GLMN | ENSG00000174842 | NCBI 11146

Details for: GLMN

Gene ID: 11146

Symbol: GLMN

Ensembl ID: ENSG00000174842

Description: glomulin, FKBP associated protein

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Cell surface receptor signaling pathway
(GO:0007166)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cul3-ring ubiquitin ligase complex
(GO:0031463)
Cul4a-ring e3 ubiquitin ligase complex
(GO:0031464)
Cullin-ring ubiquitin ligase complex
(GO:0031461)
Cytoplasm
(GO:0005737)
Epigenetic regulation of gene expression
(GO:0040029)
Hepatocyte growth factor receptor binding
(GO:0005171)
Muscle cell differentiation
(GO:0042692)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of t cell proliferation
(GO:0042130)
Neural tube closure
(GO:0001843)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of phosphorylation
(GO:0042327)
Protein binding
(GO:0005515)
Regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032434)
Signaling receptor binding
(GO:0005102)
Ubiquitin-protein transferase inhibitor activity
(GO:0055105)
Ubiquitin protein ligase binding
(GO:0031625)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Glomulin
B4DJ85_HUMAN

Genular Protein ID: 1899734519

Symbol: GLMN_HUMAN

Name: Glomulin

UniProtKB Accession Codes:

Q92990 Q5VVC3 Q9BVE8

Database IDs:

Citations:

PubMed ID: 8955134

Title: FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.

PubMed ID: 8955134

DOI: 10.1074/jbc.271.51.32923

PubMed ID: 11571281

Title: Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.

PubMed ID: 11571281

DOI: 10.1074/jbc.m104323200

PubMed ID: 11845407

Title: Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas').

PubMed ID: 11845407

DOI: 10.1086/339492

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12604780

Title: The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.

PubMed ID: 12604780

DOI: 10.1073/pnas.0438007100

PubMed ID: 11164950

Title: Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52.

PubMed ID: 11164950

DOI: 10.1016/s0167-0115(00)00206-8

PubMed ID: 12904573

Title: Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.

PubMed ID: 12904573

DOI: 10.1073/pnas.1733908100

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22405651

Title: The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.

PubMed ID: 22405651

DOI: 10.1016/j.molcel.2012.02.005

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22748924

Title: Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

PubMed ID: 22748924

DOI: 10.1016/j.molcel.2012.05.044

Sequence Information:

Length: 594
Mass: 68208
Checksum: CE19050F1F692378
Sequence:

MAVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ NEKNKVIIKN 
MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK ELLLGLLELI EEPSGKQISQ 
SILLLLQPLQ TVIQKLHNKA YSIGLALSTL WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL 
IEFTKPFVEE VIDNKENSLE NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF 
ASEIIGFLSA IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI 
DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS LLYQYLEIKS 
FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK YTLFRCLLNT SNHSGVEAFI 
IQNIKNQIDM SLKRTRNNKW FTGPQLISLL DLVLFLPEGA ETDLLQNSDR IMASLNLLRY 
LVIKDNENDN QTGLWTELGN IENNFLKPLH IGLNMSKAHY EAEIKNSQEA QKSKDLCSIT 
VSGEEIPNMP PEMQLKVLHS ALFTFDLIES VLARVEELIE IKTKSTSEEN IGIK

Genular Protein ID: 3775026778

Symbol: B4DJ85_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJ85

Database IDs:

Sequence Information:

Length: 580
Mass: 66709
Checksum: 372C74B9F4637568
Sequence:

MAVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ NEKNKVIIKN 
MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK ELLLGLLELI EEPSGKQISQ 
SILLLLQPLQ TVIQKLHNKA YSIGLALSTL WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL 
IEFTKPFVEE VIDNKENSLE NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF 
ASEIIGFLSA IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI 
DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS LLYQYLEIKS 
FLTVPQRKKS LAMLQLYINK LDSQGKYTLF RCLLNTSNHS GVEAFIIQNI KNQIDMSLKR 
TRNNKWFTGP QLISLLDLVL FLPEGAETDL LQNSDRIMAS LNLLRYLVIK DNENDNQTGL 
WTELGNIENN FLKPLHIGLN MSKAHYEAEI KNSQEAQKSK DLCSITVSGE EIPNMPPEMQ 
LKVLHSALFT FDLIESVLAR VEELIEIKTK STSEENIGIK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GLMN

Associated with

Other Information

FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. PubMed ID: 8955134

Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor. PubMed ID: 11571281

Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas'). PubMed ID: 11845407

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. PubMed ID: 12604780

Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52. PubMed ID: 11164950

Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. PubMed ID: 12904573

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. PubMed ID: 22405651

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. PubMed ID: 22748924