PRDM5 | ENSG00000138738 | NCBI 11107

Details for: PRDM5

Gene ID: 11107

Symbol: PRDM5

Ensembl ID: ENSG00000138738

Description: PR/SET domain 5

Associated with

Cellular response to leukemia inhibitory factor
(GO:1990830)
Chromatin organization
(GO:0006325)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Metal ion binding
(GO:0046872)
Methylation
(GO:0032259)
Methyltransferase activity
(GO:0008168)
Mitotic cell cycle
(GO:0000278)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of extracellular matrix organization
(GO:1903053)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

PR domain zinc finger protein 5

Genular Protein ID: 376145387

Symbol: PRDM5_HUMAN

Name: PR domain zinc finger protein 5

UniProtKB Accession Codes:

Q9NQX1 Q0VAI9 Q0VAJ0 Q6NXQ7

Database IDs:

Citations:

PubMed ID: 15077163

Title: PRDM5 is silenced in human cancers and has growth suppressive activities.

PubMed ID: 15077163

DOI: 10.1038/sj.onc.1207615

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17699856

Title: PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer.

PubMed ID: 17699856

DOI: 10.1158/1078-0432.ccr-07-0305

PubMed ID: 17636019

Title: Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.

PubMed ID: 17636019

DOI: 10.1128/mcb.00762-07

PubMed ID: 21664999

Title: Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance.

PubMed ID: 21664999

DOI: 10.1016/j.ajhg.2011.05.007

Sequence Information:

Length: 630
Mass: 73090
Checksum: D16AF81AB5A34398
Sequence:

MLGMYVPDRF SLKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE NMDYRLMWEV 
RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QEQKNLAAIQ EGENIFYLAV EDIETDTELL 
IGYLDSDMEA EEEEQQIMTV IKEGEVENSR RQSTAGRKDR LGCKEDYACP QCESSFTSED 
ILAEHLQTLH QKPTEEKEFK CKNCGKKFPV KQALQRHVLQ CTAKSSLKES SRSFQCSVCN 
SSFSSASSFE QHQETCRGDA RFVCKADSCG KRLKSKDALK RHQENVHTGD PKKKLICSVC 
NKKCSSASSL QEHRKIHEIF DCQECMKKFI SANQLKRHMI THSEKRPYNC EICNKSFKRL 
DQVGAHKVIH SEDKPYKCKL CGKGFAHRNV YKNHKKTHSE ERPFQCEECK ALFRTPFSLQ 
RHLLIHNSER TFKCHHCDAT FKRKDTLNVH VQVVHERHKK YRCELCNKAF VTPSVLRSHK 
KTHTGEKEKI CPYCGQKFAS SGTLRVHIRS HTGERPYQCP YCEKGFSKND GLKMHIRTHT 
REKPYKCSEC SKAFSQKRGL DEHKRTHTGE KPFQCDVCDL AFSLKKMLIR HKMTHNPNRP 
LAECQFCHKK FTRNDYLKVH MDNIHGVADS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRDM5

Associated with

Other Information

PRDM5 is silenced in human cancers and has growth suppressive activities. PubMed ID: 15077163

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. PubMed ID: 17699856

Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5. PubMed ID: 17636019

Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance. PubMed ID: 21664999