Details for: FOXN3

Gene ID: 1112

Symbol: FOXN3

Ensembl ID: ENSG00000053254

Description: forkhead box N3

Associated with

  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Craniofacial suture morphogenesis
    (GO:0097094)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mitotic g2 dna damage checkpoint signaling
    (GO:0007095)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.8
    Marker Score: 2096
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.93
    Marker Score: 4457
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.69
    Marker Score: 65469
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.48
    Marker Score: 11412
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.45
    Marker Score: 2269
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.35
    Marker Score: 1665
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.17
    Marker Score: 1761.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.05
    Marker Score: 5869
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.05
    Marker Score: 6694.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.02
    Marker Score: 67431.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3
    Marker Score: 3742
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.95
    Marker Score: 2045
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.91
    Marker Score: 62114
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.75
    Marker Score: 14401
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.73
    Marker Score: 996.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.72
    Marker Score: 20495.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.69
    Marker Score: 14431
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.68
    Marker Score: 4885
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.68
    Marker Score: 20563
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.67
    Marker Score: 848
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.67
    Marker Score: 39861
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.63
    Marker Score: 1373
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.62
    Marker Score: 2327
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.61
    Marker Score: 99146
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.59
    Marker Score: 5956
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.58
    Marker Score: 6457
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.57
    Marker Score: 813
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.56
    Marker Score: 10675
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.54
    Marker Score: 10620.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.52
    Marker Score: 1329
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.47
    Marker Score: 2981
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.43
    Marker Score: 2592
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.42
    Marker Score: 1352
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.38
    Marker Score: 1176
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.36
    Marker Score: 10921
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.35
    Marker Score: 676
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.34
    Marker Score: 1135.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.33
    Marker Score: 1391.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.28
    Marker Score: 1236
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.27
    Marker Score: 587.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.26
    Marker Score: 2494
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.24
    Marker Score: 938
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.21
    Marker Score: 2539
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.19
    Marker Score: 8470
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.19
    Marker Score: 1438
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.18
    Marker Score: 3070
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.17
    Marker Score: 2288
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.15
    Marker Score: 2898
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.15
    Marker Score: 772
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.12
    Marker Score: 1834
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.11
    Marker Score: 2015
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.1
    Marker Score: 1180
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.1
    Marker Score: 3056
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.1
    Marker Score: 614
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.07
    Marker Score: 528
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.07
    Marker Score: 19469
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.05
    Marker Score: 69356
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.05
    Marker Score: 32933
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.04
    Marker Score: 40587
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.02
    Marker Score: 1658
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.99
    Marker Score: 7075.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.99
    Marker Score: 2408
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.97
    Marker Score: 3603
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.97
    Marker Score: 1704
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.96
    Marker Score: 120681
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.95
    Marker Score: 71891.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.94
    Marker Score: 726
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.93
    Marker Score: 741
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.92
    Marker Score: 554
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.91
    Marker Score: 2231
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.91
    Marker Score: 2462
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.9
    Marker Score: 1102
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.88
    Marker Score: 812
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17635
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.84
    Marker Score: 7642
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.81
    Marker Score: 3675
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.81
    Marker Score: 15504
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.8
    Marker Score: 1933
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.79
    Marker Score: 779.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.78
    Marker Score: 723
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.78
    Marker Score: 573
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.78
    Marker Score: 407
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.77
    Marker Score: 422
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.75
    Marker Score: 478
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7119
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.75
    Marker Score: 12996
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.73
    Marker Score: 1703
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.73
    Marker Score: 9279
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.72
    Marker Score: 650
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.72
    Marker Score: 1324
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.69
    Marker Score: 536
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.68
    Marker Score: 527
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.68
    Marker Score: 1782.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.67
    Marker Score: 385
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.67
    Marker Score: 10743.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.67
    Marker Score: 518
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.67
    Marker Score: 327
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.66
    Marker Score: 968.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.66
    Marker Score: 1128
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.65
    Marker Score: 1519

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Other Information

**Key characteristics:** * FOXN3 is a transcription factor belonging to the forkhead box (FOX) family of transcription factors. * It is a highly conserved protein with a conserved DNA-binding domain. * FOXN3 is expressed in a variety of cell types, including embryonic stem cells, germ cells, neurons, and cancer cells. * It is a key regulator of gene expression in many cell types. **Pathways and functions:** * FOXN3 is a key regulator of chromatin remodeling and gene expression in embryonic stem cells and germ cells. * It is involved in the regulation of pluripotency, differentiation, and migration. * In adult cells, FOXN3 is expressed in various cell types and is involved in tissue development, differentiation, and apoptosis. * It is a key regulator of cell cycle regulation, proliferation, and survival. * FOXN3 is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in FOXN3 have been linked to a number of human diseases, including cancer, developmental disorders, and autoimmune diseases. * FOXN3 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases. * Understanding the role of FOXN3 in human health and disease is important for the development of new diagnostic and therapeutic strategies. **Additional points:** * FOXN3 is a highly versatile transcription factor that can interact with a wide range of DNA sequences. * It is a target for a number of transcription factors and other regulatory proteins. * FOXN3 is a highly regulated protein that is controlled by a variety of factors, including growth factors, cytokines, and hormones.

Genular Protein ID: 1229105098

Symbol: FOXN3_HUMAN

Name: Forkhead box protein N3

UniProtKB Accession Codes:

O00409 Q96II7 Q9UIE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9154802

Title: Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.

PubMed ID: 9154802

DOI: 10.1128/mcb.17.6.3037

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16102918

Title: CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor.

PubMed ID: 16102918

DOI: 10.1016/j.gene.2005.06.014

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 490
  • Mass: 53835
  • Checksum: EE07975A592C8C01
  • Sequence:
    • MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL 
TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS 
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS 
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF 
KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG 
VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS 
SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK 
RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG 
QKEQKETTKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.