Details for: CHGA

Gene ID: 1113

Symbol: CHGA

Ensembl ID: ENSG00000100604

Description: chromogranin A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.1156
    Cell Significance Index: 51.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7589
    Cell Significance Index: 960.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.6076
    Cell Significance Index: 183.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5861
    Cell Significance Index: 301.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2830
    Cell Significance Index: 67.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9409
    Cell Significance Index: 849.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5174
    Cell Significance Index: 7.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4989
    Cell Significance Index: 49.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4847
    Cell Significance Index: 78.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4737
    Cell Significance Index: 169.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4730
    Cell Significance Index: 51.4500
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.2600
    Cell Significance Index: 2.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2469
    Cell Significance Index: 14.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2361
    Cell Significance Index: 163.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2050
    Cell Significance Index: 4.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1904
    Cell Significance Index: 13.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1095
    Cell Significance Index: 3.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0973
    Cell Significance Index: 4.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0802
    Cell Significance Index: 1.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0734
    Cell Significance Index: 2.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0719
    Cell Significance Index: 14.4200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0703
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0431
    Cell Significance Index: 4.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0275
    Cell Significance Index: 1.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0144
    Cell Significance Index: 3.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0085
    Cell Significance Index: 6.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0039
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0139
    Cell Significance Index: -26.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0155
    Cell Significance Index: -28.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0185
    Cell Significance Index: -28.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0349
    Cell Significance Index: -26.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0419
    Cell Significance Index: -26.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0478
    Cell Significance Index: -3.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0483
    Cell Significance Index: -9.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0625
    Cell Significance Index: -28.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0638
    Cell Significance Index: -3.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0748
    Cell Significance Index: -21.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0886
    Cell Significance Index: -12.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1388
    Cell Significance Index: -25.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1727
    Cell Significance Index: -5.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1835
    Cell Significance Index: -26.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2032
    Cell Significance Index: -24.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2180
    Cell Significance Index: -25.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2336
    Cell Significance Index: -30.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2535
    Cell Significance Index: -26.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2686
    Cell Significance Index: -27.4400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3069
    Cell Significance Index: -3.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3333
    Cell Significance Index: -25.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3367
    Cell Significance Index: -11.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3656
    Cell Significance Index: -8.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3757
    Cell Significance Index: -21.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3779
    Cell Significance Index: -8.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3901
    Cell Significance Index: -3.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4056
    Cell Significance Index: -30.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4082
    Cell Significance Index: -13.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4534
    Cell Significance Index: -4.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4590
    Cell Significance Index: -16.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4600
    Cell Significance Index: -4.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4748
    Cell Significance Index: -11.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4880
    Cell Significance Index: -25.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4951
    Cell Significance Index: -23.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5005
    Cell Significance Index: -22.1400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5420
    Cell Significance Index: -7.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5502
    Cell Significance Index: -11.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5746
    Cell Significance Index: -21.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5849
    Cell Significance Index: -14.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5955
    Cell Significance Index: -6.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6089
    Cell Significance Index: -9.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6112
    Cell Significance Index: -6.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6119
    Cell Significance Index: -12.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6332
    Cell Significance Index: -13.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6494
    Cell Significance Index: -17.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6605
    Cell Significance Index: -13.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6730
    Cell Significance Index: -24.7100
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.6807
    Cell Significance Index: -6.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6847
    Cell Significance Index: -9.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7086
    Cell Significance Index: -14.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7274
    Cell Significance Index: -15.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7583
    Cell Significance Index: -39.3900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.7592
    Cell Significance Index: -5.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7666
    Cell Significance Index: -5.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7676
    Cell Significance Index: -35.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7721
    Cell Significance Index: -26.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7906
    Cell Significance Index: -19.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8129
    Cell Significance Index: -13.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8504
    Cell Significance Index: -17.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8777
    Cell Significance Index: -23.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8922
    Cell Significance Index: -25.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9189
    Cell Significance Index: -27.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9204
    Cell Significance Index: -24.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9276
    Cell Significance Index: -11.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9454
    Cell Significance Index: -11.2700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.9539
    Cell Significance Index: -10.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9596
    Cell Significance Index: -23.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHGA is a 35-kDa protein that belongs to the chromogranin family, which is widely expressed in secretory cells, including neurons, endocrine cells, and chromaffin cells. It is composed of 292 amino acids and exhibits a high degree of sequence homology with other chromogranins. CHGA is primarily localized to the secretory granules of chromaffin cells, where it regulates the release of catecholamines, such as dopamine, noradrenaline, and adrenaline. **Pathways and Functions:** CHGA is involved in various signaling pathways, including: 1. **Adenylate cyclase-activating adrenergic receptor signaling pathway:** CHGA regulates the activity of adenylate cyclase, an enzyme that converts ATP into cyclic AMP (cAMP), a key second messenger in cellular signaling. 2. **Negative regulation of catecholamine secretion:** CHGA inhibits the release of catecholamines from chromaffin cells, thereby regulating the amount of these neurotransmitters in the synaptic cleft. 3. **Positive regulation of cardiac muscle contraction:** CHGA stimulates the contraction of cardiac muscle cells by activating the phospholipase C (PLC) pathway, which leads to an increase in intracellular calcium levels. 4. **Regulation of blood pressure:** CHGA modulates blood pressure by regulating the release of vasoactive peptides, such as noradrenaline, which constrict blood vessels. CHGA also plays a role in immune response, where it: 1. **Regulates the defense response to microorganisms:** CHGA is involved in the production of antimicrobial peptides and the regulation of immune cell activation. 2. **Inhibits mast cell degranulation:** CHGA prevents the release of histamine and other mediators from mast cells, thereby regulating allergic responses. **Clinical Significance:** Dysregulation of CHGA expression has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Altered CHGA expression has been observed in neurodegenerative diseases, such as Parkinson's disease and multiple system atrophy. 2. **Cardiovascular diseases:** CHGA dysfunction has been linked to cardiovascular disorders, including hypertension and cardiac arrhythmias. 3. **Allergic diseases:** Abnormal CHGA expression has been associated with allergic responses and asthma. In conclusion, CHGA is a multifunctional protein that plays a crucial role in various physiological processes, including immune response, cellular regulation, and neurotransmission. Its dysregulation has been implicated in various diseases, highlighting the importance of CHGA in maintaining normal physiological function and preventing disease.

Genular Protein ID: 2056518800

Symbol: CMGA_HUMAN

Name: Chromogranin-A

UniProtKB Accession Codes:

P10645 B2R9E9 Q53FA8 Q6NR84 Q96E84 Q96GL7 Q9BQB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2445752

Title: The primary structure of human chromogranin A and pancreastatin.

PubMed ID: 2445752

DOI: 10.1016/s0021-9258(18)45486-5

PubMed ID: 3403545

Title: Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA.

PubMed ID: 3403545

DOI: 10.1016/s0021-9258(18)37995-x

PubMed ID: 8120054

Title: Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression.

PubMed ID: 8120054

DOI: 10.1016/s0021-9258(17)37462-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3704195

Title: Chromogranin from normal human adrenal glands: purification by monoclonal antibody affinity chromatography and partial N-terminal amino acid sequence.

PubMed ID: 3704195

DOI: 10.1016/0167-0115(86)90040-6

PubMed ID: 2165909

Title: Isolation and characterization of a tumor-derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48.

PubMed ID: 2165909

DOI: 10.1111/j.1432-1033.1990.tb19090.x

PubMed ID: 2830133

Title: Isolation of human pancreastatin fragment containing the active sequence from a glucagonoma.

PubMed ID: 2830133

DOI: 10.1016/0014-5793(88)80606-9

PubMed ID: 1577173

Title: Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour.

PubMed ID: 1577173

DOI: 10.1016/0014-5793(92)80266-j

PubMed ID: 12442257

Title: The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.

PubMed ID: 12442257

DOI: 10.1002/1615-9861(200211)2:11<1586::aid-prot1586>3.0.co;2-k

PubMed ID: 7535395

Title: Molecular characterization of immunoreactivities of peptides derived from chromogranin A (GE-25) and from secretogranin II (secretoneurin) in human and bovine cerebrospinal fluid.

PubMed ID: 7535395

DOI: 10.1016/0306-4522(94)90582-7

PubMed ID: 9852066

Title: Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors.

PubMed ID: 9852066

DOI: 10.1074/jbc.273.51.34087

PubMed ID: 10781584

Title: Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules.

PubMed ID: 10781584

DOI: 10.1074/jbc.m001232200

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 15723172

Title: New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A.

PubMed ID: 15723172

DOI: 10.1007/s00018-004-4461-9

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 18541522

Title: Catestatin is a novel endogenous peptide that regulates cardiac function and blood pressure.

PubMed ID: 18541522

DOI: 10.1093/cvr/cvn155

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20116404

Title: Catestatin: a multifunctional peptide from chromogranin A.

PubMed ID: 20116404

DOI: 10.1016/j.regpep.2010.01.006

PubMed ID: 21214543

Title: Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.

PubMed ID: 21214543

DOI: 10.1111/j.1365-2567.2010.03395.x

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24723458

Title: Antioxidant properties of a human neuropeptide and its protective effect on free radical-induced DNA damage.

PubMed ID: 24723458

DOI: 10.1002/psc.2634

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 14759560

Title: Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A.

PubMed ID: 14759560

DOI: 10.1016/j.regpep.2003.10.035

PubMed ID: 14740315

Title: Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology.

PubMed ID: 14740315

DOI: 10.1086/381399

PubMed ID: 15326220

Title: The catecholamine release-inhibitory 'catestatin' fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses.

PubMed ID: 15326220

DOI: 10.1124/mol.104.002139

PubMed ID: 17438154

Title: Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.

PubMed ID: 17438154

DOI: 10.1161/circulationaha.106.628859

PubMed ID: 17991725

Title: Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin.

PubMed ID: 17991725

DOI: 10.1210/en.2007-0838

Sequence Information:

  • Length: 457
  • Mass: 50688
  • Checksum: 2F634E1A83FF0BB1
  • Sequence:
    • MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM PVSQECFETL 
RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF EDELSEVLEN QSSQAELKEA 
VEEPSSKDVM EKREDSKEAE KSGEATDGAR PQALPEPMQE SKAEGNNQAP GEEEEEEEEA 
TNTHPPASLP SQKYPGPQAE GDSEGLSQGL VDREKGLSAE PGWQAKREEE EEEEEEAEAG 
EEAVPEEEGP TVVLNPHPSL GYKEIRKGES RSEALAVDGA GKPGAEEAQD PEGKGEQEHS 
QQKEEEEEMA VVPQGLFRGG KSGELEQEEE RLSKEWEDSK RWSKMDQLAK ELTAEKRLEG 
QEEEEDNRDS SMKLSFRARA YGFRGPGPQL RRGWRPSSRE DSLEAGLPLQ VRGYPEEKKE 
EEGSANRRPE DQELESLSAI EAELEKVAHQ LQALRRG

Genular Protein ID: 1957959593

Symbol: Q86T07_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86T07

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 367
  • Mass: 40456
  • Checksum: 86024ED83D2EF724
  • Sequence:
    • EPRAGELAGG STDRRTHAEA LRPQPRAGAT AARPRPPVQP PLARCLGARP HTASCSAPGS 
AMRSAAVLAL LLCAGQVTAL PVNSPMNKGD TEVMKCIVEV ISDTLSKPSP MPVSQECFET 
LRGDERILSI LRHQNLLKEL QDLALQGAKE RAHQQKKHSG FEDELSEVLE NQSSQAELKG 
RSEALAVDGA GKPGAEEAQD PEGKGEQEHS QQKEEEEEMA VVPQGLFRGG KSGELEQEEE 
RLSKEWEDSK RWSKMDQLAK ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL 
RRGWRPSSRE DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ 
LQALRRG

Genular Protein ID: 3531950971

Symbol: G5E968_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E968

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 306
  • Mass: 34269
  • Checksum: C3B1FE96C770678D
  • Sequence:
    • MRSAAVLALL LCAGQVTALP VNSPMNKGDT EVMKCIVEVI SDTLSKPSPM PVSQECFETL 
RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF EDELSEVLEN QSSQAELKGR 
SEALAVDGAG KPGAEEAQDP EGKGEQEHSQ QKEEEEEMAV VPQGLFRGGK SGELEQEEER 
LSKEWEDSKR WSKMDQLAKE LTAEKRLEGQ EEEEDNRDSS MKLSFRARAY GFRGPGPQLR 
RGWRPSSRED SLEAGLPLQV RGYPEEKKEE EGSANRRPED QELESLSAIE AELEKVAHQL 
QALRRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.