ZWINT | ENSG00000122952 | NCBI 11130

Details for: ZWINT

Gene ID: 11130

Symbol: ZWINT

Ensembl ID: ENSG00000122952

Description: ZW10 interacting kinetochore protein

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cell division
(GO:0051301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Establishment of localization in cell
(GO:0051649)
Homologous chromosome orientation in meiotic metaphase i
(GO:0031619)
Kinetochore
(GO:0000776)
Knl1/spc105 complex
(GO:0180019)
Mitotic sister chromatid segregation
(GO:0000070)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Regulation of meiosis i spindle assembly checkpoint
(GO:1905325)

Other Information

Proteins

ZW10 interactor

Genular Protein ID: 2361660968

Symbol: ZWINT_HUMAN

Name: ZW10 interactor

UniProtKB Accession Codes:

O95229 A6NNV6 Q0D2I3 Q9BWD0

Database IDs:

Citations:

PubMed ID: 10806105

Title: HZwint-1, a novel human kinetochore component that interacts with HZW10.

PubMed ID: 10806105

DOI: 10.1242/jcs.113.11.1939

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15094189

Title: Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.

PubMed ID: 15094189

DOI: 10.1016/j.gene.2004.01.028

PubMed ID: 15485811

Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.

PubMed ID: 15485811

DOI: 10.1074/jbc.m407588200

PubMed ID: 15502821

Title: A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.

PubMed ID: 15502821

DOI: 10.1038/ncb1187

PubMed ID: 15824131

Title: ZW10 links mitotic checkpoint signaling to the structural kinetochore.

PubMed ID: 15824131

DOI: 10.1083/jcb.200411118

PubMed ID: 16732327

Title: Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.

PubMed ID: 16732327

DOI: 10.1038/sj.onc.1209687

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 277
Mass: 31293
Checksum: 3335FBA5731AD0DC
Sequence:

MEAAETEAEA AALEVLAEVA GILEPVGLQE EAELPAKILV EFVVDSQKKD KLLCSQLQVA 
DFLQNILAQE DTAKGLDPLA SEDTSRQKAI AAKEQWKELK ATYREHVEAI KIGLTKALTQ 
MEEAQRKRTQ LREAFEQLQA KKQMAMEKRR AVQNQWQLQQ EKHLQHLAEV SAEVRERKTG 
TQQELDRVFQ KLGNLKQQAE QERDKLQRYQ TFLQLLYTLQ GKLLFPEAEA EAENLPDDKP 
QQPTRPQEQS TGDTMGRDPG VSFKAVGLQP AGDVNLP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZWINT

Associated with

Other Information

HZwint-1, a novel human kinetochore component that interacts with HZW10. PubMed ID: 10806105

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. PubMed ID: 15094189

Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. PubMed ID: 15485811

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. PubMed ID: 15502821

ZW10 links mitotic checkpoint signaling to the structural kinetochore. PubMed ID: 15824131

Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. PubMed ID: 16732327

Initial characterization of the human central proteome. PubMed ID: 21269460