Details for: CHEK1

Gene ID: 1111

Symbol: CHEK1

Ensembl ID: ENSG00000149554

Description: checkpoint kinase 1

Associated with

Other Information

Genular Protein ID: 3975886239

Symbol: CHK1_HUMAN

Name: Serine/threonine-protein kinase Chk1

UniProtKB Accession Codes:

O14757 A8K934 B4DDD0 B4DSK3 B5BTY6 F5H7S4 H2BI51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 4 CPTC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 38 DrugCentral 1 EC 2 ELM 1 EMBL 14 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 6 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9278511

Title: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

PubMed ID: 9278511

DOI: 10.1126/science.277.5331.1497

PubMed ID: 9382850

Title: Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.

PubMed ID: 9382850

DOI: 10.1016/s0960-9822(06)00417-9

PubMed ID: 10717241

Title: Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.

PubMed ID: 10717241

DOI: 10.3892/ijo.16.4.731

PubMed ID: 22184239

Title: Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.

PubMed ID: 22184239

DOI: 10.1073/pnas.1104767109

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10673501

Title: The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

PubMed ID: 10673501

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 11535615

Title: Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.

PubMed ID: 11535615

DOI: 10.1083/jcb.200104099

PubMed ID: 11390642

Title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.

PubMed ID: 11390642

DOI: 10.1128/mcb.21.13.4129-4139.2001

PubMed ID: 11821419

Title: Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

PubMed ID: 11821419

DOI: 10.1074/jbc.m111705200

PubMed ID: 12446774

Title: An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.

PubMed ID: 12446774

DOI: 10.1128/mcb.22.24.8552-8561.2002

PubMed ID: 11836499

Title: BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

PubMed ID: 11836499

DOI: 10.1038/ng837

PubMed ID: 12399544

Title: Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

PubMed ID: 12399544

DOI: 10.1073/pnas.182557299

PubMed ID: 12676583

Title: Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

PubMed ID: 12676583

DOI: 10.1016/s1535-6108(03)00048-5

PubMed ID: 12660173

Title: Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

PubMed ID: 12660173

DOI: 10.1093/emboj/cdg151

PubMed ID: 14681206

Title: SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

PubMed ID: 14681206

DOI: 10.1101/gad.1157503

PubMed ID: 12588868

Title: Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on ser-317 in response to ionizing radiation.

PubMed ID: 12588868

DOI: 10.1074/jbc.m210862200

PubMed ID: 12676925

Title: Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

PubMed ID: 12676925

DOI: 10.1074/jbc.m300229200

PubMed ID: 12676962

Title: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on ser-345.

PubMed ID: 12676962

DOI: 10.1074/jbc.m300070200

PubMed ID: 12759351

Title: Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.

PubMed ID: 12759351

DOI: 10.1074/jbc.m302704200

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 14559997

Title: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

PubMed ID: 14559997

DOI: 10.1128/mcb.23.21.7488-7497.2003

PubMed ID: 12955071

Title: Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

PubMed ID: 12955071

DOI: 10.1038/sj.onc.1206691

PubMed ID: 14657349

Title: MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

PubMed ID: 14657349

DOI: 10.1073/pnas.2536810100

PubMed ID: 14988723

Title: The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.

PubMed ID: 14988723

DOI: 10.1038/sj.emboj.7600113

PubMed ID: 14681223

Title: Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.

PubMed ID: 14681223

DOI: 10.1074/jbc.m312215200

PubMed ID: 15311285

Title: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

PubMed ID: 15311285

DOI: 10.1038/ncb1165

PubMed ID: 15707391

Title: DNA-dependent phosphorylation of Chk1 and claspin in a human cell-free system.

PubMed ID: 15707391

DOI: 10.1042/bj20041966

PubMed ID: 15710331

Title: Lack of PTEN sequesters CHK1 and initiates genetic instability.

PubMed ID: 15710331

DOI: 10.1016/j.ccr.2005.01.009

PubMed ID: 15870257

Title: PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

PubMed ID: 15870257

DOI: 10.1101/gad.1291305

PubMed ID: 15659650

Title: p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

PubMed ID: 15659650

DOI: 10.1091/mbc.e04-08-0689

PubMed ID: 15798197

Title: Coupling of human circadian and cell cycles by the timeless protein.

PubMed ID: 15798197

DOI: 10.1128/mcb.25.8.3109-3116.2005

PubMed ID: 15665856

Title: The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

PubMed ID: 15665856

DOI: 10.1038/ncb1212

PubMed ID: 15650047

Title: DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.

PubMed ID: 15650047

DOI: 10.1073/pnas.0409130102

PubMed ID: 16511572

Title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

PubMed ID: 16511572

DOI: 10.1038/sj.emboj.7601010

PubMed ID: 16963448

Title: Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.

PubMed ID: 16963448

DOI: 10.1074/jbc.m604373200

PubMed ID: 17380128

Title: Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

PubMed ID: 17380128

DOI: 10.1038/sj.emboj.7601652

PubMed ID: 17296736

Title: Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.

PubMed ID: 17296736

DOI: 10.1128/mcb.02357-06

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18510930

Title: Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

PubMed ID: 18510930

DOI: 10.1016/j.cell.2008.03.037

PubMed ID: 18728393

Title: Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

PubMed ID: 18728393

DOI: 10.4161/cc.7.17.6551

PubMed ID: 18451105

Title: Chk1 and Claspin potentiate PCNA ubiquitination.

PubMed ID: 18451105

DOI: 10.1101/gad.1632808

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18317453

Title: The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.

PubMed ID: 18317453

DOI: 10.1038/onc.2008.17

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19223857

Title: Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.

PubMed ID: 19223857

DOI: 10.1038/cr.2009.14

PubMed ID: 19716789

Title: The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

PubMed ID: 19716789

DOI: 10.1016/j.molcel.2009.06.030

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19734889

Title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

PubMed ID: 19734889

DOI: 10.1038/ncb1969

PubMed ID: 19330022

Title: Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

PubMed ID: 19330022

DOI: 10.1038/onc.2009.58

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20090422

Title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.

PubMed ID: 20090422

DOI: 10.4161/cc.9.3.10513

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31316063

Title: SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

PubMed ID: 31316063

DOI: 10.1038/s41467-019-11095-y

PubMed ID: 33108758

Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

PubMed ID: 33108758

DOI: 10.1016/j.molcel.2020.10.008

PubMed ID: 32357935

Title: Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation.

PubMed ID: 32357935

DOI: 10.1186/s13045-020-00869-3

PubMed ID: 10761933

Title: The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.

PubMed ID: 10761933

DOI: 10.1016/s0092-8674(00)80704-7

PubMed ID: 12244092

Title: Structural basis for Chk1 inhibition by UCN-01.

PubMed ID: 12244092

DOI: 10.1074/jbc.m201233200

PubMed ID: 15974586

Title: Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.

PubMed ID: 15974586

DOI: 10.1021/jm049022c

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 476
  • Mass: 54434
  • Checksum: 0ABD0FAB67E60F67
  • Sequence:
    • MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK 
MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY 
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK 
RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 
LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF 
SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL 
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR 
NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK IWLPAT

Genular Protein ID: 3315507261

Symbol: B4DT73_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DT73

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 492
  • Mass: 55474
  • Checksum: A8561CA15618B800
  • Sequence:
    • MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL YGAGARVCGG 
VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG TWCKPWEKVP MEKPDIGMPE 
PDAQRFFHQL MAGVVYLHGI GITHRDIKPE NLLLDERDNL KISDFGLATV FRYNNRERLL 
NKMCGTLPYV APELLKRREF HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK 
KTYLNPWKKI DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 
ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY IDKLVQGISF 
SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL DADKSYQCLK ETCEKLGYQW 
KKSCMNQVTI STTDRRNNKL IFKVNLLEMD DKILVDFRLS KGDGLEFKRH FLKIKGKLID 
IVSSQKVWLP AT

Genular Protein ID: 3957817065

Symbol: E7EPP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPP6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 492
  • Mass: 55518
  • Checksum: 0EF4C429D747EEA2
  • Sequence:
    • MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL YGAGARVCGS 
VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG TWCKPWEKVP MEKPDIGMPE 
PDAQRFFHQL MAGVVYLHGI GITHRDIKPE NLLLDERDNL KISDFGLATV FRYNNRERLL 
NKMCGTLPYV APELLKRREF HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK 
KTYLNPWKKI DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 
ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY IDKLVQGISF 
SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL DADKSYQCLK ETCEKLGYQW 
KKSCMNQVTI STTDRRNNKL IFKVNLLEMD DKILVDFRLS KGDGLEFKRH FLKIKGKLID 
IVSSQKIWLP AT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.