Details for: FOXN3

Gene ID: 1112

Symbol: FOXN3

Ensembl ID: ENSG00000053254

Description: forkhead box N3

Associated with

  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Craniofacial suture morphogenesis
    (GO:0097094)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Mitotic g2 dna damage checkpoint signaling
    (GO:0007095)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 638.0781
    Cell Significance Index: -99.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 371.5453
    Cell Significance Index: -94.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 268.4565
    Cell Significance Index: -110.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 218.1213
    Cell Significance Index: -102.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 196.8458
    Cell Significance Index: -79.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 179.2820
    Cell Significance Index: -92.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 153.4972
    Cell Significance Index: -103.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 84.1064
    Cell Significance Index: -80.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 82.3144
    Cell Significance Index: -101.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.2347
    Cell Significance Index: -91.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 32.7700
    Cell Significance Index: -71.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.6081
    Cell Significance Index: -90.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.0970
    Cell Significance Index: -102.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 5.2153
    Cell Significance Index: 145.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.2029
    Cell Significance Index: 291.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.6337
    Cell Significance Index: 70.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.4988
    Cell Significance Index: 694.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1833
    Cell Significance Index: 1141.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.1245
    Cell Significance Index: 42.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.0641
    Cell Significance Index: 235.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.9617
    Cell Significance Index: 49.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.5844
    Cell Significance Index: 37.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4308
    Cell Significance Index: 168.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3904
    Cell Significance Index: 479.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.9841
    Cell Significance Index: 42.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8019
    Cell Significance Index: 1246.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.6050
    Cell Significance Index: 20.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1194
    Cell Significance Index: 201.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.0538
    Cell Significance Index: 7.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0449
    Cell Significance Index: 26.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9751
    Cell Significance Index: 16.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8923
    Cell Significance Index: 109.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8358
    Cell Significance Index: 369.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7609
    Cell Significance Index: 45.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7243
    Cell Significance Index: 48.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5209
    Cell Significance Index: 236.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5068
    Cell Significance Index: 457.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4756
    Cell Significance Index: 6.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4754
    Cell Significance Index: 895.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4580
    Cell Significance Index: 29.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3566
    Cell Significance Index: 10.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2942
    Cell Significance Index: 186.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2019
    Cell Significance Index: 27.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1844
    Cell Significance Index: 9.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1840
    Cell Significance Index: 339.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1832
    Cell Significance Index: 281.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1754
    Cell Significance Index: 4.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1724
    Cell Significance Index: 4.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1574
    Cell Significance Index: 18.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1020
    Cell Significance Index: 19.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0665
    Cell Significance Index: 11.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0516
    Cell Significance Index: 70.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0276
    Cell Significance Index: -2.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0318
    Cell Significance Index: -0.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0541
    Cell Significance Index: -29.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0583
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0732
    Cell Significance Index: -54.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0816
    Cell Significance Index: -59.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0894
    Cell Significance Index: -55.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1185
    Cell Significance Index: -4.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1205
    Cell Significance Index: -91.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1247
    Cell Significance Index: -15.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1447
    Cell Significance Index: -81.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1978
    Cell Significance Index: -2.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1995
    Cell Significance Index: -20.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2270
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3081
    Cell Significance Index: -88.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3137
    Cell Significance Index: -45.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3384
    Cell Significance Index: -71.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3444
    Cell Significance Index: -24.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4079
    Cell Significance Index: -47.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4113
    Cell Significance Index: -19.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4422
    Cell Significance Index: -57.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5300
    Cell Significance Index: -24.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5394
    Cell Significance Index: -28.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6287
    Cell Significance Index: -27.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6877
    Cell Significance Index: -31.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6923
    Cell Significance Index: -79.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7683
    Cell Significance Index: -11.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7722
    Cell Significance Index: -88.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8675
    Cell Significance Index: -21.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8697
    Cell Significance Index: -45.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8958
    Cell Significance Index: -25.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9692
    Cell Significance Index: -36.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0365
    Cell Significance Index: -82.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0777
    Cell Significance Index: -80.3200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.1428
    Cell Significance Index: -15.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1885
    Cell Significance Index: -19.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2249
    Cell Significance Index: -75.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.3288
    Cell Significance Index: -16.5700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.3507
    Cell Significance Index: -11.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.5189
    Cell Significance Index: -19.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5606
    Cell Significance Index: -95.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.6096
    Cell Significance Index: -42.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.6765
    Cell Significance Index: -36.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7007
    Cell Significance Index: -55.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.7517
    Cell Significance Index: -55.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7832
    Cell Significance Index: -112.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.8394
    Cell Significance Index: -54.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.8681
    Cell Significance Index: -23.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXN3 exhibits several key characteristics that distinguish it from other transcription factors: 1. **DNA-binding specificity**: FOXN3 has a high affinity for binding to specific DNA sequences, which allows it to regulate gene expression in a tissue-specific manner. 2. **Transcriptional regulation**: FOXN3 acts as a transcriptional activator or repressor, depending on the context, to regulate the expression of target genes involved in various cellular processes. 3. **Cellular localization**: FOXN3 is primarily localized to the nucleus, where it regulates gene expression and interacts with other transcription factors and chromatin-modifying enzymes. 4. **Homology with other FOX family members**: FOXN3 shares high sequence homology with other FOX family members, including FOXA1, FOXA2, and FOXO1, which suggests that it may interact with these proteins to regulate cellular processes. **Pathways and Functions** FOXN3 is involved in several key pathways and functions, including: 1. **Craniofacial suture morphogenesis**: FOXN3 plays a crucial role in regulating the development and morphogenesis of craniofacial sutures, which are critical for skull development and growth. 2. **DNA damage response**: FOXN3 is involved in the regulation of the mitotic G2 DNA damage checkpoint signaling pathway, which ensures that cells with damaged DNA do not enter mitosis and undergo apoptosis. 3. **Immune responses**: FOXN3 is expressed in immune cells, including microglia and macrophages, where it regulates the expression of genes involved in immune responses and inflammation. 4. **Cellular differentiation**: FOXN3 regulates the expression of genes involved in cellular differentiation, including the development of skeletal muscle and adrenal glands. **Clinical Significance** Dysregulation of FOXN3 has been implicated in various human diseases, including: 1. **Craniosynostosis**: A congenital disorder characterized by premature fusion of craniofacial sutures, which can lead to craniosynostosis. 2. **Immune disorders**: FOXN3 has been implicated in the pathogenesis of immune disorders, including multiple sclerosis and autoimmune diseases. 3. **Cancer**: FOXN3 has been identified as a tumor suppressor gene in several types of cancer, including breast cancer and lung cancer. In conclusion, FOXN3 is a crucial regulator of cellular homeostasis and development, and its dysregulation has significant implications for human health. Further research is needed to elucidate the mechanisms by which FOXN3 regulates cellular processes and to explore its therapeutic potential in the treatment of human diseases.

Genular Protein ID: 1229105098

Symbol: FOXN3_HUMAN

Name: Forkhead box protein N3

UniProtKB Accession Codes:

O00409 Q96II7 Q9UIE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9154802

Title: Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.

PubMed ID: 9154802

DOI: 10.1128/mcb.17.6.3037

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16102918

Title: CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor.

PubMed ID: 16102918

DOI: 10.1016/j.gene.2005.06.014

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 490
  • Mass: 53835
  • Checksum: EE07975A592C8C01
  • Sequence:
    • MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL EEGAMEDEEL 
TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH SDMPYDARQN PNCKPPYSFS 
CLIFMAIEDS PTKRLPVKDI YNWILEHFPY FANAPTGWKN SVRHNLSLNK CFKKVDKERS 
QSIGKGSLWC IDPEYRQNLI QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF 
KRNGALLQDP DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG 
VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP TSDSISSSSS 
SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH SQKEPKDSLG DSGYASQHKK 
RQHFAKARKV PSDTLPLKKR RTEKPPESDD EEMKEAAGSL LHLAGIRSCL NNITNRTAKG 
QKEQKETTKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.