Details for: WDR45

Gene ID: 11152

Symbol: WDR45

Ensembl ID: ENSG00000196998

Description: WD repeat domain 45

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.45
    Marker Score: 2,186
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.91
    Marker Score: 8,257
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.89
    Marker Score: 3,996
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.55
    Marker Score: 1,091
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,483
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.34
    Marker Score: 476
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.31
    Marker Score: 795
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.25
    Marker Score: 2,855
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.24
    Marker Score: 42,101
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2,170
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.22
    Marker Score: 358
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.22
    Marker Score: 16,187
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2
    Marker Score: 1,767
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.17
    Marker Score: 13,212
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.17
    Marker Score: 994
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.16
    Marker Score: 734
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.14
    Marker Score: 4,743
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.13
    Marker Score: 2,951
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.12
    Marker Score: 544
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.11
    Marker Score: 622
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.11
    Marker Score: 11,210
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.08
    Marker Score: 4,183
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.08
    Marker Score: 453
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.06
    Marker Score: 2,001
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.06
    Marker Score: 605
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.05
    Marker Score: 714
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 696
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.04
    Marker Score: 1,103
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.04
    Marker Score: 233
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.02
    Marker Score: 408
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.02
    Marker Score: 2,128
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.02
    Marker Score: 1,633
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.01
    Marker Score: 2,458
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1
    Marker Score: 247
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,644
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,867
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.99
    Marker Score: 663
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.99
    Marker Score: 1,042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,380
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.97
    Marker Score: 1,037
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.97
    Marker Score: 54,293
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.96
    Marker Score: 272
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.95
    Marker Score: 1,264
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.94
    Marker Score: 740
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.94
    Marker Score: 271
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,383
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.93
    Marker Score: 793
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.93
    Marker Score: 2,540
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.93
    Marker Score: 496
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.92
    Marker Score: 212
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.92
    Marker Score: 6,840
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 472
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.91
    Marker Score: 624
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.91
    Marker Score: 1,491
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.91
    Marker Score: 1,246
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.91
    Marker Score: 941
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,708
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9
    Marker Score: 941
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3,170
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.88
    Marker Score: 952
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 810
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.87
    Marker Score: 1,450
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.87
    Marker Score: 303
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.86
    Marker Score: 377
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.86
    Marker Score: 625
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.86
    Marker Score: 7,428
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.86
    Marker Score: 489
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.86
    Marker Score: 289
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.86
    Marker Score: 901
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.85
    Marker Score: 4,086
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.85
    Marker Score: 2,669
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.85
    Marker Score: 8,506
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.84
    Marker Score: 344
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.84
    Marker Score: 215
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.83
    Marker Score: 288
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.83
    Marker Score: 1,326
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.83
    Marker Score: 548
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.83
    Marker Score: 553
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.83
    Marker Score: 9,667
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.83
    Marker Score: 195
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.83
    Marker Score: 457
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.83
    Marker Score: 312
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.83
    Marker Score: 838
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.83
    Marker Score: 1,944
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.82
    Marker Score: 261
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.82
    Marker Score: 4,029
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.82
    Marker Score: 1,187
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4,668
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.82
    Marker Score: 195
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.81
    Marker Score: 474
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.81
    Marker Score: 1,842
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.81
    Marker Score: 259
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.81
    Marker Score: 1,242
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8
    Marker Score: 5,228

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **WD repeat domain structure:** The WDR45 protein contains a conserved WD repeat domain, a structural motif common to many proteins involved in protein-protein interactions and signal transduction. 2. **Phosphoinositide-interacting protein:** WDR45 interacts with phosphoinositides, specifically phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate, which are essential for autophagosome formation and function. 3. **Autophagosome assembly and regulation:** WDR45 is involved in the assembly and regulation of autophagosomes, including the recruitment of autophagy-related proteins and the modulation of autophagy-related gene expression. 4. **Cell type-specific expression:** WDR45 is highly expressed in cells involved in immune responses, such as myeloid dendritic cells and CD14-low, CD16-positive monocytes, highlighting its role in immune homeostasis. **Pathways and Functions:** 1. **Autophagosome assembly:** WDR45 interacts with other autophagy-related proteins to form the phagophore assembly site, a critical structure for autophagosome formation. 2. **Autophagy of mitochondria and peroxisomes:** WDR45 regulates the autophagy of mitochondria and peroxisomes, essential for maintaining cellular energy homeostasis and reducing oxidative stress. 3. **Cellular response to starvation:** WDR45 is involved in the cellular response to starvation, regulating the expression of autophagy-related genes and promoting autophagy to maintain cellular homeostasis. 4. **Glycophagy and macroautophagy:** WDR45 is involved in glycophagy, the degradation of surface-bound proteins, and macroautophagy, the degradation of internal cellular components. **Clinical Significance:** 1. **Cancer:** Dysregulation of autophagy, including the WDR45-mediated pathway, has been implicated in various cancers, including breast, colon, and lung cancer. 2. **Neurodegenerative diseases:** Autophagy dysregulation, including the WDR45-mediated pathway, has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious diseases:** WDR45 is involved in the regulation of autophagy in immune cells, highlighting its importance in the defense against infections. 4. **Regenerative medicine:** Understanding the role of WDR45 in autophagy and cellular homeostasis may provide insights into the development of regenerative therapies for various diseases. In conclusion, the WDR45 gene plays a critical role in autophagy and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which WDR45 regulates autophagy and to explore its therapeutic potential.

Genular Protein ID: 2903623469

Symbol: WIPI4_HUMAN

Name: WD repeat domain phosphoinositide-interacting protein 4

UniProtKB Accession Codes:

Q9Y484 A6NGH5 B7WPI2 Q5MNZ5 Q6IBS7 Q6NT94 Q96H03

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15602573

Title: WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

PubMed ID: 15602573

DOI: 10.1038/sj.onc.1208331

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21802374

Title: The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

PubMed ID: 21802374

DOI: 10.1016/j.devcel.2011.06.024

PubMed ID: 23435086

Title: De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood.

PubMed ID: 23435086

DOI: 10.1038/ng.2562

PubMed ID: 28820312

Title: Architecture of the ATG2B-WDR45 complex and an aromatic Y/HF motif crucial for complex formation.

PubMed ID: 28820312

DOI: 10.1080/15548627.2017.1359381

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 31271352

Title: The autophagic membrane tether ATG2A transfers lipids between membranes.

PubMed ID: 31271352

DOI: 10.7554/elife.45777

PubMed ID: 32483132

Title: Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.

PubMed ID: 32483132

DOI: 10.1038/s41467-020-16523-y

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 25592411

Title: Analysis of the C19orf12 and WDR45 genes in patients with neurodegeneration with brain iron accumulation.

PubMed ID: 25592411

DOI: 10.1016/j.jns.2014.12.036

Sequence Information:

  • Length: 360
  • Mass: 39868
  • Checksum: E1A6746277182AF9
  • Sequence:
    • MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS 
NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK 
NRIYVYSFPD NPRKLFEFDT RDNPKGLCDL CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG 
TSSAPFTINA HQSDIACVSL NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL 
YCINFSHDSS FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF 
TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV YLDICDDDDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.