IL1RAPL1 | ENSG00000169306 | NCBI 11141

Details for: IL1RAPL1

Gene ID: 11141

Symbol: IL1RAPL1

Ensembl ID: ENSG00000169306

Description: interleukin 1 receptor accessory protein like 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-38 signaling
(R-HSA-9007892)
Neuronal system
(R-HSA-112316)
Protein-protein interactions at synapses
(R-HSA-6794362)
Receptor-type tyrosine-protein phosphatases
(R-HSA-388844)
Signaling by interleukins
(R-HSA-449147)
Axon
(GO:0030424)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Glutamatergic synapse
(GO:0098978)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Interleukin-1 binding
(GO:0019966)
Nad+ nucleotidase, cyclic adp-ribose generating
(GO:0061809)
Nadp+ nucleosidase activity
(GO:0050135)
Negative regulation of exocytosis
(GO:0045920)
Neuron differentiation
(GO:0030182)
Plasma membrane
(GO:0005886)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of synapse assembly
(GO:0051965)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane assembly
(GO:0097105)
Protein binding
(GO:0005515)
Regulation of neuron projection development
(GO:0010975)
Regulation of postsynapse organization
(GO:0099175)
Regulation of presynapse assembly
(GO:1905606)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Trans-synaptic signaling by trans-synaptic complex
(GO:0099545)

Other Information

Proteins

Interleukin-1 receptor accessory protein-like 1

Genular Protein ID: 4190789616

Symbol: IRPL1_HUMAN

Name: Interleukin-1 receptor accessory protein-like 1

UniProtKB Accession Codes:

Q9NZN1 A0AVG4 Q9UJ53

Database IDs:

Citations:

PubMed ID: 10471494

Title: A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation.

PubMed ID: 10471494

DOI: 10.1038/12623

PubMed ID: 10757639

Title: Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation.

PubMed ID: 10757639

DOI: 10.1038/sj.ejhg.5200415

PubMed ID: 10882729

Title: Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.

PubMed ID: 10882729

DOI: 10.1074/jbc.m004077200

PubMed ID: 12777533

Title: Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.

PubMed ID: 12777533

DOI: 10.1093/molbev/msg134

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12783849

Title: IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis.

PubMed ID: 12783849

DOI: 10.1093/hmg/ddg147

PubMed ID: 16470793

Title: A truncating mutation in the IL1RAPL1 gene is responsible for X-linked mental retardation in the MRX21 family.

PubMed ID: 16470793

DOI: 10.1002/ajmg.a.31107

PubMed ID: 18801879

Title: Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

PubMed ID: 18801879

DOI: 10.1093/hmg/ddn300

PubMed ID: 15123616

Title: Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

PubMed ID: 15123616

DOI: 10.1074/jbc.m403434200

Sequence Information:

Length: 696
Mass: 79969
Checksum: 9B7A0B503D73CCA9
Sequence:

MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSIDIKK YQVLVGEPVR IKCALFYGYI 
RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI 
RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL 
WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK 
PPKLLYPMES KLTIQETQLG DSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE 
SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYTVEL 
AGGLGAILLL LVCLVTIYKC YKIEIMLFYR NHFGAEELDG DNKDYDAYLS YTKVDPDQWN 
QETGEEERFA LEILPDMLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPN 
YVVRRGWSIF ELETRLRNML VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH 
GPKCNKLNSK FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL 
ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC NIPMTLINGQ 
RPQTKSSREQ NPDEAHTNSA ILPLLPRETS ISSVIW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL1RAPL1

Associated with

Other Information

A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. PubMed ID: 10471494

Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.3-Xp21.3 mental retardation. PubMed ID: 10757639

Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. PubMed ID: 10882729

Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. PubMed ID: 12777533

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. PubMed ID: 12783849

A truncating mutation in the IL1RAPL1 gene is responsible for X-linked mental retardation in the MRX21 family. PubMed ID: 16470793

Mutations in the calcium-related gene IL1RAPL1 are associated with autism. PubMed ID: 18801879

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. PubMed ID: 15123616