Details for: CHEK1

Gene ID: 1111

Symbol: CHEK1

Ensembl ID: ENSG00000149554

Description: checkpoint kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.0064
    Cell Significance Index: -6.8500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.7160
    Cell Significance Index: -4.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 23.1947
    Cell Significance Index: -9.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.5504
    Cell Significance Index: -8.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.5410
    Cell Significance Index: -10.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.2433
    Cell Significance Index: -8.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.3320
    Cell Significance Index: -9.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4556
    Cell Significance Index: -9.6900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.2515
    Cell Significance Index: 17.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7182
    Cell Significance Index: 169.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5451
    Cell Significance Index: 251.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3929
    Cell Significance Index: 37.2600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.3175
    Cell Significance Index: 0.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.1268
    Cell Significance Index: 28.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0880
    Cell Significance Index: 65.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0737
    Cell Significance Index: 204.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0381
    Cell Significance Index: 58.2500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.0098
    Cell Significance Index: 5.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9412
    Cell Significance Index: -2.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9250
    Cell Significance Index: 100.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6917
    Cell Significance Index: 7.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6417
    Cell Significance Index: 22.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5250
    Cell Significance Index: 61.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4865
    Cell Significance Index: 25.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4727
    Cell Significance Index: 93.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4593
    Cell Significance Index: 53.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4064
    Cell Significance Index: 11.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3979
    Cell Significance Index: 11.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3402
    Cell Significance Index: 7.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3318
    Cell Significance Index: 15.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3017
    Cell Significance Index: 20.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2570
    Cell Significance Index: 232.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2549
    Cell Significance Index: 6.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1835
    Cell Significance Index: 100.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1688
    Cell Significance Index: 74.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1634
    Cell Significance Index: 3.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1624
    Cell Significance Index: 4.0600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1613
    Cell Significance Index: 1.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1553
    Cell Significance Index: 4.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1348
    Cell Significance Index: 2.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1242
    Cell Significance Index: 0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1180
    Cell Significance Index: 23.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1122
    Cell Significance Index: 5.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1032
    Cell Significance Index: 6.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1023
    Cell Significance Index: 1.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0890
    Cell Significance Index: 2.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0739
    Cell Significance Index: 9.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0729
    Cell Significance Index: 1.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0571
    Cell Significance Index: 4.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0466
    Cell Significance Index: 8.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0453
    Cell Significance Index: 16.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0291
    Cell Significance Index: 1.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0134
    Cell Significance Index: 1.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -6.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0176
    Cell Significance Index: -11.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0188
    Cell Significance Index: -5.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0198
    Cell Significance Index: -2.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0210
    Cell Significance Index: -9.5300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0224
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0232
    Cell Significance Index: -2.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0250
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0300
    Cell Significance Index: -1.4000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0345
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0361
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0362
    Cell Significance Index: -6.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0393
    Cell Significance Index: -5.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0407
    Cell Significance Index: -5.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0519
    Cell Significance Index: -10.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0536
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0665
    Cell Significance Index: -4.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0690
    Cell Significance Index: -3.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0723
    Cell Significance Index: -4.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0733
    Cell Significance Index: -4.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0782
    Cell Significance Index: -1.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0796
    Cell Significance Index: -3.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0833
    Cell Significance Index: -2.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0883
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0890
    Cell Significance Index: -9.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0899
    Cell Significance Index: -6.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0919
    Cell Significance Index: -3.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0942
    Cell Significance Index: -1.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1014
    Cell Significance Index: -2.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1047
    Cell Significance Index: -1.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1063
    Cell Significance Index: -7.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1069
    Cell Significance Index: -3.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1081
    Cell Significance Index: -8.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1146
    Cell Significance Index: -0.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1177
    Cell Significance Index: -9.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1220
    Cell Significance Index: -2.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1543
    Cell Significance Index: -3.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1742
    Cell Significance Index: -5.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHEK1 is characterized by its ability to phosphorylate and activate various target proteins, including cyclin-dependent kinases (CDKs), checkpoint proteins, and transcription factors. It is also involved in the regulation of chromatin remodeling, histone modifications, and DNA repair processes. CHEK1 has been shown to interact with various proteins, including ATM, ATR, and p53, to regulate cellular responses to DNA damage. **Pathways and Functions** CHEK1 is involved in several key pathways, including: 1. **DNA damage response**: CHEK1 is activated in response to DNA double-strand breaks, leading to the activation of downstream signaling pathways that regulate DNA repair, cell cycle arrest, and apoptosis. 2. **Cell cycle regulation**: CHEK1 regulates cell cycle progression by phosphorylating and activating CDKs, which in turn regulate the G1/S and G2/M transitions. 3. **Apoptosis regulation**: CHEK1 is involved in the regulation of apoptosis by phosphorylating and activating pro-apoptotic proteins, such as BAX and BAK. 4. **Chromatin remodeling**: CHEK1 regulates chromatin remodeling by phosphorylating and activating histone-modifying enzymes, such as histone H3t11 kinase. 5. **DNA repair**: CHEK1 regulates DNA repair processes, including homologous recombination repair (HRR) and single-strand annealing (SSA). **Clinical Significance** CHEK1 has been implicated in various diseases, including: 1. **Cancer**: CHEK1 is often overexpressed in cancer cells, leading to increased cell proliferation, survival, and resistance to chemotherapy. 2. **Neurodegenerative diseases**: CHEK1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of apoptosis and DNA repair. 3. **Genetic disorders**: CHEK1 has been associated with genetic disorders, such as Fanconi anemia and Bloom syndrome, where it is involved in the regulation of DNA repair and cell cycle progression. 4. **Infectious diseases**: CHEK1 has been implicated in the regulation of immune responses to infections, where it is involved in the activation of immune cells and the regulation of cytokine production. In conclusion, CHEK1 is a crucial gene involved in the regulation of cell cycle, DNA repair, and apoptosis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CHEK1 and its role in human disease.

Genular Protein ID: 3975886239

Symbol: CHK1_HUMAN

Name: Serine/threonine-protein kinase Chk1

UniProtKB Accession Codes:

O14757 A8K934 B4DDD0 B4DSK3 B5BTY6 F5H7S4 H2BI51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 4 CPTC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 38 DrugCentral 1 EC 2 ELM 1 EMBL 14 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 6 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9278511

Title: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

PubMed ID: 9278511

DOI: 10.1126/science.277.5331.1497

PubMed ID: 9382850

Title: Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.

PubMed ID: 9382850

DOI: 10.1016/s0960-9822(06)00417-9

PubMed ID: 10717241

Title: Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.

PubMed ID: 10717241

DOI: 10.3892/ijo.16.4.731

PubMed ID: 22184239

Title: Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.

PubMed ID: 22184239

DOI: 10.1073/pnas.1104767109

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10673501

Title: The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

PubMed ID: 10673501

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 11535615

Title: Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.

PubMed ID: 11535615

DOI: 10.1083/jcb.200104099

PubMed ID: 11390642

Title: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.

PubMed ID: 11390642

DOI: 10.1128/mcb.21.13.4129-4139.2001

PubMed ID: 11821419

Title: Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

PubMed ID: 11821419

DOI: 10.1074/jbc.m111705200

PubMed ID: 12446774

Title: An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.

PubMed ID: 12446774

DOI: 10.1128/mcb.22.24.8552-8561.2002

PubMed ID: 11836499

Title: BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

PubMed ID: 11836499

DOI: 10.1038/ng837

PubMed ID: 12399544

Title: Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

PubMed ID: 12399544

DOI: 10.1073/pnas.182557299

PubMed ID: 12676583

Title: Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

PubMed ID: 12676583

DOI: 10.1016/s1535-6108(03)00048-5

PubMed ID: 12660173

Title: Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

PubMed ID: 12660173

DOI: 10.1093/emboj/cdg151

PubMed ID: 14681206

Title: SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

PubMed ID: 14681206

DOI: 10.1101/gad.1157503

PubMed ID: 12588868

Title: Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on ser-317 in response to ionizing radiation.

PubMed ID: 12588868

DOI: 10.1074/jbc.m210862200

PubMed ID: 12676925

Title: Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

PubMed ID: 12676925

DOI: 10.1074/jbc.m300229200

PubMed ID: 12676962

Title: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on ser-345.

PubMed ID: 12676962

DOI: 10.1074/jbc.m300070200

PubMed ID: 12759351

Title: Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint.

PubMed ID: 12759351

DOI: 10.1074/jbc.m302704200

PubMed ID: 12766152

Title: Human claspin is required for replication checkpoint control.

PubMed ID: 12766152

DOI: 10.1074/jbc.m301136200

PubMed ID: 14559997

Title: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

PubMed ID: 14559997

DOI: 10.1128/mcb.23.21.7488-7497.2003

PubMed ID: 12955071

Title: Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

PubMed ID: 12955071

DOI: 10.1038/sj.onc.1206691

PubMed ID: 14657349

Title: MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.

PubMed ID: 14657349

DOI: 10.1073/pnas.2536810100

PubMed ID: 14988723

Title: The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.

PubMed ID: 14988723

DOI: 10.1038/sj.emboj.7600113

PubMed ID: 14681223

Title: Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.

PubMed ID: 14681223

DOI: 10.1074/jbc.m312215200

PubMed ID: 15311285

Title: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.

PubMed ID: 15311285

DOI: 10.1038/ncb1165

PubMed ID: 15707391

Title: DNA-dependent phosphorylation of Chk1 and claspin in a human cell-free system.

PubMed ID: 15707391

DOI: 10.1042/bj20041966

PubMed ID: 15710331

Title: Lack of PTEN sequesters CHK1 and initiates genetic instability.

PubMed ID: 15710331

DOI: 10.1016/j.ccr.2005.01.009

PubMed ID: 15870257

Title: PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

PubMed ID: 15870257

DOI: 10.1101/gad.1291305

PubMed ID: 15659650

Title: p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

PubMed ID: 15659650

DOI: 10.1091/mbc.e04-08-0689

PubMed ID: 15798197

Title: Coupling of human circadian and cell cycles by the timeless protein.

PubMed ID: 15798197

DOI: 10.1128/mcb.25.8.3109-3116.2005

PubMed ID: 15665856

Title: The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.

PubMed ID: 15665856

DOI: 10.1038/ncb1212

PubMed ID: 15650047

Title: DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.

PubMed ID: 15650047

DOI: 10.1073/pnas.0409130102

PubMed ID: 16511572

Title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

PubMed ID: 16511572

DOI: 10.1038/sj.emboj.7601010

PubMed ID: 16963448

Title: Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function.

PubMed ID: 16963448

DOI: 10.1074/jbc.m604373200

PubMed ID: 17380128

Title: Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

PubMed ID: 17380128

DOI: 10.1038/sj.emboj.7601652

PubMed ID: 17296736

Title: Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway.

PubMed ID: 17296736

DOI: 10.1128/mcb.02357-06

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18510930

Title: Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

PubMed ID: 18510930

DOI: 10.1016/j.cell.2008.03.037

PubMed ID: 18728393

Title: Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

PubMed ID: 18728393

DOI: 10.4161/cc.7.17.6551

PubMed ID: 18451105

Title: Chk1 and Claspin potentiate PCNA ubiquitination.

PubMed ID: 18451105

DOI: 10.1101/gad.1632808

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18317453

Title: The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.

PubMed ID: 18317453

DOI: 10.1038/onc.2008.17

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19223857

Title: Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.

PubMed ID: 19223857

DOI: 10.1038/cr.2009.14

PubMed ID: 19716789

Title: The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

PubMed ID: 19716789

DOI: 10.1016/j.molcel.2009.06.030

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19734889

Title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

PubMed ID: 19734889

DOI: 10.1038/ncb1969

PubMed ID: 19330022

Title: Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.

PubMed ID: 19330022

DOI: 10.1038/onc.2009.58

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20090422

Title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.

PubMed ID: 20090422

DOI: 10.4161/cc.9.3.10513

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25083873

Title: ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

PubMed ID: 25083873

DOI: 10.1016/j.cell.2014.05.046

PubMed ID: 31316063

Title: SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

PubMed ID: 31316063

DOI: 10.1038/s41467-019-11095-y

PubMed ID: 33108758

Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

PubMed ID: 33108758

DOI: 10.1016/j.molcel.2020.10.008

PubMed ID: 32357935

Title: Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation.

PubMed ID: 32357935

DOI: 10.1186/s13045-020-00869-3

PubMed ID: 10761933

Title: The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.

PubMed ID: 10761933

DOI: 10.1016/s0092-8674(00)80704-7

PubMed ID: 12244092

Title: Structural basis for Chk1 inhibition by UCN-01.

PubMed ID: 12244092

DOI: 10.1074/jbc.m201233200

PubMed ID: 15974586

Title: Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.

PubMed ID: 15974586

DOI: 10.1021/jm049022c

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 33953335

Title: Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor.

PubMed ID: 33953335

DOI: 10.1038/s41422-021-00507-8

PubMed ID: 33948904

Title: Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes.

PubMed ID: 33948904

DOI: 10.1007/s13238-021-00844-9

Sequence Information:

  • Length: 476
  • Mass: 54434
  • Checksum: 0ABD0FAB67E60F67
  • Sequence:
    • MAVPFVEDWD LVQTLGEGAY GEVQLAVNRV TEEAVAVKIV DMKRAVDCPE NIKKEICINK 
MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEPDAQRF FHQLMAGVVY 
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRYNNR ERLLNKMCGT LPYVAPELLK 
RREFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 
LLHKILVENP SARITIPDIK KDRWYNKPLK KGAKRPRVTS GGVSESPSGF SKHIQSNLDF 
SPVNSASSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL 
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTISTTDRR 
NNKLIFKVNL LEMDDKILVD FRLSKGDGLE FKRHFLKIKG KLIDIVSSQK IWLPAT

Genular Protein ID: 3957817065

Symbol: E7EPP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPP6

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 3 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 6 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 492
  • Mass: 55518
  • Checksum: 0EF4C429D747EEA2
  • Sequence:
    • MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL YGAGARVCGS 
VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG TWCKPWEKVP MEKPDIGMPE 
PDAQRFFHQL MAGVVYLHGI GITHRDIKPE NLLLDERDNL KISDFGLATV FRYNNRERLL 
NKMCGTLPYV APELLKRREF HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK 
KTYLNPWKKI DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 
ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY IDKLVQGISF 
SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL DADKSYQCLK ETCEKLGYQW 
KKSCMNQVTI STTDRRNNKL IFKVNLLEMD DKILVDFRLS KGDGLEFKRH FLKIKGKLID 
IVSSQKIWLP AT

Genular Protein ID: 3315507261

Symbol: B4DT73_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DT73

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 10 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 4 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 3 Rhea 6 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 492
  • Mass: 55474
  • Checksum: A8561CA15618B800
  • Sequence:
    • MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL YGAGARVCGG 
VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG TWCKPWEKVP MEKPDIGMPE 
PDAQRFFHQL MAGVVYLHGI GITHRDIKPE NLLLDERDNL KISDFGLATV FRYNNRERLL 
NKMCGTLPYV APELLKRREF HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK 
KTYLNPWKKI DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 
ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY IDKLVQGISF 
SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL DADKSYQCLK ETCEKLGYQW 
KKSCMNQVTI STTDRRNNKL IFKVNLLEMD DKILVDFRLS KGDGLEFKRH FLKIKGKLID 
IVSSQKVWLP AT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.