Details for: CD160

Gene ID: 11126

Symbol: CD160

Ensembl ID: ENSG00000117281

Description: CD160 molecule

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Activating mhc class i receptor activity
    (GO:0032397)
  • Adaptive immune response
    (GO:0002250)
  • Angiogenesis
    (GO:0001525)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Extracellular region
    (GO:0005576)
  • Innate immune response
    (GO:0045087)
  • Kinase binding
    (GO:0019900)
  • Mhc class ib receptor activity
    (GO:0032394)
  • Mhc class i protein complex binding
    (GO:0023024)
  • Mhc class i receptor activity
    (GO:0032393)
  • Mucosal immune response
    (GO:0002385)
  • Negative regulation of adaptive immune memory response
    (GO:1905675)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cd4-positive, alpha-beta t cell costimulation
    (GO:1900280)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immune response to tumor cell
    (GO:0002857)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein binding
    (GO:0005515)
  • Side of membrane
    (GO:0098552)
  • Signaling receptor binding
    (GO:0005102)
  • T cell costimulation
    (GO:0031295)

Other Information

Genular Protein ID: 4064947586

Symbol: BY55_HUMAN

Name: CD160 antigen

UniProtKB Accession Codes:

O95971 A0A0B4J2A1 B8PRF2 Q5T2V6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9743336

Title: Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes.

PubMed ID: 9743336

PubMed ID: 19109136

Title: Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.

PubMed ID: 19109136

DOI: 10.4049/jimmunol.182.1.63

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9973372

Title: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.

PubMed ID: 9973372

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12486241

Title: Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity.

PubMed ID: 12486241

DOI: 10.1073/pnas.012681099

PubMed ID: 16809620

Title: Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells.

PubMed ID: 16809620

DOI: 10.1182/blood-2005-12-019919

PubMed ID: 17307798

Title: CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment.

PubMed ID: 17307798

DOI: 10.1093/intimm/dxm005

PubMed ID: 17237375

Title: A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity.

PubMed ID: 17237375

DOI: 10.4049/jimmunol.178.3.1293

PubMed ID: 18193050

Title: CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.

PubMed ID: 18193050

DOI: 10.1038/ni1554

PubMed ID: 23761635

Title: CD160 activation by herpesvirus entry mediator augments inflammatory cytokine production and cytolytic function by NK cells.

PubMed ID: 23761635

DOI: 10.4049/jimmunol.1300894

PubMed ID: 25255144

Title: CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression.

PubMed ID: 25255144

DOI: 10.1371/journal.ppat.1004380

Sequence Information:

  • Length: 181
  • Mass: 19810
  • Checksum: EF0B981ACC7478BD
  • Sequence:
    • MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL 
CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG 
IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.