Details for: WDR45

Gene ID: 11152

Symbol: WDR45

Ensembl ID: ENSG00000196998

Description: WD repeat domain 45

Associated with

Other Information

Genular Protein ID: 2903623469

Symbol: WIPI4_HUMAN

Name: WD repeat domain phosphoinositide-interacting protein 4

UniProtKB Accession Codes:

Q9Y484 A6NGH5 B7WPI2 Q5MNZ5 Q6IBS7 Q6NT94 Q96H03

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15602573

Title: WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

PubMed ID: 15602573

DOI: 10.1038/sj.onc.1208331

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21802374

Title: The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

PubMed ID: 21802374

DOI: 10.1016/j.devcel.2011.06.024

PubMed ID: 23435086

Title: De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood.

PubMed ID: 23435086

DOI: 10.1038/ng.2562

PubMed ID: 28820312

Title: Architecture of the ATG2B-WDR45 complex and an aromatic Y/HF motif crucial for complex formation.

PubMed ID: 28820312

DOI: 10.1080/15548627.2017.1359381

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 31271352

Title: The autophagic membrane tether ATG2A transfers lipids between membranes.

PubMed ID: 31271352

DOI: 10.7554/elife.45777

PubMed ID: 32483132

Title: Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.

PubMed ID: 32483132

DOI: 10.1038/s41467-020-16523-y

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 25592411

Title: Analysis of the C19orf12 and WDR45 genes in patients with neurodegeneration with brain iron accumulation.

PubMed ID: 25592411

DOI: 10.1016/j.jns.2014.12.036

Sequence Information:

  • Length: 360
  • Mass: 39868
  • Checksum: E1A6746277182AF9
  • Sequence:
    • MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS 
NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK 
NRIYVYSFPD NPRKLFEFDT RDNPKGLCDL CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG 
TSSAPFTINA HQSDIACVSL NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL 
YCINFSHDSS FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF 
TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV YLDICDDDDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.