Details for: CHGB

Gene ID: 1114

Symbol: CHGB

Ensembl ID: ENSG00000089199

Description: chromogranin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.2344
    Cell Significance Index: -19.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.0590
    Cell Significance Index: -18.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.1847
    Cell Significance Index: -18.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.2329
    Cell Significance Index: 72.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4772
    Cell Significance Index: -10.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.7076
    Cell Significance Index: 20.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.3872
    Cell Significance Index: 150.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9492
    Cell Significance Index: 131.0700
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.5798
    Cell Significance Index: 16.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4094
    Cell Significance Index: 74.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1560
    Cell Significance Index: 13.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1093
    Cell Significance Index: 31.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9642
    Cell Significance Index: 25.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9058
    Cell Significance Index: 11.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8602
    Cell Significance Index: 776.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8575
    Cell Significance Index: 163.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8499
    Cell Significance Index: 97.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6866
    Cell Significance Index: 42.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6681
    Cell Significance Index: 134.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5095
    Cell Significance Index: 55.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4988
    Cell Significance Index: 81.1200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.4339
    Cell Significance Index: 4.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3803
    Cell Significance Index: 22.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3736
    Cell Significance Index: 9.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3625
    Cell Significance Index: 7.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3402
    Cell Significance Index: 8.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3241
    Cell Significance Index: 116.2400
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.2424
    Cell Significance Index: 2.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2359
    Cell Significance Index: 16.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1611
    Cell Significance Index: 111.3900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1478
    Cell Significance Index: 1.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1100
    Cell Significance Index: 3.1700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1048
    Cell Significance Index: 1.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0905
    Cell Significance Index: 8.9600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0494
    Cell Significance Index: 0.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0477
    Cell Significance Index: 1.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0336
    Cell Significance Index: 7.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0215
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.0194
    Cell Significance Index: 0.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0163
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0138
    Cell Significance Index: 10.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0098
    Cell Significance Index: 1.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0052
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0055
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0093
    Cell Significance Index: -17.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -16.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0149
    Cell Significance Index: -6.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0155
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0315
    Cell Significance Index: -0.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0318
    Cell Significance Index: -17.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0351
    Cell Significance Index: -15.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0488
    Cell Significance Index: -5.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0508
    Cell Significance Index: -14.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0516
    Cell Significance Index: -10.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0557
    Cell Significance Index: -0.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0644
    Cell Significance Index: -8.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0749
    Cell Significance Index: -13.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0785
    Cell Significance Index: -4.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0877
    Cell Significance Index: -1.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0922
    Cell Significance Index: -12.6600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1046
    Cell Significance Index: -1.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1152
    Cell Significance Index: -16.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1169
    Cell Significance Index: -14.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1199
    Cell Significance Index: -3.3500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1215
    Cell Significance Index: -1.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1237
    Cell Significance Index: -5.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1267
    Cell Significance Index: -2.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1446
    Cell Significance Index: -2.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1447
    Cell Significance Index: -18.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1466
    Cell Significance Index: -17.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1605
    Cell Significance Index: -18.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1711
    Cell Significance Index: -17.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1817
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1907
    Cell Significance Index: -19.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1922
    Cell Significance Index: -6.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2059
    Cell Significance Index: -4.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2156
    Cell Significance Index: -7.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2157
    Cell Significance Index: -2.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2220
    Cell Significance Index: -17.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2247
    Cell Significance Index: -17.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2292
    Cell Significance Index: -7.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2333
    Cell Significance Index: -5.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2395
    Cell Significance Index: -2.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2438
    Cell Significance Index: -11.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2500
    Cell Significance Index: -18.6300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2602
    Cell Significance Index: -2.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2801
    Cell Significance Index: -18.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2958
    Cell Significance Index: -15.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3121
    Cell Significance Index: -13.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3250
    Cell Significance Index: -8.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3331
    Cell Significance Index: -7.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3380
    Cell Significance Index: -17.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHGB is a protein-coding gene that belongs to the chromogranin family, which are known for their role in protein secretion and storage in neuroendocrine cells. The gene is highly expressed in cells of the sympathetic and parasympathetic nervous systems, where it is involved in the regulation of hormone secretion and signaling pathways. CHGB is also found in enteroendocrine cells, where it regulates the transport and uptake of IGFs. The gene's expression is tightly regulated, with significant changes observed in various disease states. **Pathways and Functions:** CHGB is involved in several key pathways, including: 1. **Endoplasmic Reticulum Lumen**: CHGB is secreted from the endoplasmic reticulum, where it regulates protein secretion and storage in neuroendocrine cells. 2. **Extracellular Space**: CHGB is involved in the regulation of hormone activity and signaling pathways in the extracellular space. 3. **Hormone Activity**: CHGB regulates the transport and uptake of IGFs, which are involved in cell growth and differentiation. 4. **Metabolism of Proteins**: CHGB is involved in the regulation of protein binding and modification, which is essential for protein function and secretion. 5. **Post-translational Protein Modification**: CHGB regulates post-translational protein phosphorylation, which is a critical mechanism for protein function and signaling. 6. **Protein Binding**: CHGB binds to various proteins, including IGFs and insulin-like growth factor binding proteins (IGFBPs), which regulates their transport and uptake. 7. **Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)**: CHGB regulates the transport and uptake of IGFs by IGFBPs, which is essential for cell growth and differentiation. 8. **Secretory Granule**: CHGB is secreted from the secretory granule, where it regulates protein secretion and storage in neuroendocrine cells. 9. **Signal Transduction**: CHGB is involved in signal transduction pathways, including hormone activity and protein binding. **Clinical Significance:** Dysregulation of CHGB has been implicated in various diseases, including: 1. **Neuroendocrine Disorders**: CHGB dysregulation has been linked to neuroendocrine disorders, such as pheochromocytoma and neuroblastoma. 2. **Cancer**: CHGB overexpression has been observed in various types of cancer, including breast and lung cancer. 3. **Neurological Disorders**: CHGB dysregulation has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Endocrine Disorders**: CHGB dysregulation has been linked to endocrine disorders, such as diabetes and thyroid cancer. In conclusion, CHGB is a multifunctional gene that plays a crucial role in neuroendocrine function and protein secretion. Its dysregulation has significant implications for understanding various diseases, including neuroendocrine disorders, cancer, and neurological disorders. Further research is needed to fully elucidate the role of CHGB in human disease and to develop novel therapeutic strategies for the treatment of CHGB-related disorders.

Genular Protein ID: 386706698

Symbol: SCG1_HUMAN

Name: Secretogranin-1

UniProtKB Accession Codes:

P05060 A8K021 Q59EU9 Q6IBS6 Q9BQV6 Q9UC25 Q9UJA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3608978

Title: The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.

PubMed ID: 3608978

DOI: 10.1002/j.1460-2075.1987.tb02355.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1882087

Title: Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.

PubMed ID: 1882087

DOI: 10.1016/0167-0115(91)90216-4

PubMed ID: 7784254

Title: Identification of a new chromogranin B fragment (314-365) in endocrine tumors.

PubMed ID: 7784254

DOI: 10.1016/0196-9781(94)00176-6

PubMed ID: 3970711

Title: GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.

PubMed ID: 3970711

DOI: 10.1016/0006-291x(85)90648-5

PubMed ID: 3678488

Title: Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues.

PubMed ID: 3678488

DOI: 10.1016/0014-5793(87)80438-6

PubMed ID: 14997482

Title: Identification and characterization of phosphorylated proteins in the human pituitary.

PubMed ID: 14997482

DOI: 10.1002/pmic.200300584

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 677
  • Mass: 78276
  • Checksum: BFDC97F7B21245B3
  • Sequence:
    • MQPTLLLSLL GAVGLAAVNS MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV 
LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT 
EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE 
DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG 
EETGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP 
SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE 
RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR 
GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP 
GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD 
NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ 
YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA 
AMDLELQKIA EKFSQRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.