEKEEMEEL QAYNRRLLHN ILPKDVAAHF LARERRNDEL 
YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS EDRFRQLEKI 
KTIGSTYMAA SGLNDSTYDK VGKTHIKALA DFAMKLMDQM KYINEHSFNN FQMKIGLNIG 
PVVAGVIGAR KPQYDIWGNT VNVASRMDST GVPDRIQVTT DMYQVLAANT YQLECRGVVK 
VKGKGEMMTY FLNGGPPLS

Genular Protein ID: 2074900770

Symbol: B7Z2C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2C7

Database IDs:

Sequence Information:

Length: 978
Mass: 110064
Checksum: 1FF7FB611BD419A8
Sequence:

MAVLCNRAAF HQDHMGLACY ALIAVVLAVQ VVGLLLPQPR SASEGIWWTV FFIYTIYTLL 
PVRMRAAVLS GVLLSALHLA IALRTNAQDQ FLLKQLVSNV LIFSCTNIVG VCTHYPAEVS 
QRQAFQETRE CIQARLHSQR ENQQQERLLL SVLPRHVAME MKADINAKQE DMMFHKIYIQ 
KHDNVSILFA DIEGFTSLAS QCTAQELVMT LNELFARFDK LAAENHCLRI KILGDCYYCV 
SGLPEARADH AHCCVEMGMD MIEAISLVRE VTGVNVNMRV GIHSGRVHCG VLGLRKWQFD 
VWSNDVTLAN HMEAGGKAGR IHITKATLNY LNGDYEVEPG CGGERNAYLK EHSIETFLIL 
RCTQKRKEEK AMIAKMNRQR TNSIGHNPPH WGAERPFYNH LGGNQVSKEM KRMGFEDPKD 
KNAQESANPE DEVDEFLGRA IDARSIDRLR SEHVRKFLLT FREPDLEKKY SKQVDDRFGA 
YVACASLVFL FICFVQITIV PHSIFMLSFY LTCSLLLTLV VFVSVIYSCV KLFPSPLQTL 
SRKIVRSKMN STLVGVFTIT LVFLAAFVNM FTCNSRDLLG CLAQEHNISA SQVNACHVAE 
SAVNYSLGDE QGFCGSPWPN CNFPEYFTYS VLLSLLACSV FLQISCIGKL VLMLAIELIY 
VLIVEVPGVT LFDNADLLVT ANAIDFFNNG TSQCPEHATK VALKVVTPII ISVFVLALYL 
HAQQVESTAR LDFLWKLQAT EEKEEMEELQ AYNRRLLHNI LPKDVAAHFL ARERRNDELY 
YQSCECVAVM FASIANFSEF YVELEANNEG VECLRLLNEI IADFDEIISE DRFRQLEKIK 
TIGSTYMAAS GLNDSTYDKV GKTHIKALAD FAMKLMDQMK YINEHSFNNF QMKIGLNIGP 
VVAGVIGARK PQYDIWGNTV NVASRMDSTG VPDRIQVTTD MYQVLAANTY QLECRGVVKV 
KGKGEMMTYF LNGGPPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCY5

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. PubMed ID: 12503609

Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. PubMed ID: 10481931

Raf kinase activation of adenylyl cyclases: isoform-selective regulation. PubMed ID: 15385642

ADCY5 couples glucose to insulin secretion in human islets. PubMed ID: 24740569

Adenylyl cyclase 5 regulation by Gbetagamma involves isoform specific use of multiple interaction sites. PubMed ID: 26206488

Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5. PubMed ID: 22782511

Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia. PubMed ID: 24700542

ADCY5 mutations are another cause of benign hereditary chorea. PubMed ID: 26085604

Autosomal recessive inheritance of ADCY5-related generalized dystonia and myoclonus. PubMed ID: 28971144

Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders. PubMed ID: 30975617

Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability. PubMed ID: 33704598

A Novel Homozygous ADCY5 Variant is Associated with a Neurodevelopmental Disorder and Movement Abnormalities. PubMed ID: 34631954

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

Database document:

PubMed ID: 14702039

PubMed ID: 16641997

PubMed ID: 12503609

PubMed ID: 10481931

PubMed ID: 15385642

PubMed ID: 24740569

PubMed ID: 26206488

PubMed ID: 22782511

PubMed ID: 24700542

PubMed ID: 26085604

PubMed ID: 28971144

PubMed ID: 30975617

PubMed ID: 33704598

PubMed ID: 34631954

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16641997