Details for: KAT7

Gene ID: 11143

Symbol: KAT7

Ensembl ID: ENSG00000136504

Description: lysine acetyltransferase 7

Associated with

Other Information

Genular Protein ID: 2777629760

Symbol: KAT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10438470

Title: Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.

PubMed ID: 10438470

DOI: 10.1074/jbc.274.33.23027

PubMed ID: 10930412

Title: Androgen receptor interacts with a novel MYST protein, HBO1.

PubMed ID: 10930412

DOI: 10.1074/jbc.m004838200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278932

Title: Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.

PubMed ID: 11278932

DOI: 10.1074/jbc.m011556200

PubMed ID: 16997280

Title: Histone acetyltransferase HBO1 inhibits NF-kappaB activity by coactivator sequestration.

PubMed ID: 16997280

DOI: 10.1016/j.bbrc.2006.09.030

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18832067

Title: HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.

PubMed ID: 18832067

DOI: 10.1101/gad.1674108

PubMed ID: 17954561

Title: Hbo1 Links p53-dependent stress signaling to DNA replication licensing.

PubMed ID: 17954561

DOI: 10.1128/mcb.00662-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18250300

Title: Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.

PubMed ID: 18250300

DOI: 10.1073/pnas.0712063105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19187766

Title: HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

PubMed ID: 19187766

DOI: 10.1016/j.molcel.2009.01.007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20129055

Title: HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.

PubMed ID: 20129055

DOI: 10.1016/j.molcel.2009.12.012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21753189

Title: The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

PubMed ID: 21753189

DOI: 10.1182/blood-2011-01-331892

PubMed ID: 21856198

Title: JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.

PubMed ID: 21856198

DOI: 10.1016/j.molcel.2011.06.021

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24065767

Title: Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

PubMed ID: 24065767

DOI: 10.1101/gad.223396.113

PubMed ID: 23319590

Title: SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation.

PubMed ID: 23319590

DOI: 10.1074/jbc.m112.426882

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27270040

Title: KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation.

PubMed ID: 27270040

DOI: 10.1016/j.devcel.2016.05.006

PubMed ID: 26620551

Title: BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

PubMed ID: 26620551

DOI: 10.15252/embj.201591293

PubMed ID: 26572825

Title: UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation.

PubMed ID: 26572825

DOI: 10.1128/mcb.00809-15

PubMed ID: 28719581

Title: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair.

PubMed ID: 28719581

DOI: 10.1038/ncomms16102

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29382722

Title: The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.

PubMed ID: 29382722

DOI: 10.1074/jbc.ra117.000677

PubMed ID: 31767635

Title: HBO1(KAT7) does not have an essential role in cell proliferation, DNA replication or histone 4 acetylation in human cells.

PubMed ID: 31767635

DOI: 10.1128/mcb.00506-19

PubMed ID: 28334966

Title: Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.

PubMed ID: 28334966

DOI: 10.1093/nar/gkx142

PubMed ID: 31827282

Title: HBO1 is required for the maintenance of leukaemia stem cells.

PubMed ID: 31827282

DOI: 10.1038/s41586-019-1835-6

Sequence Information:

  • Length: 611
  • Mass: 70642
  • Checksum: 8368E7C4F07D8D7C
  • Sequence:
  • MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS QSSQDSSPVR 
    NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS GSETEQVVDF SDRETKNTAD 
    HDESPPRTPT GNAPSSESDI DISSPNVSHD ESIAKDMSLK DSGSDLSHRP KRRRFHESYN 
    FNMKCPTPGC NSLGHLTGKH ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ 
    DDNNRHATRH QAPTERQLRY KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN 
    LTSEYDLDLF RRAQARASED LEKLRLQGQI TEGSNMIKTI AFGRYELDTW YHSPYPEEYA 
    RLGRLYMCEF CLKYMKSQTI LRRHMAKCVW KHPPGDEIYR KGSISVFEVD GKKNKIYCQN 
    LCLLAKLFLD HKTLYYDVEP FLFYVMTEAD NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ 
    YMRQGYGKML IDFSYLLSKV EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS 
    IKEISQETAV NPVDIVSTLQ ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP 
    SCLKWTPPKG T

Genular Protein ID: 1808872548

Symbol: A0A9L9PXR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 531
  • Mass: 61831
  • Checksum: 83B3F5E894B725A0
  • Sequence:
  • MPRRKRNAGS SSDGTEDSDF STDLEHTDSS ESDGTSRRSA RVTRSSARLS QSSQDSSPVR 
    NLQSFGTEEP AYSTRRVTRS QQQPTPVTPK KYPLRQTRSS GSETEQVVDF SDRGHLTGKH 
    ERHFSISGCP LYHNLSADEC KVRAQSRDKQ IEERMLSHRQ DDNNRHATRH QAPTERQLRY 
    KEKVAELRKK RNSGLSKEQK EKYMEHRQTY GNTREPLLEN LTSEYDLDLF RRAQARASED 
    LEKLRLQGQI TEGSNMIKTI AFGRYELDTW YHSPYPEEYA RLGRLYMCEF CLKYMKSQTI 
    LRRHMAKCVW KHPPGDEIYR KGSISVFEVD GKKNKIYCQN LCLLAKLFLD HKTLYYDVEP 
    FLFYVMTEAD NTGCHLIGYF SKEKNSFLNY NVSCILTMPQ YMRQGYGKML IDFSYLLSKV 
    EEKVGSPERP LSDLGLISYR SYWKEVLLRY LHNFQGKEIS IKEISQETAV NPVDIVSTLQ 
    ALQMLKYWKG KHLVLKRQDL IDEWIAKEAK RSNSNKTMDP SCLKWTPPKG T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.