Details for: CORO1A

Gene ID: 11151

Symbol: CORO1A

Ensembl ID: ENSG00000102879

Description: coronin 1A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.87
    Marker Score: 48,240
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.49
    Marker Score: 13,094
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.46
    Marker Score: 14,060
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.23
    Marker Score: 11,679
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.08
    Marker Score: 215,711
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.05
    Marker Score: 3,912
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.02
    Marker Score: 46,678
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.96
    Marker Score: 4,396
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.95
    Marker Score: 220,622
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.93
    Marker Score: 6,745
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.8
    Marker Score: 16,311
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.8
    Marker Score: 10,668
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.78
    Marker Score: 2,303
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.73
    Marker Score: 9,099
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.73
    Marker Score: 2,187
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.58
    Marker Score: 5,279
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.54
    Marker Score: 3,328
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.49
    Marker Score: 6,237
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.43
    Marker Score: 6,692
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.35
    Marker Score: 2,431
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.33
    Marker Score: 2,929
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.32
    Marker Score: 1,638
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.29
    Marker Score: 9,762
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.25
    Marker Score: 3,919
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.2
    Marker Score: 1,597
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.2
    Marker Score: 2,058
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 3.19
    Marker Score: 3,837
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.19
    Marker Score: 2,983
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.18
    Marker Score: 1,753
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.17
    Marker Score: 2,664
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.16
    Marker Score: 2,478
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.16
    Marker Score: 2,808
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.1
    Marker Score: 1,595
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.1
    Marker Score: 7,480
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 3.08
    Marker Score: 5,374
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.07
    Marker Score: 2,222
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.07
    Marker Score: 3,022
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 3.02
    Marker Score: 5,917
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3
    Marker Score: 7,482
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.99
    Marker Score: 2,667
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.99
    Marker Score: 19,097
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.94
    Marker Score: 1,692
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.94
    Marker Score: 1,268
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.93
    Marker Score: 4,154
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.87
    Marker Score: 11,766
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.86
    Marker Score: 882
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.86
    Marker Score: 998
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.85
    Marker Score: 1,720
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.85
    Marker Score: 2,157
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.8
    Marker Score: 923
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.78
    Marker Score: 3,833
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.77
    Marker Score: 5,810
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.75
    Marker Score: 2,012
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.72
    Marker Score: 844
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.69
    Marker Score: 952
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.59
    Marker Score: 5,838
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.57
    Marker Score: 1,583
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.55
    Marker Score: 647
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.53
    Marker Score: 2,898
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.52
    Marker Score: 668
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.5
    Marker Score: 1,022
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.41
    Marker Score: 529
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.4
    Marker Score: 2,589
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.39
    Marker Score: 778
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.39
    Marker Score: 1,026
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.37
    Marker Score: 2,623
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.37
    Marker Score: 718
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.33
    Marker Score: 6,035
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.32
    Marker Score: 552
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.31
    Marker Score: 1,531
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.28
    Marker Score: 23,148
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.24
    Marker Score: 516
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.24
    Marker Score: 1,833
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.22
    Marker Score: 1,301
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.2
    Marker Score: 1,211
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2.18
    Marker Score: 1,069
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.15
    Marker Score: 5,852
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.14
    Marker Score: 1,818
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.12
    Marker Score: 2,133
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.12
    Marker Score: 737
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.05
    Marker Score: 1,494
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.04
    Marker Score: 1,692
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.97
    Marker Score: 1,342
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.96
    Marker Score: 1,034
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.91
    Marker Score: 2,541
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.9
    Marker Score: 1,442
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.89
    Marker Score: 3,083
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.89
    Marker Score: 428
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.85
    Marker Score: 2,001
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.83
    Marker Score: 1,615
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.83
    Marker Score: 1,864
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.81
    Marker Score: 1,312
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.79
    Marker Score: 2,321
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.77
    Marker Score: 1,223
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.73
    Marker Score: 1,336
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.7
    Marker Score: 735
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.67
    Marker Score: 6,930
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.65
    Marker Score: 1,796
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.64
    Marker Score: 371
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.62
    Marker Score: 904

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin Cytoskeleton Organization:** CORO1A is a key regulator of actin filament organization and dynamics, which is essential for maintaining cellular morphology and function. 2. **Immune Cell Function:** CORO1A is significantly expressed in various immune cells, including mature T cells, natural killer cells, and monocytes, highlighting its importance in immune cell function. 3. **Regulation of Actin Polymerization:** CORO1A regulates actin polymerization and depolymerization, which is essential for cell migration, phagocytosis, and cytokine production. 4. **Negative Regulation of Actin Nucleation:** CORO1A negatively regulates actin nucleation, which prevents excessive actin polymerization and maintains cellular homeostasis. **Pathways and Functions:** 1. **Actin Cytoskeleton Organization:** CORO1A regulates actin filament organization and dynamics, which is essential for maintaining cellular morphology and function. 2. **Cell Migration:** CORO1A regulates cell migration by modulating actin polymerization and depolymerization. 3. **Phagocytosis:** CORO1A regulates phagocytosis by modulating actin polymerization and depolymerization. 4. **Cytokine Production:** CORO1A regulates cytokine production by modulating actin polymerization and depolymerization. 5. **Immune Cell Homeostasis:** CORO1A regulates immune cell homeostasis by modulating actin polymerization and depolymerization. **Clinical Significance:** 1. **Inflammatory Disorders:** Dysregulation of CORO1A has been implicated in various inflammatory disorders, including autoimmune diseases and cancer. 2. **Immunodeficiency Diseases:** CORO1A plays a crucial role in maintaining immune cell function, and its dysregulation can contribute to immunodeficiency diseases. 3. **Cancer:** CORO1A expression is altered in various types of cancer, suggesting its potential as a biomarker or therapeutic target. 4. **Neurological Disorders:** CORO1A has been implicated in neurological disorders, including Alzheimer's disease and multiple sclerosis. In conclusion, CORO1A is a multifaceted gene involved in actin cytoskeleton organization and immune cell function. Its dysregulation has been implicated in various clinical disorders, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 4196003433

Symbol: COR1A_HUMAN

Name: Coronin-1A

UniProtKB Accession Codes:

P31146 B2RBL1 Q2YD73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7758584

Title: Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif.

PubMed ID: 7758584

DOI: 10.1016/0014-5793(95)00393-n

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 10338208

Title: A coat protein on phagosomes involved in the intracellular survival of mycobacteria.

PubMed ID: 10338208

DOI: 10.1016/s0092-8674(00)80754-0

PubMed ID: 19097825

Title: Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.

PubMed ID: 19097825

DOI: 10.1016/j.clim.2008.11.002

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22016387

Title: GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.

PubMed ID: 22016387

DOI: 10.1074/jbc.m111.222711

PubMed ID: 23100250

Title: Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin.

PubMed ID: 23100250

DOI: 10.1074/jbc.m112.349829

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23522482

Title: Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.

PubMed ID: 23522482

DOI: 10.1016/j.jaci.2013.01.042

Sequence Information:

  • Length: 461
  • Mass: 51026
  • Checksum: DE3FEDA57041515E
  • Sequence:
    • MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL 
VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLMLPL 
REPVVTLEGH TKRVGIVAWH TTAQNVLLSA GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY 
SVDWSRDGGL ICTSCRDKRV RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS 
RMSERQVALW DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE 
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM TVPRKSDLFQ 
EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK SRELRVNRGL DTGRRRAAPE 
ASGTPSSDAV SRLEEEMRKL QATVQELQKR LDRLEETVQA K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.